Building the Evidence Base of Blood-Based Biomarkers for Early Detection of Cancer: A Rapid Systematic Mapping Review.

abstract：:Although multiple sclerosis (MS) is considered to be a CD4, Th17-mediated autoimmune disease, supportive evidence is perhaps circumstantial, often based on animal studies, and is questioned by the perceived failure of CD4-depleting antibodies to control relapsing MS. Therefore, it was interestingly to find that curren...

journal_title：EBioMedicine

authors： Baker D,Marta M,Pryce G,Giovannoni G,Schmierer K

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Liver dysfunction is common in pregnancy but its association with adverse pregnancy outcomes such as preterm birth (PTB) remains unclear. METHODS:A prospective cohort of HBV-infected or uninfected pregnant women attending antenatal care was recruited at Nantong Maternal and Child Health Hospital between Jan...

journal_title：EBioMedicine

authors： Zhuang X,Cui AM,Wang Q,Cheng XY,Shen Y,Cai WH,Li HB,Zhang S,Qin G

更新日期：2017-12-01 00:00:00

abstract：:Although psychotropic drugs act on neurons and glial cells, how glia respond, and whether glial responses are involved in therapeutic effects are poorly understood. Here, we show that fluoxetine (FLX), an anti-depressant, mediates its anti-depressive effect by increasing the gliotransmission of ATP. FLX increased ATP ...

journal_title：EBioMedicine

authors： Kinoshita M,Hirayama Y,Fujishita K,Shibata K,Shinozaki Y,Shigetomi E,Takeda A,Le HPN,Hayashi H,Hiasa M,Moriyama Y,Ikenaka K,Tanaka KF,Koizumi S

更新日期：2018-06-01 00:00:00

abstract：:Base excision repair (BER) is the main mechanism to repair endogenous DNA lesions caused by reactive oxygen species. BER deficiency is linked with cancer susceptibility and premature aging. Single nucleotide polymorphisms (SNPs) within BER genes have been implicated in various human malignancies. Nevertheless, a compr...

journal_title：EBioMedicine

authors： Zhu J,Jia W,Wu C,Fu W,Xia H,Liu G,He J

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:α4β7 is a gut-homing integrin heterodimer that can act as a non-essential binding molecule for HIV. A previous study in heterosexual African women found that individuals with higher proportions of α4β7 expressing CD4+ T cells were more likely to become infected with HIV, as well as present with faster diseas...

journal_title：EBioMedicine

authors： Martin AR,Patel EU,Kirby C,Astemborski J,Kirk GD,Mehta SH,Marshall K,Janes H,Clayton A,Corey L,Hammer SM,Sobieszczyk ME,Arthos J,Cicala C,Redd AD,Quinn TC

更新日期：2020-12-01 00:00:00

abstract：:Acute myocardial infarction (AMI) and the heart failure (HF) that often follows are among the leading causes of death and disability worldwide. As such, new treatments are needed to protect the myocardium against the damaging effects of the acute ischaemia and reperfusion injury (IRI) that occurs in AMI, in order to r...

journal_title：EBioMedicine

authors： Ramachandra CJA,Hernandez-Resendiz S,Crespo-Avilan GE,Lin YH,Hausenloy DJ

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Human endogenous retroviruses HERV-W encode a pro-inflammatory protein, named MSRV-Env from its original identification in Multiple Sclerosis. Though not detected in various neurological controls, MSRV-Env was found in patients with chronic inflammatory demyelinating polyradiculoneuropathies (CIDPs). This st...

journal_title：EBioMedicine

authors： Faucard R,Madeira A,Gehin N,Authier FJ,Panaite PA,Lesage C,Burgelin I,Bertel M,Bernard C,Curtin F,Lang AB,Steck AJ,Perron H,Kuntzer T,Créange A

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Subcellular localization and function of L-type calcium channels (LTCCs) play an important role in regulating contraction of cardiomyocytes. Understanding how this is affected by the disruption of transverse tubules during heart failure could lead to new insights into the disease. METHODS:Cardiomyocytes wer...

journal_title：EBioMedicine

authors： Sanchez-Alonso JL,Loucks A,Schobesberger S,van Cromvoirt AM,Poulet C,Chowdhury RA,Trayanova N,Gorelik J

更新日期：2020-07-01 00:00:00

abstract：:Insulin-like Growth Factor 2 (IGF2) belongs to the IGF/Insulin pathway, a highly conserved evolutionarily network that regulates growth, aging and lifespan. Igf2 is highly expressed in the embryo and in cancer cells. During mouse development, Igf2 is expressed in all sites where hematopoietic stem cells (HSC) successi...

journal_title：EBioMedicine

authors： Barroca V,Lewandowski D,Jaracz-Ros A,Hardouin SN

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:The resistance to EGF receptor (EGFR) tyrosine kinase inhibitors (TKI) is a major challenge in the treatment of non-small cell lung cancer (NSCLC). Understanding the molecular mechanisms behind resistance is therefore an important issue. Here we assessed the role of EGFR pathway substrate 8 (EPS8) and Forkhe...

journal_title：EBioMedicine

authors： Wen Q,Jiao X,Kuang F,Hou B,Zhu Y,Guo W,Sun G,Ba Y,Yu D,Wang D,Zhang F,Qiao HC,Wang S,Tang S,Qiao H

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:The induction of heat shock protein (HSP) 72 by mild electrical stimulation with heat shock (MES + HS), which improves visceral adiposity and insulin resistance in mice, may be beneficial in treating metabolic syndrome (MS) or type 2 diabetes mellitus (T2DM). METHODS:Using open-label crossover trials, 40 su...

journal_title：EBioMedicine

authors： Kondo T,Ono K,Kitano S,Matsuyama R,Goto R,Suico MA,Kawasaki S,Igata M,Kawashima J,Motoshima H,Matsumura T,Kai H,Araki E

更新日期：2014-11-11 00:00:00

abstract：BACKGROUND:Tumor necrosis factor-like weak inducer of apoptosis (Tnfsf12; TWEAK) and its receptor Fibroblast growth factor-inducible 14 (Tnfrsf12a; Fn14) participate in the inflammatory response associated with vascular remodeling. However, the functional effect of TWEAK on vascular smooth muscle cells (VSMCs) is not c...

journal_title：EBioMedicine

authors： Méndez-Barbero N,Gutierrez-Muñoz C,Madrigal-Matute J,Mínguez P,Egido J,Michel JB,Martín-Ventura JL,Esteban V,Blanco-Colio LM

更新日期：2019-08-01 00:00:00

abstract：:In 2009 the U.S. Food and Drug Administration (FDA) placed a black box warning on metoclopramide (MCP) due to the increased risks and prevalence of tardive dyskinesia (TD). In this study, we developed a multi-step biomedical informatics screening (MSBIS) approach leveraging publicly available bioactivity and drug safe...

journal_title：EBioMedicine

authors： Xu D,Ham AG,Tivis RD,Caylor ML,Tao A,Flynn ST,Economen PJ,Dang HK,Johnson RW,Culbertson VL

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Abnormalities in membrane excitability and Na(+) channel function are characteristic of amyotrophic lateral sclerosis (ALS). We aimed to examine the neuroprotective potential, safety and tolerability of the Na(+) channel blocker and membrane stabiliser flecainide in ALS. METHODS:A double-blind, placebo-cont...

journal_title：EBioMedicine

authors： Park SB,Vucic S,Cheah BC,Lin CS,Kirby A,Mann KP,Zoing MC,Winhammar J,Kiernan MC

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Tumor cells benefit from tumor-associated macrophages (TAMs) promoting tumor growth and modulating functions of other cells in tumor microenvironment (TME). However, how tumor cells regulate the property of TAMs during tumor invasion remains to be defined. METHODS:Mouse tumor models and cancer patients' sam...

journal_title：EBioMedicine

authors： Wang R,Liu Y,Liu L,Chen M,Wang X,Yang J,Gong Y,Ding BS,Wei Y,Wei X

更新日期：2019-02-01 00:00:00

abstract：:Warming temperatures may increase the geographic spread of vector-borne diseases into temperate areas. Although a tropical mosquito-borne viral disease, a dengue outbreak occurred in Madeira, Portugal, in 2012; the first in Europe since 1920s. This outbreak emphasizes the potential for dengue re-emergence in Europe gi...

journal_title：EBioMedicine

authors： Liu-Helmersson J,Quam M,Wilder-Smith A,Stenlund H,Ebi K,Massad E,Rocklöv J

更新日期：2016-05-01 00:00:00

abstract：:Tau is a major component of the neurofibrillary tangles (NFT) that represent a pathological hallmark of Alzheimer's disease (AD). Although generally considered an axonal protein, Tau is found in the somato-dendritic compartment of degenerating neurons and this redistribution is thought to be a trigger of neurodegenera...

journal_title：EBioMedicine

authors： Kobayashi S,Tanaka T,Soeda Y,Almeida OFX,Takashima A

更新日期：2017-06-01 00:00:00

abstract：:We used next generation DNA sequencing to profile the microbiome of infected Diabetic Foot Ulcers (DFUs). The microbiota was correlated to clinical parameters and treatment outcomes to determine if directed antimicrobial therapy based on conventional microbiological cultures are relevant based on genomic analysis. Pat...

journal_title：EBioMedicine

authors： Malone M,Johani K,Jensen SO,Gosbell IB,Dickson HG,Hu H,Vickery K

更新日期：2017-07-01 00:00:00

abstract：:Lung cancer is the most frequent cause of cancer-related death world-wide. Radiotherapy alone or in conjunction with chemotherapy is the standard treatment for locally advanced non-small cell lung cancer (NSCLC). Currently there is no predictive marker with clinical utility to guide treatment decisions in NSCLC patien...

journal_title：EBioMedicine

authors： Walker MJ,Zhou C,Backen A,Pernemalm M,Williamson AJ,Priest LJ,Koh P,Faivre-Finn C,Blackhall FH,Dive C,Whetton AD

更新日期：2015-06-19 00:00:00

abstract：BACKGROUND:Individuals of low socioeconomic status experience a disproportionate burden of chronic conditions; however it is unclear whether chronic condition burden affects survival differently across socioeconomic strata. METHODS:This retrospective cohort study used health administrative data from all residents of O...

journal_title：EBioMedicine

authors： Lane NE,Maxwell CJ,Gruneir A,Bronskill SE,Wodchis WP

更新日期：2015-11-18 00:00:00

abstract：:G Protein Coupled Receptor 109A (GPR109A), which belongs to the G protein coupled receptor family, can be activated by niacin, butyrate, and β-hydroxybutyric acid. Here, we assessed the anti-inflammatory activity of sodium butyrate (SB) on 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mice, an experimenta...

journal_title：EBioMedicine

authors： Chen G,Ran X,Li B,Li Y,He D,Huang B,Fu S,Liu J,Wang W

更新日期：2018-04-01 00:00:00

abstract：:Cardiovascular diseases (CVDs) are the leading cause of death and a major cause of disability globally. Transcription factor EB (TFEB), as a member of the microphthalmia transcription factor (MITF) family, has been demonstrated to be a master regulator of autophagy and lysosomal biogenesis. Emerging studies suggest th...

journal_title：EBioMedicine

authors： Lu H,Sun J,Hamblin MH,Chen YE,Fan Y

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Non-small cell lung carcinomas (NSCLC) are prevalent, lethal cancers with especially grim prospects due to late-stage detection and chemoresistance. Circular RNAs (circRNAs) are non-coding RNAs that participate in tumor development. However, the role of circRNAs in NSCLC is not well known. This study investi...

journal_title：EBioMedicine

authors： Wei S,Zheng Y,Jiang Y,Li X,Geng J,Shen Y,Li Q,Wang X,Zhao C,Chen Y,Qian Z,Zhou J,Li W

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Non-invasive lung adenocarcinoma could benefit from limited resection, nonetheless, there is a lack of method to determine preoperative tumour invasiveness. We aimed to investigate whether folate receptor-positive circulating tumour cells (FR+-CTCs) in combination with maximum tumour diameter (MTD) determine...

journal_title：EBioMedicine

authors： Zhou Q,Geng Q,Wang L,Huang J,Liao M,Li Y,Ding Z,Yang S,Zhao H,Shen Q,Pan C,Lou J,Lu S,Chen C,Luo Q

更新日期：2019-03-01 00:00:00

abstract：:Many broadly reactive human monoclonal antibodies against the hemagglutinin (HA) stem of influenza A virus have been developed for therapeutic applications. These antibodies typically inhibit viral entry steps, especially the HA conformational change that is required for membrane fusion. To better understand the mecha...

journal_title：EBioMedicine

authors： Yamayoshi S,Uraki R,Ito M,Kiso M,Nakatsu S,Yasuhara A,Oishi K,Sasaki T,Ikuta K,Kawaoka Y

更新日期：2017-03-01 00:00:00

abstract：:A central pathogenic event of Alzheimer's disease (AD) is the accumulation of the Aβ42 peptide, which is generated from amyloid-β precursor protein (APP) via cleavages by β- and γ-secretase. We have developed a class of soluble 2-aminothiazole γ-secretase modulators (SGSMs) that preferentially decreases Aβ42 levels. H...

journal_title：EBioMedicine

authors： Raven F,Ward JF,Zoltowska KM,Wan Y,Bylykbashi E,Miller SJ,Shen X,Choi SH,Rynearson KD,Berezovska O,Wagner SL,Tanzi RE,Zhang C

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Clinical trials on multiple sclerosis with repeated injections of monoclonal antibodies depleting CD4+ T cells have not resulted in much success as a disease therapy. Here, we developed an immunotherapy for EAE in mice by combining a transient depletion of T cells together with the administration of neuron d...

journal_title：EBioMedicine

authors： Kasagi S,Wang D,Zhang P,Zanvit P,Chen H,Zhang D,Li J,Che L,Maruyama T,Nakatsukasa H,Wu R,Jin W,Sun L,Chen W

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Gene therapy has held promises for treating specific genetic diseases. However, the key to clinical application depends on effective gene delivery. METHODS:Using a large animal model, we developed two pharmaceutical formulations for gene delivery in the pigs' vagina, which were made up of poly (β-amino este...

journal_title：EBioMedicine

authors： Niu G,Jin Z,Zhang C,He D,Gao X,Zou C,Zhang W,Ding J,Das BC,Severinov K,Hitzeroth II,Debata PR,Ma X,Tian X,Gao Q,Wu J,You Z,Tian R,Cui Z,Fan W,Xie W,Huang Z,Cao C,Xu W,Xie H,Xu H,Tang X,Wang Y,Yu Z

更新日期：2020-08-01 00:00:00

abstract：:Cancer cells frequently up-regulate DNA replication and repair proteins such as the multifunctional DNA2 nuclease/helicase, counteracting DNA damage due to replication stress and promoting survival. Therefore, we hypothesized that blocking both DNA replication and repair by inhibiting the bifunctional DNA2 could be a ...

journal_title：EBioMedicine

authors： Liu W,Zhou M,Li Z,Li H,Polaczek P,Dai H,Wu Q,Liu C,Karanja KK,Popuri V,Shan SO,Schlacher K,Zheng L,Campbell JL,Shen B

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:The 5-year survival rate of patients with pancreatic ductal adenocarcinoma (PDAC) is around 5% due to the fact that the majority of patients present with advanced disease that is treatment resistant. Familial pancreatic cancer (FPC) is a rare disorder that is defined as a family with at least two affected fi...

journal_title：EBioMedicine

authors： Earl J,Galindo-Pumariño C,Encinas J,Barreto E,Castillo ME,Pachón V,Ferreiro R,Rodríguez-Garrote M,González-Martínez S,Ramon Y Cajal T,Diaz LR,Chirivella-Gonzalez I,Rodriguez M,de Castro EM,García-Seisdedos D,Muñoz G,Rosa

更新日期：2020-03-01 00:00:00