Lack of Association Between PLA2G6 Genetic Variation and Parkinson's Disease: A Systematic Review.

Abstract:

Background:The phospholipase A2 Group 6 (PLA2G6, also known as PLA2, PARK14, and iPLA2) gene encodes a group VIA calcium-independent phospholipase A2. Genetic polymorphism of PLA2G6 has been indicated to be involved in conferring susceptibility for Parkinson's disease (PD), whereas conclusive results have not been obtained. Thus, we intended to conduct a systematic review to determine if PLA2G6 genetic variation confers a greater susceptibility to PD. Methods:All case-control studies that investigated the association of the PLA2G6 polymorphisms with the risk of PD published before 15 July 2018 were included. The literature was comprehensively searched and identified in five English databases (EBSCO, Pubmed, OVID, EMBASE and ISI Web of Knowledge) and four Chinese databases (Wanfang database, Chinese Biomedical Literature Database, China Academic Journals Database and VIP database). We performed analyses of study characteristics, heterogeneity, and forest plot in analyses analogous to dominant, codominant and additive models with the pooled odds ratio (OR) in fixed- or random-effects models as the measure of association. Results:A total of 664 potentially relevant studies were retrieved with the initial search, of which eight studies fulfilled the inclusion criteria, and included 2,779 PD patients and 3,291 control participants,. Among all the reported 27 genetic variants, 15 single nucleotide polymorphisms (SNPs) were present only in patients, and only five available SNPs (rs2267369, rs140758033, c.1959T>A (Gly653Gly), rs76718524, rs199935023) were pooled in the meta-analysis. However, there was no evidence for a significant association between the five SNPs and PD risk in dominant, codominant and allele models, suggesting a lack of association between PLA2G6 genetic variation and PD susceptibility. Conclusion:The present study assessed the association of PLA2G6 genetic polymorphism with the risk PD, and the result strongly demonstrates that PLA2G6 polymorphism is not associated with PD susceptibility.

authors

Liu H,Yao Y,Liu H,Peng Y,Ren J,Wu X,Mao R,Zhao J,Zhu Y,Niu Z,Yang T,Sun X,Jiang P,Zhang C,Fang Y

doi

10.2147/NDT.S254065

subject

Has Abstract

pub_date

2020-07-23 00:00:00

pages

1755-1763

eissn

1176-6328

issn

1178-2021

pii

254065

journal_volume

16

pub_type

杂志文章
  • Risk assessment of night-eating syndrome occurrence in women in Poland, considering the obesity factor in particular.

    abstract:Introduction:Night-eating syndrome (NES) involves uncontrolled and most often repeated binge eating during the night. It is related with mood disorders as well as sleep disorders and it may cause obesity. Risks related to NES are obesity, binge eating disorder, bulimia nervosa, affective disorders, and sleep disorders....

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S159562

    authors: Olejniczak D,Bugajec D,Staniszewska A,Panczyk M,Kielan A,Czerw A,Mańczuk M,Juszczyk G,Skonieczna J,Brytek-Matera A

    更新日期:2018-06-13 00:00:00

  • Depressive and adjustment disorders - some questions about the differential diagnosis: case studies.

    abstract:BACKGROUND:Diagnosis and treatment of mood disorders in youth are still problematic because in this age the clinical presentation is atypical, and the diagnostic tools and the therapies are the same as that used for the adults. Mood disorders are categorically divided into unipolar disorders (major depressive disorder ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/ndt.s8134

    authors: Presicci A,Lecce P,Ventura P,Margari F,Tafuri S,Margari L

    更新日期:2010-09-07 00:00:00

  • Influence of patient characteristics on care time in patients hospitalized with schizophrenia.

    abstract:BACKGROUND:In the current Japanese payment system for the treatment of psychiatric inpatients, the length of hospital stay and nurse staffing levels are key determinants of the amount of payment. These factors do not fully reflect the costs of care for each patient. The objective of this study was to clarify the relati...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S63009

    authors: Sugibayashi Y,Yoshimura K,Yamauchi K,Inagaki A,Ikegami N

    更新日期:2014-08-25 00:00:00

  • Psychiatric comorbidity and suicide risk in patients with chronic migraine.

    abstract::The aim of this study was to explore the impact of mental illness among patients with migraine. We performed MedLine and PsycINFO searches from 1980 to 2008. Research has systematically documented a strong bidirectional association between migraine and psychiatric disorders. The relationship between migraine and psych...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/ndt.s8467

    authors: Pompili M,Serafini G,Di Cosimo D,Dominici G,Innamorati M,Lester D,Forte A,Girardi N,De Filippis S,Tatarelli R,Martelletti P

    更新日期:2010-04-07 00:00:00

  • The cost reduction in hospitalization associated with paliperidone palmitate in the People's Republic of China, Korea, and Malaysia.

    abstract:BACKGROUND:Schizophrenia results in substantial health care utilization costs. Much of these costs can be attributed to health care use resulting from nonadherence to treatment, relapse, and hospitalization. AIMS OF THE STUDY:The objective of this research is to further estimate the health care resource utilization co...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S86722

    authors: Chiou CF,Wang BC,Caldwell R,Furnback W,Lee JS,Kothandaraman N,Lee S,Wang J,Zhang F

    更新日期:2015-08-05 00:00:00

  • A family-oriented therapy program for youths with substance abuse: long-term outcomes related to relapse and academic or social status.

    abstract:OBJECTIVE:The abuse of illegal substances by youths in Taiwan has become a major public health issue. This study explores the outcomes (relapse rate and academic or social status) of a family-oriented therapy program conducted for substance-using youths who were referred by a judge to participate in it. METHODS:The pr...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S105199

    authors: Wang LJ,Lu SF,Chong MY,Chou WJ,Hsieh YL,Tsai TN,Chen C,Lee YH

    更新日期:2016-03-30 00:00:00

  • Obsessive-compulsive disorder with bipolar diathesis following isotretinoin therapy remitting upon treatment with olanzapine and fluvoxamine.

    abstract::Isotretinoin, a drug used for moderate to severe acne, has been repeatedly associated with various psychiatric complications, although a definitive causal relationship has not been established to date. This case report describes a 25-year-old male who developed obsessive-compulsive disorder at the age of 23 years foll...

    journal_title:Neuropsychiatric disease and treatment

    pub_type:

    doi:10.2147/NDT.S14438

    authors: Fornaro M

    更新日期:2010-10-29 00:00:00

  • Psychosis in behavioral variant frontotemporal dementia.

    abstract:BACKGROUND:Dementia is generally characterized by cognitive impairment that can be accompanied by psychotic symptoms; for example, visual hallucinations are a core feature of dementia with Lewy bodies, and delusions are often seen in Alzheimer's disease. However, for behavioral variant of frontotemporal dementia (bvFTD...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S127863

    authors: Gossink FT,Vijverberg EG,Krudop W,Scheltens P,Stek ML,Pijnenburg YA,Dols A

    更新日期:2017-04-13 00:00:00

  • Transcranial Magnetic Stimulation (TMS) Safety with Respect to Seizures: A Literature Review.

    abstract::Transcranial magnetic stimulation is an increasingly popular FDA-approved treatment for resistant depression, migraines, and OCD. Research is also underway for its use in various other psychiatric and medical disorders. Although rare, seizures are a potential adverse event of TMS treatment. In this article, we discuss...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章,评审

    doi:10.2147/NDT.S276635

    authors: Stultz DJ,Osburn S,Burns T,Pawlowska-Wajswol S,Walton R

    更新日期:2020-12-07 00:00:00

  • Association between reduced quality of life and depression in patients with type 2 diabetes mellitus: a cohort study in a Mexican population.

    abstract:Background:Diabetes mellitus is a chronic disease that requires attention and commitment on the part of patients; improving the quality of life of these patients reduces health costs, morbidity, and mortality. We focused on investigating the factors related with the quality of life and depression symptomatology in pati...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S167622

    authors: Juárez-Rojop IE,Fortuny-Falconi CM,González-Castro TB,Tovilla-Zárate CA,Villar-Soto M,Sanchez ER,Hernández-Díaz Y,López-Narvaez ML,Ble-Castillo JL,Pérez-Hernández N,Rodríguez-Pérez JM

    更新日期:2018-10-04 00:00:00

  • Serum BICC1 levels are significantly different in various mood disorders.

    abstract:Purpose:Mood disorders are recurrent chronic disorders with fluctuating mood states and energy, and misdiagnosis is common when based solely on clinical interviews because of overlapping symptoms. Because misdiagnosis may lead to inappropriate treatment and poor prognosis, finding an easily implemented objective tool f...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S190048

    authors: Chen S,Jiang H,Xu Z,Zhao J,Wang M,Lu Y,Li J,Sun F,Yuan Y

    更新日期:2019-01-15 00:00:00

  • Suicidal behavior among Turkish patients with Parkinson's disease.

    abstract:OBJECTIVE:To investigate the predictors of suicidal ideation and attempts among Turkish Parkinson's disease (PD) patients. MATERIALS AND METHODS:The study comprised 120 patients with PD. Clinical findings were obtained by using the Unified Parkinson's Disease Rating Scale. Disease severity was measured by the Hoehn an...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S60450

    authors: Ozdilek B,Gultekin BK

    更新日期:2014-03-26 00:00:00

  • SoCIAL - training cognition in schizophrenia: a pilot study.

    abstract::The purpose of this pilot study was to assess the efficacy of a new social cognition (SC) remediation intervention, the Social Cognition Individualized Activities Lab (SoCIAL), for subjects with schizophrenia. The training includes a module for emotion recognition and one for theory of mind. A comparison with a valida...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S136732

    authors: Palumbo D,Mucci A,Piegari G,D'Alise V,Mazza A,Galderisi S

    更新日期:2017-07-20 00:00:00

  • Ropinirole for the treatment of restless legs syndrome.

    abstract::Dopaminergic agents, anticonvulsants, benzodiazepines, opiates, and iron supplementation comprise the classes of medications commonly used to treat restless legs syndrome (RLS), which is a disorder that is estimated to affect about 1 in 10 individuals worldwide and impacts an affected patient's sleep, mood, daytime fu...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/nedt.2006.2.4.407

    authors: Kushida CA

    更新日期:2006-12-01 00:00:00

  • Sigma-1 receptor concentration in plasma of patients with late-life depression: a preliminary study.

    abstract:BACKGROUND:Recently, the sigma-1 receptor has been shown to play a significant role in the neural transmission of mood by regulating N-methyl-D-aspartate receptors. Additionally, the sigma-1 receptor has been reported to influence cognitive functions including learning and memory. In this study, we measured plasma sigm...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S53386

    authors: Shimizu H,Takebayashi M,Tani M,Tanaka H,Yamagata B,Kurosawa K,Yamada H,Hachisu M,Hisaoka-Nakashima K,Okada-Tsuchioka M,Mimura M,Iwanami A

    更新日期:2013-01-01 00:00:00

  • Stigmasterol Exerts Neuro-Protective Effect Against Ischemic/Reperfusion Injury Through Reduction Of Oxidative Stress And Inactivation Of Autophagy.

    abstract:Purpose:Stroke remains the primary cause of pain, suffering, and death in patients. One of the major thrusts in stroke therapy is to find an effective prevention strategy. Objectives of this study are to testify the neuro-protection effect of stigmasterol in ischemic/reperfusion injury model. Methods:The dosage-depend...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S220224

    authors: Sun J,Li X,Liu J,Pan X,Zhao Q

    更新日期:2019-10-18 00:00:00

  • MiRNA-532-5p Regulates CUMS-Induced Depression-Like Behaviors and Modulates LPS-Induced Proinflammatory Cytokine Signaling by Targeting STAT3.

    abstract:Background:It is known that miR-532-5p is critical for neuronal differentiation. However, the role of miR-532-5p in depression remains unknown. This study aimed to investigate the role and mechanism of miR-532-5p in major depressive disorder (MDD). Methods:The depression mice model was established by chronic unpredict...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S251152

    authors: Yan X,Zeng D,Zhu H,Zhang Y,Shi Y,Wu Y,Tang H,Li D

    更新日期:2020-11-12 00:00:00

  • Update on the role of antipsychotics in the treatment of Tourette syndrome.

    abstract::Tourette syndrome (TS) is a neuropsychiatric disorder with typical onset in childhood and characterized by chronic occurrence of motor and vocal tics. The disorder can lead to serious impairments of both quality of life and psychosocial functioning, particularly for those individuals displaying complex tics. In such p...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S12990

    authors: Huys D,Hardenacke K,Poppe P,Bartsch C,Baskin B,Kuhn J

    更新日期:2012-01-01 00:00:00

  • Psychogenic non-epileptic seizures: so-called psychiatric comorbidity and underlying defense mechanisms.

    abstract::In Diagnostic and Statistical Manual of Mental Disorders, fifth edition, psychogenic non-epileptic seizures (PNES) do not have a unique classification as they can be found within different categories: conversion, dissociative, and somatization disorders. The ICD-10, instead, considers PNES within dissociative disorder...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章,评审

    doi:10.2147/NDT.S82079

    authors: Beghi M,Negrini PB,Perin C,Peroni F,Magaudda A,Cerri C,Cornaggia CM

    更新日期:2015-09-30 00:00:00

  • Disability in patients consulting for anxiety or mood disorders in primary care: response to antidepressant treatment.

    abstract:BACKGROUND:The primary objective of this prospective observational study was to evaluate changes in self-reported disability in patients with anxiety or mood disorders 3 months after initiating antidepressant treatment. METHODS:This study included 8396 patients consulting 2433 general practitioners in France for a maj...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S34132

    authors: Gérard A,Liard F,Crochard A,Goni S,Millet B

    更新日期:2012-01-01 00:00:00

  • Post hoc analyses of the impact of previous medication on the efficacy of lisdexamfetamine dimesylate in the treatment of attention-deficit/hyperactivity disorder in a randomized, controlled trial.

    abstract:BACKGROUND:Following the approval of lisdexamfetamine dimesylate (LDX) in several European countries for the treatment of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents with an inadequate response to methylphenidate (MPH) treatment, the aim of the present analysis was to establish the respo...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S68273

    authors: Coghill DR,Banaschewski T,Lecendreux M,Soutullo C,Zuddas A,Adeyi B,Sorooshian S

    更新日期:2014-10-29 00:00:00

  • Are 24-hour motor activity patterns associated with continued rapid response to ketamine?

    abstract:Purpose:This study examined the links between 24-hour activity patterns (specifically, amplitude and timing of wrist activity) and the persisting qualities of clinical antidepressant response to the glutamatergic modulator ketamine. Methods:Twenty-four-hour activity patterns were compared across 5 days of 24-hour acti...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S172089

    authors: Duncan WC Jr,Slonena EE,Hejazi NS,Brutsche N,Park LT,Henter ID,Ballard ED,Zarate CA Jr

    更新日期:2018-10-16 00:00:00

  • Identifying predictive clinical characteristics of the treatment efficacy of mirtazapine monotherapy for major depressive disorder.

    abstract:BACKGROUND:Mirtazapine, which is classified as a noradrenergic and specific serotonergic antidepressant, is widely prescribed for the treatment of major depressive disorder. The potential predictive factors of the efficacy of mirtazapine and the tolerability based on the incidence of oversedation and jitteriness/anxiet...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S112901

    authors: Tsutsumi T,Sugawara H,Ito R,Asano M,Shimizu S,Ishigooka J,Nishimura K

    更新日期:2016-10-05 00:00:00

  • Absent activation in medial prefrontal cortex and temporoparietal junction but not superior temporal sulcus during the perception of biological motion in schizophrenia: a functional MRI study.

    abstract:BACKGROUND:Patients with schizophrenia show disturbances in both visual perception and social cognition. Perception of biological motion (BM) is a higher-level visual process, and is known to be associated with social cognition. BM induces activation in the "social brain network", including the superior temporal sulcus...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S70074

    authors: Hashimoto N,Toyomaki A,Hirai M,Miyamoto T,Narita H,Okubo R,Kusumi I

    更新日期:2014-11-17 00:00:00

  • Effectiveness and tolerability of transdermal rivastigmine in the treatment of Alzheimer's disease in daily practice.

    abstract:BACKGROUND:Oral cholinesterase inhibitors at doses efficacious for the treatment of Alzheimer's disease (AD) are often prematurely discontinued due to gastrointestinal side effects. In controlled clinical trials, transdermal rivastigmine demonstrated less such effects at similar efficacy. The current study aimed to ver...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S29116

    authors: Seibert J,Tracik F,Articus K,Spittler S

    更新日期:2012-01-01 00:00:00

  • Cortical gyrification in schizophrenia: current perspectives.

    abstract::The cerebral cortex of the human brain has a complex morphological structure consisting of folded or smooth cortical surfaces. These morphological features are referred to as cortical gyrification and are characterized by the gyrification index (GI). A number of cortical gyrification studies have been published using ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章,评审

    doi:10.2147/NDT.S145273

    authors: Matsuda Y,Ohi K

    更新日期:2018-07-19 00:00:00

  • Lisdexamfetamine in the treatment of moderate-to-severe binge eating disorder in adults: systematic review and exploratory meta-analysis of publicly available placebo-controlled, randomized clinical trials.

    abstract:BACKGROUND:Preliminary placebo-controlled evidence paved the ground to the US Food and Drug Administration approval extension of lisdexamfetamine for the treatment of moderate-to-severe binge eating disorder (BED) in adults. OBJECTIVES:To provide a preliminary qualitative and quantitative synthesis of the placebo-cont...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S109637

    authors: Fornaro M,Solmi M,Perna G,De Berardis D,Veronese N,Orsolini L,Ganança L,Stubbs B

    更新日期:2016-07-25 00:00:00

  • Intranasal Delivery of Bone Marrow Stromal Cells Preconditioned with Fasudil to Treat a Mouse Model of Parkinson's Disease.

    abstract:Objective:Stem cell transplantation is a promising strategy with great potential to treat Parkinson's disease (PD). Nevertheless, improving the cell delivery route and optimising implanted cells are necessary to increase the therapeutic effect. Herein, we investigated whether intranasal delivery of bone marrow stromal ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S238646

    authors: Tang Y,Han L,Bai X,Liang X,Zhao J,Huang F,Wang J

    更新日期:2020-01-23 00:00:00

  • Can a physician predict the clinical response to first-line immunomodulatory treatment in relapsing-remitting multiple sclerosis?

    abstract:BACKGROUND:Decreased relapse rate and slower disease progression have been reported with long-term use of immunomodulatory treatments (IMTs, interferon beta or glatiramer acetate) in relapsing-remitting multiple sclerosis. There are, however, patients who do not respond to such treatments, and they can be potential can...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S36771

    authors: Mezei Z,Bereczki D,Racz L,Csiba L,Csepany T

    更新日期:2012-01-01 00:00:00

  • Effectiveness and safety of Nintendo Wii Fit Plus™ training in children with migraine without aura: a preliminary study.

    abstract:BACKGROUND:Migraine without aura (MoA) is a painful syndrome, particularly in childhood; it is often accompanied by severe impairments, including emotional dysfunction, absenteeism from school, and poor academic performance, as well as issues relating to poor cognitive function, sleep habits, and motor coordination. M...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S53853

    authors: Esposito M,Ruberto M,Gimigliano F,Marotta R,Gallai B,Parisi L,Lavano SM,Roccella M,Carotenuto M

    更新日期:2013-01-01 00:00:00