Potential of caveolae in the therapy of cardiovascular and neurological diseases.

Abstract:

:Caveolae are membrane micro-domains enriched in cholesterol, sphingolipids and caveolins, which are transmembrane proteins with a hairpin-like structure. Caveolae participate in receptor-mediated trafficking of cell surface receptors and receptor-mediated signaling. Furthermore, caveolae participate in clathrin-independent endocytosis of membrane receptors. On the one hand, caveolins are involved in vascular and cardiac dysfunction. Also, neurological abnormalities in caveolin-1 knockout mice and a link between caveolin-1 gene haplotypes and neurodegenerative diseases have been reported. The aim of this article is to present the rationale for considering caveolae as potential targets in cardiovascular and neurological diseases.

journal_name

Front Physiol

journal_title

Frontiers in physiology

authors

Navarro G,Borroto-Escuela DO,Fuxe K,Franco R

doi

10.3389/fphys.2014.00370

subject

Has Abstract

pub_date

2014-09-30 00:00:00

pages

370

issn

1664-042X

journal_volume

5

pub_type

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