Abstract:
Aim of the study:Genetic (idiopathic) generalized epilepsies (GGEs) account for nearly one-third of all epilepsies. The frequency of status epilepticus (SE) in patients with GGEs has been poorly studied. Therefore, this study aimed to evaluate the frequency of different forms of SE in a cohort of patients with GGEs. Materials and methods:Among 153 patients with GGEs treated at the university epilepsy clinic in the period between 1998 and 2018, those with SE were retrospectively identified. Results:Absence SE was diagnosed in 8 patients (13 episodes), while myoclonic SE was found in 2 patients (2 episodes). No cases of tonic-clonic SE were detected in the study cohort. Most SE episodes were found to be provoked by ill-advised antiepileptic drugs or changes in drug regimen. In all the subjects, SE was stopped by intravenous administration of diazepam and/or valproate. Long-term outcome of epilepsy was good, with most patients (70%) being seizure-free. Conclusion:Status epilepticus is not a rare phenomenon in patients with genetic generalized epilepsies, with absence SE being the most common type. Most cases of SE are provoked by ill-advised AEDs or changes in drug regimen. Status epilepticus in GGEs can be easily treated with benozdiazepines and/or valproate. Status epilepticus in GGEs can be easily treated with benozdiazepines and/or valproate.
journal_name
Neuropsychiatr Dis Treatjournal_title
Neuropsychiatric disease and treatmentauthors
Bosak M,Pawełczak D,Słowik Adoi
10.2147/NDT.S209084subject
Has Abstractpub_date
2019-06-20 00:00:00pages
1585-1592eissn
1176-6328issn
1178-2021pii
209084journal_volume
15pub_type
杂志文章abstract::Epilepsy is a common pediatric neurologic disorder that is difficult to manage in a substantial portion of children. Levetiracetam (LEV) is a novel antiepileptic drug (AED) that has recently been approved as add-on treatment for various seizure types in epilepsy populations that include children: for refractory partia...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:
更新日期:2007-08-01 00:00:00
abstract::Gerstmann's syndrome encompasses the tetrad of finger agnosia, agraphia, acalculia, and right-left confusion. An elderly man with a history of several cardiovascular diseases was initially brought to the psychiatric outpatient department by his family because of worsening of recent memory, executive function, and mixe...
journal_title:Neuropsychiatric disease and treatment
pub_type:
doi:10.2147/NDT.S43527
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:In Japan, the effects of reduced water, such as hydrogen-rich electrolyzed reduced water and natural reduced water, like Hita Tenryosui water®, have been examined. The purpose of the present study was to identify the role of natural reduced water in anxiety and blood biochemical analysis. MATERIALS AND METH...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S138289
更新日期:2017-09-08 00:00:00
abstract::Multiple system atrophy is a progressive neurodegenerative disorder that is characterized by autonomic failure, cerebellar ataxia and parkinsonism syndrome in various combinations. In spite of the presence of well-established clinical criteria for multiple system atrophy, ante-mortem diagnosis is difficult. In our cas...
journal_title:Neuropsychiatric disease and treatment
pub_type:
doi:10.2147/NDT.S146080
更新日期:2018-01-04 00:00:00
abstract:BACKGROUND:Recent studies have suggested that the interactions among several factors affect the onset, progression, and prognosis of major depressive disorder. This study investigated how childhood abuse, neuroticism, and adult stressful life events interact with one another and affect depressive symptoms in the genera...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S128557
更新日期:2017-02-15 00:00:00
abstract:Background:Intentional methanol intoxication (IMI) is an emerging public health issue in Asian countries, but few data are available in the literature on underlying psychiatric comorbidities in these suicide attempters. Patients and methods:We conducted a retrospective chart review on patients with methanol intoxicati...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S192943
更新日期:2019-01-31 00:00:00
abstract:Aim:This meta-analysis aimed to assess the effect of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) for the treatment of depression in patients with Parkinson's disease (PD). Methods:The design was a meta-analysis of randomized controlled trials (RCTs). The participants were patients with PD who...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S156695
更新日期:2018-01-11 00:00:00
abstract:Introduction:The incidence of corpus callosum infarction is low, and sudden cognitive dysfunction caused by corpus callosum infarction is very rare. We report two cases of acute corpus callosum infarction with sudden cognitive impairment, and the related basis, clinical manifestations, diagnosis, differential diagnosis...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S155487
更新日期:2018-02-13 00:00:00
abstract::Headaches in children and adolescents are still under-diagnosed. 75% of children are affected by primary headache by the age of 15 with 28% fitting the ICHD2 criteria of migraine. Migraine is considered a chronic disorder that can severely impact a child's daily activities, including schooling and socializing. Early r...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/ndt.s495
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Relapse is common in schizophrenia, and seriously impacts patients' quality of life and social functioning. Many factors have been identified that may potentially increase the risk of relapse. This study was designed to investigate the relapse rate in the year following hospital discharge among Chinese patie...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S72367
更新日期:2015-05-08 00:00:00
abstract::Aripiprazole is a third generation atypical antipsychotic with compelling evidence as a highly effective treatment option in the management of acute manic and mixed episodes of bipolar I disorders. It has a unique mode of action, acting as a partial agonist at dopamine D2 and D3, and serotonin 5-HT1A; and exhibiting a...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章,评审
doi:10.2147/NDT.S40066
更新日期:2014-03-13 00:00:00
abstract:Purpose:Parkinson's disease (PD) is a common neurodegenerative movement disorder, but the pathogenesis remains elusive. This study was aimed to explore key genes and long noncoding RNAs (lncRNAs) associated with PD. Materials and methods:Three patients with PD and three normal controls were enrolled in the present stu...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S178435
更新日期:2018-11-22 00:00:00
abstract:Objective:Stem cell transplantation is a promising strategy with great potential to treat Parkinson's disease (PD). Nevertheless, improving the cell delivery route and optimising implanted cells are necessary to increase the therapeutic effect. Herein, we investigated whether intranasal delivery of bone marrow stromal ...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S238646
更新日期:2020-01-23 00:00:00
abstract:BACKGROUND:Encephalitis with antibodies against N-methyl-D-aspartate receptor (NMDA-R) is classified as an autoimmune disorder with psychotic symptoms, which are frequently dominant. However, it remains unclear how frequently NMDA-R antibodies lead to a condition that mimics psychosis and first-episode schizophrenia. I...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S80746
更新日期:2015-03-06 00:00:00
abstract:BACKGROUND:With the advent of the fifth edition of Diagnostic and Statistical Manual of Mental Disorders, body dysmorphic disorder (BDD) has been subsumed into the obsessive-compulsive disorders and related disorders (OCDRD) category. OBJECTIVE:We aimed to determine the empirical evidence regarding the potential relat...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章,评审
doi:10.2147/NDT.S67636
更新日期:2015-08-26 00:00:00
abstract:OBJECTIVE:The main aim of this case series report is to alert physicians to the occurrence of catatonia in Down syndrome (DS). A second aim is to stimulate the study of regression in DS and of catatonia. A subset of individuals with DS is noted to experience unexplained regression in behavior, mood, activities of daily...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S77307
更新日期:2015-04-02 00:00:00
abstract:OBJECTIVE:To investigate the predictors of suicidal ideation and attempts among Turkish Parkinson's disease (PD) patients. MATERIALS AND METHODS:The study comprised 120 patients with PD. Clinical findings were obtained by using the Unified Parkinson's Disease Rating Scale. Disease severity was measured by the Hoehn an...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S60450
更新日期:2014-03-26 00:00:00
abstract:BACKGROUND:The aim of this paper is to report maternal and neonatal outcomes in pregnant women treated with escitalopram during pregnancy and breastfeeding. METHODS:Women enrolled in the DEGRA Database at the Clinic of Affective Disorders in Pregnancy and Postpartum in Italy, treated during pregnancy with escitalopram...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S45951
更新日期:2013-01-01 00:00:00
abstract::Lacosamide is a newly registered antiepileptic drug with dual mechanisms of action. It selectively enhances slow inactivation of voltage-gated sodium channels, resulting in stabilization of hyperexcitable neuronal membranes and inhibition of repetitive neuronal firing. It also binds to a collapsing-response mediator p...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/ndt.s7967
更新日期:2010-09-07 00:00:00
abstract:OBJECTIVES:Although bipolar disorder has been understood classically as a cyclic disease with full recovery between mood episodes, in the last decade, evidence has accumulated supporting progressive features. The clinical picture of advanced or end-stage bipolar disorder is heterogeneous with possible deficits in cogni...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S99229
更新日期:2016-09-07 00:00:00
abstract:Purpose:Mood disorders are recurrent chronic disorders with fluctuating mood states and energy, and misdiagnosis is common when based solely on clinical interviews because of overlapping symptoms. Because misdiagnosis may lead to inappropriate treatment and poor prognosis, finding an easily implemented objective tool f...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S190048
更新日期:2019-01-15 00:00:00
abstract:BACKGROUND:Dementia is generally characterized by cognitive impairment that can be accompanied by psychotic symptoms; for example, visual hallucinations are a core feature of dementia with Lewy bodies, and delusions are often seen in Alzheimer's disease. However, for behavioral variant of frontotemporal dementia (bvFTD...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S127863
更新日期:2017-04-13 00:00:00
abstract:BACKGROUND:The aim of this research was to determine the prevalence and etiology of acquired ataxia in Al-Kharga district, New Valley, Egypt. METHODS:A population-based study of acquired ataxia was conducted in a defined geographical region with a total population of 62,583. A door-to-door survey was used to identify ...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S14497
更新日期:2011-01-01 00:00:00
abstract:Background:Various personality traits mediate the association between childhood stress and depressive symptoms in adulthood. The aim of this study was to clarify the indirect effects of the experience of child maltreatment on depressive symptoms and appraisal of life events in adulthood through trait anxiety. Subjects...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S182783
更新日期:2018-11-27 00:00:00
abstract:Background:Early-onset major depressive disorder (EO-MDD), beginning during childhood and adolescence, is associated with more illness burden and a worse prognosis than adult-onset MDD (AO-MDD), but little is known about the neural features distinguishing these subgroup phenotypes. Functional abnormalities of the amygd...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S145042
更新日期:2018-01-14 00:00:00
abstract::Abnormal prion proteins are responsible for several fatal neurodegenerative diseases in humans and in animals, including Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker disease, and fatal familial insomnia. Genetics is important in prion diseases, but in the most cases, cause of diseases remained unkno...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章,评审
doi:10.2147/NDT.S165445
更新日期:2018-08-14 00:00:00
abstract::Diagnosis of complex partial epilepsy is based on the clinical history, and laboratory tests, including EEG and neuroimaging studies, corroborate the diagnosis. The goal of epilepsy management is to make the patient completely seizure-free without drug-induced side effects, even in the patient with refractory complex ...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/ndt.s4489
更新日期:2010-06-24 00:00:00
abstract:BACKGROUND:High-dose use of benzodiazepines (BZPs) reportedly causes adverse effects on cognitive function and quality of life in patients with schizophrenia. However, effects of BZPs on the clinical course of schizophrenia have not been clarified. This study was set out to investigate the association between BZPs and ...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S118759
更新日期:2016-12-15 00:00:00
abstract::A series of cases are reported in which patients on aripiprazole have developed akathisia, although the literature states that the rate is negligible. ...
journal_title:Neuropsychiatric disease and treatment
pub_type:
doi:10.2147/nedt.2006.2.2.241
更新日期:2006-06-01 00:00:00
abstract::Cognitive impairment is closely related to real-life functioning in patients with schizophrenia. The aim of the present study was to evaluate the effects of adjunctive treatment with donepezil on cognition in patients with chronic schizophrenia. This was a 12-week, double-blind, randomized, placebo-controlled study of...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S64189
更新日期:2014-07-14 00:00:00