Natural reduced water suppressed anxiety and protected the heightened oxidative stress in rats.

Abstract:

BACKGROUND:In Japan, the effects of reduced water, such as hydrogen-rich electrolyzed reduced water and natural reduced water, like Hita Tenryosui water®, have been examined. The purpose of the present study was to identify the role of natural reduced water in anxiety and blood biochemical analysis. MATERIALS AND METHODS:Natural reduced water and distilled water were administered to rats for 180 consecutive days, and their effect on anxiety-like behavior and depression was examined by using elevated plus maze, light/dark, forced swimming, and conditioned fear tests. Before and after administration of natural reduced or distilled water, we performed blood and urine analyses. RESULTS:Natural reduced water exhibited anxiolytic-like effects in the conditioned fear and elevated plus maze tests. The mean levels of urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) in the natural reduced water were significantly lower than the distilled water group. Natural reduced water group also showed decrease in blood-urea nitrogen levels compared with the distilled water group. CONCLUSION:These results indicate that natural reduced water may decrease anxiety-related behaviors and prevent heightened oxidative stress.

authors

Masuda K,Tanaka Y,Kanehisa M,Ninomiya T,Inoue A,Higuma H,Kawashima C,Nakanishi M,Okamoto K,Akiyoshi J

doi

10.2147/NDT.S138289

subject

Has Abstract

pub_date

2017-09-08 00:00:00

pages

2357-2362

eissn

1176-6328

issn

1178-2021

pii

ndt-13-2357

journal_volume

13

pub_type

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