Differentially sensitive neuronal subpopulations in the central nervous system and the formation of hindbrain heterotopias in ethanol-exposed zebrafish.


BACKGROUND:A cardinal feature of prenatal ethanol exposure is CNS damage, resulting in a continuum of neurological and behavioral impairments that are described by the term fetal alcohol spectrum disorders (FASD). FASDs are variable and depend on several factors, including the amount, timing, and duration of prenatal ethanol exposure. To enhance interventions for CNS dysfunction, it is necessary to identify ethanol-sensitive neuronal populations and expand the understanding of factors that modify ethanol teratogenesis. METHODS:To investigate the susceptibility of different neuronal subtypes, we exposed transgenic zebrafish (Danio rerio) to several ethanol concentrations (0.25, 0.5, 1.0, 1.5, or 2.0%), at different hours post fertilization (hpf; 0, 6, or 24 hpf), for various durations (0-24, 0-48, 4-24, 6-24, 6-48,or 24-48 hpf). Following exposure, embryo survival rates were determined, and CNS neurogenesis, differentiation, and patterning were assessed. RESULTS:Embryo survival rates decrease as ethanol concentrations increase and drastically decline when exposed from 0-24 hpf compared to 4-24 hpf. Abnormal tangential migration of facial motor neurons is observed in isl1:gfp embryos exposed to ethanol concentrations as low as 0.25%, and the formation of IVth ventricle heterotopias are revealed by embryos exposed to ≥1.0% ethanol. Whereas, expression of olig2:dsred and ptf1a:gfp in the cerebellum and spinal cord are largely unaffected. While levels of etv4 mRNA are overtly resistant to ethanol, we observe significant reductions in ptch2 mRNA levels. CONCLUSIONS:These data show differentially sensitive CNS neuron subpopulations with susceptibility to low levels of ethanol. In addition, these data reveal the formation of ethanol-induced hindbrain heterotopias.


Birth Defects Res


Birth defects research


Buckley DM,Sidik A,Kar RD,Eberhart JK




Has Abstract


2019-07-15 00:00:00










  • Temporal trends in diagnoses of congenital microcephaly, Texas Hospital Discharge Diagnoses, 2000-2015.

    abstract:OBJECTIVE:Assess temporal trends in congenital microcephaly. METHODS:We used Texas inpatient discharge diagnoses between 2000 and 2015, restricting to newborns. Between 2000 and 2003, the maximum number of fields for recording diagnostic codes was eight, and between 2004 and 2015 it was 24. Microcephaly was classified...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Waller DK,Tark JY,Agopian AJ,Shewale J,Ganduglia-Cazaban C,Hoyt AT,Scheuerle AE,Langlois PH

    更新日期:2019-06-01 00:00:00

  • How microplastic components influence the immune system and impact on children health: Focus on cancer.

    abstract:BACKGROUND:As a result of human socioeconomic activity, industrial wastes have increased distressingly. Plastic pollution is globally distributed across the world due to its properties of buoyancy and durability. A big health hazard is the sorption of toxicants to plastic while traveling through the environment. Two br...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: Segovia-Mendoza M,Nava-Castro KE,Palacios-Arreola MI,Garay-Canales C,Morales-Montor J

    更新日期:2020-10-01 00:00:00

  • OEIS complex: Prevalence, clinical, and epidemiologic findings in a multicenter Mexican birth defects surveillance program.

    abstract::OEIS is the acronym of a malformations complex association including omphalocele, exstrophy of bladder or cloaca, imperforate anus, and spinal defects. It has a very low prevalence, ranging from 1/82,000 to 1/200,000 live births (LB). The etiology of OEIS is unknown. Virtually all cases are sporadic, and specific asso...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Arteaga-Vázquez J,Luna-Muñoz L,Morales-Suárez JJ,Mutchinick OM

    更新日期:2019-07-01 00:00:00

  • Rare copy number variants in a population-based investigation of hypoplastic right heart syndrome.

    abstract:BACKGROUND:Hypoplastic right heart syndrome (HRHS) is a rare congenital defect characterized by underdevelopment of the right heart structures commonly accompanied by an atrial septal defect. Familial HRHS reports suggest genetic factor involvement. We examined the role of copy number variants (CNVs) in HRHS. METHODS:...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Dimopoulos A,Sicko RJ,Kay DM,Rigler SL,Druschel CM,Caggana M,Browne ML,Fan R,Romitti PA,Brody LC,Mills JL

    更新日期:2017-01-20 00:00:00

  • The impact of mesenchymal stem cells on doxorubicin-induced testicular toxicity and progeny outcome of male prepubertal rats.

    abstract:BACKGROUND:Many therapies to treat cancer are gonadotoxic and can lead to infertility. New strategies to diminish the side effects and protective plans during and after chemotherapy are needed. Therefore, bone marrow mesenchymal stem cells (BM-MSCs) as a novel solution were investigated against doxorubicin (Dox)-induce...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Abdelaziz MH,Salah El-Din EY,El-Dakdoky MH,Ahmed TA

    更新日期:2019-08-01 00:00:00

  • Maternal Medicaid Recipient Status and Congenital Malformations among New York State Live Births in 2010.

    abstract:BACKGROUND:Congenital malformations are a leading cause of infant mortality in the United States, and risk for some congenital malformations varies by socioeconomic status (SES). Medicaid provides health insurance for people with low income, and covers approximately half of all live births in the United States. Income ...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Richardson SD,Josberger RE

    更新日期:2017-11-01 00:00:00

  • Screening, genetics, risk factors, and treatment of neonatal cataracts.

    abstract::Neonatal cataracts remain the most common cause of visual loss in children worldwide and have diverse, often unknown, etiologies. This review summarizes current knowledge about the detection, treatment, genetics, risk factors, and molecular mechanisms of congenital cataracts. We emphasize significant progress and topi...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: Li J,Xia CH,Wang E,Yao K,Gong X

    更新日期:2017-06-01 00:00:00

  • Cigarette smoke induced neural tube defects by down-regulating noggin expression.

    abstract:BACKGROUND:Maternal smoking or passive smoking during gestation increases the risk of congenital birth defects, including neural tube defects (NTDs). Cigarette smoke is a recognized teratogen that causes NTDs, although the mechanisms are not well understood. METHODS:An established model of passive smoking in pregnant ...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Yin C,Cai H,Yang D,Jian Y,Zhang J,Li Z,Wang D

    更新日期:2021-01-01 00:00:00

  • Understanding how the concentration of neighborhood advantage and disadvantage affects spina bifida risk among births to non-Hispanic white and Hispanic women, Texas, 1999-2014.

    abstract:BACKGROUND:This is the first study to utilize the index of concentration at the extremes (ICE) to examine risk factors for spina bifida in Texas. The ICE is a useful measure for providing the degree to which residents in a certain area are concentrated into groups at the extremes of disadvantage and privilege. We intro...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Shumate C,Hoyt A,Liu C,Kleinert A,Canfield M

    更新日期:2019-08-15 00:00:00

  • Malformations among infants of mothers with insulin-dependent diabetes: Is there a recognizable pattern of abnormalities?

    abstract:BACKGROUND:Infants of diabetic mothers have been shown in several studies to have an increased frequency of malformations. In previous studies, an increased frequency of several specific malformations has been noted, including anencephaly, bilateral renal agenesis, and double outlet right ventricle. Surveillance, used ...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Nasri HZ,Houde Ng K,Westgate MN,Hunt AT,Holmes LB

    更新日期:2018-01-01 00:00:00

  • Case series: Amniotic band sequence with craniofacial abnormalities.

    abstract:BACKGROUND:To objectively describe craniofacial, visual, and neurological features associated with amniotic band syndrome (ABS) and discuss likely associated multifactorial etiology. METHODS:A retrospective review of patients identified with ABS and concomitant limb involvement and craniofacial features was conducted....

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Lies S,Beckwith T,Mills J,Butler L,Ezaki M,Oishi S

    更新日期:2019-11-15 00:00:00

  • Exploratory analysis of machine learning approaches for surveillance of Zika-associated birth defects.

    abstract::In 2016, Centers for Disease Control and Prevention (CDC) established surveillance of pregnant women with Zika virus infection and their infants in the U.S. states, territories, and freely associated states. To identify cases of Zika-associated birth defects, subject matter experts review data reported from medical re...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Lusk R,Zimmerman J,VanMaldeghem K,Kim S,Roth NM,Lavinder J,Fulton A,Raycraft M,Ellington SR,Galang RR

    更新日期:2020-11-01 00:00:00

  • Placental transfer of 125 iodinated humanized immunoglobulin G2Δa in the cynomolgus monkey.

    abstract::Antibody-like biopharmaceuticals cross the placenta by utilizing existing transport pathways (e.g., FcRn receptor). There are limited data evaluating this transfer during organogenesis in any species. Understanding placental transfer of antibody-like biopharmaceuticals can help to predict risk of developmental toxicit...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Catlin NR,Mitchell AZ,Potchoiba MJ,O'Hara DM,Wang M,Zhang M,Weinbauer GF,Bowman CJ

    更新日期:2020-01-01 00:00:00

  • Cannabis and the developing brain: What does the evidence say?

    abstract::Cannabis use during adolescence has been linked to deleterious effects on brain integrity. This article summarizes findings from two prospective investigations (3 and 6 years, on average) on adolescent cannabis use from our laboratory that utilize structural neuroimaging and neurocognitive assessment approaches. Acros...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: Jacobus J,Courtney KE,Hodgdon EA,Baca R

    更新日期:2019-10-15 00:00:00

  • High Ratios of C20:4n-6/C20:5n-3 and Thromboxane B2 /6-Keto-Prostaglandin F1α in Placenta Are Potential Risk Contributors for Neural Tube Defects: A Case-Control Study in Shanxi Province, China.

    abstract:BACKGROUND:Neural tube defects (NTDs) are severe congenital malformations. Folate supplementation can reduce the risk, but cannot prevent all NTDs, suggesting other reasons for folate-resistant NTDs. The present study assesses placental fatty acid composition, eicosanoids, and cytokines as risk factors for NTDs in a Ch...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Li K,Zhang X,Pei L,Chen G,Liu J,Wahlqvist ML,Zheng X,Li D

    更新日期:2017-05-01 00:00:00

  • Recognition of clinical characteristics for population-based surveillance of fetal alcohol syndrome.

    abstract:BACKGROUND:The diagnosis of fetal alcohol syndrome (FAS) rests on identification of characteristic facial, growth, and central nervous system (CNS) features. Public health surveillance of FAS depends on documentation of these characteristics. We evaluated if reporting of FAS characteristics is associated with the type ...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Andrews JG,Galindo MK,Meaney FJ,Benavides A,Mayate L,Fox D,Pettygrove S,O'Leary L,Cunniff C

    更新日期:2018-06-01 00:00:00

  • Early fetal echocardiography.

    abstract:OBJECTIVES:To explore the technical aspects and clinical utility of early fetal echocardiography and screening of the fetal heart in early pregnancy. Also, to document differences in cardiac structure and function which can be demonstrated in the late first/early second trimesters. METHODS:In addition to summarizing o...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: McBrien A,Hornberger LK

    更新日期:2019-05-01 00:00:00

  • Birth practices: Maternal-neonate separation as a source of toxic stress.

    abstract::Maternal-neonate separation for human newborns has been the standard of care since the last century; low birth weight and preterm infants are still routinely separated from their mothers. With advanced technology, survival is good, but long-term developmental outcomes are very poor for these especially vulnerable newb...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: Bergman NJ

    更新日期:2019-09-01 00:00:00

  • Electronic nicotine delivery systems and pregnancy: Recent research on perceptions, cessation, and toxicant delivery.

    abstract::Electronic nicotine delivery systems (ENDS), which includes e-cigarettes (ECIGs), are a rapidly-expanding class of products that heat a liquid (which may or may not contain nicotine) to produce an aerosol. The variation of ECIG components is extensive as are their effects on users. Epidemiological data show that while...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: Breland A,McCubbin A,Ashford K

    更新日期:2019-10-15 00:00:00

  • Chronic exposure to high doses of selenium in the first trimester of pregnancy: Case report and brief literature review.

    abstract:BACKGROUND:Obstetricians usually prescribe supplements during pregnancy without actual indication. The use of selenium during pregnancy has increased, due to its function in several antioxidant mechanisms. CASE:A pregnant woman received 200,000 micrograms (μg) per day of a selenium galenic formulation, since gestation...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: D'Oria L,Apicella M,De Luca C,Licameli A,Neri C,Pellegrino M,Simeone D,De Santis M

    更新日期:2018-03-01 00:00:00

  • Dose range finding approach for rodent preweaning juvenile animal studies.

    abstract:OBJECTIVES:Strategies for conducting juvenile dose ranging studies before definitive toxicity juvenile animal studies (JAS) have evolved, but the aim of demonstrating study design robustness and efficient animal use remains the same. The objective of dose selection is to identify a strategy to achieve consistent system...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Posobiec LM,Laffan SB

    更新日期:2020-12-14 00:00:00

  • Gestational and Lactational Exposure to an Environmentally-Relevant Mixture of Brominated Flame Retardants: Effects on Neurodevelopment and Metabolism.

    abstract:BACKGROUND:Developmental exposure to brominated flame retardants (BFRs), including polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCDD), has been associated with impaired neurodevelopment and some symptoms of metabolic syndrome. However, there are inconsistencies in studies reporting neurodevelopme...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Tung EWY,Kawata A,Rigden M,Bowers WJ,Caldwell D,Holloway AC,Robaire B,Hales BF,Wade MG

    更新日期:2017-04-17 00:00:00

  • Environmental exposures during pregnancy: Mechanistic effects on immunity.

    abstract::In human studies, it is well established that exposures during embryonic and fetal development periods can influence immune health. Coupled with genetic predisposition, these exposures can alter lifetime chronic and infectious disease trajectory, and, ultimately, life expectancy. Fortunately, as research advances, mec...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: Rychlik KA,Sillé FCM

    更新日期:2019-03-01 00:00:00

  • Analytic Methods for Evaluating Patterns of Multiple Congenital Anomalies in Birth Defect Registries.

    abstract:BACKGROUND:It is estimated that 20 to 30% of infants with birth defects have two or more birth defects. Among these infants with multiple congenital anomalies (MCA), co-occurring anomalies may represent either chance (i.e., unrelated etiologies) or pathogenically associated patterns of anomalies. While some MCA pattern...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: Agopian AJ,Evans JA,Lupo PJ

    更新日期:2018-01-15 00:00:00

  • Limb body wall complex: Its delineation and relationship with amniotic bands using clustering methods.

    abstract:BACKGROUND:Despite the numerous reports on the limb body wall complex (LBWC), this association has never been adequately defined. Amniotic bands (AB) are frequently present but their role remains unclear. Since most reports were based on clinical and often subjective diagnoses, the aim of this work was to define LBWC a...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Rittler M,Campaña H,Poletta FA,Santos MR,Gili JA,Pawluk MS,Cosentino VR,Gimenez L,Lopez-Camelo JS

    更新日期:2019-03-01 00:00:00

  • Prevalence and descriptive epidemiology of infantile hypertrophic pyloric stenosis in the United States: A multistate, population-based retrospective study, 1999-2010.

    abstract:BACKGROUND:Antecedents for infantile hypertrophic pyloric stenosis (IHPS) vary across studies; therefore, we conducted a multistate, population-based retrospective study of the prevalence and descriptive epidemiology of IHPS in the United States (US). METHODS:Data for IHPS cases (n = 29,554) delivered from 1999-2010 a...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Kapoor R,Kancherla V,Cao Y,Oleson J,Suhl J,Canfield MA,Druschel CM,Kirby RS,Meyer RE,Romitti PA

    更新日期:2019-02-01 00:00:00

  • Diverse application of MRI for mouse phenotyping.

    abstract::Small animal models, particularly mouse models, of human diseases are becoming an indispensable tool for biomedical research. Studies in animal models have provided important insights into the etiology of diseases and accelerated the development of therapeutic strategies. Detailed phenotypic characterization is essent...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: Wu YL,Lo CW

    更新日期:2017-06-01 00:00:00

  • Combined effects of maternal exposure to fungicides on behavioral development in F1 -generation mice: 2. Fixed-dose study of thiabendazole.

    abstract:BACKGROUND:Few published studies are reported for the neurobehavioral toxicity of combined exposure to fungicides in mammals. This study was aimed to re-evaluate the reproductive and neurobehavioral effects of maternal exposure to combined imazalil (IMZ) and thiabendazole (TBZ) with fixed-dose of TBZ in mice. METHODS:...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Tanaka T,Suzuki T,Inomata A,Moriyasu T

    更新日期:2020-12-01 00:00:00

  • Suicide risk in adolescents with fetal alcohol spectrum disorders.

    abstract:BACKGROUND:The teratogenic effects of prenatal alcohol exposure (PAE) have been extensively documented over the course of 45 years of research and psychiatric problems are pervasive in this population. In adults with PAE, suicidal risk is high but less is known about the suicidal risk in adolescents with fetal alcohol ...

    journal_title:Birth defects research

    pub_type: 临床试验,杂志文章


    authors: O'Connor MJ,Portnoff LC,Lebsack-Coleman M,Dipple KM

    更新日期:2019-07-15 00:00:00

  • Array-based molecular karyotyping in 115 VATER/VACTERL and VATER/VACTERL-like patients identifies disease-causing copy number variations.

    abstract:BACKGROUND:The acronym VATER/VACTERL refers to the rare nonrandom association of the following component features (CF): vertebral defects (V), anorectal malformations (A), cardiac defects (C), tracheoesophageal fistula with or without esophageal atresia, renal malformations (R), and limb defects (L). Patients presentin...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Zhang R,Marsch F,Kause F,Degenhardt F,Schmiedeke E,Märzheuser S,Hoppe B,Bachour H,Boemers TM,Schäfer M,Spychalski N,Neser J,Leonhardt J,Kosch F,Ure B,Gómez B,Lacher M,Deffaa OJ,Palta M,Wittekindt B,Kleine K,Schm

    更新日期:2017-07-17 00:00:00