The prevalence and risk factors of young male schizophrenics with non-alcoholic fatty liver disease.

Abstract:

OBJECTIVE:In this study, we compared the prevalence rate of non-alcoholic fatty liver disease (NAFLD) between young males with schizophrenia and the general young males as the control group, and we also investigated the risk factors of NAFLD in young males with schizophrenia. MATERIALS AND METHODS:This is a large cross-sectional study consisting of the study group and parallel control group. The study group comprises 202 cases of young males with schizophrenia recruited from Liaoning province Demobilized Soldiers Kangning Hospital, and 149 healthy young males were recruited as the control group. The clinical evaluation included Positive and Negative Syndrome Scale (PANSS), basic information, disease-related information, and physical examination information. The laboratory tests included fasting blood glucose, total cholesterol, triglyceride, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). The physical examination included liver ultrasonography. RESULTS:No statistical difference was observed between the study and control groups regarding age (30.5±3.9 vs 30.7±3.6), body mass index (BMI), blood pressure, fasting glucose level, and total cholesterol. NAFLD was observed in both the study and control groups. The prevalence of NAFLD was 49.5% (100/202) in the study group, and 20.1% (30/149) in the control group. The study group was further divided into NAFLD group and non-NAFLD group. There were significant differences in medication combination, drug dosage, negative factor score in PANSS (14.1±4.0 vs 12.7±4.5), BMI, fasting glucose level, total cholesterol, triglyceride, ALT, and AST between NAFLD group and non-NAFLD group. According to the results of the multiple-factor analysis, the onset of NAFLD among young males with schizophrenia was significantly correlated with the following factors: triglyceride, BMI, medication combination, drug dosage, and negative factor score in PANSS. CONCLUSION:The prevalence of NAFLD in the study group was significantly higher than that in the control group. Multivariate analysis indicated that, triglyceride, BMI, medication combination, drug dosage, and negative factor score in PANSS were significantly related to NAFLD in patients with schizophrenia.

authors

Yan J,Hou C,Liang Y

doi

10.2147/NDT.S137183

subject

Has Abstract

pub_date

2017-06-12 00:00:00

pages

1493-1498

eissn

1176-6328

issn

1178-2021

pii

ndt-13-1493

journal_volume

13

pub_type

杂志文章
  • Stress, anxiety, and depression among medical students in a multiethnic setting.

    abstract:BACKGROUND:Contemporary literature suggests that medical education might adversely affect students' mental health. Alfaisal University in Riyadh, Saudi Arabia is a developing institution; hence, there has been a concern regarding the mental well-being of the students. OBJECTIVES:This study was designed to assess the t...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S83577

    authors: Kulsoom B,Afsar NA

    更新日期:2015-07-16 00:00:00

  • Metabolite-related antidepressant action of diterpene ginkgolides in the prefrontal cortex.

    abstract:Purpose:Ginkgo biloba extract (GBE) contains diterpene ginkgolides (DGs), which have been shown to have neuroprotective effects by a number of previous studies. We previously demonstrated part of the action of DG. However, the impact of DG on the prefrontal cortex (PFC) remains unclear. Here, we evaluated the effects o...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S161351

    authors: Hu Q,Shen P,Bai S,Dong M,Liang Z,Chen Z,Wang W,Wang H,Gui S,Li P,Xie P

    更新日期:2018-04-13 00:00:00

  • Shen-Qi-Jie-Yu-Fang exerts effects on a rat model of postpartum depression by regulating inflammatory cytokines and CD4(+)CD25(+) regulatory T cells.

    abstract:BACKGROUND:Shen-Qi-Jie-Yu-Fang (SJF) is composed of eight Chinese medicinal herbs. It is widely used in traditional Chinese medicine for treating postpartum depression (PPD). Previous studies have shown that SJF treats PPD through the neuroendocrine mechanism. AIM:To further investigate the effect of SJF on the immune...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S98131

    authors: Li J,Zhao R,Li X,Sun W,Qu M,Tang Q,Yang X,Zhang S

    更新日期:2016-04-15 00:00:00

  • Thyroid functions in patients with bipolar disorder and the impact of quetiapine monotherapy: a retrospective, naturalistic study.

    abstract:Objective:Previous studies have demonstrated a potentially close relationship between mood disorders and thyroid abnormalities. The aims of this study are to investigate: 1) whether significant differences of thyroid profiles exist between manic and depressive episodes in patients with bipolar disorder (BD); 2) the imp...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S196661

    authors: Li C,Lai J,Huang T,Han Y,Du Y,Xu Y,Hu S

    更新日期:2019-08-09 00:00:00

  • Recognized homonymous hemianopsia and delirium during the admission examination leading to diagnosis and appropriate treatment of a new stroke.

    abstract::This case report describes the detection of homonymous hemianopsia and delirium during the admission physical examination of a patient with esophageal adenocarcinoma, resulting in the new diagnosis of subacute hemorrhagic stroke. The poststroke visual field defect can result in significant disability and reduction in ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type:

    doi:10.2147/NDT.S109345

    authors: Tsymbalov KS,Fetkenhour DR

    更新日期:2016-06-15 00:00:00

  • The Impact of Event Scale - Revised: psychometric properties of the Italian version in a sample of flood victims.

    abstract:BACKGROUND:This study aims to verify the main psychometric properties of the Italian version of the Impact of Event Scale - Revised (IES-R) in a sample of flood victims. METHODS:The sample was composed of 262 subjects involved in the natural disaster of 2009 in the city of Messina (Italy). All participants completed t...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S51793

    authors: Craparo G,Faraci P,Rotondo G,Gori A

    更新日期:2013-01-01 00:00:00

  • Natural reduced water suppressed anxiety and protected the heightened oxidative stress in rats.

    abstract:BACKGROUND:In Japan, the effects of reduced water, such as hydrogen-rich electrolyzed reduced water and natural reduced water, like Hita Tenryosui water®, have been examined. The purpose of the present study was to identify the role of natural reduced water in anxiety and blood biochemical analysis. MATERIALS AND METH...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S138289

    authors: Masuda K,Tanaka Y,Kanehisa M,Ninomiya T,Inoue A,Higuma H,Kawashima C,Nakanishi M,Okamoto K,Akiyoshi J

    更新日期:2017-09-08 00:00:00

  • Disrupted Brain Entropy And Functional Connectivity Patterns Of Thalamic Subregions In Major Depressive Disorder.

    abstract:Purpose:Entropy analysis of resting-state functional magnetic resonance imaging (R-fMRI) has recently been adopted to characterize brain temporal dynamics in some neuropsychological or psychiatric diseases. Thalamus-related dysfunction might be a potential trait marker of major depressive disorder (MDD), but the abnorm...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S220743

    authors: Xue SW,Wang D,Tan Z,Wang Y,Lian Z,Sun Y,Hu X,Wang X,Zhou X

    更新日期:2019-09-11 00:00:00

  • Selegiline remarkably improved stage 5 treatment-resistant major depressive disorder: a case report.

    abstract::We report a case in which selegiline, an irreversible monoamine oxidase B (MAO-B) inhibitor, greatly improved depressive symptoms in an adult with stage 5 treatment-resistant major depressive disorder. Four antidepressants and four augmentation therapies had previously been ineffective or intolerable, and electroconvu...

    journal_title:Neuropsychiatric disease and treatment

    pub_type:

    doi:10.2147/NDT.S49261

    authors: Kitaichi Y,Inoue T,Mitsui N,Nakagawa S,Kameyama R,Hayashishita Y,Shiga T,Kusumi I,Koyama T

    更新日期:2013-01-01 00:00:00

  • Acute parietal lobe infarction presenting as Gerstmann's syndrome and cognitive decline mimicking senile dementia.

    abstract::Gerstmann's syndrome encompasses the tetrad of finger agnosia, agraphia, acalculia, and right-left confusion. An elderly man with a history of several cardiovascular diseases was initially brought to the psychiatric outpatient department by his family because of worsening of recent memory, executive function, and mixe...

    journal_title:Neuropsychiatric disease and treatment

    pub_type:

    doi:10.2147/NDT.S43527

    authors: Chen TY,Chen CY,Yen CH,Kuo SC,Yeh YW,Chang S,Huang SY

    更新日期:2013-01-01 00:00:00

  • Characteristics, burden of illness, and physical functioning of patients with relapsing-remitting and secondary progressive multiple sclerosis: a cross-sectional US survey.

    abstract:BACKGROUND:Although most patients with relapsing-remitting multiple sclerosis (RRMS) will develop secondary progressive multiple sclerosis (SPMS), little is known about the burden of multiple sclerosis by disease subtype. This study describes the burden of disease in terms of demographics, disease severity, symptoms, h...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S132079

    authors: Gross HJ,Watson C

    更新日期:2017-05-18 00:00:00

  • The role of ziprasidone in adjunctive use with lithium or valproate in maintenance treatment of bipolar disorder.

    abstract:OBJECTIVES:This article addresses the clinical role for ziprasidone used adjunctively with a mood stabilizer in maintenance treatment of bipolar disorder. This review also addresses the strengths and limitations of design features in adjunctive studies of second-generation antipsychotic drugs added to mood stabilizers....

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S9932

    authors: Bowden CL

    更新日期:2011-01-01 00:00:00

  • Frequent nightmares in Chinese patients undergoing methadone maintenance therapy: prevalence, correlates, and their association with functional impairment.

    abstract:Purpose:Nightmares are associated with many negative health outcomes; however, little is known about the characteristics of nightmares in heroin-dependent patients (HDPs). This study examined the prevalence and correlates of frequent nightmares (FNs) and their association with functional impairment in Chinese patients ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S202813

    authors: Zhong BL,Xu YM,Xie WX,Lu J

    更新日期:2019-07-18 00:00:00

  • Assessing suicidal risk with antiepileptic drugs.

    abstract::Recently, the US Food and Drug Administration issued an alert about an increased risk for suicidality during treatment with antiepileptic drugs (AEDs) for different indications, including epilepsy. We discuss the issue of suicide in epilepsy with special attention to AEDs and the assessment of suicide in people with e...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S11999

    authors: Mula M,Bell GS,Sander JW

    更新日期:2010-10-05 00:00:00

  • Psychosis in behavioral variant frontotemporal dementia.

    abstract:BACKGROUND:Dementia is generally characterized by cognitive impairment that can be accompanied by psychotic symptoms; for example, visual hallucinations are a core feature of dementia with Lewy bodies, and delusions are often seen in Alzheimer's disease. However, for behavioral variant of frontotemporal dementia (bvFTD...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S127863

    authors: Gossink FT,Vijverberg EG,Krudop W,Scheltens P,Stek ML,Pijnenburg YA,Dols A

    更新日期:2017-04-13 00:00:00

  • Effectiveness of high-intensity interval training on the mental and physical health of people with chronic schizophrenia.

    abstract:BACKGROUND:Low-volume high-intensity interval training (HIIT) is emerging as a time-efficient exercise strategy for improving cardiorespiratory fitness and for controlling blood sugar levels and hypertension. In addition, patient acceptance of HIIT may improve adherence to exercise programs. This study evaluated the ef...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S81482

    authors: Wu MH,Lee CP,Hsu SC,Chang CM,Chen CY

    更新日期:2015-05-25 00:00:00

  • Treatment Of Magnesium-L-Threonate Elevates The Magnesium Level In The Cerebrospinal Fluid And Attenuates Motor Deficits And Dopamine Neuron Loss In A Mouse Model Of Parkinson's disease.

    abstract:Purpose:Epidemiology research has demonstrated that magnesium (Mg) deficiency is associated with a high incidence of Parkinson's disease (PD). It is known that the systemic administration of MgSO4 is not able to elevate the Mg concentration in cerebrospinal fluid (CSF). This study aims to verify the protective effect o...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S230688

    authors: Shen Y,Dai L,Tian H,Xu R,Li F,Li Z,Zhou J,Wang L,Dong J,Sun L

    更新日期:2019-11-11 00:00:00

  • Deep brain stimulation in Tourette's syndrome: evidence to date.

    abstract::Tourette's syndrome (TS) is a neurodevelopmental disorder that comprises vocal and motor tics associated with a high frequency of psychiatric comorbidities, which has an important impact on quality of life. The onset is mainly in childhood and the symptoms can either fade away or require pharmacological therapies asso...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章,评审

    doi:10.2147/NDT.S139368

    authors: Casagrande SCB,Cury RG,Alho EJL,Fonoff ET

    更新日期:2019-04-29 00:00:00

  • Frequency of inborn errors of metabolism screening for children with unexplained acute encephalopathy at an emergency department.

    abstract:Objective:Our study aimed to estimate the frequency of inborn errors of metabolism (IEMs) in patients presenting with acute encephalopathy-like picture at an emergency department (ED). Subjects and methods:Our study was a prospective observational study conducted on 30 patients admitted to the pediatric ED with unexpl...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S165833

    authors: Abdel Maksoud M,ELsayed SM,Shatla RH,Imam AA,Elsayed RM,Mosabah AA,Sherif AM

    更新日期:2018-06-29 00:00:00

  • Analysis concerning nutritional behaviors in the context of the risk of orthorexia.

    abstract::Orthorexia is recognized as an eating disorder, an obsessive-compulsive spectrum disorder, or a somatoform disorder. The aim of our research was to analyze nutritional behaviors for the assessment of the risk of orthorexia. The authors developed a questionnaire in which 981 respondents participated and used it as a re...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S129660

    authors: Olejniczak D,Bugajec D,Panczyk M,Brytek-Matera A,Religioni U,Czerw A,Grąbczewska A,Juszczyk G,Jabłkowska-Górecka K,Staniszewska A

    更新日期:2017-02-21 00:00:00

  • Effects of sequential nutritional support on nutritional status and expression of regulatory T lymphocyte in patients with early severe traumatic brain injury.

    abstract:Objective:To investigate the effects of sequential nutritional support on nutritional status and immune regulation in patients with early severe traumatic brain injury (STBI). Patients and methods:A total of 62 patients diagnosed with STBI enrolled from Chaoyang Hospital (Beijing, China) from February 2015 to October ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S149802

    authors: Jia K,Tong X,Liang F

    更新日期:2018-06-14 00:00:00

  • Atypical depression: current perspectives.

    abstract::The history and present status of the definition, prevalence, neurobiology, and treatment of atypical depression (AD) is presented. The concept of AD has evolved through the years, and currently, in Diagnostic and Statistical Manual of Mental Disorders (DSM), Fifth Edition, the specifier of depressive episode with aty...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章,评审

    doi:10.2147/NDT.S147317

    authors: Łojko D,Rybakowski JK

    更新日期:2017-09-20 00:00:00

  • Social support networks and eating disorders: an integrative review of the literature.

    abstract:AIMS:This study aimed to analyze the scientific literature about social networks and social support in eating disorders (ED). METHODS:By combining keywords, an integrative review was performed. It included publications from 2006-2013, retrieved from the MEDLINE, LILACS, PsycINFO, and CINAHL databases. The selection of...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章,评审

    doi:10.2147/NDT.S60735

    authors: Leonidas C,Dos Santos MA

    更新日期:2014-05-21 00:00:00

  • Anti-NMDA receptor antibodies in patients with a first episode of schizophrenia.

    abstract:BACKGROUND:Encephalitis with antibodies against N-methyl-D-aspartate receptor (NMDA-R) is classified as an autoimmune disorder with psychotic symptoms, which are frequently dominant. However, it remains unclear how frequently NMDA-R antibodies lead to a condition that mimics psychosis and first-episode schizophrenia. I...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S80746

    authors: Masopust J,Andrýs C,Bažant J,Vyšata O,Kuca K,Vališ M

    更新日期:2015-03-06 00:00:00

  • Profile of everolimus in the treatment of tuberous sclerosis complex: an evidence-based review of its place in therapy.

    abstract::Tuberous sclerosis complex (TSC) is a relatively rare genetic disorder, affecting one in 6,000 births. Mammalian target of rapamycin (mTOR) inhibitors, such as everolimus, which have been previously used to prevent solid organ transplant rejection, augment anticancer treatment regimens, and prevent neovascularization ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章,评审

    doi:10.2147/NDT.S91248

    authors: Capal JK,Franz DN

    更新日期:2016-08-25 00:00:00

  • Psychotherapy and medication management strategies for obsessive-compulsive disorder.

    abstract::Obsessive-compulsive disorder (OCD) is a chronic anxiety disorder. While medication and psychotherapy advances have been very helpful to patients, many patients do not respond adequately to initial trials of serotonergic medication or cognitive-behavioral therapy (CBT) and require multiple treatment trials or combinat...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S13205

    authors: Walsh KH,McDougle CJ

    更新日期:2011-01-01 00:00:00

  • Optimal management of night eating syndrome: challenges and solutions.

    abstract::Night Eating Syndrome (NES) is a unique disorder characterized by a delayed pattern of food intake in which recurrent episodes of nocturnal eating and/or excessive food consumption occur after the evening meal. NES is a clinically important disorder due to its relationship to obesity, its association with other psychi...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章,评审

    doi:10.2147/NDT.S70312

    authors: Kucukgoncu S,Midura M,Tek C

    更新日期:2015-03-19 00:00:00

  • Mycophenolate mofetil for myasthenia gravis: a clear and present controversy.

    abstract::Mycophenolate mofetil (MMF) has been used to treat myasthenia gravis (MG) for over 10 years. MMF's use in the MG population stems from its theoretical mechanism of action and the medical literature that supports its benefit in MG patients. Recently, two large, double-blinded, placebo-controlled, randomized clinical tr...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/ndt.s3309

    authors: Heatwole C,Ciafaloni E

    更新日期:2008-12-01 00:00:00

  • The abnormal activation of D1R/Shp-2 complex involved in levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned Parkinson's rats.

    abstract:Background:Levodopa-induced dyskinesia (LID) is a troublesome problem in the treatment of Parkinson's disease (PD). The mechanisms of LID are still mysterious. Recently, the interaction between Shp-2 and D1 dopamine receptor (D1R) has been identified to be indispensable in the D1R-mediated extracellular signal-regulate...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S162562

    authors: Wu N,Wan Y,Song L,Qi C,Liu Z,Gan J

    更新日期:2018-07-05 00:00:00

  • Biomarkers for depression: recent insights, current challenges and future prospects.

    abstract::A plethora of research has implicated hundreds of putative biomarkers for depression, but has not yet fully elucidated their roles in depressive illness or established what is abnormal in which patients and how biologic information can be used to enhance diagnosis, treatment and prognosis. This lack of progress is par...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章,评审

    doi:10.2147/NDT.S114542

    authors: Strawbridge R,Young AH,Cleare AJ

    更新日期:2017-05-10 00:00:00