Hypospadias risk is increased with maternal residential exposure to hormonally active hazardous air pollutants.

abstract：:Antibody-like biopharmaceuticals cross the placenta by utilizing existing transport pathways (e.g., FcRn receptor). There are limited data evaluating this transfer during organogenesis in any species. Understanding placental transfer of antibody-like biopharmaceuticals can help to predict risk of developmental toxicit...

journal_title：Birth defects research

authors： Catlin NR,Mitchell AZ,Potchoiba MJ,O'Hara DM,Wang M,Zhang M,Weinbauer GF,Bowman CJ

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Zika virus has recently emerged as a novel cause of microcephaly. CDC has asked states to rapidly ascertain and report cases of Zika-linked birth defects, including microcephaly. Massachusetts added head circumference to its birth certificate (BC) in 2011. The accuracy of head circumference measurements from...

journal_title：Birth defects research

authors： Somerville NJ,Chen X,Heinke D,Stone SL,Higgins C,Manning SE,Pagnano S,Yazdy MM,Anderka M

更新日期：2018-03-15 00:00:00

abstract：:The aerodigestive and communicative behaviors of anencephalic and hydranencephalic patients are assessed from literature sources and are compared with documented neural structures present in the brainstem, subcortical, and cortical regions of the brain. Much of the data analyzed corroborate previous neurological studi...

journal_title：Birth defects research

authors： Radford K,Taylor RC,Hall JG,Gick B

更新日期：2019-01-15 00:00:00

abstract：:Small animal models, particularly mouse models, of human diseases are becoming an indispensable tool for biomedical research. Studies in animal models have provided important insights into the etiology of diseases and accelerated the development of therapeutic strategies. Detailed phenotypic characterization is essent...

journal_title：Birth defects research

authors： Wu YL,Lo CW

更新日期：2017-06-01 00:00:00

abstract：:Maternal-neonate separation for human newborns has been the standard of care since the last century; low birth weight and preterm infants are still routinely separated from their mothers. With advanced technology, survival is good, but long-term developmental outcomes are very poor for these especially vulnerable newb...

journal_title：Birth defects research

authors： Bergman NJ

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:The teratogenic effects of prenatal alcohol exposure (PAE) have been extensively documented over the course of 45 years of research and psychiatric problems are pervasive in this population. In adults with PAE, suicidal risk is high but less is known about the suicidal risk in adolescents with fetal alcohol ...

journal_title：Birth defects research

authors： O'Connor MJ,Portnoff LC,Lebsack-Coleman M,Dipple KM

更新日期：2019-07-15 00:00:00

abstract：:The World Health Organization currently recommends quinine+clindamycin for use against malaria in the first trimester. This may soon change to recommending artemisinin-based combination therapies (standard duration of dosing = 3 days). The non-artemisinin partner drugs include amodiaquine, lumefantrine, mefloquine, pi...

journal_title：Birth defects research

authors： Clark RL

更新日期：2017-08-15 00:00:00

abstract：:OEIS is the acronym of a malformations complex association including omphalocele, exstrophy of bladder or cloaca, imperforate anus, and spinal defects. It has a very low prevalence, ranging from 1/82,000 to 1/200,000 live births (LB). The etiology of OEIS is unknown. Virtually all cases are sporadic, and specific asso...

journal_title：Birth defects research

authors： Arteaga-Vázquez J,Luna-Muñoz L,Morales-Suárez JJ,Mutchinick OM

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Many therapies to treat cancer are gonadotoxic and can lead to infertility. New strategies to diminish the side effects and protective plans during and after chemotherapy are needed. Therefore, bone marrow mesenchymal stem cells (BM-MSCs) as a novel solution were investigated against doxorubicin (Dox)-induce...

journal_title：Birth defects research

authors： Abdelaziz MH,Salah El-Din EY,El-Dakdoky MH,Ahmed TA

更新日期：2019-08-01 00:00:00

abstract：:Electronic nicotine delivery systems (ENDS), which includes e-cigarettes (ECIGs), are a rapidly-expanding class of products that heat a liquid (which may or may not contain nicotine) to produce an aerosol. The variation of ECIG components is extensive as are their effects on users. Epidemiological data show that while...

journal_title：Birth defects research

authors： Breland A,McCubbin A,Ashford K

更新日期：2019-10-15 00:00:00

abstract：OBJECTIVE:Assess temporal trends in congenital microcephaly. METHODS:We used Texas inpatient discharge diagnoses between 2000 and 2015, restricting to newborns. Between 2000 and 2003, the maximum number of fields for recording diagnostic codes was eight, and between 2004 and 2015 it was 24. Microcephaly was classified...

journal_title：Birth defects research

authors： Waller DK,Tark JY,Agopian AJ,Shewale J,Ganduglia-Cazaban C,Hoyt AT,Scheuerle AE,Langlois PH

更新日期：2019-06-01 00:00:00

abstract：:In human studies, it is well established that exposures during embryonic and fetal development periods can influence immune health. Coupled with genetic predisposition, these exposures can alter lifetime chronic and infectious disease trajectory, and, ultimately, life expectancy. Fortunately, as research advances, mec...

journal_title：Birth defects research

authors： Rychlik KA,Sillé FCM

更新日期：2019-03-01 00:00:00

abstract：:Evidences indicate that the decline of female fertility is becoming a common problem over the past few decades. Environmental exposure of Bisphenol A (BPA) has been considered as an endocrine-disrupting chemical deleteriously affecting human reproductions. To better understand the effect of BPA exposure on human ovari...

journal_title：Birth defects research

authors： Qi J,Liu L,Yang J,Gao X,Zhang W

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Obstetricians usually prescribe supplements during pregnancy without actual indication. The use of selenium during pregnancy has increased, due to its function in several antioxidant mechanisms. CASE:A pregnant woman received 200,000 micrograms (μg) per day of a selenium galenic formulation, since gestation...

journal_title：Birth defects research

authors： D'Oria L,Apicella M,De Luca C,Licameli A,Neri C,Pellegrino M,Simeone D,De Santis M

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:There is considerable variability in the prevalence of birth defects among racial/ethnic groups. This study estimated birth defect prevalence among the less studied non-Hispanic (NH) Asian/Pacific Islander (PI) and American Indian/Alaska Native (AI/AN) populations in Texas relative to NH Whites. METHODS:Dat...

journal_title：Birth defects research

authors： Le MT,Shumate CJ,Hoyt AT,Wilkinson AV,Canfield MA

更新日期：2019-11-01 00:00:00

abstract：:Birth defects are the leading cause of infant death in the United States and among the top causes of pediatric death and hospitalization. Despite the devastating impact of birth defects, we understand little of their etiology impeding progress towards treatment and prevention. Moreover, while surgical interventions ha...

journal_title：Birth defects research

authors： Khokha MK,Mitchell LE,Wallingford JB

更新日期：2017-01-30 00:00:00

abstract：BACKGROUND:The different mechanisms leading to a solitary kidney should be differentiated because the long-term outcome might be different. The fetal period is the best moment to make a true diagnosis of congenital unilateral renal agenesis (URA). The objective was to determine the prevalence of URA at birth. The secon...

journal_title：Birth defects research

authors： Laurichesse Delmas H,Kohler M,Doray B,Lémery D,Francannet C,Quistrebert J,Marie C,Perthus I

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Hypoplastic right heart syndrome (HRHS) is a rare congenital defect characterized by underdevelopment of the right heart structures commonly accompanied by an atrial septal defect. Familial HRHS reports suggest genetic factor involvement. We examined the role of copy number variants (CNVs) in HRHS. METHODS:...

journal_title：Birth defects research

authors： Dimopoulos A,Sicko RJ,Kay DM,Rigler SL,Druschel CM,Caggana M,Browne ML,Fan R,Romitti PA,Brody LC,Mills JL

更新日期：2017-01-20 00:00:00

abstract：BACKGROUND:Developmental exposure to brominated flame retardants (BFRs), including polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCDD), has been associated with impaired neurodevelopment and some symptoms of metabolic syndrome. However, there are inconsistencies in studies reporting neurodevelopme...

journal_title：Birth defects research

authors： Tung EWY,Kawata A,Rigden M,Bowers WJ,Caldwell D,Holloway AC,Robaire B,Hales BF,Wade MG

更新日期：2017-04-17 00:00:00

abstract：BACKGROUND:As a result of human socioeconomic activity, industrial wastes have increased distressingly. Plastic pollution is globally distributed across the world due to its properties of buoyancy and durability. A big health hazard is the sorption of toxicants to plastic while traveling through the environment. Two br...

journal_title：Birth defects research

authors： Segovia-Mendoza M,Nava-Castro KE,Palacios-Arreola MI,Garay-Canales C,Morales-Montor J

更新日期：2020-10-01 00:00:00

abstract：:Over 50% of patients with 22q11.2 deletion syndrome (DS) have a conotruncal or related cardiac defect (CTRD). We hypothesized that similar genetic variants, developmental pathways and biological functions, contribute to disease risk for CTRD in patients without a 22q11.2 deletion (ND-CTRD) and with a 22q11.2 deletion ...

journal_title：Birth defects research

authors： Xie HM,Taylor DM,Zhang Z,McDonald-McGinn DM,Zackai EH,Stambolian D,Hakonarson H,Morrow BE,Emanuel BS,Goldmuntz E

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Breastfeeding women who are prescribed with psychotropic medications on a regular basis are often concerned, regarding the possible implications of such treatment on the breastfed infant. A mother's well-being has a direct influence on the well-being of the baby. However, the notorious reputation of psychotr...

journal_title：Birth defects research

authors： Kronenfeld N,Berlin M,Shaniv D,Berkovitch M

更新日期：2017-07-17 00:00:00

abstract：BACKGROUND:Antecedents for infantile hypertrophic pyloric stenosis (IHPS) vary across studies; therefore, we conducted a multistate, population-based retrospective study of the prevalence and descriptive epidemiology of IHPS in the United States (US). METHODS:Data for IHPS cases (n = 29,554) delivered from 1999-2010 a...

journal_title：Birth defects research

authors： Kapoor R,Kancherla V,Cao Y,Oleson J,Suhl J,Canfield MA,Druschel CM,Kirby RS,Meyer RE,Romitti PA

更新日期：2019-02-01 00:00:00

abstract：:The AV7909 vaccine, consists of the Anthrax Vaccine Adsorbed (AVA) bulk drug substance and the immunostimulatory Toll-like receptor 9 agonist oligodeoxynucleotide adjuvant CPG 7909. The purpose of this research was to evaluate the potential maternal, reproductive, and developmental toxicity of AV7909 in rats to suppor...

journal_title：Birth defects research

authors： Mylchreest E,Smiley MA,Ballin JD,Blauth B,Shearer J,Reece J,Ionin B,Savransky V

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Infants of diabetic mothers have been shown in several studies to have an increased frequency of malformations. In previous studies, an increased frequency of several specific malformations has been noted, including anencephaly, bilateral renal agenesis, and double outlet right ventricle. Surveillance, used ...

journal_title：Birth defects research

authors： Nasri HZ,Houde Ng K,Westgate MN,Hunt AT,Holmes LB

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:To objectively describe craniofacial, visual, and neurological features associated with amniotic band syndrome (ABS) and discuss likely associated multifactorial etiology. METHODS:A retrospective review of patients identified with ABS and concomitant limb involvement and craniofacial features was conducted....

journal_title：Birth defects research

authors： Lies S,Beckwith T,Mills J,Butler L,Ezaki M,Oishi S

更新日期：2019-11-15 00:00:00

abstract：BACKGROUND:Quaternary ammonium compounds are a large class of chemicals used for their antimicrobial and antistatic properties. Two common quaternary ammonium compounds, alkyldimethylbenzyl ammonium chloride (ADBAC) and didecyldimethyl ammonium chloride (DDAC), are combined in common cleaners and disinfectants. Introdu...

journal_title：Birth defects research

authors： Hrubec TC,Melin VE,Shea CS,Ferguson EE,Garofola C,Repine CM,Chapman TW,Patel HR,Razvi RM,Sugrue JE,Potineni H,Magnin-Bissel G,Hunt PA

更新日期：2017-08-15 00:00:00

abstract：BACKGROUND:It is estimated that 20 to 30% of infants with birth defects have two or more birth defects. Among these infants with multiple congenital anomalies (MCA), co-occurring anomalies may represent either chance (i.e., unrelated etiologies) or pathogenically associated patterns of anomalies. While some MCA pattern...

journal_title：Birth defects research

authors： Agopian AJ,Evans JA,Lupo PJ

更新日期：2018-01-15 00:00:00

abstract：BACKGROUND:The diagnosis of fetal alcohol syndrome (FAS) rests on identification of characteristic facial, growth, and central nervous system (CNS) features. Public health surveillance of FAS depends on documentation of these characteristics. We evaluated if reporting of FAS characteristics is associated with the type ...

journal_title：Birth defects research

authors： Andrews JG,Galindo MK,Meaney FJ,Benavides A,Mayate L,Fox D,Pettygrove S,O'Leary L,Cunniff C

更新日期：2018-06-01 00:00:00

abstract：:Neonatal cataracts remain the most common cause of visual loss in children worldwide and have diverse, often unknown, etiologies. This review summarizes current knowledge about the detection, treatment, genetics, risk factors, and molecular mechanisms of congenital cataracts. We emphasize significant progress and topi...

journal_title：Birth defects research

authors： Li J,Xia CH,Wang E,Yao K,Gong X

更新日期：2017-06-01 00:00:00