Abstract:
CLINICAL QUESTION:What is the best current disease-modifying therapy for relapsing-remitting multiple sclerosis? RESULTS:The evidence shows that the most effective disease-modifying therapy for delaying short- to medium-term disability progression, prevention of relapses, reducing the area and activity of lesions on magnetic resonance imaging, with the least side effects, is high-dose, high-frequency subcutaneous interferon-β1a 44 μg three times per week. IMPLEMENTATION:The pitfalls in treatment of MS can be avoided by remembering the following points: The most effective therapy to prevent or delay the appearance of permanent neurological disability with the fewest side effects should be chosen, and treatment should not be delayed.Adherence to treatment should be monitored closely, and needs comprehensive patient information and education to establish long-term adherence, which is a critical determinant of long-term outcome.The correct approach to the disease includes disease management, symptom management, and patient management. A combination of tools is necessary to ease the various symptoms, which fall into three broad categories, i.e. rehabilitation, pharmacological, and procedural.It is important to understand that no treatment modality should be used alone, unless it is in itself sufficient to remedy the particular symptom/problem.
journal_name
Neuropsychiatr Dis Treatjournal_title
Neuropsychiatric disease and treatmentauthors
González-Andrade F,Alcaraz-Alvarez JLdoi
10.2147/ndt.s11079subject
Has Abstractpub_date
2010-09-07 00:00:00pages
365-73eissn
1176-6328issn
1178-2021journal_volume
6pub_type
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章,评审
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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doi:
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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doi:10.2147/NDT.S115800
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journal_title:Neuropsychiatric disease and treatment
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doi:10.2147/nedt.2007.3.1.87
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章,评审
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更新日期:2018-07-19 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S129660
更新日期:2017-02-21 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章,评审
doi:10.2147/NDT.S104384
更新日期:2016-05-10 00:00:00
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更新日期:2008-06-01 00:00:00
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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更新日期:2012-01-01 00:00:00
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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journal_title:Neuropsychiatric disease and treatment
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