Abstract:
Purpose:Paliperidone extended release (ER) is an oral psychotropic treatment formulated to release paliperidone at a controlled, gradually ascending rate. We evaluated the efficacy and safety of switching to paliperidone ER in Taiwanese patients with schizophrenia who were unresponsive or intolerant to previous antipsychotic therapy. Patients and methods:This was a 24-week, open-label, single-arm, multicenter, Phase IV trial. Based on consulting psychiatrists' judgment, patients were deemed eligible for the switch to paliperidone ER; the switch was achieved by cross-tapering, using a recommended starting dose of 6 mg. Eligibility considerations included lack of efficacy, tolerability, and/or adherence to previous oral antipsychotic medication. Results:Of the 297 enrolled patients, 178 (59.5%) completed the study. The main reasons for discontinuation included insufficient efficacy (8.7%), patient decision (8.4%), and adverse events (AEs; 6.4%). Improvements in the: Positive and Negative Syndrome Scale total score and Clinical Global Impression-Severity score were observed only in patients treated at medical centers and not in those treated at psychiatric hospitals. The most common AEs were insomnia, headache, constipation, and extrapyramidal syndrome. One or more serious AEs were reported in 11 (3.7%) patients; none resulted in death. No significant changes in body weight, plasma glucose, or lipid levels were observed. Conclusion:Switching to paliperidone ER was effective and well tolerated for up to 24 weeks in patients with schizophrenia who were unresponsive or intolerant to previous antipsychotic therapy. The observed differences in treatment between psychiatric hospitals and medical centers with regard to dosage and titration of paliperidone ER warrant further investigation.
journal_name
Neuropsychiatr Dis Treatjournal_title
Neuropsychiatric disease and treatmentauthors
Chen CY,Tang TC,Chen TT,Bai YM,Tsai HH,Chen HL,Huang CJ,Chen CK,Chen CC,Hsiao MC,Liu CY,Yeh HS,Chiu NY,Hsiao CC,Chen CS,Su TPdoi
10.2147/NDT.S161186subject
Has Abstractpub_date
2018-03-08 00:00:00pages
725-732eissn
1176-6328issn
1178-2021pii
ndt-14-725journal_volume
14pub_type
杂志文章abstract:BACKGROUND:Although most patients with relapsing-remitting multiple sclerosis (RRMS) will develop secondary progressive multiple sclerosis (SPMS), little is known about the burden of multiple sclerosis by disease subtype. This study describes the burden of disease in terms of demographics, disease severity, symptoms, h...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S132079
更新日期:2017-05-18 00:00:00
abstract:Goal:The goal of this study was to explore the impact of self-stigma on the treatment outcomes in patients with anxiety disorders and to find possible mediators of this relationship. Method:Two hundred and nine patients with anxiety disorders, who were hospitalized in a psychotherapeutic department, attended the study...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S152208
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abstract::At present, the number of elderly people is rapidly increasing, which represents a significant threat in terms of their care when they fall ill. One of the most common aging diseases nowadays is dementia, whose symptoms sooner or later include loss of cognitive functioning. Cognitive disorders can vary from serious me...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章,评审
doi:10.2147/NDT.S95903
更新日期:2016-02-29 00:00:00
abstract:Background:Intentional methanol intoxication (IMI) is an emerging public health issue in Asian countries, but few data are available in the literature on underlying psychiatric comorbidities in these suicide attempters. Patients and methods:We conducted a retrospective chart review on patients with methanol intoxicati...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/nedt.2006.2.4.521
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abstract:Introduction:Sleep disturbance is a major health concern for heroin users receiving methadone maintenance treatment (MMT). The present study was aimed to investigate the predictors for new-onset clinically predominant sleep disturbance (CPSD) among heroin users receiving MMT. Methods:This 2-year retrospective study in...
journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章,评审
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章,评审
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更新日期:2018-04-23 00:00:00
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journal_title:Neuropsychiatric disease and treatment
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更新日期:2016-06-15 00:00:00
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journal_title:Neuropsychiatric disease and treatment
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doi:10.2147/NDT.S9932
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/ndt.s4489
更新日期:2010-06-24 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章,评审
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S115800
更新日期:2016-09-22 00:00:00
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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更新日期:2012-01-01 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S122423
更新日期:2017-01-23 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type:
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更新日期:2014-04-02 00:00:00
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章,评审
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更新日期:2018-11-02 00:00:00
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journal_title:Neuropsychiatric disease and treatment
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abstract:CLINICAL QUESTION:What is the best current disease-modifying therapy for relapsing-remitting multiple sclerosis? RESULTS:The evidence shows that the most effective disease-modifying therapy for delaying short- to medium-term disability progression, prevention of relapses, reducing the area and activity of lesions on m...
journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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更新日期:2018-02-07 00:00:00
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journal_title:Neuropsychiatric disease and treatment
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更新日期:2008-12-01 00:00:00
abstract::It is proposed that lithium's therapeutic effects occur indirectly by augmenting a cascade of protective "fail-safe" pathways pre-configured to activate in response to a dangerous low cell [Mg++] situation, eg, posttraumatic brain injury, alongside relative cell adenosine triphosphate depletion. Lithium activates cell...
journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00