Abstract:
Background:The phospholipase A2 Group 6 (PLA2G6, also known as PLA2, PARK14, and iPLA2) gene encodes a group VIA calcium-independent phospholipase A2. Genetic polymorphism of PLA2G6 has been indicated to be involved in conferring susceptibility for Parkinson's disease (PD), whereas conclusive results have not been obtained. Thus, we intended to conduct a systematic review to determine if PLA2G6 genetic variation confers a greater susceptibility to PD. Methods:All case-control studies that investigated the association of the PLA2G6 polymorphisms with the risk of PD published before 15 July 2018 were included. The literature was comprehensively searched and identified in five English databases (EBSCO, Pubmed, OVID, EMBASE and ISI Web of Knowledge) and four Chinese databases (Wanfang database, Chinese Biomedical Literature Database, China Academic Journals Database and VIP database). We performed analyses of study characteristics, heterogeneity, and forest plot in analyses analogous to dominant, codominant and additive models with the pooled odds ratio (OR) in fixed- or random-effects models as the measure of association. Results:A total of 664 potentially relevant studies were retrieved with the initial search, of which eight studies fulfilled the inclusion criteria, and included 2,779 PD patients and 3,291 control participants,. Among all the reported 27 genetic variants, 15 single nucleotide polymorphisms (SNPs) were present only in patients, and only five available SNPs (rs2267369, rs140758033, c.1959T>A (Gly653Gly), rs76718524, rs199935023) were pooled in the meta-analysis. However, there was no evidence for a significant association between the five SNPs and PD risk in dominant, codominant and allele models, suggesting a lack of association between PLA2G6 genetic variation and PD susceptibility. Conclusion:The present study assessed the association of PLA2G6 genetic polymorphism with the risk PD, and the result strongly demonstrates that PLA2G6 polymorphism is not associated with PD susceptibility.
journal_name
Neuropsychiatr Dis Treatjournal_title
Neuropsychiatric disease and treatmentauthors
Liu H,Yao Y,Liu H,Peng Y,Ren J,Wu X,Mao R,Zhao J,Zhu Y,Niu Z,Yang T,Sun X,Jiang P,Zhang C,Fang Ydoi
10.2147/NDT.S254065subject
Has Abstractpub_date
2020-07-23 00:00:00pages
1755-1763eissn
1176-6328issn
1178-2021pii
254065journal_volume
16pub_type
杂志文章abstract:Introduction:Night-eating syndrome (NES) involves uncontrolled and most often repeated binge eating during the night. It is related with mood disorders as well as sleep disorders and it may cause obesity. Risks related to NES are obesity, binge eating disorder, bulimia nervosa, affective disorders, and sleep disorders....
journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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doi:10.2147/NDT.S86722
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章,评审
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journal_title:Neuropsychiatric disease and treatment
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更新日期:2019-01-15 00:00:00
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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doi:10.2147/NDT.S136732
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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更新日期:2019-10-18 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
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更新日期:2020-11-12 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S12990
更新日期:2012-01-01 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章,评审
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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更新日期:2014-11-17 00:00:00
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journal_title:Neuropsychiatric disease and treatment
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更新日期:2012-01-01 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章,评审
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更新日期:2018-07-19 00:00:00
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journal_title:Neuropsychiatric disease and treatment
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更新日期:2016-07-25 00:00:00
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journal_title:Neuropsychiatric disease and treatment
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更新日期:2020-01-23 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00