Abstract:
:About half of all bipolar patients have an alcohol abuse problem at some point of their lifetime. However, only one randomized, controlled trial of pharmacotherapy (valproate) in this patient population was published as of 2006. Therefore, we reviewed clinical trials in this indication of the last four years (using mood stabilizers, atypical antipsychotics, and other drugs). Priority was given to randomized trials, comparing drugs with placebo or active comparator. Published studies were found through systematic database search (PubMed, Scirus, EMBASE, Cochrane Library, Science Direct). In these last four years, the only randomized, clinically relevant study in bipolar patients with comorbid alcoholism is that of Brown and colleagues (2008) showing that quetiapine therapy decreased depressive symptoms in the early weeks of use, without modifying alcohol use. Several other open-label trials have been generally positive and support the efficacy and tolerability of agents from different classes in this patient population. Valproate efficacy to reduce excessive alcohol consumption in bipolar patients was confirmed and new controlled studies revealed its therapeutic benefit to prevent relapse in newly abstinent alcoholics and to improve alcohol hallucinosis. Topiramate deserves to be investigated in bipolar patients with comorbid alcoholism since this compound effectively improves physical health and quality of life of alcohol-dependent individuals. In conclusion, randomized, controlled research is still needed to provide guidelines for possible use of valproate and other agents in patients with a dual diagnosis of bipolar disorder and substance abuse or dependence.
journal_name
Neuropsychiatr Dis Treatjournal_title
Neuropsychiatric disease and treatmentauthors
Azorin JM,Bowden CL,Garay RP,Perugi G,Vieta E,Young AHdoi
10.2147/ndt.s6741subject
Has Abstractpub_date
2010-03-24 00:00:00pages
37-46eissn
1176-6328issn
1178-2021journal_volume
6pub_type
杂志文章abstract::Previous studies on cognitive training in Alzheimer's disease (AD) were principally aimed at making patients learn items not related to functional needs. However, AD patients also experience difficulties with instrumental activities of daily living (IADL). The goal of the present multiple baseline case report study wa...
journal_title:Neuropsychiatric disease and treatment
pub_type:
doi:10.2147/ndt.s3684
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章,评审
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S217098
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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doi:10.2147/NDT.S42628
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journal_title:Neuropsychiatric disease and treatment
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更新日期:2014-04-02 00:00:00
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S26123
更新日期:2011-01-01 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type:
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
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更新日期:2018-05-22 00:00:00
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journal_title:Neuropsychiatric disease and treatment
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更新日期:2018-03-08 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:
更新日期:2007-08-01 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/ndt.s3850
更新日期:2009-01-01 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S145042
更新日期:2018-01-14 00:00:00
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S118759
更新日期:2016-12-15 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章,评审
doi:10.2147/NDT.S50961
更新日期:2015-08-19 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章,评审
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更新日期:2017-08-30 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章,评审
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更新日期:2014-03-13 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/ndt.s8134
更新日期:2010-09-07 00:00:00
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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更新日期:2020-04-16 00:00:00
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journal_title:Neuropsychiatric disease and treatment
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更新日期:2021-01-20 00:00:00