Abstract:
:To date, the role of metabotropic glutamate receptor 3 (GRM3) rs274622, rs1468412, rs917071, rs6465084, and rs2299225 polymorphisms in schizophrenia remains controversial. To provide a clearer picture for the effect of the five most studied GRM3 polymorphisms on risk of schizophrenia, this meta-analysis with eligible data from published studies was performed. Relevant case-control studies were retrieved by literature search and selected according to established inclusion criteria. Odds ratios with 95% confidence intervals were used to assess the strength of association. A total of 33 individual studies were identified and included in our meta-analysis: nine for rs1468412, with 5,314 cases and 6,147 controls; six for rs917071, with 2,660 cases and 3,517 controls; seven for rs274622, with 3,820 cases and 4,015 controls; five for rs2299225, with 3,492 cases and 3,735 controls; and six for rs6465084, with 4,960 cases and 5,613 controls. However, no significant association was found between these GRM3 polymorphisms and schizophrenia in the overall population. With respect to rs1468412 polymorphism, a finding of very borderline statistical significance emerged in dominant comparison model for non-Asian populations, calling for large-scale verification to assess the marginally elevated risk of schizophrenia. In conclusion, these GRM3 polymorphisms have limited effect on the risks of schizophrenia. Further large and well-designed studies are needed to confirm this conclusion.
journal_name
Neuropsychiatr Dis Treatjournal_title
Neuropsychiatric disease and treatmentauthors
Yang X,Wang G,Wang Y,Yue Xdoi
10.2147/NDT.S77966subject
Has Abstractpub_date
2015-03-25 00:00:00pages
823-33eissn
1176-6328issn
1178-2021pii
ndt-11-823journal_volume
11pub_type
杂志文章abstract:BACKGROUND:Deltamethrin (DLM) is a broad-spectrum synthetic dibromo-pyrethroid pesticide that is widely used for agricultural and veterinary purposes. However, human exposure to the pesticide leads to neurotoxicity. Glutamine is one of the principal, free intracellular amino acids and may also be an antioxidant. This s...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S104011
更新日期:2016-04-21 00:00:00
abstract:BACKGROUND:Dementia is generally characterized by cognitive impairment that can be accompanied by psychotic symptoms; for example, visual hallucinations are a core feature of dementia with Lewy bodies, and delusions are often seen in Alzheimer's disease. However, for behavioral variant of frontotemporal dementia (bvFTD...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S127863
更新日期:2017-04-13 00:00:00
abstract:BACKGROUND:Recently, the sigma-1 receptor has been shown to play a significant role in the neural transmission of mood by regulating N-methyl-D-aspartate receptors. Additionally, the sigma-1 receptor has been reported to influence cognitive functions including learning and memory. In this study, we measured plasma sigm...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S53386
更新日期:2013-01-01 00:00:00
abstract::With respect to the high burden of ischemic stroke and the absence of pharmacological treatment for promoting rehabilitation, promising candidates with specific effects on long-term functional recovery are highly desired. Candidates need reasonable experimental paradigms to evaluate the long-term functional outcome fo...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S127094
更新日期:2017-04-26 00:00:00
abstract::Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of hereditary cerebral microangiopathy, and is caused by over 170 different mutations in the NOTCH3 gene at locus 19p13.1-13.26. We report the first study of familial CADASIL in a 39-y...
journal_title:Neuropsychiatric disease and treatment
pub_type:
doi:10.2147/NDT.S19399
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:Insomnia can be broadly defined as difficulty initiating or maintaining sleep, or sleep that is not refreshing or of poor quality with negative effect on daytime function. Insomnia can be a primary condition or comorbid to an underlying disorder. Subjective measures of insomnia used in population studies, usu...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S15123
更新日期:2010-12-20 00:00:00
abstract:BACKGROUND:There have not been any reports in Japan clarifying the efficacy and safety of intramuscular (IM) olanzapine and IM levomepromazine in agitated elderly patients with schizophrenia. This study was a comparative investigation of the clinical efficacy and safety of IM olanzapine and IM levomepromazine in agitat...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S50754
更新日期:2013-01-01 00:00:00
abstract::Restless legs syndrome (RLS) is one of the commonest movement disorders affecting sleep and also daytime functioning. The prevalence may be 8%-10% of the white Caucasian population. The diagnosis is simple and is based on a well-validated clinical questionnaire, yet misdiagnosis is common and the condition remains und...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/nedt.2006.2.2.155
更新日期:2006-06-01 00:00:00
abstract:Purpose:This study aims to evaluate the quality of the Finnish clinical practice guideline related to schizophrenia care and how it can be utilized in psychiatric services. Participants and methods:The data were collected from one psychiatric ward and seven psychiatric outpatient units situated in two cities in Southe...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S192752
更新日期:2019-05-09 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S84602
更新日期:2015-07-17 00:00:00
abstract:OBJECTIVE:To study clinical correlates of religiosity in Parkinson's disease (PD). METHODS:Measures of life goals, religiosity, mood, and neuropsychologic function were assessed in 22 persons with mid-stage PD and 20 age-matched healthy controls. Levodopa dose equivalents (LDE) were also computed for the patients. RE...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/nedt.2006.2.3.341
更新日期:2006-09-01 00:00:00
abstract::Cerebral palsy (CP) is the most frequent cause of motor handicap. The present door-to-door survey was conducted in Al-Quseir City, Egypt, to investigate the epidemiology of CP. All inhabitants were screened by three neurologists. Medical and neurological examinations were performed for all residents and suspected case...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S59599
更新日期:2014-07-08 00:00:00
abstract::Tuberous sclerosis complex (TSC) is a relatively rare genetic disorder, affecting one in 6,000 births. Mammalian target of rapamycin (mTOR) inhibitors, such as everolimus, which have been previously used to prevent solid organ transplant rejection, augment anticancer treatment regimens, and prevent neovascularization ...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章,评审
doi:10.2147/NDT.S91248
更新日期:2016-08-25 00:00:00
abstract:Purpose:Mood disorders are recurrent chronic disorders with fluctuating mood states and energy, and misdiagnosis is common when based solely on clinical interviews because of overlapping symptoms. Because misdiagnosis may lead to inappropriate treatment and poor prognosis, finding an easily implemented objective tool f...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S190048
更新日期:2019-01-15 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/ndt.s9810
更新日期:2010-05-25 00:00:00
abstract::Orthorexia is recognized as an eating disorder, an obsessive-compulsive spectrum disorder, or a somatoform disorder. The aim of our research was to analyze nutritional behaviors for the assessment of the risk of orthorexia. The authors developed a questionnaire in which 981 respondents participated and used it as a re...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S129660
更新日期:2017-02-21 00:00:00
abstract:OBJECTIVE:The abuse of illegal substances by youths in Taiwan has become a major public health issue. This study explores the outcomes (relapse rate and academic or social status) of a family-oriented therapy program conducted for substance-using youths who were referred by a judge to participate in it. METHODS:The pr...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S105199
更新日期:2016-03-30 00:00:00
abstract:Background:There is evidence that incarcerated people show higher rates of symptoms of psychopathology. In the present study, we assessed male Iranian incarcerated people with borderline personality disorders (BPD) and investigated the occurrence of past and current trauma and their associations with dissociative exper...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S266016
更新日期:2020-10-21 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S79586
更新日期:2015-11-04 00:00:00
abstract:Introduction:The study was designed to explore the possible adverse effects of prenatal polycyclic aromatic hydrocarbons (PAHs) on the neurodevelopment of the infants at the age of 12 months in a birth cohort in Qingdao of China. Benzo[a]pyrene (BaP)-DNA adduct level in umbilical cord blood was measured by enzyme immun...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S219244
更新日期:2019-12-02 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S134930
更新日期:2017-04-03 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/nedt.1.1.9.52299
更新日期:2005-03-01 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S152784
更新日期:2017-11-23 00:00:00
abstract:BACKGROUND:The primary aim of the present study was to compare temperament and character traits and levels of alexithymia between patients with panic disorder and healthy controls. METHODS:Sixty patients with panic disorder admitted to the psychiatry clinic at Fırat University Hospital were enrolled in the study, alon...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S62647
更新日期:2014-05-16 00:00:00
abstract:Background:Suicidal ideation (SI) is a cardinal aspect of major depressive disorder (MDD); however, patient-reported outcomes data from large-scale surveys are limited concerning SI in the context of MDD. This study aims to understand the association between varying levels of SI and health-related quality of life (HRQo...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S229530
更新日期:2021-01-18 00:00:00
abstract::Peripheral benzodiazepine (BDZ) receptors were investigated by means of the binding of the specific ligand (3)H-PK 11195 to platelet membranes in patients suffering from bipolar disorder and in healthy controls. The results showed that the density (Bmax) of peripheral BDZ receptors was significantly higher in patients...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/nedt.1.2.151.61046
更新日期:2005-06-01 00:00:00
abstract:Purpose:Typically, the diagnosis of conversion motor disorder (CMD) is achieved by the exclusion of a wide range of organic illnesses rather than by applying positive criteria. New diagnostic criteria are highly needed in this scenario. The main aim of this study was to explore the use of behavioral features as an incl...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S151695
更新日期:2018-05-18 00:00:00
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journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S82881
更新日期:2015-06-12 00:00:00
abstract:Introduction:Night-eating syndrome (NES) involves uncontrolled and most often repeated binge eating during the night. It is related with mood disorders as well as sleep disorders and it may cause obesity. Risks related to NES are obesity, binge eating disorder, bulimia nervosa, affective disorders, and sleep disorders....
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S159562
更新日期:2018-06-13 00:00:00
abstract::Elevation of plasma inflammatory factors in major depressive disorder (MDD) has been repeatedly observed, but contradictory results have also been reported. Alteration of complement components in MDD may also contribute to the pathophysiology of MDD by participating in inflammation. The recent findings that complement...
journal_title:Neuropsychiatric disease and treatment
pub_type: 杂志文章
doi:10.2147/NDT.S151238
更新日期:2017-12-20 00:00:00