Abstract:
:Acute liver failure (ALF) is characterized by a sudden and severe deterioration of liver function, typically mirrored by a marked increase of the international normalized ratio (INR) and hepatic encephalopathy (HE). Due to various possible causes hepatocytes get damaged via either apoptotic or necrotic pathways. Anticipating the natural prognosis of a patient with ALF is one of the most challenging tasks in hepatology critical care. Important factors that influence the chance of spontaneous recovery are the underlying etiology of acute liver failure, the acuity of disease, and the severity of HE. Once an estimation of the prognosis in the individual patient has been made, this quickly has to be integrated in the discussion whether high-urgency liver transplantation is necessary and justifiable. This decision has to cover several medical, social, and organizational issues. Well organized liver transplantation programs around the world have achieved an impressive improvement of the 1 year survival rate in ALF from around 40% without transplantation up to nearly 80% with transplantation. The recent debate on whether severe acute alcoholic hepatitis could represent a new candidate eligible for high-urgency liver transplantation shows that the topic is still open for discussion.
journal_name
Front Physioljournal_title
Frontiers in physiologyauthors
Hadem J,Strassburg CP,Manns MPdoi
10.3389/fphys.2012.00340subject
Has Abstractpub_date
2012-08-28 00:00:00pages
340issn
1664-042Xjournal_volume
3pub_type
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2017.00309
更新日期:2017-05-17 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2020-10-22 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2020.593841
更新日期:2020-10-23 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2019.01495
更新日期:2019-12-12 00:00:00
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pub_type: 杂志文章
doi:10.3389/fphys.2020.00426
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2018.01085
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2018.00642
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pub_type: 杂志文章,评审
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journal_title:Frontiers in physiology
pub_type: 杂志文章,评审
doi:10.3389/fphys.2014.00510
更新日期:2015-01-05 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2016.00078
更新日期:2016-03-08 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2020.606287
更新日期:2020-11-27 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2019.00217
更新日期:2019-03-11 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2017.01108
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pub_type: 杂志文章,评审
doi:10.3389/fphys.2017.00434
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2019.00351
更新日期:2019-03-29 00:00:00
abstract::The extensive literature dealing with the Golgi system emphasizes its role in protein secretion and modification, usually without specifying from which evolutionary ancient cell physiological necessity such secretion originated. Neither does it specify which functional requirements the secreted proteins must meet. Fro...
journal_title:Frontiers in physiology
pub_type: 杂志文章,评审
doi:10.3389/fphys.2020.542879
更新日期:2020-10-15 00:00:00
abstract::Trehalases (treh) have been found in different organisms, such as bacteria, fungi, yeast, nematodes, insects, vertebrates, and plants. Their biochemical properties are extremely variable and not yet fully understood. Gene expression patterns have shown differences among insect species suggesting a potential functional...
journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2019.00062
更新日期:2019-02-15 00:00:00
abstract::This mini-review provides an updated summary of various analogs for adaptations of humans to the microgravity of space. Microgravity analogs discussed in this paper include dry immersion, wet immersion, unilateral lower-extremity limb suspension, head down tilt (HDT), and supine bed rest. All Earth-based analogs are i...
journal_title:Frontiers in physiology
pub_type: 杂志文章,评审
doi:10.3389/fphys.2020.00716
更新日期:2020-06-23 00:00:00
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更新日期:2020-08-05 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章,评审
doi:10.3389/fphys.2013.00407
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journal_title:Frontiers in physiology
pub_type: 杂志文章
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更新日期:2020-04-03 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2014.00370
更新日期:2014-09-30 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2018.00730
更新日期:2018-06-25 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2015.00360
更新日期:2015-12-18 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2017.00444
更新日期:2017-06-29 00:00:00
abstract::Heart failure with preserved ejection fraction (HFpEF) is an increasingly studied entity accounting for 50% of all diagnosed heart failure and that has claimed its own dignity being markedly different from heart failure with reduced EF in terms of etiology and natural history (Graziani et al., 2018). Recently, a growi...
journal_title:Frontiers in physiology
pub_type: 杂志文章,评审
doi:10.3389/fphys.2019.01347
更新日期:2019-11-05 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章,评审
doi:10.3389/fphys.2018.00574
更新日期:2018-05-17 00:00:00
abstract::[This corrects the article DOI: 10.3389/fphys.2019.00116.]. ...
journal_title:Frontiers in physiology
pub_type: 杂志文章,已发布勘误
doi:10.3389/fphys.2019.00669
更新日期:2019-05-28 00:00:00