Analysis of the 5'UTR of HCV genotype 3 grown in vitro in human B cells, T cells, and macrophages.

abstract：:The most common etiologic agents causing chronic hepatitis are hepatitis C and B viruses (HCV and HBV, respectively). Chronic infection caused by HCV is considered one of the major causative agents of liver cirrhosis and hepatocellular carcinoma worldwide. In combination with the increasing rate of new HCV infections,...

journal_title：Virology journal

authors： Hoffmann TW,Duverlie G,Bengrine A

更新日期：2012-06-12 00:00:00

abstract：BACKGROUND:The avian influenza virus (AIV) causes frequent disease with high morbidity and mortality. RNA interference (RNAi) has been shown to provide an effective antiviral defense in animals, and several studies have focused on harnessing small interfering RNAs (siRNAs) to inhibit viral infections. In addition, sing...

journal_title：Virology journal

authors： Wang S,Zhang P,He F,Wang JG,Sun JZ,Li ZL,Yi B,Xi J,Mao YP,Hou Q,Yuan DL,Zhang ZD,Liu WQ

更新日期：2014-11-29 00:00:00

abstract：BACKGROUND:Since its emergence in March 2009, the pandemic 2009 H1N1 influenza A virus has posed a serious threat to public health. To trace the evolutionary path of these new pathogens, we performed a selection-pressure analysis of a large number of hemagglutinin (HA) and neuraminidase (NA) gene sequences of H1N1 infl...

journal_title：Virology journal

authors： Li W,Shi W,Qiao H,Ho SY,Luo A,Zhang Y,Zhu C

更新日期：2011-04-21 00:00:00

abstract：BACKGROUND:Crimean-Congo Hemorrhagic Fever virus (CCHFV), a member of the genus Nairovirus, family Bunyaviridae, is a tick-borne pathogen causing severe disease in humans. To better understand the CCHFV life cycle and explore potential intervention strategies, we studied the biosynthesis and intracellular targeting of ...

journal_title：Virology journal

authors： Haferkamp S,Fernando L,Schwarz TF,Feldmann H,Flick R

更新日期：2005-04-25 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a worldwide public health burden and it is estimated that 185 million people are or have previously been infected worldwide. There is no effective vaccine for prevention of HCV infection; however, a number of drugs are available for the treatment of infection. The availability of d...

journal_title：Virology journal

authors： Jardim ACG,Shimizu JF,Rahal P,Harris M

更新日期：2018-02-13 00:00:00

abstract：BACKGROUND:Few studies have used quantitative polymerase chain reaction (qPCR) as an approach to measure virus neutralization assay endpoints. Its lack of use may not be surprising considering that sample nucleic acid extraction and purification can be expensive, labor-intensive, and rate-limiting. METHODS:Virus/antib...

journal_title：Virology journal

authors： Varada JC,Teferedegne B,Crim RL,Mdluli T,Audet S,Peden K,Beeler J,Murata H

更新日期：2013-06-15 00:00:00

abstract：BACKGROUND:Controversy remains as to whether antiviral agents contribute to renal dysfunction in patients with chronic hepatitis B virus (HBV) infection. Thus, the aim of study was to analyze the changes in renal function of chronic hepatitis B (CHB) patients in response to anti-HBV therapy and the association with tre...

journal_title：Virology journal

authors： Zhang Y,Zhang WL,Pang XW,Wang LX,Wei X,Huang CX,Bai XF,Han S,Liu LN,Lian JQ

更新日期：2017-03-09 00:00:00

abstract：BACKGROUND:HIV-1 subtype B' isolates have been predominantly circulating in China. Their intra- and inter-subtype neutralization sensitivity to autologous and heterologous plasmas has not been well studied. RESULTS:Twelve HIV-1 B' clinical isolates obtained from patients were tested for their intra- and inter-subtype ...

journal_title：Virology journal

authors： OuYang Y,Sun J,Huang Y,Lu L,Xu W,Hu X,Hong K,Jiang S,Shao Y,Ma L

更新日期：2013-01-05 00:00:00

abstract：BACKGROUND:Highly-pathogenic avian influenza (HPAI) H5N1 and Newcastle disease (ND) viruses are the two most important poultry viruses in the world, with the ability to cause classic central nervous system dysfunction in poultry and migratory birds. To elucidate the mechanisms of neurovirulence caused by these viruses,...

journal_title：Virology journal

authors： Balasubramaniam VR,Wai TH,Omar AR,Othman I,Hassan SS

更新日期：2012-02-23 00:00:00

abstract：BACKGROUND:Increased numbers of Interleukin-17-producing CD4+ T cells (Th17) have been found in association with hepatitis B virus (HBV)-induced liver injury. However, the mechanism underlying the increase of Th17 responses in patients with HBV infection remains unclear. In this study, we investigate the possible regul...

journal_title：Virology journal

authors： Zhang F,Yao S,Yuan J,Zhang M,He Q,Yang G,Gao Z,Liu H,Chen X,Zhou B

更新日期：2011-06-03 00:00:00

abstract：BACKGROUND:Tomato yellow leaf curl virus (TYLCV), a monopartite begomovirus (family Geminiviridae) is responsible for heavy yield losses for tomato production around the globe. In Oman at least five distinct begomoviruses cause disease in tomato, including TYLCV. Unusually, TYLCV infections in Oman are sometimes associ...

journal_title：Virology journal

authors： Ammara Ue,Mansoor S,Saeed M,Amin I,Briddon RW,Al-Sadi AM

更新日期：2015-03-04 00:00:00

abstract：BACKGROUND:The major structural protein of coronaviruses, the membrane (M) protein, can elicit the formation of protective antibodies, but little information is available about the M protein of porcine epidemic diarrhea virus (PEDV). Identification of epitopes on the PEDV M protein will be helpful in the elucidation of...

journal_title：Virology journal

authors： Zhang Z,Chen J,Shi H,Chen X,Shi D,Feng L,Yang B

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Pseudorabies virus (PRV) of the family Herpesviridae is the causative agent of Aujeszky's disease. Attenuation of PRV by serial passaging in vitro is a well-established method; however, the dynamic variations occurring on viral genome during this process have not been characterized. METHODS:Genome sequencin...

journal_title：Virology journal

authors： Ye C,Wu J,Tong W,Shan T,Cheng X,Xu J,Liang C,Zheng H,Li G,Tong G

更新日期：2018-12-29 00:00:00

abstract：BACKGROUND:One requisite of quantitative reverse transcription PCR (qRT-PCR) is to normalise the data with an internal reference gene that is invariant regardless of treatment, such as virus infection. Several studies have found variability in the expression of commonly used housekeeping genes, such as beta-actin (ACTB...

journal_title：Virology journal

authors： Kuchipudi SV,Tellabati M,Nelli RK,White GA,Perez BB,Sebastian S,Slomka MJ,Brookes SM,Brown IH,Dunham SP,Chang KC

更新日期：2012-10-08 00:00:00

abstract：BACKGROUND:A vaccine against all four dengue virus (DENV) serotypes includes the formulation of one genotype of each serotype. Although genetic similarities among genotypes within a serotype are higher as compared to those among serotypes, differences in the immunogenicity of the included genotypes would be a critical ...

journal_title：Virology journal

authors： Azami NAM,Moi ML,Ami Y,Suzaki Y,Lim CK,Taniguchi S,Saijo M,Takasaki T,Kurane I

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:The genetic element s2m seems to represent one of very few examples of mobile genetic elements in viruses. The function remains obscure and a scattered taxonomical distribution has been reported by numerous groups. METHODS:We have searched GenBank in order to identify all viral accessions that have s2m(-lik...

journal_title：Virology journal

authors： Tengs T,Kristoffersen AB,Bachvaroff TR,Jonassen CM

更新日期：2013-04-25 00:00:00

abstract：BACKGROUND:The high genetic diversity of HIV-1 has been shown to influence the global distribution, disease progression, treatment success, and the development of an effective vaccine. Despite the low HIV prevalence in Cameroon, all the major HIV subtypes alongside several circulating recombinant forms (CRFs) and uniqu...

journal_title：Virology journal

authors： Abongwa LE,Nyamache AK,Torimiro JN,Okemo P,Charles F

更新日期：2019-08-15 00:00:00

abstract：BACKGROUND:A number of gene therapy applications would benefit from vectors capable of expressing multiple genes. In this study we explored the feasibility and efficiency of expressing two or three transgenes in HIV-1 based lentiviral vector. Bicistronic and tricistronic self-inactivating lentiviral vectors were constr...

journal_title：Virology journal

authors： Chinnasamy D,Milsom MD,Shaffer J,Neuenfeldt J,Shaaban AF,Margison GP,Fairbairn LJ,Chinnasamy N

更新日期：2006-03-15 00:00:00

abstract：:Dengue virus (DENV) is a mosquito-borne virus that has four serotypes. Collection of serum from patients is time- and labor- consuming, and presents a high injury risk for infants and children. The genomic and serological diagnosis of imported dengue fever from a urine sample was used as a non-invasive diagnostic meth...

journal_title：Virology journal

authors： Ma X,Zhen W,Yang P,Sun X,Nie W,Zhang L,Xu H,Hu K

更新日期：2014-03-25 00:00:00

abstract：BACKGROUND:Human cytomegalovirus (HCMV) is a betaherpesvirus that causes severe disease in situations where the immune system is immature or compromised. HCMV immediate early (IE) gene expression is stimulated by the virion phosphoprotein pp71, encoded by open reading frame (ORF) UL82, and this transactivation activity...

journal_title：Virology journal

authors： Nicholson IP,Sutherland JS,Chaudry TN,Blewett EL,Barry PA,Nicholl MJ,Preston CM

更新日期：2009-05-27 00:00:00

abstract：BACKGROUND:Duck circovirus (DuCV) infection in farmed ducks is associated with growth problems or retardation syndromes. Rapid identification of DuCV infected ducks is essential to control DuCV effectively. Therefore, this study aims to develop of an assay for DuCV to be highly specific, sensitive, and simple without a...

journal_title：Virology journal

authors： Xie L,Xie Z,Zhao G,Liu J,Pang Y,Deng X,Xie Z,Fan Q,Luo S

更新日期：2014-04-29 00:00:00

abstract：:HIV expressed in genital secretions provides the inoculum from which transmitting variants are selected, both in sexual transmission and mother-to-infant transmission during partuition. Characterization of HIV levels and genotypes found in vaginal secretions and the impact of anti-retroviral therapy (ART) on this viru...

journal_title：Virology journal

authors： Randolph TC,Kissinger PJ,Clark RA,Lacour N,Amedee AM

更新日期：2008-07-29 00:00:00

abstract：BACKGROUND:The Hepatitis B Virus X protein (HBx) plays a major role in hepatocellular carcinoma (HCC) development, however, its contribution to tumor invasion and metastasis has not been established so far. Heat shock protein 90 alpha (HSP90alpha) isoform is an ATP-dependent molecular chaperone that maintains the activ...

journal_title：Virology journal

authors： Li W,Miao X,Qi Z,Zeng W,Liang J,Liang Z

更新日期：2010-02-20 00:00:00

abstract：BACKGROUND:Epstein-Barr virus (EBV) is associated with 20-40% of Hodgkin's Lymphoma (HL) cases. EBV-encoded latent membrane protein 1 (LMP1) is a well-known oncogenic protein and two C-terminal deletion variants, del30-LMP1 and del69-LMP1, have been described in animal models to be more tumorigenic than the wild-type f...

journal_title：Virology journal

authors： Sueur C,Lupo J,Mas P,Morand P,Boyer V

更新日期：2014-05-19 00:00:00

abstract：BACKGROUND:There has been a recent resurgent interest in bacteriophage biology. Research was initiated to examine Campylobacter jejuni-specific bacteriophage in the Russian Federation to develop alternative control measures for this pathogen. RESULTS:A C. jejuni flagellum-specific phage PV22 from Proteus vulgaris was ...

journal_title：Virology journal

authors： Zhilenkov EL,Popova VM,Popov DV,Zavalsky LY,Svetoch EA,Stern NJ,Seal BS

更新日期：2006-06-27 00:00:00

abstract：BACKGROUND:Zika virus (ZIKV) is a major human pathogen and member of the Flavivirus genus. Previous studies have identified neutralizing antibodies from Zika patients that bind to quaternary epitopes across neighboring envelope (E) proteins, called E dimer epitopes (EDE). An asparagine-linked glycan on the "glycan loop...

journal_title：Virology journal

authors： Henderson EA,Tam CC,Cheng LW,Ngono AE,Nguyen AV,Shresta S,McGee M,Padgett H,Grill LK,Martchenko Shilman M

更新日期：2020-03-31 00:00:00

abstract：:The study was carried out to investigate the effects of inoculating three cowpea cultivars: "OLO II", "OLOYIN" and IT86D-719 with three unrelated viruses: Cowpea aphid-borne mosaic virus (CABMV), genus Potyvirus, Cowpea mottle virus (CMeV), genus Carmovirus and Southern bean mosaic virus (SBMV), genus Sobemovirus sing...

journal_title：Virology journal

authors： Kareem KT,Taiwo MA

更新日期：2007-02-08 00:00:00

abstract：BACKGROUND:Using a murine model of parainfluenza virus infection (mPIV1 or Sendai virus; SeV), we compared the inflammatory responses to lethal and sub-lethal infections in inbred DBA/2 mice. METHODS:Mice were intranasally inoculated with either 1.6×10(3) or 1.6×10(5) infectious units (IU) of SeV or diluent control. C...

journal_title：Virology journal

authors： Suryadevara M,Bonville CA,Rosenberg HF,Domachowske JB

更新日期：2013-12-21 00:00:00

abstract：BACKGROUND:Uukuniemi virus (UUKV) belongs to the Phlebovirus genus in the family Bunyaviridae. As a non-pathogenic virus for humans UUKV has served as a safe model bunyavirus in a number of studies addressing fundamental questions such as organization and regulation of viral genes, genome replication, structure and ass...

journal_title：Virology journal

authors： Katz A,Freiberg AN,Backström V,Schulz AR,Mateos A,Holm L,Pettersson RF,Vaheri A,Flick R,Plyusnin A

更新日期：2010-08-10 00:00:00

abstract：BACKGROUND:Polyomaviruses (PyVs) have a wide range of hosts, from humans to fish, and their effects on hosts vary. The differences in the infection characteristics of PyV with respect to the host are assumed to be influenced by the biochemical function of the LT-Ag protein, which is related to the cytopathic effect and...

journal_title：Virology journal

authors： Cho M,Kim H,Son HS

更新日期：2019-11-14 00:00:00