Molecular and neural bases underlying roles of BDNF in the control of body weight.

abstract：:We previously demonstrated that, in the early stages of tau processing in Alzheimer's disease, the N-terminal part of the molecule undergoes a characteristic cascade of phosphorylation and progressive misfolding of the proteins resulting in a structural conformation detected by Alz-50. In this immunohistochemical stud...

journal_title：Frontiers in neuroscience

authors： Flores-Rodríguez P,Ontiveros-Torres MA,Cárdenas-Aguayo MC,Luna-Arias JP,Meraz-Ríos MA,Viramontes-Pintos A,Harrington CR,Wischik CM,Mena R,Florán-Garduño B,Luna-Muñoz J

更新日期：2015-02-11 00:00:00

abstract：:Motor neurons (MN) degeneration is a main feature of amyotrophic lateral sclerosis (ALS), a neurological disorder with a progressive course. The diagnosis of ALS is essentially a clinical one. Most common symptoms include a gradual neurological deterioration that reflect the impairment and subsequent loss of muscle fu...

journal_title：Frontiers in neuroscience

authors： Forostyak S,Sykova E

更新日期：2017-10-24 00:00:00

abstract：:Stereotactic electroencephalogaphy (sEEG) utilizes localized, penetrating depth electrodes to measure electrophysiological brain activity. It is most commonly used in the identification of epileptogenic zones in cases of refractory epilepsy. The implanted electrodes generally provide a sparse sampling of a unique set ...

journal_title：Frontiers in neuroscience

authors： Herff C,Krusienski DJ,Kubben P

更新日期：2020-02-27 00:00:00

abstract：:Familiarity in music has been reported as an important factor modulating emotional and hedonic responses in the brain. Familiarity and repetition may increase the liking of a piece of music, thus inducing positive emotions. Neuroimaging studies have focused on identifying the brain regions involved in the processing o...

journal_title：Frontiers in neuroscience

authors： Freitas C,Manzato E,Burini A,Taylor MJ,Lerch JP,Anagnostou E

更新日期：2018-10-05 00:00:00

abstract：Purpose:To improve the metoprolol therapeutic effectiveness, we aimed to explore whether baseline heart rate variability (HRV) indicators before metoprolol treatment were useful for predicting its efficacy for postural tachycardia syndrome (POTS). Methods:We recruited 45 children with POTS who received metoprolol and ...

journal_title：Frontiers in neuroscience

authors： Wang Y,Zhang C,Chen S,Liu P,Wang Y,Tang C,Jin H,Du J

更新日期：2019-11-12 00:00:00

abstract：:A well-defined granular layer 4 is a defining cytoarchitectonic feature associated with sensory areas of mammalian cerebral cortex, and one with hodological significance: the local axons ascending from cells in thalamorecipient layer 4 and connecting to layer 2/3 pyramidal neurons form a major feedforward excitatory i...

journal_title：Frontiers in neuroscience

authors： Shepherd GM

更新日期：2009-12-15 00:00:00

abstract：:Evidence is mounting that LRRK2 function, particularly its kinase activity, is elevated in multiple forms of Parkinson's disease, both idiopathic as well as familial forms linked to mutations in the LRRK2 gene. However, sensitive quantitative markers of LRRK2 activation in clinical samples remain at the early stages o...

journal_title：Frontiers in neuroscience

authors： Rideout HJ,Chartier-Harlin MC,Fell MJ,Hirst WD,Huntwork-Rodriguez S,Leyns CEG,Mabrouk OS,Taymans JM

更新日期：2020-08-18 00:00:00

abstract：BACKGROUND AND AIMS:Malfunctions of enteric neurons are believed to play an important role in the pathophysiology of irritable bowel syndrome (IBS). Our aim was to investigate whether neuronal activity in biopsies from IBS patients is altered in comparison to healthy controls (HC). METHODS:Activity of human submucous ...

journal_title：Frontiers in neuroscience

authors： Ostertag D,Buhner S,Michel K,Pehl C,Kurjak M,Götzberger M,Schulte-Frohlinde E,Frieling T,Enck P,Phillip J,Schemann M

更新日期：2015-12-16 00:00:00

abstract：:Interaural time differences (ITD) and interaural level differences (ILD) both signal horizontal sound source location. To achieve a unified percept of our acoustic environment, these two cues require integration. In the present study, we tested this integration of ITD and ILD with electroencephalography (EEG) by measu...

journal_title：Frontiers in neuroscience

authors： Altmann CF,Ueda R,Furukawa S,Kashino M,Mima T,Fukuyama H

更新日期：2017-07-06 00:00:00

abstract：:The value of an object acquired by a particular action often determines the motivation to produce that action. Previous studies found neural signals related to the values of different objects or goods in the orbitofrontal cortex, while the values of outcomes expected from different actions are broadly represented in m...

journal_title：Frontiers in neuroscience

authors： Kim S,Cai X,Hwang J,Lee D

更新日期：2012-07-17 00:00:00

abstract：:Women with epilepsy commonly have premature onset of menopause. The decrease in estrogen levels is associated with increased occurrence of neurodegenerative processes and cognitive decline. Previously, we found that estradiol (E2) replacement in ovariectomized (OVX) female rats significantly reduced the seizure-relate...

journal_title：Frontiers in neuroscience

authors： Iacobas DA,Iacobas S,Nebieridze N,Velíšek L,Velíšková J

更新日期：2018-06-20 00:00:00

abstract：:Self-control exertion on an initial task has been associated with impaired performance on subsequent physical tasks also requiring self-control; an effect suggested to be mediated by changes in perceptions of pain and motivation. However, the effects of spending longer on the initial self-control task are unknown. Thi...

journal_title：Frontiers in neuroscience

authors： Boat R,Hunte R,Welsh E,Dunn A,Treadwell E,Cooper SB

更新日期：2020-10-08 00:00:00

abstract：:Decades of research dedicated toward Alzheimer's disease (AD) has culminated in much of the current understanding of the neurodegeneration associated with disease. However, delineating the pathophysiology and finding a possible cure for the disease is still wanting. This is in part due to the lack of knowledge pertain...

journal_title：Frontiers in neuroscience

authors： Kumar A,Dhull DK,Mishra PS

更新日期：2015-06-09 00:00:00

abstract：:Information processing in the cerebral cortex requires the activation of diverse neurons across layers and columns, which are established through the coordinated production of distinct neuronal subtypes and their placement along the three-dimensional axis. Over recent years, our knowledge of the regulatory mechanisms ...

journal_title：Frontiers in neuroscience

authors： Toma K,Hanashima C

更新日期：2015-08-11 00:00:00

abstract：:Evaluating the effectiveness and performance of neuromorphic hardware is difficult. It is even more difficult when the task of interest is a closed-loop task; that is, a task where the output from the neuromorphic hardware affects some environment, which then in turn affects the hardware's future input. However, close...

journal_title：Frontiers in neuroscience

authors： Stewart TC,DeWolf T,Kleinhans A,Eliasmith C

更新日期：2015-12-15 00:00:00

abstract：:There is increasing evidence of associations between the presence of temporomandibular joint (TMJ) disorders and tinnitus. It has been recently proposed that tinnitus patients with TMJ complaints could constitute a subtype, meaning a subgroup of tinnitus patients responsive to specific treatments. Tinnitus patients wi...

journal_title：Frontiers in neuroscience

authors： Edvall NK,Gunan E,Genitsaridi E,Lazar A,Mehraei G,Billing M,Tullberg M,Bulla J,Whitton J,Canlon B,Hall DA,Cederroth CR

更新日期：2019-08-22 00:00:00

abstract：:Dopamine system plays a pivotal role in specific kinds of substance use disorders (SUD, i. e., cocaine and methamphetamine use disorders). Many studies addressed whether dopamine-involved craving could be alleviated by non-invasive brain stimulation (NIBS) techniques. Nevertheless, the outcomes were highly inconsisten...

journal_title：Frontiers in neuroscience

authors： Ma T,Sun Y,Ku Y

更新日期：2019-10-18 00:00:00

abstract：:The R47H coding variant of the triggering receptor expressed on myeloid cells-2 (TREM2) increases the risk of Alzheimer's disease (AD) similar to apolipoprotein E4. TREM2 R47H has recently been shown to have impaired binding to damage-associated lipid or apolipoprotein ligands. However, it is not known how this R47H v...

journal_title：Frontiers in neuroscience

authors： Park JS,Ji IJ,Kim DH,An HJ,Yoon SY

更新日期：2017-01-18 00:00:00

abstract：:Cellular respiration is a vital process for the existence of life. Any condition that results in deprivation of oxygen (also termed as hypoxia) may eventually lead to deleterious effects on the functioning of tissues. Brain being the highest consumer of oxygen is prone to increased risk of hypoxia-induced neurological...

journal_title：Frontiers in neuroscience

authors： Minhas G,Mathur D,Ragavendrasamy B,Sharma NK,Paanu V,Anand A

更新日期：2017-07-11 00:00:00

abstract：:Extrapancreatic nerves project to pancreatic islets directly or converge onto intrapancreatic ganglia. Intrapancreatic ganglia constitute a complex information-processing center that contains various neurotransmitters and forms an endogenous neural network. Both intrapancreatic ganglia and extrapancreatic nerves have ...

journal_title：Frontiers in neuroscience

authors： Li W,Yu G,Liu Y,Sha L

更新日期：2019-02-20 00:00:00

abstract：:Animal functional magnetic resonance imaging (fMRI) has provided key insights into the physiological mechanisms underlying healthy and diseased brain states. In non-human primates, resting-state fMRI studies are commonly conducted under isoflurane anesthesia, where anesthetic concentration is used to roughly infer ane...

journal_title：Frontiers in neuroscience

authors： Zhang Z,Cai DC,Wang Z,Zeljic K,Wang Z,Wang Y

更新日期：2019-04-11 00:00:00

abstract：:Recent neuroimaging studies in primates aim to define the functional properties of auditory cortical areas, especially areas beyond A1, in order to further our understanding of the auditory cortical organization. Precise mapping of functional magnetic resonance imaging (fMRI) results and interpretation of their locali...

journal_title：Frontiers in neuroscience

authors： Joly O,Baumann S,Balezeau F,Thiele A,Griffiths TD

更新日期：2014-07-21 00:00:00

abstract：:Pain and stress are both phenomena that challenge an individual's homeostasis and have significant overlap in conceptual and physiological processes. Allostasis is the ability to adapt to pain and stress and maintain homeostasis; however, if either process becomes chronic, it may result in negative long-term outcomes....

journal_title：Frontiers in neuroscience

authors： Lunde CE,Sieberg CB

更新日期：2020-03-26 00:00:00

abstract：:The formation of the six-layered structure of the mammalian cortex via the inside-out pattern of neuronal migration is fundamental to neocortical functions. Extracellular cues such as Reelin induce intracellular signaling cascades through the protein phosphorylation. Migrating neurons also have intrinsic machineries t...

journal_title：Frontiers in neuroscience

authors： Ohshima T

更新日期：2015-01-13 00:00:00

abstract：:Several studies of semantic memory in non-musical domains involving recognition of items from long-term memory have shown an age-related shift from the medial temporal lobe structures to the frontal lobe. However, the effects of aging on musical semantic memory remain unexamined. We compared activation associated with...

journal_title：Frontiers in neuroscience

authors： Sikka R,Cuddy LL,Johnsrude IS,Vanstone AD

更新日期：2015-10-06 00:00:00

abstract：:The effects of transcranial direct current stimulation (tDCS) on dorsolateral prefrontal cortex functions, such as working memory (WM), have been examined in a number of studies. However, much less is known about the behavioral effects of tDCS over other important WM-related brain regions, such as the ventrolateral pr...

journal_title：Frontiers in neuroscience

authors： Lukasik KM,Lehtonen M,Salmi J,Meinzer M,Joutsa J,Laine M

更新日期：2018-01-10 00:00:00

abstract：Background:Emerging evidence demonstrates that diet-induced obesity disrupts corticolimbic circuits underlying emotional regulation. Studies directed at understanding how obesity alters brain and behavior are easily confounded by a myriad of complications related to obesity. This study investigated the early neurobiolo...

journal_title：Frontiers in neuroscience

authors： Vega-Torres JD,Azadian M,Rios-Orsini RA,Reyes-Rivera AL,Ontiveros-Angel P,Figueroa JD

更新日期：2020-06-30 00:00:00

abstract：:While brain stimulation techniques have been examined as treatment options for chronic tinnitus for many years, they have recently been extended to multimodal treatment approaches. As chronic tinnitus is often accompanied by comorbid muscular tension in the neck and back, we performed a one-arm pilot study to explore ...

journal_title：Frontiers in neuroscience

authors： Vielsmeier V,Schecklmann M,Schlee W,Kreuzer PM,Poeppl TB,Rupprecht R,Langguth B,Lehner A

更新日期：2018-02-20 00:00:00

abstract：Background and Purpose:Oncological neurosurgery relies heavily on making continuous, intra-operative tumor-brain delineations based on image-guidance. Limitations of currently available imaging techniques call for the development of real-time image-guided resection tools, which allow for reliable functional and anatomi...

journal_title：Frontiers in neuroscience

authors： Soloukey S,Vincent AJPE,Satoer DD,Mastik F,Smits M,Dirven CMF,Strydis C,Bosch JG,van der Steen AFW,De Zeeuw CI,Koekkoek SKE,Kruizinga P

更新日期：2020-01-09 00:00:00

abstract：:Decisions are faster and less accurate when conditions favor speed, and are slower and more accurate when they favor accuracy. This phenomenon is referred to as the speed-accuracy trade-off (SAT). Behavioral studies of the SAT have a long history, and the data from these studies are well characterized within the frame...

journal_title：Frontiers in neuroscience

authors： Standage D,Blohm G,Dorris MC

更新日期：2014-08-13 00:00:00