Abstract:
BACKGROUND:The different mechanisms leading to a solitary kidney should be differentiated because the long-term outcome might be different. The fetal period is the best moment to make a true diagnosis of congenital unilateral renal agenesis (URA). The objective was to determine the prevalence of URA at birth. The secondary objectives were to describe the evolution of sensitivity of prenatal diagnosis over time and the different forms of URA (isolated and associated with other malformations) detected up to 1 year. METHODS:The cases were retrospectively identified through two French population-based birth defect registries (Auvergne and Bas-Rhin) between 1995 and 2013. Stillbirths and fetuses up to 22 weeks of gestation and infants up to 1 year old with URA were included. RESULTS:A total of 177 cases of URA were registered. The prevalence at birth was 4.0/10,000. The overall prenatal prevalence was 3.6/10,000 (isolated URA: 2.8/10,000). URA were isolated (59.9%), associated with isolated contralateral congenital anomaly of kidney or urinary tract (CAKUT) (7.3%) and with other extra-renal anomalies (32.8%). The total proportion of contralateral CAKUT was 15%. Only three cases presented an aneuploidy, prenatally detected and conducting to a termination of pregnancy. The sensitivity of prenatal diagnosis improved over time (from 54.2% in 1995 to 1997 to 95.8% in 2010 to 2013; p = 0.002). CONCLUSION:Our study provides estimates of prevalence of URA at birth. A longitudinal cohort from the antenatal period to puberty should be performed to determine the prognosis of the contralateral kidney among these children with isolated, associated with contralateral CAKUT and URA with extra-renal anomalies. Birth Defects Research 109:1204-1211, 2017. © 2017 Wiley Periodicals, Inc.
journal_name
Birth Defects Resjournal_title
Birth defects researchauthors
Laurichesse Delmas H,Kohler M,Doray B,Lémery D,Francannet C,Quistrebert J,Marie C,Perthus Idoi
10.1002/bdr2.1065subject
Has Abstractpub_date
2017-09-01 00:00:00pages
1204-1211issue
15issn
2472-1727journal_volume
109pub_type
杂志文章abstract:BACKGROUND:This is the first study to utilize the index of concentration at the extremes (ICE) to examine risk factors for spina bifida in Texas. The ICE is a useful measure for providing the degree to which residents in a certain area are concentrated into groups at the extremes of disadvantage and privilege. We intro...
journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1374
更新日期:2019-08-15 00:00:00
abstract:BACKGROUND:Neural tube defects (NTDs) are severe congenital malformations. Folate supplementation can reduce the risk, but cannot prevent all NTDs, suggesting other reasons for folate-resistant NTDs. The present study assesses placental fatty acid composition, eicosanoids, and cytokines as risk factors for NTDs in a Ch...
journal_title:Birth defects research
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abstract:BACKGROUND:Many therapies to treat cancer are gonadotoxic and can lead to infertility. New strategies to diminish the side effects and protective plans during and after chemotherapy are needed. Therefore, bone marrow mesenchymal stem cells (BM-MSCs) as a novel solution were investigated against doxorubicin (Dox)-induce...
journal_title:Birth defects research
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:Assess temporal trends in congenital microcephaly. METHODS:We used Texas inpatient discharge diagnoses between 2000 and 2015, restricting to newborns. Between 2000 and 2003, the maximum number of fields for recording diagnostic codes was eight, and between 2004 and 2015 it was 24. Microcephaly was classified...
journal_title:Birth defects research
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journal_title:Birth defects research
pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00
abstract::Electronic nicotine delivery systems (ENDS), which includes e-cigarettes (ECIGs), are a rapidly-expanding class of products that heat a liquid (which may or may not contain nicotine) to produce an aerosol. The variation of ECIG components is extensive as are their effects on users. Epidemiological data show that while...
journal_title:Birth defects research
pub_type: 杂志文章,评审
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journal_title:Birth defects research
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journal_title:Birth defects research
pub_type: 杂志文章
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journal_title:Birth defects research
pub_type: 杂志文章
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journal_title:Birth defects research
pub_type: 杂志文章
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abstract::The AV7909 vaccine, consists of the Anthrax Vaccine Adsorbed (AVA) bulk drug substance and the immunostimulatory Toll-like receptor 9 agonist oligodeoxynucleotide adjuvant CPG 7909. The purpose of this research was to evaluate the potential maternal, reproductive, and developmental toxicity of AV7909 in rats to suppor...
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pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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journal_title:Birth defects research
pub_type: 杂志文章,评审
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更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Breastfeeding women who are prescribed with psychotropic medications on a regular basis are often concerned, regarding the possible implications of such treatment on the breastfed infant. A mother's well-being has a direct influence on the well-being of the baby. However, the notorious reputation of psychotr...
journal_title:Birth defects research
pub_type: 杂志文章,评审
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更新日期:2017-07-17 00:00:00
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journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1107
更新日期:2017-11-01 00:00:00
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journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdra.23596
更新日期:2017-01-20 00:00:00
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journal_title:Birth defects research
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
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journal_title:Birth defects research
pub_type: 杂志文章,评审
doi:10.1002/bdra.23601
更新日期:2017-03-15 00:00:00
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journal_title:Birth defects research
pub_type: 杂志文章,评审
doi:10.1002/bdr2.1035
更新日期:2017-08-15 00:00:00
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journal_title:Birth defects research
pub_type: 杂志文章
doi:10.1002/bdr2.1125
更新日期:2017-10-16 00:00:00
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pub_type: 杂志文章
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abstract::Evidences indicate that the decline of female fertility is becoming a common problem over the past few decades. Environmental exposure of Bisphenol A (BPA) has been considered as an endocrine-disrupting chemical deleteriously affecting human reproductions. To better understand the effect of BPA exposure on human ovari...
journal_title:Birth defects research
pub_type: 杂志文章
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journal_title:Birth defects research
pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
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journal_title:Birth defects research
pub_type: 杂志文章,评审
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更新日期:2020-07-15 00:00:00
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journal_title:Birth defects research
pub_type: 杂志文章,评审
doi:10.1002/bdr2.1414
更新日期:2019-05-01 00:00:00
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journal_title:Birth defects research
pub_type: 杂志文章,评审
doi:10.1002/bdr2.1115
更新日期:2018-01-15 00:00:00
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journal_title:Birth defects research
pub_type: 杂志文章,评审
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更新日期:2017-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00
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更新日期:2019-03-01 00:00:00
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journal_title:Birth defects research
pub_type: 杂志文章
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更新日期:2021-01-15 00:00:00