Atypical antipsychotics to treat the neuropsychiatric symptoms of dementia.

Abstract:

:Neuropsychiatric symptoms are common in older adults with dementia and can be associated with a rapid decline in cognitive and functional status. This article reviews the current literature supporting the use of atypical antipsychotic medications in this population. Among the currently available atypical antipsychotics, risperidone and olanzapine have been the most widely studied in double-blind, randomized, placebo-controlled clinical trials. Despite the common use of other atypical antipsychotic medications, their efficacy and safety in older adults with dementia has not been as extensively studied. Some controversy surrounds the use of atypical antipsychotic agents in older adults with the suggestion that they may increase the incidence of stroke or even death. Despite the potential for increased risk of harm from the use of these medications, atypical antipsychotics are often effective in treating troublesome neuropsychiatric symptoms refractory to other treatments. Whenever possible, these atypical antipsychotic drug treatments should be combined with non-pharmacological treatments to limit the need and dose of antipsychotic drugs and constant monitoring for potential harms should be maintained. The choice of which atypical antipsychotic agent can be guided by the nature and severity of the target symptom and the medication least likely to cause harm to the patient.

authors

Lee PE,Gill SS,Rochon P

doi

10.2147/nedt.2006.2.4.521

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

521-9

issue

4

eissn

1176-6328

issn

1178-2021

journal_volume

2

pub_type

杂志文章
  • Clinical relevance of paliperidone palmitate 3-monthly in treating schizophrenia.

    abstract::Antipsychotics are the mainstay in schizophrenia management, and long-acting injectable (LAI) antipsychotics contribute to the successful maintenance of treatment by improving non-adherence and preventing relapses. Paliperidone palmitate 3-monthly (PP3M) formulation is the only available LAI antipsychotic that offers ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章,评审

    doi:10.2147/NDT.S197225

    authors: Mathews M,Gopal S,Nuamah I,Hargarter L,Savitz AJ,Kim E,Tan W,Soares B,Correll CU

    更新日期:2019-05-21 00:00:00

  • Escitalopram tolerability as mono- versus augmentative therapy in patients with affective disorders: a naturalistic study.

    abstract:BACKGROUND:Escitalopram is a selective serotonin reuptake inhibitor, widely used in the treatment of affective disorders. The purpose of this study was to examine its safety and tolerability, as mono- versus augmentative therapy, in a group of patients with affective disorders. MATERIALS AND METHODS:The sample consist...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S39322

    authors: Dell'osso B,Arici C,Dobrea C,Camuri G,Benatti B,Altamura AC

    更新日期:2013-01-01 00:00:00

  • Predictors of sleep disturbance in heroin users receiving methadone maintenance therapy: a naturalistic study in Taiwan.

    abstract:Introduction:Sleep disturbance is a major health concern for heroin users receiving methadone maintenance treatment (MMT). The present study was aimed to investigate the predictors for new-onset clinically predominant sleep disturbance (CPSD) among heroin users receiving MMT. Methods:This 2-year retrospective study in...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S177370

    authors: Li DJ,Chung KS,Wu HC,Hsu CY,Yen CF

    更新日期:2018-10-26 00:00:00

  • Anxiolytics may promote locomotor function recovery in spinal cord injury patients.

    abstract::Recent findings in animal models of paraplegia suggest that specific nonbenzodiazepine anxiolytics may temporarily restore locomotor functions after spinal cord injury (SCI). Experiments using in vitro models have revealed, indeed, that selective serotonin receptor (5-HTR) ligands such as 5-HTR(1A) agonists, known as ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/ndt.s2839

    authors: Guertin PA

    更新日期:2008-08-01 00:00:00

  • Protective Role of Astrocyte-Derived Exosomal microRNA-361 in Cerebral Ischemic-Reperfusion Injury by Regulating the AMPK/mTOR Signaling Pathway and Targeting CTSB.

    abstract:Background:Evidence has shown that microRNAs (miRNAs) are implicated in ischemic diseases. Therefore, the aim of the present study was to identify the functions of astrocyte (ATC)-derived exosomal miR-361 on cerebral ischemic-reperfusion (I/R) injury. Methods:A rat model of cerebral I/R injury was initially establishe...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S260748

    authors: Bu X,Li D,Wang F,Sun Q,Zhang Z

    更新日期:2020-07-31 00:00:00

  • Clinical characteristics of synthetic cannabinoid-induced psychosis in relation to schizophrenia: a single-center cross-sectional analysis of concurrently hospitalized patients.

    abstract:BACKGROUND:This study aimed to evaluate synthetic cannabinoid (SC)-induced psychosis in terms of patient profile and clinical characteristics with reference to concurrently hospitalized schizophrenic patients. METHODS:A total of 81 male patients diagnosed with psychotic disorder induced by the use of SCs (n=50; mean (...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S107622

    authors: Altintas M,Inanc L,Oruc GA,Arpacioglu S,Gulec H

    更新日期:2016-08-02 00:00:00

  • The role of paliperidone extended release for the treatment of bipolar disorder.

    abstract:BACKGROUND:Bipolar disorder (BD) is a chronic, relapsing, episodic mental illness associated with other psychiatric comorbidities. There is a substantial economic burden with BD, which makes it challenging to treat. The aim of this review is to evaluate the pharmacology, clinical efficacy, and safety data related to pa...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S20675

    authors: Marino J,English C,Caballero J,Harrington C

    更新日期:2012-01-01 00:00:00

  • Functional neuroimaging of traumatic brain injury: advances and clinical utility.

    abstract::Functional deficits due to traumatic brain injury (TBI) can have significant and enduring consequences upon patients' life quality and expectancy. Although functional neuroimaging is essential for understanding TBI pathophysiology, an insufficient amount of effort has been dedicated to the task of translating function...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章,评审

    doi:10.2147/NDT.S79174

    authors: Irimia A,Van Horn JD

    更新日期:2015-09-15 00:00:00

  • Possible new ways in the pharmacological treatment of bipolar disorder and comorbid alcoholism.

    abstract::About half of all bipolar patients have an alcohol abuse problem at some point of their lifetime. However, only one randomized, controlled trial of pharmacotherapy (valproate) in this patient population was published as of 2006. Therefore, we reviewed clinical trials in this indication of the last four years (using mo...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/ndt.s6741

    authors: Azorin JM,Bowden CL,Garay RP,Perugi G,Vieta E,Young AH

    更新日期:2010-03-24 00:00:00

  • Are 24-hour motor activity patterns associated with continued rapid response to ketamine?

    abstract:Purpose:This study examined the links between 24-hour activity patterns (specifically, amplitude and timing of wrist activity) and the persisting qualities of clinical antidepressant response to the glutamatergic modulator ketamine. Methods:Twenty-four-hour activity patterns were compared across 5 days of 24-hour acti...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S172089

    authors: Duncan WC Jr,Slonena EE,Hejazi NS,Brutsche N,Park LT,Henter ID,Ballard ED,Zarate CA Jr

    更新日期:2018-10-16 00:00:00

  • Mental toughness, sleep disturbances, and physical activity in patients with multiple sclerosis compared to healthy adolescents and young adults.

    abstract:BACKGROUND:Multiple sclerosis (MS) is the most common chronic autoimmune demyelinating and inflammatory disease of the central nervous system, afflicting both the body and mind. The risk of suffering from MS is 2.5-3.5 times greater in females than in males. While there is extant research on fatigue, depression, and co...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S111208

    authors: Sadeghi Bahmani D,Gerber M,Kalak N,Lemola S,Clough PJ,Calabrese P,Shaygannejad V,Pühse U,Holsboer-Trachsler E,Brand S

    更新日期:2016-06-27 00:00:00

  • Sexual dysfunction, mood, anxiety, and personality disorders in female patients with fibromyalgia.

    abstract:BACKGROUND:We aimed to investigate the current prevalence of sexual dysfunction (SD), mood, anxiety, and personality disorders in female patients with fibromyalgia (FM). METHODS:This case-control study involved 96 patients with FM and 94 healthy women. The SD diagnosis was based on a psychiatric interview in accordanc...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S99160

    authors: Kayhan F,Küçük A,Satan Y,İlgün E,Arslan Ş,İlik F

    更新日期:2016-02-16 00:00:00

  • Posttraumatic Stress Disorder and Associated Factors Among Drivers Surviving Road Traffic Crashes in Southwest Ethiopia.

    abstract:Background:Road traffic crashes (RTCs) can cause serious and long-lasting consequences for drivers, both in terms of physical and mental health outcomes. Posttraumatic stress disorder (PTSD) is the most frequent mental disorder occurring after traumatic exposure. Ethiopian drivers experience RTCs more frequently than o...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S233976

    authors: Alenko A,Berhanu H,Abera Tareke A,Reta W,Bariso M,Mulat E,Kenenisa C,Debebe W,Tolesa K,Girma S

    更新日期:2019-12-24 00:00:00

  • Lack of Association Between PLA2G6 Genetic Variation and Parkinson's Disease: A Systematic Review.

    abstract:Background:The phospholipase A2 Group 6 (PLA2G6, also known as PLA2, PARK14, and iPLA2) gene encodes a group VIA calcium-independent phospholipase A2. Genetic polymorphism of PLA2G6 has been indicated to be involved in conferring susceptibility for Parkinson's disease (PD), whereas conclusive results have not been obta...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S254065

    authors: Liu H,Yao Y,Liu H,Peng Y,Ren J,Wu X,Mao R,Zhao J,Zhu Y,Niu Z,Yang T,Sun X,Jiang P,Zhang C,Fang Y

    更新日期:2020-07-23 00:00:00

  • Korean Medication Algorithm Project for Bipolar Disorder: third revision.

    abstract:OBJECTIVE:To constitute the third revision of the guidelines for the treatment of bipolar disorder issued by the Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP 2014). METHODS:A 56-item questionnaire was used to obtain the consensus of experts regarding pharmacological treatment strategies for the va...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S77838

    authors: Woo YS,Lee JG,Jeong JH,Kim MD,Sohn I,Shim SH,Jon DI,Seo JS,Shin YC,Min KJ,Yoon BH,Bahk WM

    更新日期:2015-02-26 00:00:00

  • A fully integrated new paradigm for lithium's mode of action - lithium utilizes latent cellular fail-safe mechanisms.

    abstract::It is proposed that lithium's therapeutic effects occur indirectly by augmenting a cascade of protective "fail-safe" pathways pre-configured to activate in response to a dangerous low cell [Mg++] situation, eg, posttraumatic brain injury, alongside relative cell adenosine triphosphate depletion. Lithium activates cell...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S123612

    authors: van Woerkom AE

    更新日期:2017-01-31 00:00:00

  • Analysis of HAM-D scores and working ability in an observational study of Japanese patients with major depressive disorder and painful physical symptoms treated with duloxetine or SSRI monotherapy.

    abstract:Objective:To investigate the relationship between Hamilton Depression Rating Scale (HAM-D) score and psychiatrists' judgment of working ability in patients with major depressive disorder (MDD) and painful physical symptoms. Methods:This was a prospective, observational, 12-week study in patients who received duloxetin...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S195445

    authors: Kuga A,Otsubo T,Tsuji T,Hayashi S,Imagawa H,Fujikoshi S,Escobar R

    更新日期:2019-04-05 00:00:00

  • Reduction in apathy following epilepsy surgery.

    abstract:Introduction:Surgical treatment for patients with epilepsy who do not respond to antiepileptic medication can lead to changes in behavior, including new onset of neuropsychiatric symptoms such as depression and anxiety. In other cases, neuropsychiatric symptoms present before surgery may be alleviated. Because applicat...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S189603

    authors: Mah L,Swearer J,Phillips CA,Benjamin S

    更新日期:2019-06-28 00:00:00

  • Update on the use of pramipexole in the treatment of Parkinson's disease.

    abstract::Pramipexole is a non-ergot dopamine agonist shown to be efficacious in the treatment of Parkinson's disease (PD). This review addresses the literature concerning pramipexole's efficacy in treating motor and non-motor symptoms in PD, its impact on the development of dyskinesias and response fluctuations, the issue of n...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/ndt.s2325

    authors: Constantinescu R

    更新日期:2008-04-01 00:00:00

  • Clinical Characteristics of Women with ADHD in Japan.

    abstract:Purpose:Although gender differences have been reported in various aspects of adult attention-deficit hyperactivity disorder (ADHD), such as prevalence, comorbidities, and social functioning, there have been few such studies conducted in Japan. Our research investigated gender differences in sociodemographic and clinica...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S232565

    authors: Hayashi W,Suzuki H,Saga N,Arai G,Igarashi R,Tokumasu T,Ota H,Yamada H,Takashio O,Iwanami A

    更新日期:2019-12-04 00:00:00

  • A family-oriented therapy program for youths with substance abuse: long-term outcomes related to relapse and academic or social status.

    abstract:OBJECTIVE:The abuse of illegal substances by youths in Taiwan has become a major public health issue. This study explores the outcomes (relapse rate and academic or social status) of a family-oriented therapy program conducted for substance-using youths who were referred by a judge to participate in it. METHODS:The pr...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S105199

    authors: Wang LJ,Lu SF,Chong MY,Chou WJ,Hsieh YL,Tsai TN,Chen C,Lee YH

    更新日期:2016-03-30 00:00:00

  • Agomelatine in the treatment of mild-to-moderate depression in patients with cardiovascular disease: results of the national multicenter observational study PULSE.

    abstract:BACKGROUND:PULSE was a large, observational, multicenter study designed to evaluate the efficacy and safety of agomelatine in the treatment of major depression in patients with cardiovascular disease (CVD). METHODS:Patients with mild-to-moderate major depressive episodes, without psychotic symptoms, were treated as ou...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S129793

    authors: Medvedev VE

    更新日期:2017-04-21 00:00:00

  • Minor Physical Anomalies Among Schizophrenic Patients as a Biomarker of Its Developmental Origin in Northwest Ethiopia.

    abstract:Purpose:Although there are highly precise and advanced diagnostic methods, the etiology and pathophysiology of schizophrenia remain poorly understood. There are several theories about schizophrenia origin, among which the neurodevelopmental theory is widely accepted. Our study aimed to assess minor physical anomalies a...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S275582

    authors: Tsehay B,Shitie D

    更新日期:2020-10-28 00:00:00

  • Whole genome association studies of neuropsychiatric disease: An emerging era of collaborative genetic discovery.

    abstract::Family history, which includes both common environmental and genetic effects, is associated with an increased risk for many neuropsychiatric diseases. Investigators have identified several disease-causing mutations for specific neuropsychiatric disorders that display Mendelian segregation. Such discoveries can lead to...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:

    authors: Keller MA,Gwinn K,Nash J,Horsford J,Zhang R,Rich SS,Corriveau RA

    更新日期:2007-01-01 00:00:00

  • Psychiatric comorbidities in patients with intentional methanol intoxication.

    abstract:Background:Intentional methanol intoxication (IMI) is an emerging public health issue in Asian countries, but few data are available in the literature on underlying psychiatric comorbidities in these suicide attempters. Patients and methods:We conducted a retrospective chart review on patients with methanol intoxicati...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S192943

    authors: Yang WS,Yen TH,Juang YY,Lee SH,Wang BH,Lee CP

    更新日期:2019-01-31 00:00:00

  • An alternative approach to measuring treatment persistence with antipsychotic agents among patients with schizophrenia in the Veterans Health Administration.

    abstract::Prior studies have demonstrated the importance of treatment persistence with anti-psychotic agents in sustaining control of schizophrenic symptoms. However, the conventional approach in measuring treatment persistence tended to use only the first prescription episode even though some patients received multiple prescri...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/nedt.2007.3.2.277

    authors: Ren XS,Qian S,Kazis LE

    更新日期:2007-04-01 00:00:00

  • Patterns of anterior cingulate activation in schizophrenia: a selective review.

    abstract:BACKGROUND:Anterior cingulate cortex (ACC) dysfunction is implicated in schizophrenia by numerous strands of scientific investigation. Functional neuroimaging studies of the ACC in schizophrenia have shown task-related hypo-activation, hyper-activation, and normal activation relative to comparison subjects. Interpretin...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/nedt.2007.3.1.87

    authors: Adams R,David AS

    更新日期:2007-02-01 00:00:00

  • Imitation and communication skills development in children with pervasive developmental disorders.

    abstract::This study evaluates the correlation between failure to develop spontaneous imitation and language skills in pervasive developmental disorders. Sixty-four children between the age of 3 and 8 years were assessed using the Autism Diagnostic Interview-Revised (ADI-R), the Childhood Autism Rating Scale (CARS), and the Aut...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/ndt.s5679

    authors: De Giacomo A,Portoghese C,Martinelli D,Fanizza I,L'abate L,Margari L

    更新日期:2009-01-01 00:00:00

  • Impulsivity, Unplanned Pregnancies, and Contraception Among Women with Bipolar Disorder.

    abstract:Background:Impulsivity is one of the principal symptoms of bipolar and related disorders (BD). Unsafe sex and unplanned pregnancies are serious problems in clinical practice. The aim of this study was to investigate impulsivity levels, contraception methods, and levels of planned pregnancies among women with bipolar an...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S238887

    authors: Zengin Eroglu M,Lus MG

    更新日期:2020-02-07 00:00:00

  • Restless legs syndrome: diagnosis and review of management options.

    abstract::Restless legs syndrome (RLS) is one of the commonest movement disorders affecting sleep and also daytime functioning. The prevalence may be 8%-10% of the white Caucasian population. The diagnosis is simple and is based on a well-validated clinical questionnaire, yet misdiagnosis is common and the condition remains und...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/nedt.2006.2.2.155

    authors: Byrne R,Sinha S,Chaudhuri KR

    更新日期:2006-06-01 00:00:00