当前位置： SCI文献检索 > EBioMedicine期刊下所有文献 > Bach1-induced suppression of angiogenesis is dependent on the BTB domain.

Bach1-induced suppression of angiogenesis is dependent on the BTB domain.

Abstract：

:The transcription factor Bach1 impairs angiogenesis after ischemic injury by suppressing Wnt/β-catenin signaling; however, the specific domains responsible for the anti-angiogenic effects of Bach1 remain unclear. This study determined the role of the BTB domain of Bach1 in ischemic angiogenesis. Bach1 is highly expressed in circulating endothelial cells from acute myocardial infarction patients and is the early induction gene after ischemia. Mice were treated with adenoviruses coding for GFP (AdGFP), Bach1 (AdBach1), or a Bach1 mutant lacking the BTB domain (AdBach1-ΔBTB) after surgically induced hind-limb ischemia. Measures of blood-flow recovery, capillary density, and the expression of vascular endothelial growth factor (VEGF) and heme oxygenase-1 (HO-1) were significantly lower and ROS levels were higher in the AdBach1 group, but not in AdBach1-ΔBTB animals. Furthermore, transfection with AdBach1, but not AdBach1-ΔBTB, in human endothelial cells was associated with significant declines in 1) capillary density and hemoglobin content in the Matrigel-plug assay, 2) proliferation, migration, tube formation, and VEGF and HO-1 expression in endothelial cells. Bach1 binds directly with TCF4, and this interaction is mediated by residues 81-89 of the Bach1 BTB domain and the N-terminal domain of TCF4. Bach1, but not Bach1-ΔBTB, also co-precipitated with histone deacetylase 1 (HDAC1), while the full-length HDAC1 proteins, but not HDAC1 mutants lacking the protein-interaction domain, co-precipitated with Bach1. Collectively, these results demonstrate that the anti-angiogenic activity of Bach1 is crucially dependent on molecular interactions that are mediated by the protein's BTB domain, and this domain could be a drug target for angiogenic therapy.

journal_name

EBioMedicine

journal_title

EBioMedicine

authors

Jiang L,Jia M,Wei X,Guo J,Hao S,Mei A,Zhi X,Wang X,Li Q,Jin J,Zhang J,Li S,Meng D

doi

10.1016/j.ebiom.2019.102617

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

102617

issn

2352-3964

pii

S2352-3964(19)30832-1

journal_volume

51

pub_type

杂志文章

相关文献

EBioMedicine文献大全
  • Evaluation of antiviral - passive - active immunization ("sandwich") therapeutic strategy for functional cure of chronic hepatitis B in mice.

    abstract：BACKGROUND:Chronic Hepatitis B (CHB) remains a major problem for global public health. Viral persistence and immune defects are the two major reasons for CHB, and it was hypothesized that based on a transient clearance of serum viral DNA and HBsAg "window stage", active immunization against hepatitis B virus (HBV) migh...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.10.043

    authors： Shi B,Wu Y,Wang C,Li X,Yu F,Wang B,Yang Z,Li J,Liang M,Wen Y,Ying T,Yuan Z

    更新日期：2019-11-01 00:00:00

  • Quantification, epitope mapping and genotype cross-reactivity of hepatitis B preS-specific antibodies in subjects vaccinated with different dosage regimens of BM32.

    abstract：BACKGROUND:Chronic hepatitis B virus (HBV) infections are a global health problem. There is a need for therapeutic strategies blocking continuous infection of liver cells. The grass pollen allergy vaccine BM32 containing the preS domain of the large HBV surface protein (LHBs) as immunogenic carrier induced IgG antibodi...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102953

    authors： Tulaeva I,Cornelius C,Zieglmayer P,Zieglmayer R,Schmutz R,Lemell P,Weber M,Focke-Tejkl M,Karaulov A,Henning R,Valenta R

    更新日期：2020-09-01 00:00:00

  • A PREVIOUSLY UNKNOWN UNIQUE CHALLENGE FOR INHIBITORS OF SYK ATP-BINDING SITE: ROLE OF SYK AS A CELL CYCLE CHECKPOINT REGULATOR.

    abstract：:The identification of SYK as a molecular target in B-lineage leukemia/lymphoma cells prompted the development of SYK inhibitors as a new class of anti-cancer drug candidates. Here we report that induction of the SYK gene expression in human cells causes a significant down-regulation of evolutionarily conserved genes a...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2014.10.019

    authors： Uckun FM,Ma H,Ozer Z,Goodman P,Zhang J,Qazi S

    更新日期：2014-11-01 00:00:00

  • Anti-Tumour Necrosis Factor Therapy for Dupuytren's Disease: A Randomised Dose Response Proof of Concept Phase 2a Clinical Trial.

    abstract：BACKGROUND:Dupuytren's disease is a common fibrotic condition of the hand that causes irreversible flexion contractures of the fingers, with no approved therapy for early stage disease. Our previous analysis of surgically-excised tissue defined tumour necrosis factor (TNF) as a potential therapeutic target. Here we ass...

    journal_title：EBioMedicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ebiom.2018.06.022

    authors： Nanchahal J,Ball C,Davidson D,Williams L,Sones W,McCann FE,Cabrita M,Swettenham J,Cahoon NJ,Copsey B,Anne Francis E,Taylor PC,Black J,Barber VS,Dutton S,Feldmann M,Lamb SE

    更新日期：2018-07-01 00:00:00

  • Endotype-phenotyping may predict a treatment response in progressive fibrosing interstitial lung disease.

    abstract：BACKGROUND:Some interstitial lung disease (ILD) patients develop a progressive fibrosing-ILD phenotype (PF-ILD), with similar persistent lung function decline suggesting common molecular pathways involved. Nintedanib, a tyrosine kinase inhibitor targeting the PDGF, FGF, VEGF and M-CSF pathways, has shown comparable eff...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.10.050

    authors： Hoffmann-Vold AM,Weigt SS,Saggar R,Palchevskiy V,Volkmann ER,Liang LL,Ross D,Ardehali A,Lynch JP 3rd,Belperio JA

    更新日期：2019-12-01 00:00:00

  • Artificial intelligence-assisted prediction of preeclampsia: Development and external validation of a nationwide health insurance dataset of the BPJS Kesehatan in Indonesia.

    abstract：BACKGROUND:We developed and validated an artificial intelligence (AI)-assisted prediction of preeclampsia applied to a nationwide health insurance dataset in Indonesia. METHODS:The BPJS Kesehatan dataset have been preprocessed using a nested case-control design into preeclampsia/eclampsia (n = 3318) and normotensive p...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102710

    authors： Sufriyana H,Wu YW,Su EC

    更新日期：2020-04-01 00:00:00

  • Skeletal muscle as potential central link between sarcopenia and immune senescence.

    abstract：:As our population grows older, age-related pathologies are becoming more prevalent. Deterioration of skeletal muscle and the immune system manifests as sarcopenia and immune senescence respectively. The disease burden of these pathologies emphasizes the need for a better understanding of the underlying mechanisms. Ske...

    journal_title：EBioMedicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ebiom.2019.10.034

    authors： Nelke C,Dziewas R,Minnerup J,Meuth SG,Ruck T

    更新日期：2019-11-01 00:00:00

  • Downregulation of circRNA DMNT3B contributes to diabetic retinal vascular dysfunction through targeting miR-20b-5p and BAMBI.

    abstract：BACKGROUND:Diabetic retinopathy, a vascular complication of diabetes mellitus, is the leading cause of visual impairment and blindness. circRNAs act as competing endogenous RNA, sponging target miRNA and thus influencing mRNA expression in vascular diseases. We investigated whether and how circDNMT3B is involved in ret...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.10.004

    authors： Zhu K,Hu X,Chen H,Li F,Yin N,Liu AL,Shan K,Qin YW,Huang X,Chang Q,Xu GZ,Wang Z

    更新日期：2019-11-01 00:00:00

  • The association of α4β7 expression with HIV acquisition and disease progression in people who inject drugs and men who have sex with men: Case control studies.

    abstract：BACKGROUND:α4β7 is a gut-homing integrin heterodimer that can act as a non-essential binding molecule for HIV. A previous study in heterosexual African women found that individuals with higher proportions of α4β7 expressing CD4+ T cells were more likely to become infected with HIV, as well as present with faster diseas...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.103102

    authors： Martin AR,Patel EU,Kirby C,Astemborski J,Kirk GD,Mehta SH,Marshall K,Janes H,Clayton A,Corey L,Hammer SM,Sobieszczyk ME,Arthos J,Cicala C,Redd AD,Quinn TC

    更新日期：2020-12-01 00:00:00

  • Pathophysiologic Response to Burns in the Elderly.

    abstract：:Over the last decades advancements have improved survival and outcomes of severely burned patients except one population, elderly. The Lethal Dose 50 (LD50) burn size in elderly has remained the same over the past three decades, and so has morbidity and mortality, despite the increased demand for elderly burn care. Th...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2015.07.040

    authors： Jeschke MG,Patsouris D,Stanojcic M,Abdullahi A,Rehou S,Pinto R,Chen P,Burnett M,Amini-Nik S

    更新日期：2015-07-31 00:00:00

  • Beyond multidrug resistance: Leveraging rare variants with machine and statistical learning models in Mycobacterium tuberculosis resistance prediction.

    abstract：BACKGROUND:The diagnosis of multidrug resistant and extensively drug resistant tuberculosis is a global health priority. Whole genome sequencing of clinical Mycobacterium tuberculosis isolates promises to circumvent the long wait times and limited scope of conventional phenotypic antimicrobial susceptibility, but gaps ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.04.016

    authors： Chen ML,Doddi A,Royer J,Freschi L,Schito M,Ezewudo M,Kohane IS,Beam A,Farhat M

    更新日期：2019-05-01 00:00:00

  • Neurobiological Correlates and Predictors of Two Distinct Personality Trait Pathways to Escalated Alcohol Use.

    abstract：BACKGROUND:The delineation of the behavioral neurobiological mechanisms underlying the heterogeneous pathways for alcohol use disorders (AUDs) is ostensibly imperative for the development of more cost-effective treatments predicated on better understanding of this complex psychopathology. METHODS:1) Forty-eight high a...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.11.025

    authors： Shakra MA,Leyton M,Moghnieh H,Pruessner J,Dagher A,Pihl R

    更新日期：2018-01-01 00:00:00

  • A PDGFRβ-based score predicts significant liver fibrosis in patients with chronic alcohol abuse, NAFLD and viral liver disease.

    abstract：BACKGROUND:Platelet Derived Growth Factor Receptor beta (PDGFRβ) has been associated to hepatic stellate cell activation and has been the target of multiple therapeutic studies. However, little is known concerning its use as a diagnostic agent. METHODS:Circulating PDGFRβ levels were analysed in a cohort of patients wi...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.04.036

    authors： Lambrecht J,Verhulst S,Mannaerts I,Sowa JP,Best J,Canbay A,Reynaert H,van Grunsven LA

    更新日期：2019-05-01 00:00:00

  • Transcription factor EB regulates cardiovascular homeostasis.

    abstract：:Cardiovascular diseases (CVDs) are the leading cause of death and a major cause of disability globally. Transcription factor EB (TFEB), as a member of the microphthalmia transcription factor (MITF) family, has been demonstrated to be a master regulator of autophagy and lysosomal biogenesis. Emerging studies suggest th...

    journal_title：EBioMedicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ebiom.2020.103207

    authors： Lu H,Sun J,Hamblin MH,Chen YE,Fan Y

    更新日期：2021-01-01 00:00:00

  • Local Somatodendritic Translation and Hyperphosphorylation of Tau Protein Triggered by AMPA and NMDA Receptor Stimulation.

    abstract：:Tau is a major component of the neurofibrillary tangles (NFT) that represent a pathological hallmark of Alzheimer's disease (AD). Although generally considered an axonal protein, Tau is found in the somato-dendritic compartment of degenerating neurons and this redistribution is thought to be a trigger of neurodegenera...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.05.012

    authors： Kobayashi S,Tanaka T,Soeda Y,Almeida OFX,Takashima A

    更新日期：2017-06-01 00:00:00

  • Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients.

    abstract：BACKGROUND:The dynamic changes of lymphocyte subsets and cytokines profiles of patients with novel coronavirus disease (COVID-19) and their correlation with the disease severity remain unclear. METHODS:Peripheral blood samples were longitudinally collected from 40 confirmed COVID-19 patients and examined for lymphocyt...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102763

    authors： Liu J,Li S,Liu J,Liang B,Wang X,Wang H,Li W,Tong Q,Yi J,Zhao L,Xiong L,Guo C,Tian J,Luo J,Yao J,Pang R,Shen H,Peng C,Liu T,Zhang Q,Wu J,Xu L,Lu S,Wang B,Weng Z,Han C,Zhu H,Zhou R,Zhou H,Chen X,

    更新日期：2020-05-01 00:00:00

  • DsbA-L ameliorates high glucose induced tubular damage through maintaining MAM integrity.

    abstract：BACKGROUND:The mitochondrial associated endoplasmic reticulum (ER) membrane (MAM) provides a platform for communication between the mitochondria and ER, and it plays a vital role in many biological functions. Disulphide-bond A oxidoreductase-like protein (DsbA-L), expressed in the MAM, serves as an antioxidant and redu...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.04.044

    authors： Yang M,Zhao L,Gao P,Zhu X,Han Y,Chen X,Li L,Xiao Y,Wei L,Li C,Xiao L,Yuan S,Liu F,Dong LQ,Kanwar YS,Sun L

    更新日期：2019-05-01 00:00:00

  • Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease.

    abstract：:Chronic kidney disease (CKD) is a global health problem, and novel therapies to treat CKD are urgently needed. Here, we show that inhibition of G0/G1 switch 2 (G0s2) ameliorates renal inflammation in a mouse model of CKD. Renal expression of chemokine (C-C motif) ligand 2 (Ccl2) was increased in response to p65 activa...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.10.008

    authors： Matsunaga N,Ikeda E,Kakimoto K,Watanabe M,Shindo N,Tsuruta A,Ikeyama H,Hamamura K,Higashi K,Yamashita T,Kondo H,Yoshida Y,Matsuda M,Ogino T,Tokushige K,Itcho K,Furuichi Y,Nakao T,Yasuda K,Doi A,Amamoto T,Aramaki

    更新日期：2016-11-01 00:00:00

  • Tumor cells induce LAMP2a expression in tumor-associated macrophage for cancer progression.

    abstract：BACKGROUND:Tumor cells benefit from tumor-associated macrophages (TAMs) promoting tumor growth and modulating functions of other cells in tumor microenvironment (TME). However, how tumor cells regulate the property of TAMs during tumor invasion remains to be defined. METHODS:Mouse tumor models and cancer patients' sam...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.01.045

    authors： Wang R,Liu Y,Liu L,Chen M,Wang X,Yang J,Gong Y,Ding BS,Wei Y,Wei X

    更新日期：2019-02-01 00:00:00

  • Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice.

    abstract：:Wnt/β-catenin is involved in every aspect of embryonic development and in the pathogenesis of many human diseases, and is also implicated in organ fibrosis. However, the role of β-catenin-mediated signaling on liver fibrosis remains unclear. To explore this issue, the effects of PRI-724, a selective inhibitor of the c...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2015.10.010

    authors： Osawa Y,Oboki K,Imamura J,Kojika E,Hayashi Y,Hishima T,Saibara T,Shibasaki F,Kohara M,Kimura K

    更新日期：2015-10-08 00:00:00

  • Serotonin Activates Bacterial Quorum Sensing and Enhances the Virulence of Pseudomonas aeruginosa in the Host.

    abstract：:Bacteria in humans play an important role in health and disease. Considerable emphasis has been placed in understanding the role of bacteria in host-microbiome interkingdom communication. Here we show that serotonin, responsible for mood in the brain and motility in the gut, can also act as a bacterial signaling molec...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.05.037

    authors： Knecht LD,O'Connor G,Mittal R,Liu XZ,Daftarian P,Deo SK,Daunert S

    更新日期：2016-07-01 00:00:00

  • Human Endogenous Retrovirus and Neuroinflammation in Chronic Inflammatory Demyelinating Polyradiculoneuropathy.

    abstract：BACKGROUND:Human endogenous retroviruses HERV-W encode a pro-inflammatory protein, named MSRV-Env from its original identification in Multiple Sclerosis. Though not detected in various neurological controls, MSRV-Env was found in patients with chronic inflammatory demyelinating polyradiculoneuropathies (CIDPs). This st...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.03.001

    authors： Faucard R,Madeira A,Gehin N,Authier FJ,Panaite PA,Lesage C,Burgelin I,Bertel M,Bernard C,Curtin F,Lang AB,Steck AJ,Perron H,Kuntzer T,Créange A

    更新日期：2016-04-01 00:00:00

  • Context-dependent effect of sPLA2-IIA induced proliferation on murine hair follicle stem cells and human epithelial cancer.

    abstract：BACKGROUND:Tissue stem cells (SCs) and cancer cells proliferation is regulated by many common signalling mechanisms. These mechanisms temporally balance proliferation and differentiation events during normal tissue homeostasis and repair. However, the effect of these aberrant signalling mechanisms on the ultimate fate ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.08.053

    authors： Chovatiya GL,Sunkara RR,Roy S,Godbole SR,Waghmare SK

    更新日期：2019-10-01 00:00:00

  • Memory B Cells are Major Targets for Effective Immunotherapy in Relapsing Multiple Sclerosis.

    abstract：:Although multiple sclerosis (MS) is considered to be a CD4, Th17-mediated autoimmune disease, supportive evidence is perhaps circumstantial, often based on animal studies, and is questioned by the perceived failure of CD4-depleting antibodies to control relapsing MS. Therefore, it was interestingly to find that curren...

    journal_title：EBioMedicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ebiom.2017.01.042

    authors： Baker D,Marta M,Pryce G,Giovannoni G,Schmierer K

    更新日期：2017-02-01 00:00:00

  • Paternal Insulin-like Growth Factor 2 (Igf2) Regulates Stem Cell Activity During Adulthood.

    abstract：:Insulin-like Growth Factor 2 (IGF2) belongs to the IGF/Insulin pathway, a highly conserved evolutionarily network that regulates growth, aging and lifespan. Igf2 is highly expressed in the embryo and in cancer cells. During mouse development, Igf2 is expressed in all sites where hematopoietic stem cells (HSC) successi...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.11.035

    authors： Barroca V,Lewandowski D,Jaracz-Ros A,Hardouin SN

    更新日期：2017-02-01 00:00:00

  • Genetic Variation in the Dopamine System Influences Intervention Outcome in Children with Cerebral Palsy.

    abstract：BACKGROUND:There is large variation in treatment responses in children with cerebral palsy. Experimental and clinical results suggest that dopamine neurotransmission and brain-derived neurotrophic factor (BDNF) signalling are involved in motor learning and plasticity, which are key factors in modern habilitation succes...

    journal_title：EBioMedicine

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ebiom.2017.12.028

    authors： Diaz Heijtz R,Almeida R,Eliasson AC,Forssberg H

    更新日期：2018-02-01 00:00:00

  • An effective vaginal gel to deliver CRISPR/Cas9 system encapsulated in poly (β-amino ester) nanoparticles for vaginal gene therapy.

    abstract：BACKGROUND:Gene therapy has held promises for treating specific genetic diseases. However, the key to clinical application depends on effective gene delivery. METHODS:Using a large animal model, we developed two pharmaceutical formulations for gene delivery in the pigs' vagina, which were made up of poly (β-amino este...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102897

    authors： Niu G,Jin Z,Zhang C,He D,Gao X,Zou C,Zhang W,Ding J,Das BC,Severinov K,Hitzeroth II,Debata PR,Ma X,Tian X,Gao Q,Wu J,You Z,Tian R,Cui Z,Fan W,Xie W,Huang Z,Cao C,Xu W,Xie H,Xu H,Tang X,Wang Y,Yu Z

    更新日期：2020-08-01 00:00:00

  • Intra-tumour heterogeneity of diffuse large B-cell lymphoma involves the induction of diversified stroma-tumour interfaces.

    abstract：BACKGROUND:Intra-tumour heterogeneity in lymphoid malignancies encompasses selection of genetic events and epigenetic regulation of transcriptional programs. Clonal-related neoplastic cell populations are unsteadily subjected to immune editing and metabolic adaptations within different tissue microenvironments. How tis...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.103055

    authors： Sangaletti S,Iannelli F,Zanardi F,Cancila V,Portararo P,Botti L,Vacca D,Chiodoni C,Di Napoli A,Valenti C,Rizzello C,Vegliante MC,Pisati F,Gulino A,Ponzoni M,Colombo MP,Tripodo C

    更新日期：2020-11-01 00:00:00

  • Accumulation of mitochondrial 7S DNA in idiopathic and LRRK2 associated Parkinson's disease.

    abstract：BACKGROUND:Both idiopathic and familial Parkinson's disease are associated with mitochondrial dysfunction. Mitochondria have their own mitochondrial DNA (mtDNA) and previous studies have reported that the release of mtDNA is a biomarker of Parkinson's disease. METHODS:We have now investigated the relationship between ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.09.015

    authors： Podlesniy P,Puigròs M,Serra N,Fernández-Santiago R,Ezquerra M,Tolosa E,Trullas R

    更新日期：2019-10-01 00:00:00

  • A miR-567-PIK3AP1-PI3K/AKT-c-Myc feedback loop regulates tumour growth and chemoresistance in gastric cancer.

    abstract：BACKGROUND:Gastric cancer (GC) ranks the fifth most common cancer, and chemotherapy is one of the most common treatments for GC. However, chemoresistance limits the effectiveness of chemotherapy and leads to treatment failure. This study aims to investigate the biological effect of miR-567 on gastric tumourigenesis and...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.05.003

    authors： Zhang F,Li K,Yao X,Wang H,Li W,Wu J,Li M,Zhou R,Xu L,Zhao L

    更新日期：2019-06-01 00:00:00