Abstract:
BACKGROUND:Few published studies are reported for the neurobehavioral toxicity of combined exposure to fungicides in mammals. This study was aimed to re-evaluate the reproductive and neurobehavioral effects of maternal exposure to combined imazalil (IMZ) and thiabendazole (TBZ) with fixed-dose of TBZ in mice. METHODS:IMZ/TBZ were given in the diet to provide levels of 0%/0% (control), 0.0015%/0.018% (IMZ/TBZ), 0.006%/0.018% and 0.024%/0.018% during the gestation and lactation periods. Selected reproductive and neurobehavioral parameters were measured in the F1 generation. RESULTS:No adverse effect of IMZ/TBZ was observed in litter size, litter weight, or sex ratio at birth. Concerning behavioral developmental parameters, the cliff avoidance on PND 7 of male offspring was restrained significantly in the treatment groups in a dose-related manner. Exploratory behavior examination indicated that the average time of rearing significantly lengthened in the high-dose group of male offspring. After weaning, the average time of rearing in exploratory behavior lengthened in a significant dose-related trend in adult females of the F1 generation. Spontaneous behavior examination indicated that the average speed decreased significantly through 120 min in the high-dose group of the F1 -generation males. In females, the average time of rearing lengthened significantly through 120 min in the high-dose group. In the longitudinal patterns, the parallel lines of the control and treatment groups indicated a significant distance in the average time of rearing in the F1 -generation females. CONCLUSIONS:The results from two combined exposure studies of IMZ/TBZ suggest that TBZ concentrations have caused major effects on exploratory and spontaneous behavior.
journal_name
Birth Defects Resjournal_title
Birth defects researchauthors
Tanaka T,Suzuki T,Inomata A,Moriyasu Tdoi
10.1002/bdr2.1793subject
Has Abstractpub_date
2020-12-01 00:00:00pages
1809-1824issue
20issn
2472-1727journal_volume
112pub_type
杂志文章abstract::The World Health Organization currently recommends quinine+clindamycin for use against malaria in the first trimester. This may soon change to recommending artemisinin-based combination therapies (standard duration of dosing = 3 days). The non-artemisinin partner drugs include amodiaquine, lumefantrine, mefloquine, pi...
journal_title:Birth defects research
pub_type: 杂志文章,评审
doi:10.1002/bdr2.1035
更新日期:2017-08-15 00:00:00
abstract:BACKGROUND:Infants of diabetic mothers have been shown in several studies to have an increased frequency of malformations. In previous studies, an increased frequency of several specific malformations has been noted, including anencephaly, bilateral renal agenesis, and double outlet right ventricle. Surveillance, used ...
journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1155
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:There is considerable variability in the prevalence of birth defects among racial/ethnic groups. This study estimated birth defect prevalence among the less studied non-Hispanic (NH) Asian/Pacific Islander (PI) and American Indian/Alaska Native (AI/AN) populations in Texas relative to NH Whites. METHODS:Dat...
journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1543
更新日期:2019-11-01 00:00:00
abstract::OEIS is the acronym of a malformations complex association including omphalocele, exstrophy of bladder or cloaca, imperforate anus, and spinal defects. It has a very low prevalence, ranging from 1/82,000 to 1/200,000 live births (LB). The etiology of OEIS is unknown. Virtually all cases are sporadic, and specific asso...
journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1512
更新日期:2019-07-01 00:00:00
abstract::Neonatal cataracts remain the most common cause of visual loss in children worldwide and have diverse, often unknown, etiologies. This review summarizes current knowledge about the detection, treatment, genetics, risk factors, and molecular mechanisms of congenital cataracts. We emphasize significant progress and topi...
journal_title:Birth defects research
pub_type: 杂志文章,评审
doi:10.1002/bdr2.1050
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:The teratogenic effects of prenatal alcohol exposure (PAE) have been extensively documented over the course of 45 years of research and psychiatric problems are pervasive in this population. In adults with PAE, suicidal risk is high but less is known about the suicidal risk in adolescents with fetal alcohol ...
journal_title:Birth defects research
pub_type: 临床试验,杂志文章
doi:10.1002/bdr2.1465
更新日期:2019-07-15 00:00:00
abstract:BACKGROUND:The acronym VATER/VACTERL refers to the rare nonrandom association of the following component features (CF): vertebral defects (V), anorectal malformations (A), cardiac defects (C), tracheoesophageal fistula with or without esophageal atresia, renal malformations (R), and limb defects (L). Patients presentin...
journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1042
更新日期:2017-07-17 00:00:00
abstract::As a result of human socio-economic activity, industrial wastes have increased alarmingly. Plastic pollution is globally distributed across the world due to its properties of buoyancy and durability. Two broad classes of plastic-related chemicals are of critical concern for human health-bisphenol-A or BPA, and additiv...
journal_title:Birth defects research
pub_type: 杂志文章,评审
doi:10.1002/bdr2.1776
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:The tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine is recommended during pregnancy to protect newborns against pertussis infection in the months prior to their primary pertussis vaccination. Although research on the safety of the vaccine has been reassuring, most previous s...
journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1642
更新日期:2020-03-01 00:00:00
abstract::Over 50% of patients with 22q11.2 deletion syndrome (DS) have a conotruncal or related cardiac defect (CTRD). We hypothesized that similar genetic variants, developmental pathways and biological functions, contribute to disease risk for CTRD in patients without a 22q11.2 deletion (ND-CTRD) and with a 22q11.2 deletion ...
journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1534
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Zika virus has recently emerged as a novel cause of microcephaly. CDC has asked states to rapidly ascertain and report cases of Zika-linked birth defects, including microcephaly. Massachusetts added head circumference to its birth certificate (BC) in 2011. The accuracy of head circumference measurements from...
journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1174
更新日期:2018-03-15 00:00:00
abstract:BACKGROUND:It is estimated that 20 to 30% of infants with birth defects have two or more birth defects. Among these infants with multiple congenital anomalies (MCA), co-occurring anomalies may represent either chance (i.e., unrelated etiologies) or pathogenically associated patterns of anomalies. While some MCA pattern...
journal_title:Birth defects research
pub_type: 杂志文章,评审
doi:10.1002/bdr2.1115
更新日期:2018-01-15 00:00:00
abstract:BACKGROUND:Obstetricians usually prescribe supplements during pregnancy without actual indication. The use of selenium during pregnancy has increased, due to its function in several antioxidant mechanisms. CASE:A pregnant woman received 200,000 micrograms (μg) per day of a selenium galenic formulation, since gestation...
journal_title:Birth defects research
pub_type: 杂志文章,评审
doi:10.1002/bdr2.1148
更新日期:2018-03-01 00:00:00
abstract::Birth defects are the leading cause of infant death in the United States and among the top causes of pediatric death and hospitalization. Despite the devastating impact of birth defects, we understand little of their etiology impeding progress towards treatment and prevention. Moreover, while surgical interventions ha...
journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdra.23590
更新日期:2017-01-30 00:00:00
abstract::The aerodigestive and communicative behaviors of anencephalic and hydranencephalic patients are assessed from literature sources and are compared with documented neural structures present in the brainstem, subcortical, and cortical regions of the brain. Much of the data analyzed corroborate previous neurological studi...
journal_title:Birth defects research
pub_type: 杂志文章,评审
doi:10.1002/bdr2.1424
更新日期:2019-01-15 00:00:00
abstract:BACKGROUND:As a result of human socioeconomic activity, industrial wastes have increased distressingly. Plastic pollution is globally distributed across the world due to its properties of buoyancy and durability. A big health hazard is the sorption of toxicants to plastic while traveling through the environment. Two br...
journal_title:Birth defects research
pub_type: 杂志文章,评审
doi:10.1002/bdr2.1779
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:Strategies for conducting juvenile dose ranging studies before definitive toxicity juvenile animal studies (JAS) have evolved, but the aim of demonstrating study design robustness and efficient animal use remains the same. The objective of dose selection is to identify a strategy to achieve consistent system...
journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1856
更新日期:2020-12-14 00:00:00
abstract:BACKGROUND:This is the first study to utilize the index of concentration at the extremes (ICE) to examine risk factors for spina bifida in Texas. The ICE is a useful measure for providing the degree to which residents in a certain area are concentrated into groups at the extremes of disadvantage and privilege. We intro...
journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1374
更新日期:2019-08-15 00:00:00
abstract:BACKGROUND:Despite the numerous reports on the limb body wall complex (LBWC), this association has never been adequately defined. Amniotic bands (AB) are frequently present but their role remains unclear. Since most reports were based on clinical and often subjective diagnoses, the aim of this work was to define LBWC a...
journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1442
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:During the Zika virus (ZIKV) outbreak, an urgent need existed for strong partnerships to disseminate Zika-related information to pregnant women and women of child-bearing age. METHODS:The Centers for Disease Control and Prevention (CDC) partnered with MotherToBaby, a national organization experienced in pro...
journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1787
更新日期:2020-11-01 00:00:00
abstract::Small animal models, particularly mouse models, of human diseases are becoming an indispensable tool for biomedical research. Studies in animal models have provided important insights into the etiology of diseases and accelerated the development of therapeutic strategies. Detailed phenotypic characterization is essent...
journal_title:Birth defects research
pub_type: 杂志文章,评审
doi:10.1002/bdr2.1051
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Maternal smoking or passive smoking during gestation increases the risk of congenital birth defects, including neural tube defects (NTDs). Cigarette smoke is a recognized teratogen that causes NTDs, although the mechanisms are not well understood. METHODS:An established model of passive smoking in pregnant ...
journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1804
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:With the increasing birth prevalence of hypospadias, there is growing concern for pollutant exposure interfering with normal penile development. We assess the association between hypospadias and hormonally active hazardous air pollutants (HAHAPs) through a nationwide database of hazardous air pollutants and ...
journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1461
更新日期:2019-04-15 00:00:00
abstract:BACKGROUND:Quaternary ammonium compounds are a large class of chemicals used for their antimicrobial and antistatic properties. Two common quaternary ammonium compounds, alkyldimethylbenzyl ammonium chloride (ADBAC) and didecyldimethyl ammonium chloride (DDAC), are combined in common cleaners and disinfectants. Introdu...
journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1064
更新日期:2017-08-15 00:00:00
abstract:BACKGROUND:A cardinal feature of prenatal ethanol exposure is CNS damage, resulting in a continuum of neurological and behavioral impairments that are described by the term fetal alcohol spectrum disorders (FASD). FASDs are variable and depend on several factors, including the amount, timing, and duration of prenatal e...
journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1477
更新日期:2019-07-15 00:00:00
abstract:OBJECTIVE:Assess temporal trends in congenital microcephaly. METHODS:We used Texas inpatient discharge diagnoses between 2000 and 2015, restricting to newborns. Between 2000 and 2003, the maximum number of fields for recording diagnostic codes was eight, and between 2004 and 2015 it was 24. Microcephaly was classified...
journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1491
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Developmental exposure to brominated flame retardants (BFRs), including polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCDD), has been associated with impaired neurodevelopment and some symptoms of metabolic syndrome. However, there are inconsistencies in studies reporting neurodevelopme...
journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1021
更新日期:2017-04-17 00:00:00
abstract:BACKGROUND:To objectively describe craniofacial, visual, and neurological features associated with amniotic band syndrome (ABS) and discuss likely associated multifactorial etiology. METHODS:A retrospective review of patients identified with ABS and concomitant limb involvement and craniofacial features was conducted....
journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1576
更新日期:2019-11-15 00:00:00
abstract:BACKGROUND:Breastfeeding women who are prescribed with psychotropic medications on a regular basis are often concerned, regarding the possible implications of such treatment on the breastfed infant. A mother's well-being has a direct influence on the well-being of the baby. However, the notorious reputation of psychotr...
journal_title:Birth defects research
pub_type: 杂志文章,评审
doi:10.1002/bdr2.1077
更新日期:2017-07-17 00:00:00
abstract::Electronic nicotine delivery systems (ENDS), which includes e-cigarettes (ECIGs), are a rapidly-expanding class of products that heat a liquid (which may or may not contain nicotine) to produce an aerosol. The variation of ECIG components is extensive as are their effects on users. Epidemiological data show that while...
journal_title:Birth defects research
pub_type: 杂志文章,评审
doi:10.1002/bdr2.1561
更新日期:2019-10-15 00:00:00