Abstract:
BACKGROUND:Close to 800 million people in the world are at risk of schistosomiasis, 85 per cent of whom live in Africa. Recent studies have indicated that female genital schistosomiasis might increase the risk of human immunodeficiency virus (HIV) infection. The aim of this study is to quantify and analyse the characteristics of the vasculature surrounding Schistosoma haematobium ova in the female genital mucosa. METHODOLOGY/PRINCIPAL FINDINGS:Cervicovaginal biopsies with S. haematobium ova (n=20) and control biopsies (n=69) were stained with immunohistochemical blood vessel markers CD31 and von Willebrand Factor (vWF), which stain endothelial cells in capillary buds and established blood vessels respectively. Haematoxylin and eosin (HE) were applied for histopathological assessment. The tissue surrounding S. haematobium ova had a higher density of established blood vessels stained by vWF compared to healthy controls (p=0.017). Immunostain to CD31 identified significantly more granulation tissue surrounding viable compared to calcified ova (p=0.032), and a tendency to neovascularisation in the tissue surrounding viable ova compared to healthy cervical mucosa (p=0.052). CONCLUSIONS/SIGNIFICANCE:In this study female genital mucosa with S. haematobium ova was significantly more vascularised compared to healthy cervical tissue. Viable parasite ova were associated with granulation tissue rich in sprouting blood vessels. Although the findings of blood vessel proliferation in this study may be a step to better understand the implications of S. haematobium infection, further studies are needed to explore the biological, clinical and epidemiological features of female genital schistosomiasis and its possible influence on HIV susceptibility.
journal_name
PLoS Negl Trop Disjournal_title
PLoS neglected tropical diseasesauthors
Jourdan PM,Roald B,Poggensee G,Gundersen SG,Kjetland EFdoi
10.1371/journal.pntd.0001170subject
Has Abstractpub_date
2011-06-01 00:00:00pages
e1170issue
6eissn
1935-2727issn
1935-2735pii
PNTD-D-10-00047journal_volume
5pub_type
杂志文章abstract:BACKGROUND:Human outbreaks of Ebola virus (EBOV) are a serious human health concern in Central Africa. Great apes (gorillas/chimpanzees) are an important source of EBOV transmission to humans due to increased hunting of wildlife including the 'bush-meat' trade. Cytomegalovirus (CMV) is an highly immunogenic virus that ...
journal_title:PLoS neglected tropical diseases
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更新日期:2012-01-01 00:00:00
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abstract::[This corrects the article DOI: 10.1371/journal.pntd.0006797.]. ...
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pub_type: 已发布勘误
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