Adjunctive treatment for cognitive impairment in patients with chronic schizophrenia: a double-blind, placebo-controlled study.

Abstract:

:Cognitive impairment is closely related to real-life functioning in patients with schizophrenia. The aim of the present study was to evaluate the effects of adjunctive treatment with donepezil on cognition in patients with chronic schizophrenia. This was a 12-week, double-blind, randomized, placebo-controlled study of donepezil as an adjunct to antipsychotic drug therapy in patients with chronic stable schizophrenia. Sixty-one subjects were randomized to receive donepezil 5 mg/day (n=31) and/or placebo (n=30). A nine-test neuropsychological assessment battery was administered at baseline and at the end of the study. At the 12-week end point, the donepezil group showed significant improvements in the Wechsler Memory Scale Third Edition Spatial Span, Brief Visuospatial Memory Test total recall and delayed recall, Trail-Making Test Part A, and Category Fluency Test-animal naming (all P≤0.018). Compared with placebo, donepezil was associated with significant improvement in several cognitive domains, including working memory, speed of information processing, and visual learning and memory (P≤0.008). The results of the present study suggest that adjunctive use of donepezil is beneficial for improving cognitive function in patients with schizophrenia.

authors

Zhu W,Zhang Z,Qi J,Liu F,Chen J,Zhao J,Guo X

doi

10.2147/NDT.S64189

subject

Has Abstract

pub_date

2014-07-14 00:00:00

pages

1317-23

eissn

1176-6328

issn

1178-2021

pii

ndt-10-1317

journal_volume

10

pub_type

杂志文章
  • Evaluation of BPPV with vertebral artery values.

    abstract:Objectives:The aim of this study was to investigate the association between benign paroxysmal positional vertigo (BPPV) and vertebral artery (VA) flow rates and diameters by using Doppler ultrasonography in patients with BPPV. Additionally, we aimed to investigate the abnormalities of VA values obtained by extracranial...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S169991

    authors: Yazıcı A,İnanç Y

    更新日期:2018-08-06 00:00:00

  • The prevalence and risk factors of young male schizophrenics with non-alcoholic fatty liver disease.

    abstract:OBJECTIVE:In this study, we compared the prevalence rate of non-alcoholic fatty liver disease (NAFLD) between young males with schizophrenia and the general young males as the control group, and we also investigated the risk factors of NAFLD in young males with schizophrenia. MATERIALS AND METHODS:This is a large cros...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S137183

    authors: Yan J,Hou C,Liang Y

    更新日期:2017-06-12 00:00:00

  • Patterns of anterior cingulate activation in schizophrenia: a selective review.

    abstract:BACKGROUND:Anterior cingulate cortex (ACC) dysfunction is implicated in schizophrenia by numerous strands of scientific investigation. Functional neuroimaging studies of the ACC in schizophrenia have shown task-related hypo-activation, hyper-activation, and normal activation relative to comparison subjects. Interpretin...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/nedt.2007.3.1.87

    authors: Adams R,David AS

    更新日期:2007-02-01 00:00:00

  • Ceruloplasmin and superoxide dismutase (SOD1) in heterozygotes for Wilson disease: A case control study.

    abstract::At the time of this study, there were five known patients with Wilson disease (WD) in Iceland. The mutation, a 7-bp deletion in exon 7 on chromosome 13 for WD, is only known in Iceland. In twenty healthy Icelandic heterozygotes for WD and their age- and gender-matched controls, copper concentration in plasma, cerulopl...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/ndt.s4360

    authors: Tórsdóttir G,Gudmundsson G,Kristinsson J,Snaedal J,Jóhannesson T

    更新日期:2009-01-01 00:00:00

  • Productivity and deadweight losses due to relapses of schizophrenia in Japan.

    abstract:BACKGROUND:No study has examined the financial impact of relapses on schizophrenia from the perspective of Japanese society. This study aimed to estimate the societal costs in Japan caused by the relapses of schizophrenia. METHODS:The societal costs in Japan in 2013 due to relapses of schizophrenia were estimated by s...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S138033

    authors: Nakamura Y,Mahlich J

    更新日期:2017-05-17 00:00:00

  • Aberrantly expressed long noncoding RNAs and genes in Parkinson's disease.

    abstract:Purpose:Parkinson's disease (PD) is a common neurodegenerative movement disorder, but the pathogenesis remains elusive. This study was aimed to explore key genes and long noncoding RNAs (lncRNAs) associated with PD. Materials and methods:Three patients with PD and three normal controls were enrolled in the present stu...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S178435

    authors: Zhou Y,Gu C,Li J,Zhu L,Huang G,Dai J,Huang H

    更新日期:2018-11-22 00:00:00

  • Association between the high-dose use of benzodiazepines and rehospitalization in patients with schizophrenia: a 2-year naturalistic study.

    abstract:BACKGROUND:High-dose use of benzodiazepines (BZPs) reportedly causes adverse effects on cognitive function and quality of life in patients with schizophrenia. However, effects of BZPs on the clinical course of schizophrenia have not been clarified. This study was set out to investigate the association between BZPs and ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S118759

    authors: Takita Y,Takaesu Y,Ono K,Futenma K,Shimura A,Murakoshi A,Komada Y,Inoue Y,Inoue T

    更新日期:2016-12-15 00:00:00

  • Elevated factor VIII level and stroke in patients without traditional risk factors associated with cardiovascular diseases.

    abstract:INTRODUCTION:Hemostasis is affected by interactions between physiological processes, including those connected with the coagulation system, whose essence is converting fibrinogen into fibrin. The role of factor VIII (FVIII) consists in activating factor X, which directly participates in the generation of thrombin, whic...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S43461

    authors: Lasek-Bal A,Puz P,Kazibutowska Z

    更新日期:2013-01-01 00:00:00

  • Update on the use of pramipexole in the treatment of Parkinson's disease.

    abstract::Pramipexole is a non-ergot dopamine agonist shown to be efficacious in the treatment of Parkinson's disease (PD). This review addresses the literature concerning pramipexole's efficacy in treating motor and non-motor symptoms in PD, its impact on the development of dyskinesias and response fluctuations, the issue of n...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/ndt.s2325

    authors: Constantinescu R

    更新日期:2008-04-01 00:00:00

  • Influence of trait anxiety, child maltreatment, and adulthood life events on depressive symptoms.

    abstract:Background:Various personality traits mediate the association between childhood stress and depressive symptoms in adulthood. The aim of this study was to clarify the indirect effects of the experience of child maltreatment on depressive symptoms and appraisal of life events in adulthood through trait anxiety. Subjects...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S182783

    authors: Uchida Y,Takahashi T,Katayama S,Masuya J,Ichiki M,Tanabe H,Kusumi I,Inoue T

    更新日期:2018-11-27 00:00:00

  • Associations among depressive symptoms, childhood abuse, neuroticism, and adult stressful life events in the general adult population.

    abstract:BACKGROUND:Recent studies have suggested that the interactions among several factors affect the onset, progression, and prognosis of major depressive disorder. This study investigated how childhood abuse, neuroticism, and adult stressful life events interact with one another and affect depressive symptoms in the genera...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S128557

    authors: Ono K,Takaesu Y,Nakai Y,Shimura A,Ono Y,Murakoshi A,Matsumoto Y,Tanabe H,Kusumi I,Inoue T

    更新日期:2017-02-15 00:00:00

  • Transcranial magnetic stimulation for treating depression in elderly patients.

    abstract:PURPOSE:The aim of the study reported here was to examine the safety and effectiveness of high-frequency repetitive transcranial magnetic stimulation (rTMS) in elderly patients with depression. PATIENTS AND METHODS:Sixty-five depressed elderly patients received rTMS over their left prefrontal cortex for 6 days per wee...

    journal_title:Neuropsychiatric disease and treatment

    pub_type:

    doi:10.2147/NDT.S44241

    authors: Hizli Sayar G,Ozten E,Tan O,Tarhan N

    更新日期:2013-01-01 00:00:00

  • Corpus callosum infarction with cognitive dysfunction: two case reports and literature review.

    abstract:Introduction:The incidence of corpus callosum infarction is low, and sudden cognitive dysfunction caused by corpus callosum infarction is very rare. We report two cases of acute corpus callosum infarction with sudden cognitive impairment, and the related basis, clinical manifestations, diagnosis, differential diagnosis...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S155487

    authors: Zhang J,Tang Y,Sun Y,Xu Y,Pang L,Li J,Wu T,He M

    更新日期:2018-02-13 00:00:00

  • Daily activity level improvement with antidepressant medications predicts long-term clinical outcomes in outpatients with major depressive disorder.

    abstract:BACKGROUND:Major depressive disorder (MDD) significantly impacts performance of both work- and nonwork-related routine daily activities. We have shown that work productivity is significantly impaired in employed MDD patients, but the extent of impairments in nonwork-related routine activities and its association with a...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S128407

    authors: Jha MK,Teer RB,Minhajuddin A,Greer TL,Rush AJ,Trivedi MH

    更新日期:2017-03-15 00:00:00

  • Mycophenolate mofetil for myasthenia gravis: a clear and present controversy.

    abstract::Mycophenolate mofetil (MMF) has been used to treat myasthenia gravis (MG) for over 10 years. MMF's use in the MG population stems from its theoretical mechanism of action and the medical literature that supports its benefit in MG patients. Recently, two large, double-blinded, placebo-controlled, randomized clinical tr...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/ndt.s3309

    authors: Heatwole C,Ciafaloni E

    更新日期:2008-12-01 00:00:00

  • The role of paliperidone extended release for the treatment of bipolar disorder.

    abstract:BACKGROUND:Bipolar disorder (BD) is a chronic, relapsing, episodic mental illness associated with other psychiatric comorbidities. There is a substantial economic burden with BD, which makes it challenging to treat. The aim of this review is to evaluate the pharmacology, clinical efficacy, and safety data related to pa...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S20675

    authors: Marino J,English C,Caballero J,Harrington C

    更新日期:2012-01-01 00:00:00

  • Update on the role of antipsychotics in the treatment of Tourette syndrome.

    abstract::Tourette syndrome (TS) is a neuropsychiatric disorder with typical onset in childhood and characterized by chronic occurrence of motor and vocal tics. The disorder can lead to serious impairments of both quality of life and psychosocial functioning, particularly for those individuals displaying complex tics. In such p...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S12990

    authors: Huys D,Hardenacke K,Poppe P,Bartsch C,Baskin B,Kuhn J

    更新日期:2012-01-01 00:00:00

  • The Impact of Event Scale - Revised: psychometric properties of the Italian version in a sample of flood victims.

    abstract:BACKGROUND:This study aims to verify the main psychometric properties of the Italian version of the Impact of Event Scale - Revised (IES-R) in a sample of flood victims. METHODS:The sample was composed of 262 subjects involved in the natural disaster of 2009 in the city of Messina (Italy). All participants completed t...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S51793

    authors: Craparo G,Faraci P,Rotondo G,Gori A

    更新日期:2013-01-01 00:00:00

  • Long noncoding RNA CASC2 predicts the prognosis of glioma patients and functions as a suppressor for gliomas by suppressing Wnt/β-catenin signaling pathway.

    abstract:BACKGROUND:Previous studies have demonstrated that long noncoding RNA cancer susceptibility candidate 2 (lncRNA CASC2) is frequently downregulated in several types of tumors and functions as a tumor-suppressive factor. However, the clinical significance and function of CASC2 in human glioma remain largely unknown. The ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S137171

    authors: Wang R,Li Y,Zhu G,Tian B,Zeng W,Yang Y,Li Z

    更新日期:2017-07-11 00:00:00

  • Dose-dependent rapid-onset akathisia with aripiprazole in patients with schizoaffective disorder.

    abstract::A series of cases are reported in which patients on aripiprazole have developed akathisia, although the literature states that the rate is negligible. ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type:

    doi:10.2147/nedt.2006.2.2.241

    authors: Basu R,Brar JS

    更新日期:2006-06-01 00:00:00

  • Possible new ways in the pharmacological treatment of bipolar disorder and comorbid alcoholism.

    abstract::About half of all bipolar patients have an alcohol abuse problem at some point of their lifetime. However, only one randomized, controlled trial of pharmacotherapy (valproate) in this patient population was published as of 2006. Therefore, we reviewed clinical trials in this indication of the last four years (using mo...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/ndt.s6741

    authors: Azorin JM,Bowden CL,Garay RP,Perugi G,Vieta E,Young AH

    更新日期:2010-03-24 00:00:00

  • Assessment of current clinical practices for major depression in Japan using a web-based questionnaire.

    abstract:Purpose:To investigate the current clinical practice of Japanese physicians in the diagnosis and management of major depression (major depressive disorder [MDD]). Patients and methods:Japanese physicians specializing in psychiatry or psychosomatic medicine in the medical database of Nihon Ultmarc Inc. (Chuo-Ku, Tokyo,...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S217098

    authors: Hori H,Yamato K

    更新日期:2019-10-01 00:00:00

  • Sexual dysfunction, mood, anxiety, and personality disorders in female patients with fibromyalgia.

    abstract:BACKGROUND:We aimed to investigate the current prevalence of sexual dysfunction (SD), mood, anxiety, and personality disorders in female patients with fibromyalgia (FM). METHODS:This case-control study involved 96 patients with FM and 94 healthy women. The SD diagnosis was based on a psychiatric interview in accordanc...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S99160

    authors: Kayhan F,Küçük A,Satan Y,İlgün E,Arslan Ş,İlik F

    更新日期:2016-02-16 00:00:00

  • Atypical antipsychotics to treat the neuropsychiatric symptoms of dementia.

    abstract::Neuropsychiatric symptoms are common in older adults with dementia and can be associated with a rapid decline in cognitive and functional status. This article reviews the current literature supporting the use of atypical antipsychotic medications in this population. Among the currently available atypical antipsychotic...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/nedt.2006.2.4.521

    authors: Lee PE,Gill SS,Rochon P

    更新日期:2006-12-01 00:00:00

  • Abnormal Baseline Brain Activity in Neuromyelitis Optica Patients Without Brain Lesion Detected by Resting-State Functional Magnetic Resonance Imaging.

    abstract:Objective:To investigate the baseline brain activity in neuromyelitis optica patients without brain lesion using the regional amplitude of low-frequency fluctuation (ALFF) and fractional amplitude of low-frequency fluctuation (fALFF) as indexes. Materials and methods:Forty-two patients of NMO with normal performance in ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S232924

    authors: Liu Y,Xiong H,Li X,Zhang D,Yang C,Yu J,Liao R,Zhou B,Huang X,Tang Z

    更新日期:2020-01-08 00:00:00

  • Association between reduced quality of life and depression in patients with type 2 diabetes mellitus: a cohort study in a Mexican population.

    abstract:Background:Diabetes mellitus is a chronic disease that requires attention and commitment on the part of patients; improving the quality of life of these patients reduces health costs, morbidity, and mortality. We focused on investigating the factors related with the quality of life and depression symptomatology in pati...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S167622

    authors: Juárez-Rojop IE,Fortuny-Falconi CM,González-Castro TB,Tovilla-Zárate CA,Villar-Soto M,Sanchez ER,Hernández-Díaz Y,López-Narvaez ML,Ble-Castillo JL,Pérez-Hernández N,Rodríguez-Pérez JM

    更新日期:2018-10-04 00:00:00

  • Undertreatment of human immunodeficiency virus in psychiatric inpatients: a cross-sectional study of seroprevalence and associated factors.

    abstract:BACKGROUND:The aims of this study were to evaluate the prevalence of HIV and its associated demographic and clinical factors among psychiatric inpatients of a general hospital. METHODS:This was a single-center, observational, cross-sectional study that included patients consecutively admitted to our unit aged 16 years...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S79939

    authors: Gonzalez-Torres MA,Salazar MA,Imaz M,Inchausti L,Ibañez B,Fernandez-Rivas A,Pastor J,Anguiano B,Muñoz P,Ruiz E,Oraa R,Bustamante S,de Eulate SA,Cisterna R

    更新日期:2015-06-11 00:00:00

  • Inefficient understanding of non-factive mental verbs with social aspect in adults: comparison to cognitive factive verb processing.

    abstract:Introduction:Mental verbs denote inner mental states and are an important link between language and Theory of Mind ability conceptualized as mental state understanding. Non-factive mental verbs denote an obligation or intention and constitute a discrete class of mental verbs which are characterized by their social aspe...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S165893

    authors: Nazlidou EI,Moraitou D,Natsopoulos D,Papaliagkas V,Masoura E,Papantoniou G

    更新日期:2018-10-10 00:00:00

  • Sensory function in cluster headache: an observational study comparing the symptomatic and asymptomatic sides.

    abstract:Background:Based on inconsistent sensory alterations demonstrated in cluster headache (CH), the aim of this study was to determine whether patients with CH develop sensory changes in the symptomatic side compared to the asymptomatic side. Methods:Quantitative sensory testing (QST), including pressure pain threshold (P...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S186051

    authors: Malo-Urriés M,Hidalgo-García C,Estébanez-de-Miguel E,Tricás-Moreno JM,Santos-Lasaosa S,Jahanshahi M

    更新日期:2018-12-10 00:00:00

  • Metabolite-related antidepressant action of diterpene ginkgolides in the prefrontal cortex.

    abstract:Purpose:Ginkgo biloba extract (GBE) contains diterpene ginkgolides (DGs), which have been shown to have neuroprotective effects by a number of previous studies. We previously demonstrated part of the action of DG. However, the impact of DG on the prefrontal cortex (PFC) remains unclear. Here, we evaluated the effects o...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S161351

    authors: Hu Q,Shen P,Bai S,Dong M,Liang Z,Chen Z,Wang W,Wang H,Gui S,Li P,Xie P

    更新日期:2018-04-13 00:00:00