A modification of intraluminal middle cerebral artery occlusion/reperfusion model for ischemic stroke with laser Doppler flowmetry guidance in mice.

Abstract:

:Stroke is one of the common causes of death and disability in the world. The intraluminal middle cerebral artery occlusion/reperfusion (MCAO/R) model is a "gold standard" in surgical ischemic stroke models. Here, we optimized the procedure of this model by ligating on external carotid artery (ECA) stump and two ligatures prepared on internal carotid artery, which could improve the success and survival rate in mice. The results show that ECA approach was superior to common carotid artery approach. Meanwhile, we found that the exposure of pterygopalatine artery was not an essential step for MCAO/R model in mice.

authors

Cai Q,Xu G,Liu J,Wang L,Deng G,Liu J,Chen Z

doi

10.2147/NDT.S118531

subject

Has Abstract

pub_date

2016-11-03 00:00:00

pages

2851-2858

eissn

1176-6328

issn

1178-2021

pii

ndt-12-2851

journal_volume

12

pub_type

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