Suicide risk in adolescents with fetal alcohol spectrum disorders.


BACKGROUND:The teratogenic effects of prenatal alcohol exposure (PAE) have been extensively documented over the course of 45 years of research and psychiatric problems are pervasive in this population. In adults with PAE, suicidal risk is high but less is known about the suicidal risk in adolescents with fetal alcohol spectrum disorders (FASD). This study describes the prevalence of suicidal ideation and serious suicide attempts in a sample of 54 adolescents between the ages of 13 and 18 years with FASD. METHODS:Adolescents were diagnosed with FASD using the Updated Clinical Guidelines for Diagnosing Fetal Alcohol Spectrum Disorders. The Children's Interview for Psychiatric Syndromes was used to identify those adolescents who experienced suicidal ideation and/or who had made a serious suicide attempt in the last 12 months. RESULTS:The prevalence of suicidal behaviors in this sample was high with 35.2% of teens reporting incidences of suicidal ideation and 13.0% reporting at least one serious suicide attempt in the past year. This finding is in contrast to the 17.2% and 2.4% for ideation and serious attempts, respectively, reported in the general U.S. adolescent population. Alarmingly, 29.2% of males with FASD reported a serious suicide attempt which was 19½ times higher than national norms for males. No females reported attempts. Number of home placements and the presence of a depressive disorder contributed to study outcomes. CONCLUSIONS:Findings demonstrate the significant risk for suicidality in this population, particularly adolescent males, and the need to assess and treat this life threatening behavior.


Birth Defects Res


Birth defects research


O'Connor MJ,Portnoff LC,Lebsack-Coleman M,Dipple KM




Has Abstract


2019-07-15 00:00:00










  • A model partnership for communication and dissemination of scientific recommendations for pregnant women during the emergency response to the Zika virus outbreak: MotherToBaby and the Centers for Disease Control and Prevention.

    abstract:BACKGROUND:During the Zika virus (ZIKV) outbreak, an urgent need existed for strong partnerships to disseminate Zika-related information to pregnant women and women of child-bearing age. METHODS:The Centers for Disease Control and Prevention (CDC) partnered with MotherToBaby, a national organization experienced in pro...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Harris-Sagaribay L,Chambers CD,Perrotta K,Polen KD,Honein MA,Wasternack E

    更新日期:2020-11-01 00:00:00

  • Maternal Medicaid Recipient Status and Congenital Malformations among New York State Live Births in 2010.

    abstract:BACKGROUND:Congenital malformations are a leading cause of infant mortality in the United States, and risk for some congenital malformations varies by socioeconomic status (SES). Medicaid provides health insurance for people with low income, and covers approximately half of all live births in the United States. Income ...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Richardson SD,Josberger RE

    更新日期:2017-11-01 00:00:00

  • Exome sequencing provides additional evidence for the involvement of ARHGAP29 in Mendelian orofacial clefting and extends the phenotypic spectrum to isolated cleft palate.

    abstract:BACKGROUND:Recent advances in genomics methodologies, in particular the availability of next-generation sequencing approaches have made it possible to identify risk loci throughout the genome, in particular the exome. In the current study, we present findings from an exome study conducted in five affected individuals o...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Liu H,Busch T,Eliason S,Anand D,Bullard S,Gowans LJJ,Nidey N,Petrin A,Augustine-Akpan EA,Saadi I,Dunnwald M,Lachke SA,Zhu Y,Adeyemo A,Amendt B,Roscioli T,Cornell R,Murray J,Butali A

    更新日期:2017-01-20 00:00:00

  • Electronic nicotine delivery systems and pregnancy: Recent research on perceptions, cessation, and toxicant delivery.

    abstract::Electronic nicotine delivery systems (ENDS), which includes e-cigarettes (ECIGs), are a rapidly-expanding class of products that heat a liquid (which may or may not contain nicotine) to produce an aerosol. The variation of ECIG components is extensive as are their effects on users. Epidemiological data show that while...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: Breland A,McCubbin A,Ashford K

    更新日期:2019-10-15 00:00:00

  • Screening, genetics, risk factors, and treatment of neonatal cataracts.

    abstract::Neonatal cataracts remain the most common cause of visual loss in children worldwide and have diverse, often unknown, etiologies. This review summarizes current knowledge about the detection, treatment, genetics, risk factors, and molecular mechanisms of congenital cataracts. We emphasize significant progress and topi...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: Li J,Xia CH,Wang E,Yao K,Gong X

    更新日期:2017-06-01 00:00:00

  • The impact of mesenchymal stem cells on doxorubicin-induced testicular toxicity and progeny outcome of male prepubertal rats.

    abstract:BACKGROUND:Many therapies to treat cancer are gonadotoxic and can lead to infertility. New strategies to diminish the side effects and protective plans during and after chemotherapy are needed. Therefore, bone marrow mesenchymal stem cells (BM-MSCs) as a novel solution were investigated against doxorubicin (Dox)-induce...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Abdelaziz MH,Salah El-Din EY,El-Dakdoky MH,Ahmed TA

    更新日期:2019-08-01 00:00:00

  • Hypospadias risk is increased with maternal residential exposure to hormonally active hazardous air pollutants.

    abstract:BACKGROUND:With the increasing birth prevalence of hypospadias, there is growing concern for pollutant exposure interfering with normal penile development. We assess the association between hypospadias and hormonally active hazardous air pollutants (HAHAPs) through a nationwide database of hazardous air pollutants and ...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Sheth KR,Kovar E,White JT,Chambers TM,Peckham-Gregory EC,O'Neill M,Langlois PH,Seth A,Scheurer ME,Lupo PJ,Jorgez CJ

    更新日期:2019-04-15 00:00:00

  • Diverse application of MRI for mouse phenotyping.

    abstract::Small animal models, particularly mouse models, of human diseases are becoming an indispensable tool for biomedical research. Studies in animal models have provided important insights into the etiology of diseases and accelerated the development of therapeutic strategies. Detailed phenotypic characterization is essent...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: Wu YL,Lo CW

    更新日期:2017-06-01 00:00:00

  • Accuracy of birth certificate head circumference measurements: Massachusetts, 2012-2013.

    abstract:BACKGROUND:Zika virus has recently emerged as a novel cause of microcephaly. CDC has asked states to rapidly ascertain and report cases of Zika-linked birth defects, including microcephaly. Massachusetts added head circumference to its birth certificate (BC) in 2011. The accuracy of head circumference measurements from...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Somerville NJ,Chen X,Heinke D,Stone SL,Higgins C,Manning SE,Pagnano S,Yazdy MM,Anderka M

    更新日期:2018-03-15 00:00:00

  • Chronic exposure to high doses of selenium in the first trimester of pregnancy: Case report and brief literature review.

    abstract:BACKGROUND:Obstetricians usually prescribe supplements during pregnancy without actual indication. The use of selenium during pregnancy has increased, due to its function in several antioxidant mechanisms. CASE:A pregnant woman received 200,000 micrograms (μg) per day of a selenium galenic formulation, since gestation...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: D'Oria L,Apicella M,De Luca C,Licameli A,Neri C,Pellegrino M,Simeone D,De Santis M

    更新日期:2018-03-01 00:00:00

  • White paper on the study of birth defects.

    abstract::Birth defects are the leading cause of infant death in the United States and among the top causes of pediatric death and hospitalization. Despite the devastating impact of birth defects, we understand little of their etiology impeding progress towards treatment and prevention. Moreover, while surgical interventions ha...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Khokha MK,Mitchell LE,Wallingford JB

    更新日期:2017-01-30 00:00:00

  • Ambient and Dosed Exposure to Quaternary Ammonium Disinfectants Causes Neural Tube Defects in Rodents.

    abstract:BACKGROUND:Quaternary ammonium compounds are a large class of chemicals used for their antimicrobial and antistatic properties. Two common quaternary ammonium compounds, alkyldimethylbenzyl ammonium chloride (ADBAC) and didecyldimethyl ammonium chloride (DDAC), are combined in common cleaners and disinfectants. Introdu...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Hrubec TC,Melin VE,Shea CS,Ferguson EE,Garofola C,Repine CM,Chapman TW,Patel HR,Razvi RM,Sugrue JE,Potineni H,Magnin-Bissel G,Hunt PA

    更新日期:2017-08-15 00:00:00

  • Use of Psychotropic Medications in Breastfeeding Women.

    abstract:BACKGROUND:Breastfeeding women who are prescribed with psychotropic medications on a regular basis are often concerned, regarding the possible implications of such treatment on the breastfed infant. A mother's well-being has a direct influence on the well-being of the baby. However, the notorious reputation of psychotr...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: Kronenfeld N,Berlin M,Shaniv D,Berkovitch M

    更新日期:2017-07-17 00:00:00

  • High Ratios of C20:4n-6/C20:5n-3 and Thromboxane B2 /6-Keto-Prostaglandin F1α in Placenta Are Potential Risk Contributors for Neural Tube Defects: A Case-Control Study in Shanxi Province, China.

    abstract:BACKGROUND:Neural tube defects (NTDs) are severe congenital malformations. Folate supplementation can reduce the risk, but cannot prevent all NTDs, suggesting other reasons for folate-resistant NTDs. The present study assesses placental fatty acid composition, eicosanoids, and cytokines as risk factors for NTDs in a Ch...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Li K,Zhang X,Pei L,Chen G,Liu J,Wahlqvist ML,Zheng X,Li D

    更新日期:2017-05-01 00:00:00

  • Aerodigestive and communicative behaviors in anencephalic and hydranencephalic infants.

    abstract::The aerodigestive and communicative behaviors of anencephalic and hydranencephalic patients are assessed from literature sources and are compared with documented neural structures present in the brainstem, subcortical, and cortical regions of the brain. Much of the data analyzed corroborate previous neurological studi...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: Radford K,Taylor RC,Hall JG,Gick B

    更新日期:2019-01-15 00:00:00

  • Environmental exposures during pregnancy: Mechanistic effects on immunity.

    abstract::In human studies, it is well established that exposures during embryonic and fetal development periods can influence immune health. Coupled with genetic predisposition, these exposures can alter lifetime chronic and infectious disease trajectory, and, ultimately, life expectancy. Fortunately, as research advances, mec...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: Rychlik KA,Sillé FCM

    更新日期:2019-03-01 00:00:00

  • Birth practices: Maternal-neonate separation as a source of toxic stress.

    abstract::Maternal-neonate separation for human newborns has been the standard of care since the last century; low birth weight and preterm infants are still routinely separated from their mothers. With advanced technology, survival is good, but long-term developmental outcomes are very poor for these especially vulnerable newb...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: Bergman NJ

    更新日期:2019-09-01 00:00:00

  • Rare copy number variants in a population-based investigation of hypoplastic right heart syndrome.

    abstract:BACKGROUND:Hypoplastic right heart syndrome (HRHS) is a rare congenital defect characterized by underdevelopment of the right heart structures commonly accompanied by an atrial septal defect. Familial HRHS reports suggest genetic factor involvement. We examined the role of copy number variants (CNVs) in HRHS. METHODS:...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Dimopoulos A,Sicko RJ,Kay DM,Rigler SL,Druschel CM,Caggana M,Browne ML,Fan R,Romitti PA,Brody LC,Mills JL

    更新日期:2017-01-20 00:00:00

  • Cytomegalovirus infection in pregnancy.

    abstract::Cytomegalovirus (CMV) is a DNA herpesvirus that is common worldwide. The two known main sources of primary CMV infection during pregnancy are through sexual activity and contact with young children. Primary infection occurs in approximately 1 to 4% of pregnancies, and is mostly asymptomatic in immunocompetent adults. ...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: Davis NL,King CC,Kourtis AP

    更新日期:2017-03-15 00:00:00

  • Bisphenol A decreases progesterone synthesis in human ovarian granulosa cells.

    abstract::Evidences indicate that the decline of female fertility is becoming a common problem over the past few decades. Environmental exposure of Bisphenol A (BPA) has been considered as an endocrine-disrupting chemical deleteriously affecting human reproductions. To better understand the effect of BPA exposure on human ovari...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Qi J,Liu L,Yang J,Gao X,Zhang W

    更新日期:2020-12-01 00:00:00

  • Gestational and Lactational Exposure to an Environmentally-Relevant Mixture of Brominated Flame Retardants: Effects on Neurodevelopment and Metabolism.

    abstract:BACKGROUND:Developmental exposure to brominated flame retardants (BFRs), including polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCDD), has been associated with impaired neurodevelopment and some symptoms of metabolic syndrome. However, there are inconsistencies in studies reporting neurodevelopme...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Tung EWY,Kawata A,Rigden M,Bowers WJ,Caldwell D,Holloway AC,Robaire B,Hales BF,Wade MG

    更新日期:2017-04-17 00:00:00

  • Cigarette smoke induced neural tube defects by down-regulating noggin expression.

    abstract:BACKGROUND:Maternal smoking or passive smoking during gestation increases the risk of congenital birth defects, including neural tube defects (NTDs). Cigarette smoke is a recognized teratogen that causes NTDs, although the mechanisms are not well understood. METHODS:An established model of passive smoking in pregnant ...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Yin C,Cai H,Yang D,Jian Y,Zhang J,Li Z,Wang D

    更新日期:2021-01-01 00:00:00

  • Recognition of clinical characteristics for population-based surveillance of fetal alcohol syndrome.

    abstract:BACKGROUND:The diagnosis of fetal alcohol syndrome (FAS) rests on identification of characteristic facial, growth, and central nervous system (CNS) features. Public health surveillance of FAS depends on documentation of these characteristics. We evaluated if reporting of FAS characteristics is associated with the type ...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Andrews JG,Galindo MK,Meaney FJ,Benavides A,Mayate L,Fox D,Pettygrove S,O'Leary L,Cunniff C

    更新日期:2018-06-01 00:00:00

  • Combined effects of maternal exposure to fungicides on behavioral development in F1 -generation mice: 2. Fixed-dose study of thiabendazole.

    abstract:BACKGROUND:Few published studies are reported for the neurobehavioral toxicity of combined exposure to fungicides in mammals. This study was aimed to re-evaluate the reproductive and neurobehavioral effects of maternal exposure to combined imazalil (IMZ) and thiabendazole (TBZ) with fixed-dose of TBZ in mice. METHODS:...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Tanaka T,Suzuki T,Inomata A,Moriyasu T

    更新日期:2020-12-01 00:00:00

  • Placental transfer of 125 iodinated humanized immunoglobulin G2Δa in the cynomolgus monkey.

    abstract::Antibody-like biopharmaceuticals cross the placenta by utilizing existing transport pathways (e.g., FcRn receptor). There are limited data evaluating this transfer during organogenesis in any species. Understanding placental transfer of antibody-like biopharmaceuticals can help to predict risk of developmental toxicit...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Catlin NR,Mitchell AZ,Potchoiba MJ,O'Hara DM,Wang M,Zhang M,Weinbauer GF,Bowman CJ

    更新日期:2020-01-01 00:00:00

  • Teratogen update: Zika virus and pregnancy.

    abstract::Zika virus was first identified in Uganda in 1947 but received little attention until 2015 when a large outbreak of Zika virus illness followed by an increased number of babies born with microcephaly occurred in Brazil. Zika virus spread rapidly throughout the Americas, and in 2016 was identified as a cause of microce...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Rasmussen SA,Jamieson DJ

    更新日期:2020-09-01 00:00:00

  • Adverse maternal environment leads to cardiac fibrosis in adult male mice.

    abstract:BACKGROUND:Cardiac fibrosis is a cardinal feature of multiple types of cardiovascular disease, which lead to heart failure. Multiple studies connect adverse maternal environment (AME) with cardiac fibrosis. AME does not always result in fibrosis, though. An additional "insult", such as an adult Western diet (WD), is fr...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Spearman AD,Ke X,Fu Q,Lane RH,Majnik A

    更新日期:2018-12-01 00:00:00

  • Limb body wall complex: Its delineation and relationship with amniotic bands using clustering methods.

    abstract:BACKGROUND:Despite the numerous reports on the limb body wall complex (LBWC), this association has never been adequately defined. Amniotic bands (AB) are frequently present but their role remains unclear. Since most reports were based on clinical and often subjective diagnoses, the aim of this work was to define LBWC a...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Rittler M,Campaña H,Poletta FA,Santos MR,Gili JA,Pawluk MS,Cosentino VR,Gimenez L,Lopez-Camelo JS

    更新日期:2019-03-01 00:00:00

  • Analytic Methods for Evaluating Patterns of Multiple Congenital Anomalies in Birth Defect Registries.

    abstract:BACKGROUND:It is estimated that 20 to 30% of infants with birth defects have two or more birth defects. Among these infants with multiple congenital anomalies (MCA), co-occurring anomalies may represent either chance (i.e., unrelated etiologies) or pathogenically associated patterns of anomalies. While some MCA pattern...

    journal_title:Birth defects research

    pub_type: 杂志文章,评审


    authors: Agopian AJ,Evans JA,Lupo PJ

    更新日期:2018-01-15 00:00:00

  • Congenital unilateral renal agenesis: Prevalence, prenatal diagnosis, associated anomalies. Data from two birth-defect registries.

    abstract:BACKGROUND:The different mechanisms leading to a solitary kidney should be differentiated because the long-term outcome might be different. The fetal period is the best moment to make a true diagnosis of congenital unilateral renal agenesis (URA). The objective was to determine the prevalence of URA at birth. The secon...

    journal_title:Birth defects research

    pub_type: 杂志文章


    authors: Laurichesse Delmas H,Kohler M,Doray B,Lémery D,Francannet C,Quistrebert J,Marie C,Perthus I

    更新日期:2017-09-01 00:00:00