当前位置： SCI文献检索 > EBioMedicine期刊下所有文献 > Discovery and Validation of Predictive Biomarkers of Survival for Non-small Cell Lung Cancer Patients Undergoing Radical Radiotherapy: Two Proteins With Predictive Value.

Discovery and Validation of Predictive Biomarkers of Survival for Non-small Cell Lung Cancer Patients Undergoing Radical Radiotherapy: Two Proteins With Predictive Value.

Abstract：

:Lung cancer is the most frequent cause of cancer-related death world-wide. Radiotherapy alone or in conjunction with chemotherapy is the standard treatment for locally advanced non-small cell lung cancer (NSCLC). Currently there is no predictive marker with clinical utility to guide treatment decisions in NSCLC patients undergoing radiotherapy. Identification of such markers would allow treatment options to be considered for more effective therapy. To enable the identification of appropriate protein biomarkers, plasma samples were collected from patients with non-small cell lung cancer before and during radiotherapy for longitudinal comparison following a protocol that carries sufficient power for effective discovery proteomics. Plasma samples from patients pre- and during radiotherapy who had survived > 18 mo were compared to the same time points from patients who survived < 14 mo using an 8 channel isobaric tagging tandem mass spectrometry discovery proteomics platform. Over 650 proteins were detected and relatively quantified. Proteins which showed a change during radiotherapy were selected for validation using an orthogonal antibody-based approach. Two of these proteins were verified in a separate patient cohort: values of CRP and LRG1 combined gave a highly significant indication of extended survival post one week of radiotherapy treatment.

journal_name

EBioMedicine

journal_title

EBioMedicine

authors

Walker MJ,Zhou C,Backen A,Pernemalm M,Williamson AJ,Priest LJ,Koh P,Faivre-Finn C,Blackhall FH,Dive C,Whetton AD

doi

10.1016/j.ebiom.2015.06.013

subject

Has Abstract

pub_date

2015-06-19 00:00:00

pages

841-50

issue

8

issn

2352-3964

pii

S2352-3964(15)30043-8

journal_volume

2

pub_type

杂志文章

相关文献

EBioMedicine文献大全
  • Circular RNA circPICALM sponges miR-1265 to inhibit bladder cancer metastasis and influence FAK phosphorylation.

    abstract：BACKGROUND:Metastasis is a major obstacle in the treatment of bladder cancer (BC). Circular RNAs exert various functions in the aggressive biological behaviour of cancers. In this study, we aimed to elucidate how circPICALM influences BC metastasis. METHODS:The expression of circPICALM was analysed by real-time PCR. T...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.08.074

    authors： Yan D,Dong W,He Q,Yang M,Huang L,Kong J,Qin H,Lin T,Huang J

    更新日期：2019-10-01 00:00:00

  • Bach1-induced suppression of angiogenesis is dependent on the BTB domain.

    abstract：:The transcription factor Bach1 impairs angiogenesis after ischemic injury by suppressing Wnt/β-catenin signaling; however, the specific domains responsible for the anti-angiogenic effects of Bach1 remain unclear. This study determined the role of the BTB domain of Bach1 in ischemic angiogenesis. Bach1 is highly expres...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.102617

    authors： Jiang L,Jia M,Wei X,Guo J,Hao S,Mei A,Zhi X,Wang X,Li Q,Jin J,Zhang J,Li S,Meng D

    更新日期：2020-01-01 00:00:00

  • Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastoma.

    abstract：BACKGROUND:In neuroblastoma, genetic alterations in ATRX, define a distinct poor outcome patient subgroup. Despite the need for new therapies, there is a lack of available models and a dearth of pre-clinical research. METHODS:To evaluate the impact of ATRX loss of function (LoF) in neuroblastoma, we utilized CRISPR-Ca...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102971

    authors： George SL,Lorenzi F,King D,Hartlieb S,Campbell J,Pemberton H,Toprak UH,Barker K,Tall J,da Costa BM,van den Boogaard ML,Dolman MEM,Molenaar JJ,Bryant HE,Westermann F,Lord CJ,Chesler L

    更新日期：2020-09-01 00:00:00

  • A major role of TWEAK/Fn14 axis as a therapeutic target for post-angioplasty restenosis.

    abstract：BACKGROUND:Tumor necrosis factor-like weak inducer of apoptosis (Tnfsf12; TWEAK) and its receptor Fibroblast growth factor-inducible 14 (Tnfrsf12a; Fn14) participate in the inflammatory response associated with vascular remodeling. However, the functional effect of TWEAK on vascular smooth muscle cells (VSMCs) is not c...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.07.072

    authors： Méndez-Barbero N,Gutierrez-Muñoz C,Madrigal-Matute J,Mínguez P,Egido J,Michel JB,Martín-Ventura JL,Esteban V,Blanco-Colio LM

    更新日期：2019-08-01 00:00:00

  • Loss of Scribble confers cisplatin resistance during NSCLC chemotherapy via Nox2/ROS and Nrf2/PD-L1 signaling.

    abstract：BACKGROUND:Cisplatin resistance remains a major clinical obstacle to the successful treatment of non-small cell lung cancer (NSCLC). Scribble contributes to ROS-induced inflammation and cisplatin-elevated toxic reactive oxygen species (ROS) promotes cell death. However, it is unknown whether and how Scribble is involve...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.08.057

    authors： Wang N,Song L,Xu Y,Zhang L,Wu Y,Guo J,Ji W,Li L,Zhao J,Zhang X,Zhan L

    更新日期：2019-09-01 00:00:00

  • The neuropeptide calcitonin gene-related peptide alpha is essential for bone healing.

    abstract：BACKGROUND:Impaired fracture healing represents an ongoing clinical challenge, as treatment options remain limited. Calcitonin gene-related peptide (CGRP), a neuropeptide targeted by emerging anti-migraine drugs, is also expressed in sensory nerve fibres innervating bone tissue. METHOD:Bone healing following a femoral...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102970

    authors： Appelt J,Baranowsky A,Jahn D,Yorgan T,Köhli P,Otto E,Farahani SK,Graef F,Fuchs M,Herrera A,Amling M,Schinke T,Frosch KH,Duda GN,Tsitsilonis S,Keller J

    更新日期：2020-09-01 00:00:00

  • Comprehending a Killer: The Akt/mTOR Signaling Pathways Are Temporally High-Jacked by the Highly Pathogenic 1918 Influenza Virus.

    abstract：:Previous transcriptomic analyses suggested that the 1918 influenza A virus (IAV1918), one of the most devastating pandemic viruses of the 20th century, induces a dysfunctional cytokine storm and affects other innate immune response patterns. Because all viruses are obligate parasites that require host cells for replic...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.05.027

    authors： Ranadheera C,Coombs KM,Kobasa D

    更新日期：2018-06-01 00:00:00

  • Value of folate receptor-positive circulating tumour cells in the clinical management of indeterminate lung nodules: A non-invasive biomarker for predicting malignancy and tumour invasiveness.

    abstract：BACKGROUND:Non-invasive lung adenocarcinoma could benefit from limited resection, nonetheless, there is a lack of method to determine preoperative tumour invasiveness. We aimed to investigate whether folate receptor-positive circulating tumour cells (FR+-CTCs) in combination with maximum tumour diameter (MTD) determine...

    journal_title：EBioMedicine

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.ebiom.2019.02.028

    authors： Zhou Q,Geng Q,Wang L,Huang J,Liao M,Li Y,Ding Z,Yang S,Zhao H,Shen Q,Pan C,Lou J,Lu S,Chen C,Luo Q

    更新日期：2019-03-01 00:00:00

  • Amphiregulin Antibody and Reduction of Axial Elongation in Experimental Myopia.

    abstract：:To examine the mechanism of ocular axial elongation in myopia, guinea pigs (age: 2-3weeks) which either underwent unilateral or bilateral lens-induced myopization (group 1) or which were primarily myopic at baseline (group 2) received unilateral intraocular injections of amphiregulin antibody (doses: 5, 10, or 15μg) t...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.02.021

    authors： Jiang WJ,Song HX,Li SY,Guo B,Wu JF,Li GP,Guo DD,Shi L,Bi HS,Jonas JB

    更新日期：2017-03-01 00:00:00

  • Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytes.

    abstract：BACKGROUND:Psoriasis is a common chronic inflammatory skin disease which lacks effective strategies for the treatment. Natural compounds with biological activities are good tools to identify new targets with therapeutic potentials. Acetyl-11-keto-β-boswellic acid (AKBA) is the most bioactive ingredient of boswellic aci...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.12.036

    authors： Bai J,Gao Y,Chen L,Yin Q,Lou F,Wang Z,Xu Z,Zhou H,Li Q,Cai W,Sun Y,Niu L,Wang H,Wei Z,Lu S,Zhou A,Zhang J,Wang H

    更新日期：2019-01-01 00:00:00

  • Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1) is associated with bevacizumab resistance in colorectal cancer via regulation of vascular endothelial growth factor A.

    abstract：BACKGROUND:The identification of new biomarkers and the development of novel, targetable contexts of vulnerability are of urgent clinical need in drug-resistant metastatic colorectal cancer (mCRC). Aryl-Hydrocarbon-Receptor-Nuclear-Translocator-Like (ARNTL/BMAL1) is a circadian clock-regulated transcription factor prom...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.07.004

    authors： Burgermeister E,Battaglin F,Eladly F,Wu W,Herweck F,Schulte N,Betge J,Härtel N,Kather JN,Weis CA,Gaiser T,Marx A,Weiss C,Hofheinz R,Miller IS,Loupakis F,Lenz HJ,Byrne AT,Ebert MP

    更新日期：2019-07-01 00:00:00

  • Local Somatodendritic Translation and Hyperphosphorylation of Tau Protein Triggered by AMPA and NMDA Receptor Stimulation.

    abstract：:Tau is a major component of the neurofibrillary tangles (NFT) that represent a pathological hallmark of Alzheimer's disease (AD). Although generally considered an axonal protein, Tau is found in the somato-dendritic compartment of degenerating neurons and this redistribution is thought to be a trigger of neurodegenera...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.05.012

    authors： Kobayashi S,Tanaka T,Soeda Y,Almeida OFX,Takashima A

    更新日期：2017-06-01 00:00:00

  • Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients.

    abstract：BACKGROUND:The dynamic changes of lymphocyte subsets and cytokines profiles of patients with novel coronavirus disease (COVID-19) and their correlation with the disease severity remain unclear. METHODS:Peripheral blood samples were longitudinally collected from 40 confirmed COVID-19 patients and examined for lymphocyt...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102763

    authors： Liu J,Li S,Liu J,Liang B,Wang X,Wang H,Li W,Tong Q,Yi J,Zhao L,Xiong L,Guo C,Tian J,Luo J,Yao J,Pang R,Shen H,Peng C,Liu T,Zhang Q,Wu J,Xu L,Lu S,Wang B,Weng Z,Han C,Zhu H,Zhou R,Zhou H,Chen X,

    更新日期：2020-05-01 00:00:00

  • Chronic Kidney Disease, Time in Therapeutic Range and Adverse Clinical Outcomes in Anticoagulated Patients with Non-valvular Atrial Fibrillation: Observations from the SPORTIF Trials.

    abstract：BACKGROUND:Chronic kidney disease (CKD) is highly prevalent in atrial fibrillation (AF) patients and associated with an increased risk of adverse outcomes. Our objectives were to study clinical features associated with CKD in AF patients and the impact of CKD on anticoagulation control, as reflected by time in therapeu...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.04.013

    authors： Proietti M,Lane DA,Lip GYH

    更新日期：2016-06-01 00:00:00

  • PLAGL2 and POFUT1 are regulated by an evolutionarily conserved bidirectional promoter and are collaboratively involved in colorectal cancer by maintaining stemness.

    abstract：BACKGROUND:Our previous study revealed that PLAGL2 or POFUT1 can promote tumorigenesis and maintain significant positive correlations in colorectal cancer (CRC). However, the mechanism leading to the co-expression and the underlying functional and biological implications remain unclear. METHODS:Clinical tumor tissues ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.06.051

    authors： Li D,Lin C,Li N,Du Y,Yang C,Bai Y,Feng Z,Su C,Wu R,Song S,Yan P,Chen M,Jain A,Huang L,Zhang Y,Li X

    更新日期：2019-07-01 00:00:00

  • Climate Change and Aedes Vectors: 21st Century Projections for Dengue Transmission in Europe.

    abstract：:Warming temperatures may increase the geographic spread of vector-borne diseases into temperate areas. Although a tropical mosquito-borne viral disease, a dengue outbreak occurred in Madeira, Portugal, in 2012; the first in Europe since 1920s. This outbreak emphasizes the potential for dengue re-emergence in Europe gi...

    journal_title：EBioMedicine

    pub_type： 历史文章,杂志文章

    doi：10.1016/j.ebiom.2016.03.046

    authors： Liu-Helmersson J,Quam M,Wilder-Smith A,Stenlund H,Ebi K,Massad E,Rocklöv J

    更新日期：2016-05-01 00:00:00

  • A prognostic gene expression signature for oropharyngeal squamous cell carcinoma.

    abstract：BACKGROUND:Robust prognostic stratification of patients with oropharyngeal squamous cell carcinoma (OPSCC) is important for developing individualized treatment plans. This study was conducted to develop and validate a clinically feasible prognostic classifier based on transcriptome-wide gene expression profiles. METHO...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102805

    authors： Liu X,Liu P,Chernock RD,Kuhs KAL,Lewis JS Jr,Luo J,Gay HA,Thorstad WL,Wang X

    更新日期：2020-11-01 00:00:00

  • Building the Evidence Base of Blood-Based Biomarkers for Early Detection of Cancer: A Rapid Systematic Mapping Review.

    abstract：BACKGROUND:The Early Cancer Detection Consortium is developing a blood-test to screen the general population for early identification of cancer, and has therefore conducted a systematic mapping review to identify blood-based biomarkers that could be used for early identification of cancer. METHODS:A mapping review wit...

    journal_title：EBioMedicine

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ebiom.2016.07.004

    authors： Uttley L,Whiteman BL,Woods HB,Harnan S,Philips ST,Cree IA,Early Cancer Detection Consortium.

    更新日期：2016-08-01 00:00:00

  • Evaluation of antiviral - passive - active immunization ("sandwich") therapeutic strategy for functional cure of chronic hepatitis B in mice.

    abstract：BACKGROUND:Chronic Hepatitis B (CHB) remains a major problem for global public health. Viral persistence and immune defects are the two major reasons for CHB, and it was hypothesized that based on a transient clearance of serum viral DNA and HBsAg "window stage", active immunization against hepatitis B virus (HBV) migh...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.10.043

    authors： Shi B,Wu Y,Wang C,Li X,Yu F,Wang B,Yang Z,Li J,Liang M,Wen Y,Ying T,Yuan Z

    更新日期：2019-11-01 00:00:00

  • Quantification, epitope mapping and genotype cross-reactivity of hepatitis B preS-specific antibodies in subjects vaccinated with different dosage regimens of BM32.

    abstract：BACKGROUND:Chronic hepatitis B virus (HBV) infections are a global health problem. There is a need for therapeutic strategies blocking continuous infection of liver cells. The grass pollen allergy vaccine BM32 containing the preS domain of the large HBV surface protein (LHBs) as immunogenic carrier induced IgG antibodi...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102953

    authors： Tulaeva I,Cornelius C,Zieglmayer P,Zieglmayer R,Schmutz R,Lemell P,Weber M,Focke-Tejkl M,Karaulov A,Henning R,Valenta R

    更新日期：2020-09-01 00:00:00

  • Vitamin D3-vitamin D receptor axis suppresses pulmonary emphysema by maintaining alveolar macrophage homeostasis and function.

    abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is characterized by emphysema and/or obstructive bronchiolitis. Deficiency in vitamin D3 (VD3), which regulates gene expression through binding to vitamin D receptor (VDR), is associated with high risks of COPD susceptibility. Alveolar macrophages (AM), which are ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.06.039

    authors： Hu G,Dong T,Wang S,Jing H,Chen J

    更新日期：2019-07-01 00:00:00

  • miR-4739 mediates pleural fibrosis by targeting bone morphogenetic protein 7.

    abstract：BACKGROUND:Pleural fibrosis is defined as excessive depositions of matrix components that result in pleural tissue architecture destruction and dysfunction. In severe cases, the progression of pleural fibrosis leads to lung entrapment, resulting in dyspnea and respiratory failure. However, the mechanism of pleural fibr...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.02.057

    authors： Wang M,Xiong L,Jiang LJ,Lu YZ,Liu F,Song LJ,Xiang F,He XL,Yu F,Shuai SY,Ma WL,Ye H

    更新日期：2019-03-01 00:00:00

  • MSBIS: A Multi-Step Biomedical Informatics Screening Approach for Identifying Medications that Mitigate the Risks of Metoclopramide-Induced Tardive Dyskinesia.

    abstract：:In 2009 the U.S. Food and Drug Administration (FDA) placed a black box warning on metoclopramide (MCP) due to the increased risks and prevalence of tardive dyskinesia (TD). In this study, we developed a multi-step biomedical informatics screening (MSBIS) approach leveraging publicly available bioactivity and drug safe...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.11.015

    authors： Xu D,Ham AG,Tivis RD,Caylor ML,Tao A,Flynn ST,Economen PJ,Dang HK,Johnson RW,Culbertson VL

    更新日期：2017-12-01 00:00:00

  • Epidemiologic and genomic insights on mcr-1-harbouring Salmonella from diarrhoeal outpatients in Shanghai, China, 2006-2016.

    abstract：BACKGROUND:Colistin resistance mediated by mcr-1-harbouring plasmids is an emerging threat in Enterobacteriaceae, like Salmonella. Based on its major contribution to the diarrhoea burden, the epidemic state and threat of mcr-1-harbouring Salmonella in community-acquired infections should be estimated. METHODS:This ret...

    journal_title：EBioMedicine

    pub_type： 历史文章,杂志文章

    doi：10.1016/j.ebiom.2019.03.006

    authors： Lu X,Zeng M,Xu J,Zhou H,Gu B,Li Z,Jin H,Wang X,Zhang W,Hu Y,Xiao W,Zhu B,Xu X,Kan B

    更新日期：2019-04-01 00:00:00

  • MiR-652-3p inhibition enhances endothelial repair and reduces atherosclerosis by promoting Cyclin D2 expression.

    abstract：BACKGROUND:Atherosclerosis is a hyperlipidemia-induced condition affecting the arterial wall that damages healthy endothelial cell (EC) function, leading to enhanced risk of atherothrombotic events. Certain microRNAs regulate EC dysfunction in response to hyperlipidemia and may be suitable therapeutic targets to combat...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.01.032

    authors： Huang R,Hu Z,Cao Y,Li H,Zhang H,Su W,Xu Y,Liang L,Melgiri ND,Jiang L

    更新日期：2019-02-01 00:00:00

  • Bifidobacterium longum counters the effects of obesity: Partial successful translation from rodent to human.

    abstract：BACKGROUND:The human gut microbiota has emerged as a key factor in the development of obesity. Certain probiotic strains have shown anti-obesity effects. The objective of this study was to investigate whether Bifidobacterium longum APC1472 has anti-obesity effects in high-fat diet (HFD)-induced obese mice and whether B...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.103176

    authors： Schellekens H,Torres-Fuentes C,van de Wouw M,Long-Smith CM,Mitchell A,Strain C,Berding K,Bastiaanssen TFS,Rea K,Golubeva AV,Arboleya S,Verpaalen M,Pusceddu MM,Murphy A,Fouhy F,Murphy K,Ross P,Roy BL,Stanton C,Dinan

    更新日期：2021-01-01 00:00:00

  • Skeletal muscle as potential central link between sarcopenia and immune senescence.

    abstract：:As our population grows older, age-related pathologies are becoming more prevalent. Deterioration of skeletal muscle and the immune system manifests as sarcopenia and immune senescence respectively. The disease burden of these pathologies emphasizes the need for a better understanding of the underlying mechanisms. Ske...

    journal_title：EBioMedicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ebiom.2019.10.034

    authors： Nelke C,Dziewas R,Minnerup J,Meuth SG,Ruck T

    更新日期：2019-11-01 00:00:00

  • Allogeneic Mesenchymal Stem Cells Restore Endothelial Function in Heart Failure by Stimulating Endothelial Progenitor Cells.

    abstract：BACKGROUND:Endothelial dysfunction, characterized by diminished endothelial progenitor cell (EPC) function and flow-mediated vasodilation (FMD), is a clinically significant feature of heart failure (HF). Mesenchymal stem cells (MSCs), which have pro-angiogenic properties, have the potential to restore endothelial funct...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2015.03.020

    authors： Premer C,Blum A,Bellio MA,Schulman IH,Hurwitz BE,Parker M,Dermarkarian CR,DiFede DL,Balkan W,Khan A,Hare JM

    更新日期：2015-03-28 00:00:00

  • Cell-Mediated Immune Predictors of Vaccine Effect on Viral Load and CD4 Count in a Phase 2 Therapeutic HIV-1 Vaccine Clinical Trial.

    abstract：BACKGROUND:In a placebo-controlled trial of the peptide-based therapeutic HIV-1 p24Gag vaccine candidate Vacc-4x, participants on combination antiretroviral therapy (cART) received six immunizations over 18weeks, followed by analytical treatment interruption (ATI) between weeks 28 and 52. Cell-mediated immune responses...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.09.028

    authors： Huang Y,Pantaleo G,Tapia G,Sanchez B,Zhang L,Trondsen M,Hovden AO,Pollard R,Rockstroh J,Ökvist M,Sommerfelt MA

    更新日期：2017-10-01 00:00:00

  • OVA66 promotes tumour angiogenesis and progression through enhancing autocrine VEGF-VEGFR2 signalling.

    abstract：BACKGROUND:Activation of autocrine VEGF-VEGFR2 signalling in tumour cells activates cell proliferation, survival, and angiogenesis, all of which are crucial for tumour progression. Ovarian cancer-associated antigen 66 (OVA66) is now known to be overexpressed in multiple tumours and plays a role in tumour development, b...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.02.051

    authors： Song F,Chen Q,Rao W,Zhang R,Wang Y,Ge H,Wei Q

    更新日期：2019-03-01 00:00:00