The Evolutionary History and Functional Divergence of Trehalase (treh) Genes in Insects.

abstract：:Alcohol use disorder (AUD) is a major health, social and economic problem for which there are few effective treatments. The opiate antagonist naltrexone is currently prescribed clinically with mixed success. We have used naltrexone in an established behavioral assay (CAFE) in Drosophila melanogaster that measures the ...

journal_title：Frontiers in physiology

authors： Koyyada R,Latchooman N,Jonaitis J,Ayoub SS,Corcoran O,Casalotti SO

更新日期：2018-03-14 00:00:00

abstract：:Rapidly expanding aging populations and a concomitant increase in the prevalence of age-related diseases are global health problems today. Over the past three decades, a large body of work has led to the identification of genes and regulatory networks that affect longevity and health span, often benefiting from the tr...

journal_title：Frontiers in physiology

authors： Hou NS,Taubert S

更新日期：2012-05-18 00:00:00

abstract：:Hyperglycemia induces vascular endothelial dysfunction, which contributes to the development of vascular complication of diabetes. A classic prescription of traditional medicine, HuangqiGuizhiWuwu Decoction (HGWWD) has been used for the treatment of various cardiovascular and cerebrovascular diseases, which all are re...

journal_title：Frontiers in physiology

authors： Cheng H,Lu T,Wang J,Xia Y,Chai X,Zhang M,Yao Y,Zhou N,Zhou S,Chen X,Su W,Liu C,Yi W,Chen Y,Yao L

更新日期：2020-03-25 00:00:00

abstract：:Kir7.1 encoded by the Kcnj13 gene in the mouse is an inwardly rectifying K+ channel present in epithelia where it shares membrane localization with the Na+/K+-pump. Further investigations of the localisation and function of Kir7.1 would benefit from the availability of a knockout mouse, but perinatal mortality attribu...

journal_title：Frontiers in physiology

authors： Cornejo I,Villanueva S,Burgos J,López-Cayuqueo KI,Chambrey R,Julio-Kalajzić F,Buelvas N,Niemeyer MI,Figueiras-Fierro D,Brown PD,Sepúlveda FV,Cid LP

更新日期：2018-04-23 00:00:00

abstract：:Yeast-like symbiotes (YLS), harbored in the abdomen fat-body cells of the rice brown planthopper (BPH), Nilaparvata lugens Stål (Hemiptera: Delphacidae), are vital to the growth and reproduction of their host. It is feasible to manipulate BPH infestation on rice by inhibiting YLS using fungicide. In this study, the fu...

journal_title：Frontiers in physiology

authors： Shentu X,Wang X,Xiao Y,Yu X

更新日期：2019-02-11 00:00:00

abstract：:Background: Non-invasive cardiac mapping-also known as Electrocardiographic imaging (ECGi)-is a novel, painless and relatively economic method to map the electrical activation and repolarization patterns of the heart, providing a valuable tool for early identification and diagnosis of conduction abnormalities and arrh...

journal_title：Frontiers in physiology

authors： Perez Alday EA,Whittaker DG,Benson AP,Colman MA

更新日期：2019-04-05 00:00:00

abstract：:The purpose of this study is to quantitatively analyze the effect of an ectopic beat on heart rate variability (HRV) in the time domain, frequency domain, and in a non-linear analysis. A quantitative analysis was carried out by generating artificial ectopic beats that probabilistically contained a missed beat or a fal...

journal_title：Frontiers in physiology

authors： Choi A,Shin H

更新日期：2018-07-12 00:00:00

abstract：:Botrytis-induced kinase1 (BIK1), a receptor-like cytoplasmic kinase, plays an important role in resistance against pathogens and insects in Arabidopsis thaliana. However, it remains unknown whether BIK1 functions against Plasmodiophora brassicae, an obligate biotrophic protist that attacks cruciferous plants and induc...

journal_title：Frontiers in physiology

authors： Chen T,Bi K,He Z,Gao Z,Zhao Y,Fu Y,Cheng J,Xie J,Jiang D

更新日期：2016-09-13 00:00:00

abstract：:As arteries become stiffer with aging, reflected waves move faster and augment late systolic pressure. Few studies have described the age-related changes in both peripheral and central systolic blood pressures in populations. We investigated the age dependency of peripheral (pSBP) and central (cSBP) systolic pressure ...

journal_title：Frontiers in physiology

authors： Wojciechowska W,Li Y,Stolarz-Skrzypek K,Kawecka-Jaszcz K,Staessen JA,Wang JG,European Project on Genes in Hypertension and the JingNing Study Investigators.

更新日期：2012-06-15 00:00:00

abstract：:Fibrosis is intimately linked to wound healing and is one of the largest causes of wound-related morbidity. While scar formation is the normal and inevitable outcome of adult mammalian cutaneous wound healing, scarring varies widely between different anatomical sites. The spectrum of craniofacial wound healing spans a...

journal_title：Frontiers in physiology

authors： desJardins-Park HE,Mascharak S,Chinta MS,Wan DC,Longaker MT

更新日期：2019-03-29 00:00:00

abstract：:Current cardiac drug safety assessments focus on hERG channel block and QT prolongation for evaluating arrhythmic risks, whereas the optogenetic approach focuses on the action potential (AP) waveform generated by a monolayer of human cardiomyocytes beating synchronously, thus assessing the contribution of several ion ...

journal_title：Frontiers in physiology

authors： Björk S,Ojala EA,Nordström T,Ahola A,Liljeström M,Hyttinen J,Kankuri E,Mervaala E

更新日期：2017-11-02 00:00:00

abstract：:The grand challenge to physiology, as was first described in an essay published in the inaugural issue of Frontiers in Physiology in 2010, remains to integrate function from molecules to intact organisms. In order to make sense of the vast volume of information derived from, and increasingly dependent upon, reductioni...

journal_title：Frontiers in physiology

authors： Billman GE

更新日期：2020-03-10 00:00:00

abstract：:Co-expressed genes often share similar functions, and gene co-expression networks have been widely used in studying the functionality of gene modules. Previous analysis indicated that genes are more likely to be co-expressed if they are either regulated by the same transcription factors, forming protein complexes or s...

journal_title：Frontiers in physiology

authors： Zhang C,Lee S,Mardinoglu A,Hua Q

更新日期：2016-05-02 00:00:00

abstract：:Electrical stimulation of the central and peripheral nervous systems - such as deep brain stimulation, spinal cord stimulation, and epidural cortical stimulation are common therapeutic options increasingly used to treat a large variety of neurological and psychiatric conditions. Despite their remarkable success, there...

journal_title：Frontiers in physiology

authors： Golestanirad L,Gale JT,Manzoor NF,Park HJ,Glait L,Haer F,Kaltenbach JA,Bonmassar G

更新日期：2018-07-27 00:00:00

abstract：:A rich chapter in the history of insect endocrinology has focused on hormonal control of diapause, especially the major roles played by juvenile hormones (JHs), ecdysteroids, and the neuropeptides that govern JH and ecdysteroid synthesis. More recently, experiments with adult diapause in Drosophila melanogaster and th...

journal_title：Frontiers in physiology

authors： Sim C,Denlinger DL

更新日期：2013-07-22 00:00:00

abstract：:When compared to the previous generations, younger generations have become sedentary on a global level. Physical activity positively contributes to human growth and development, causing, indeed, both physiological and psychological benefits. The aim of the current study was examining the relationship between physical ...

journal_title：Frontiers in physiology

authors： Padulo J,Bragazzi NL,De Giorgio A,Grgantov Z,Prato S,Ardigò LP

更新日期：2019-03-05 00:00:00

abstract：Background:Spontaneously Hypertensive Rats (SHR) have chronically elevated blood pressures at 30 weeks of age (systolic: 191.0 ± 1.0, diastolic: 128.8 ± 0.9). However, despite this chronic malignant hypertension, SHR kidneys remain relatively free of pathology due to having an augmented myogenic constriction (MC). We h...

journal_title：Frontiers in physiology

authors： Nademi S,Lu C,Dickhout JG

更新日期：2020-07-22 00:00:00

abstract：Background:The development of childhood motor competence demonstrates a high degree of inter-individual variation. Some children's competence levels increase whilst others' competence levels remain unchanged or even decrease over time. However, few studies have examined this developmental change in motor competence acr...

journal_title：Frontiers in physiology

authors： Coppens E,Bardid F,Deconinck FJA,Haerens L,Stodden D,D'Hondt E,Lenoir M

更新日期：2019-10-02 00:00:00

abstract：:Regular exercise prevents lipid abnormalities and conditions such as diabetes mellitus, hypertension, and obesity; it considerably benefits sedentary individuals. However, individuals exhibit highly variable responses to exercise, probably due to genetic variations. Animal models are typically used to investigate the ...

journal_title：Frontiers in physiology

authors： Tung YT,Hsu YJ,Liao CC,Ho ST,Huang CC,Huang WC

更新日期：2019-09-18 00:00:00

abstract：:Defects in mid-facial development, including cleft lip/palate, account for a large number of human birth defects annually. In many cases, aberrant gene expression results in either a reduction in the number of neural crest cells (NCCs) that reach the frontonasal region and form much of the facial skeleton or subsequen...

journal_title：Frontiers in physiology

authors： Ding HL,Hooper JE,Batzel P,Eames BF,Postlethwait JH,Artinger KB,Clouthier DE

更新日期：2016-07-14 00:00:00

abstract：:Although cardiac recovery is an important criterion for ranking horses in endurance competitions, heart rate variability (HRV) has hardly ever been studied in the context of this equestrian discipline. In the present study, we sought to determine whether HRV is affected by parameters such as age, exercise duration and...

journal_title：Frontiers in physiology

authors： Younes M,Robert C,Barrey E,Cottin F

更新日期：2016-05-02 00:00:00

abstract：:Exercise and exogenous heat each stimulate multiple adaptations, but their roles are not well delineated, and that of the related stressor, dehydration, is largely unknown. While severe and prolonged hypohydration potentially "silences" the long-term heat acclimated phenotype, mild and transient dehydration may enhanc...

journal_title：Frontiers in physiology

authors： Akerman AP,Lucas SJE,Katare R,Cotter JD

更新日期：2017-10-09 00:00:00

abstract：:This study aimed to simultaneously examine the differences of human nerve conduction velocity (NCV) and nerve cross-sectional area (nCSA) between the upper and lower limbs and between different regions of the upper and lower limbs. Thirty healthy subjects volunteered for the study. NCV and nCSA of the ulnar and tibial...

journal_title：Frontiers in physiology

authors： Nobue A,Kunimasa Y,Tsuneishi H,Sano K,Oda H,Ishikawa M

更新日期：2020-12-03 00:00:00

abstract：:Genome-scale metabolic models (GEMs) have become a popular tool for systems biology, and they have been used in many fields such as industrial biotechnology and systems medicine. Since more and more studies are being conducted using GEMs, they have recently received considerable attention. In this review, we introduce...

journal_title：Frontiers in physiology

authors： Zhang C,Hua Q

更新日期：2016-01-07 00:00:00

abstract：:Arrhythmogenic cardiomyopathy (AC) has originally been described as a disorder characterized by fibrofatty replacement of the myocardium, primarily of the right ventricle (RV), and ventricular tachyarrhythmias, sudden death, and at a late stage progressive heart failure. Arrhythmogenic right ventricular dysplasia or c...

journal_title：Frontiers in physiology

authors： Hauer RN,Cox MG,Groeneweg JA

更新日期：2012-09-17 00:00:00

abstract：:Circadian clocks consist of molecular negative feedback loops that coordinate physiological, neurological, and behavioral variables into "circa" 24-h rhythms. Rhythms in behavioral and other circadian outputs tend to weaken during aging, as evident in progressive disruptions of sleep-wake cycles in aging organisms. Ho...

journal_title：Frontiers in physiology

authors： Long DM,Giebultowicz JM

更新日期：2018-01-09 00:00:00

abstract：:We tested the hypotheses that prior aerobic (Study 1) or anaerobic (Study 2) exercise attenuates the increase in renal vascular resistance (RVR) during sympathetic stimulation. Ten healthy young adults (5 females) participated in both Study 1 (aerobic exercise) and Study 2 (anaerobic exercise). In Study 1, subjects co...

journal_title：Frontiers in physiology

authors： Schlader ZJ,Chapman CL,Benati JM,Gideon EA,Vargas NT,Lema PC,Johnson BD

更新日期：2019-01-10 00:00:00

abstract：:Moonlighting proteins are a subset of multifunctional proteins characterized by their multiple, independent, and unrelated biological functions. We recently set up a large-scale identification of moonlighting proteins using a protein-protein interaction (PPI) network approach. We established that 3% of the current hum...

journal_title：Frontiers in physiology

authors： Zanzoni A,Chapple CE,Brun C

更新日期：2015-06-23 00:00:00

abstract：:Increased central sympathetic drive is a hallmark of several important clinical conditions including essential hypertension, heart failure, chronic kidney disease, and insulin resistance. Afferent signaling from the kidneys has been identified as an important contributor to elevated central sympathetic drive and incre...

journal_title：Frontiers in physiology

authors： Schlaich MP,Hering D,Sobotka P,Krum H,Lambert GW,Lambert E,Esler MD

更新日期：2012-02-02 00:00:00

abstract：:Eryptosis is the suicidal destruction-process of erythrocytes, much like apoptosis of nucleated cells, in the course of which the stressed red cell undergoes cell-shrinkage, vesiculation and externalization of membrane phosphatidylserine. Currently, there exist numerous methods to detect eryptosis, both morphometrical...

journal_title：Frontiers in physiology

authors： Jacob SS,Prasad K,Rao P,Kamath A,Hegde RB,Baby PM,Rao RK

更新日期：2019-09-24 00:00:00