When to start aripiprazole therapy in patients with bipolar mania.

Abstract:

:Aripiprazole is a third generation atypical antipsychotic with compelling evidence as a highly effective treatment option in the management of acute manic and mixed episodes of bipolar I disorders. It has a unique mode of action, acting as a partial agonist at dopamine D2 and D3, and serotonin 5-HT1A; and exhibiting antagonistic action at the 5-HT2A and H1 receptors. Overall, it has a favorable safety and tolerability profile, with low potential for clinically significant weight gain and metabolic effects, especially compared to other well-established treatments. It also has a superior tolerability profile when used as maintenance treatment. Side effects like headache, insomnia, and extrapyramidal side effects (EPSEs), such as tremor and akathisia may be treatment limiting in some cases. It is efficacious in both acute mania and mixed states, and in the long-term prevention of manic relapses. Aripiprazole therefore, is a significant player in the current portfolio of anti-manic pharmacological treatments. The data sources for this article are from EMBASE, MEDLINE, and the clinical trial database searches for all the literature published between January 2003 and September 2013. The key search terms were "aripiprazole" combined with "bipolar disorder", "mania", "antipsychotics", "mood stabilizer", "randomized controlled trial", and "pharmacology". Abstracts and proceedings from national and international psychiatric meetings were also reviewed, along with reviews of the reference lists of relevant articles.

authors

Sayyaparaju KK,Grunze H,Fountoulakis KN

doi

10.2147/NDT.S40066

subject

Has Abstract

pub_date

2014-03-13 00:00:00

pages

459-70

eissn

1176-6328

issn

1178-2021

pii

ndt-10-459

journal_volume

10

pub_type

杂志文章,评审
  • No association between dopamine D3 receptor gene Ser9Gly polymorphism (rs6280) and risk of schizophrenia: an updated meta-analysis.

    abstract:Objective:Ser9Gly (rs6280) is a functional single-nucleotide polymorphism (SNP) in the dopamine receptor D3 (DRD3) gene that may be associated with schizophrenia. We performed a meta-analysis to determine whether Ser9Gly influences the risk of schizophrenia and examined the relationship between the Ser9Gly SNP and the ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S152784

    authors: Qi XL,Xuan JF,Xing JX,Wang BJ,Yao J

    更新日期:2017-11-23 00:00:00

  • Attitudes toward antipsychotic treatment among patients with bipolar disorders and their clinicians: a systematic review.

    abstract:INTRODUCTION:Antipsychotics are recommended as first-line therapy for acute mania and maintenance treatment of bipolar disorder; however, published literature suggests their real-world use remains limited. Understanding attitudes toward these medications may help identify barriers and inform personalized therapy. This ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章,评审

    doi:10.2147/NDT.S139557

    authors: Sajatovic M,DiBiasi F,Legacy SN

    更新日期:2017-08-30 00:00:00

  • Clinical features and imaging findings in a case of Capgras syndrome.

    abstract::Capgras syndrome consists of the delusional belief that a person or persons have been replaced by doubles or impostors. It can occur in the context of both psychiatric and organic illness, and seems to be related to lesions of the bifrontal and right limbic and temporal regions. Indeed, magnetic resonance imaging has ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type:

    doi:10.2147/NDT.S47293

    authors: Luca M,Bordone A,Luca A,Patti A,Sortino G,Calandra C

    更新日期:2013-01-01 00:00:00

  • miR-455 inhibits neuronal cell death by targeting TRAF3 in cerebral ischemic stroke.

    abstract::Ischemic stroke is one of the leading causes of brain disease, with high morbidity, disability, and mortality. MicroRNAs (miRNAs) have been identified as vital gene regulators in various types of human diseases. Accumulating evidence has suggested that aberrant expression of miRNAs play critical roles in the pathologi...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S121183

    authors: Yao S,Tang B,Li G,Fan R,Cao F

    更新日期:2016-12-05 00:00:00

  • Evaluation of BPPV with vertebral artery values.

    abstract:Objectives:The aim of this study was to investigate the association between benign paroxysmal positional vertigo (BPPV) and vertebral artery (VA) flow rates and diameters by using Doppler ultrasonography in patients with BPPV. Additionally, we aimed to investigate the abnormalities of VA values obtained by extracranial...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S169991

    authors: Yazıcı A,İnanç Y

    更新日期:2018-08-06 00:00:00

  • Transcranial Magnetic Stimulation (TMS) Safety with Respect to Seizures: A Literature Review.

    abstract::Transcranial magnetic stimulation is an increasingly popular FDA-approved treatment for resistant depression, migraines, and OCD. Research is also underway for its use in various other psychiatric and medical disorders. Although rare, seizures are a potential adverse event of TMS treatment. In this article, we discuss...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章,评审

    doi:10.2147/NDT.S276635

    authors: Stultz DJ,Osburn S,Burns T,Pawlowska-Wajswol S,Walton R

    更新日期:2020-12-07 00:00:00

  • Orthostatic hypotension and dementia incidence: links and implications.

    abstract::Orthostatic hypotension (OH) is a common condition, particularly in patients with α-synucleinopathies such as Parkinson's disease, and has a significant impact on activities of daily living and quality of life. Recent data suggest an association with cognitive impairment. Herein, we review the evidence that OH increas...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S182123

    authors: Robertson AD,Udow SJ,Espay AJ,Merola A,Camicioli R,Lang AE,Masellis M

    更新日期:2019-08-02 00:00:00

  • Primary Whipple disease of the brain: case report with long-term clinical and MRI follow-up.

    abstract::Whipple disease (WD) is a rare systemic disorder caused by the bacteria Tropheryma whipplei. In its classic form, it manifests with gastrointestinal problems including diarrhea, abdominal pain, and weight loss. However, various other systems can be affected, including the central nervous system (CNS). Even more rarely...

    journal_title:Neuropsychiatric disease and treatment

    pub_type:

    doi:10.2147/NDT.S92066

    authors: Peregrin J,Malikova H

    更新日期:2015-09-25 00:00:00

  • Public Awareness, Beliefs, And Attitudes Toward Bipolar Disorder In Saudi Arabia.

    abstract:Objectives:To examine public's knowledge, beliefs, and attitudes toward bipolar disorder (BP) in Saudi Arabia (SA). Methods:A cross-sectional survey was performed in 2016 in Riyadh, SA. The survey included sociodemographic characteristics and BP awareness scale. Results:Of 416 participants, 49.5% had prior knowledge ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S209037

    authors: Alosaimi FD,AlAteeq DA,Bin Hussain SI,Alhenaki RS,Bin Salamah AA,AlModihesh NA

    更新日期:2019-09-27 00:00:00

  • Rehabilitation for a child with recalcitrant anti-N-methyl-d-aspartate receptor encephalitis: case report and literature review.

    abstract::Anti-N-methyl-d-aspartate (anti-NMDA) receptor encephalitis is a newly recognized, potentially fatal, but treatable autoimmune disease. Good outcome predictors include milder severity of symptoms, no need for intensive care unit admission, early aggressive immunotherapy, and prompt tumor removal. We report a case of a...

    journal_title:Neuropsychiatric disease and treatment

    pub_type:

    doi:10.2147/NDT.S74205

    authors: Guo YH,Kuan TS,Hsieh PC,Lien WC,Chang CK,Lin YC

    更新日期:2014-11-24 00:00:00

  • Depressive and adjustment disorders - some questions about the differential diagnosis: case studies.

    abstract:BACKGROUND:Diagnosis and treatment of mood disorders in youth are still problematic because in this age the clinical presentation is atypical, and the diagnostic tools and the therapies are the same as that used for the adults. Mood disorders are categorically divided into unipolar disorders (major depressive disorder ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/ndt.s8134

    authors: Presicci A,Lecce P,Ventura P,Margari F,Tafuri S,Margari L

    更新日期:2010-09-07 00:00:00

  • HPA-axis genes as potential risk variants for neurocognitive decline in trauma-exposed, HIV-positive females.

    abstract:Purpose:Previous studies have independently provided evidence for the effects of HIV infection, hypothalamic-pituitary-adrenal (HPA) axis dysfunction and early life trauma on neurocognitive impairment (NCI). This study examined the interaction between single-nucleotide polymorphisms (SNPs) of two HPA axis genes, cortic...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S166992

    authors: Jacobs S,Moxley K,Womersley JS,Spies G,Hemmings SM,Seedat S

    更新日期:2018-09-28 00:00:00

  • Social support networks and eating disorders: an integrative review of the literature.

    abstract:AIMS:This study aimed to analyze the scientific literature about social networks and social support in eating disorders (ED). METHODS:By combining keywords, an integrative review was performed. It included publications from 2006-2013, retrieved from the MEDLINE, LILACS, PsycINFO, and CINAHL databases. The selection of...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章,评审

    doi:10.2147/NDT.S60735

    authors: Leonidas C,Dos Santos MA

    更新日期:2014-05-21 00:00:00

  • Self-stigma and treatment effectiveness in patients with anxiety disorders - a mediation analysis.

    abstract:Goal:The goal of this study was to explore the impact of self-stigma on the treatment outcomes in patients with anxiety disorders and to find possible mediators of this relationship. Method:Two hundred and nine patients with anxiety disorders, who were hospitalized in a psychotherapeutic department, attended the study...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S152208

    authors: Ociskova M,Prasko J,Vrbova K,Kasalova P,Holubova M,Grambal A,Machu K

    更新日期:2018-01-26 00:00:00

  • Efficacy and safety of paliperidone palmitate 3-month versus 1-month formulation in patients with schizophrenia: comparison between European and non-European population.

    abstract:Purpose:This randomized, double-blind (DB), non-inferiority phase 3 study was conducted to assess the efficacy and safety of paliperidone palmitate 3-month (PP3M) vs 1-month formulation (PP1M) in European and non-European patients with schizophrenia. Patients and methods:In this randomized, DB, parallel-group study, a...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S189668

    authors: Savitz AJ,Xu H,Gopal S,Nuamah I,Ravenstijn P,Hough D,Hargarter L

    更新日期:2019-02-21 00:00:00

  • Epileptic and cognitive changes in children with cerebral palsy: an Egyptian study.

    abstract:BACKGROUND:Cerebral palsy (CP) is the most frequent cause of motor handicap among children. AIM OF THE STUDY:We aim to study the relation of epilepsy in children with CP to various risk factors that affect the development of seizures. PATIENTS AND METHODS:In a cross-sectional, descriptive, population-based, case-cont...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S59600

    authors: El-Tallawy HN,Farghaly WM,Shehata GA,Badry R,Rageh TA

    更新日期:2014-05-29 00:00:00

  • Celiac plexus neurolysis for the treatment of upper abdominal cancer pain.

    abstract::Optimal treatment of oncologic pain is a challenge to all professionals who deal with cancer and its complications. The management of upper abdominal pain is usually difficult and it is often refractory to conservative therapies. In this context, celiac plexus neurolysis (CPN) appears to be an important and indispensa...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S43730

    authors: Teixeira MJ,Neto ER,da Nóbrega JC,Dos Ângelos JS,Martin MS,de Monaco BA,Fonoff ET

    更新日期:2013-01-01 00:00:00

  • Frequent nightmares in Chinese patients undergoing methadone maintenance therapy: prevalence, correlates, and their association with functional impairment.

    abstract:Purpose:Nightmares are associated with many negative health outcomes; however, little is known about the characteristics of nightmares in heroin-dependent patients (HDPs). This study examined the prevalence and correlates of frequent nightmares (FNs) and their association with functional impairment in Chinese patients ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S202813

    authors: Zhong BL,Xu YM,Xie WX,Lu J

    更新日期:2019-07-18 00:00:00

  • Restless legs syndrome: diagnosis and review of management options.

    abstract::Restless legs syndrome (RLS) is one of the commonest movement disorders affecting sleep and also daytime functioning. The prevalence may be 8%-10% of the white Caucasian population. The diagnosis is simple and is based on a well-validated clinical questionnaire, yet misdiagnosis is common and the condition remains und...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/nedt.2006.2.2.155

    authors: Byrne R,Sinha S,Chaudhuri KR

    更新日期:2006-06-01 00:00:00

  • Analysis concerning nutritional behaviors in the context of the risk of orthorexia.

    abstract::Orthorexia is recognized as an eating disorder, an obsessive-compulsive spectrum disorder, or a somatoform disorder. The aim of our research was to analyze nutritional behaviors for the assessment of the risk of orthorexia. The authors developed a questionnaire in which 981 respondents participated and used it as a re...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S129660

    authors: Olejniczak D,Bugajec D,Panczyk M,Brytek-Matera A,Religioni U,Czerw A,Grąbczewska A,Juszczyk G,Jabłkowska-Górecka K,Staniszewska A

    更新日期:2017-02-21 00:00:00

  • Clinical relevance of paliperidone palmitate 3-monthly in treating schizophrenia.

    abstract::Antipsychotics are the mainstay in schizophrenia management, and long-acting injectable (LAI) antipsychotics contribute to the successful maintenance of treatment by improving non-adherence and preventing relapses. Paliperidone palmitate 3-monthly (PP3M) formulation is the only available LAI antipsychotic that offers ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章,评审

    doi:10.2147/NDT.S197225

    authors: Mathews M,Gopal S,Nuamah I,Hargarter L,Savitz AJ,Kim E,Tan W,Soares B,Correll CU

    更新日期:2019-05-21 00:00:00

  • Predictors of sleep disturbance in heroin users receiving methadone maintenance therapy: a naturalistic study in Taiwan.

    abstract:Introduction:Sleep disturbance is a major health concern for heroin users receiving methadone maintenance treatment (MMT). The present study was aimed to investigate the predictors for new-onset clinically predominant sleep disturbance (CPSD) among heroin users receiving MMT. Methods:This 2-year retrospective study in...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S177370

    authors: Li DJ,Chung KS,Wu HC,Hsu CY,Yen CF

    更新日期:2018-10-26 00:00:00

  • A modification of intraluminal middle cerebral artery occlusion/reperfusion model for ischemic stroke with laser Doppler flowmetry guidance in mice.

    abstract::Stroke is one of the common causes of death and disability in the world. The intraluminal middle cerebral artery occlusion/reperfusion (MCAO/R) model is a "gold standard" in surgical ischemic stroke models. Here, we optimized the procedure of this model by ligating on external carotid artery (ECA) stump and two ligatu...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S118531

    authors: Cai Q,Xu G,Liu J,Wang L,Deng G,Liu J,Chen Z

    更新日期:2016-11-03 00:00:00

  • Association of metabotropic glutamate receptor 3 gene polymorphisms with schizophrenia risk: evidence from a meta-analysis.

    abstract::To date, the role of metabotropic glutamate receptor 3 (GRM3) rs274622, rs1468412, rs917071, rs6465084, and rs2299225 polymorphisms in schizophrenia remains controversial. To provide a clearer picture for the effect of the five most studied GRM3 polymorphisms on risk of schizophrenia, this meta-analysis with eligible ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S77966

    authors: Yang X,Wang G,Wang Y,Yue X

    更新日期:2015-03-25 00:00:00

  • Schizophrenia Treatment with Second-Generation Antipsychotics: A Multi-Country Comparison of the Costs of Cardiovascular and Metabolic Adverse Events and Weight Gain.

    abstract:Purpose:Cardiovascular and metabolic adverse events are costly to treat, and their incidence is increased amongst people with schizophrenia, with different rates observed for second-generation antipsychotics. To inform treatment choice, this study sought to estimate the lifetime costs associated with antipsychotic choi...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S282856

    authors: Kearns B,Cooper K,Cantrell A,Thomas C

    更新日期:2021-01-20 00:00:00

  • Stress, anxiety, and depression among medical students in a multiethnic setting.

    abstract:BACKGROUND:Contemporary literature suggests that medical education might adversely affect students' mental health. Alfaisal University in Riyadh, Saudi Arabia is a developing institution; hence, there has been a concern regarding the mental well-being of the students. OBJECTIVES:This study was designed to assess the t...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S83577

    authors: Kulsoom B,Afsar NA

    更新日期:2015-07-16 00:00:00

  • The societal costs of insomnia.

    abstract:OBJECTIVE:Insomnia can be broadly defined as difficulty initiating or maintaining sleep, or sleep that is not refreshing or of poor quality with negative effect on daytime function. Insomnia can be a primary condition or comorbid to an underlying disorder. Subjective measures of insomnia used in population studies, usu...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S15123

    authors: Wade AG

    更新日期:2010-12-20 00:00:00

  • Abnormal functional connectivity of the posterior cingulate cortex is associated with depressive symptoms in patients with Alzheimer's disease.

    abstract:BACKGROUND:Depressive symptoms are significant and very common psychiatric complications in patients with Alzheimer's disease (AD), which can aggravate the decline in social function. However, changes in the functional connectivity (FC) of the brain in AD patients with depressive symptoms (D-AD) remain unclear. OBJECT...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S146077

    authors: Zhang J,Guo Z,Liu X,Jia X,Li J,Li Y,Lv D,Chen W

    更新日期:2017-10-11 00:00:00

  • Assistive technologies for managing language disorders in dementia.

    abstract::At present, the number of elderly people is rapidly increasing, which represents a significant threat in terms of their care when they fall ill. One of the most common aging diseases nowadays is dementia, whose symptoms sooner or later include loss of cognitive functioning. Cognitive disorders can vary from serious me...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章,评审

    doi:10.2147/NDT.S95903

    authors: Klimova B,Maresova P,Kuca K

    更新日期:2016-02-29 00:00:00

  • Long noncoding RNA CASC2 predicts the prognosis of glioma patients and functions as a suppressor for gliomas by suppressing Wnt/β-catenin signaling pathway.

    abstract:BACKGROUND:Previous studies have demonstrated that long noncoding RNA cancer susceptibility candidate 2 (lncRNA CASC2) is frequently downregulated in several types of tumors and functions as a tumor-suppressive factor. However, the clinical significance and function of CASC2 in human glioma remain largely unknown. The ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S137171

    authors: Wang R,Li Y,Zhu G,Tian B,Zeng W,Yang Y,Li Z

    更新日期:2017-07-11 00:00:00