Post hoc analyses of the impact of previous medication on the efficacy of lisdexamfetamine dimesylate in the treatment of attention-deficit/hyperactivity disorder in a randomized, controlled trial.

Abstract:

BACKGROUND:Following the approval of lisdexamfetamine dimesylate (LDX) in several European countries for the treatment of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents with an inadequate response to methylphenidate (MPH) treatment, the aim of the present analysis was to establish the response to LDX in subgroups of patients with different ADHD medication histories. METHODS:This was a post hoc subgroup analysis of data from a 7-week, European, double-blind, dose-optimized, Phase III study. Patients aged 6-17 years were randomized 1:1:1 to LDX, placebo, or osmotic-release oral system methylphenidate (OROS-MPH). OROS-MPH was included as a reference arm rather than as a direct comparator. Efficacy was assessed in patients categorized according to their ADHD medication history using the ADHD Rating Scale IV and Clinical Global Impressions-Improvement (CGI-I) scores. RESULTS:The difference between active drug and placebo in least-squares mean change from baseline to endpoint in ADHD Rating Scale IV total score (95% confidence interval) was similar between the overall study population (n=317; LDX, -18.6 [-21.5, -15.7]; OROS-MPH, -13.0 [-15.9, -10.2]) and treatment-naïve individuals (n=147; LDX, -15.1 [-19.4, -10.9]; OROS-MPH, -12.7 [-16.8, -8.5]) or patients previously treated with any ADHD medication (n=170; LDX, -21.5 [-25.5, -17.6]; OROS-MPH, -14.2 [-18.1, -10.3]). In addition, similar proportions of patients receiving active treatment were categorized as improved based on CGI-I score (CGI-I of 1 or 2) in the overall study population and among treatment-naïve individuals or patients previously treated with any ADHD medication. CONCLUSION:In these post hoc analyses, the response to LDX treatment, and to the reference treatment OROS-MPH, was similar to that observed for the overall study population in subgroups of patients categorized according to whether or not they had previously received ADHD medication.

authors

Coghill DR,Banaschewski T,Lecendreux M,Soutullo C,Zuddas A,Adeyi B,Sorooshian S

doi

10.2147/NDT.S68273

subject

Has Abstract

pub_date

2014-10-29 00:00:00

pages

2039-47

eissn

1176-6328

issn

1178-2021

pii

ndt-10-2039

journal_volume

10

pub_type

杂志文章
  • Early stages of pediatric bipolar disorder: retrospective analysis of a Czech inpatient sample.

    abstract:BACKGROUND:Approximately 30%-60% of adults diagnosed with bipolar disorder (BD) report onset between the ages 15 and 19 years; however, a correct diagnosis is often delayed by several years. Therefore, investigations of the early features of BD are important for adequately understanding the prodromal stages of the illn...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S79586

    authors: Goetz M,Novak T,Vesela M,Hlavka Z,Brunovsky M,Povazan M,Ptacek R,Sebela A

    更新日期:2015-11-04 00:00:00

  • Psychiatric comorbidities in patients with intentional methanol intoxication.

    abstract:Background:Intentional methanol intoxication (IMI) is an emerging public health issue in Asian countries, but few data are available in the literature on underlying psychiatric comorbidities in these suicide attempters. Patients and methods:We conducted a retrospective chart review on patients with methanol intoxicati...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S192943

    authors: Yang WS,Yen TH,Juang YY,Lee SH,Wang BH,Lee CP

    更新日期:2019-01-31 00:00:00

  • Clinical features and imaging findings in a case of Capgras syndrome.

    abstract::Capgras syndrome consists of the delusional belief that a person or persons have been replaced by doubles or impostors. It can occur in the context of both psychiatric and organic illness, and seems to be related to lesions of the bifrontal and right limbic and temporal regions. Indeed, magnetic resonance imaging has ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type:

    doi:10.2147/NDT.S47293

    authors: Luca M,Bordone A,Luca A,Patti A,Sortino G,Calandra C

    更新日期:2013-01-01 00:00:00

  • Religiosity in patients with Parkinson's disease.

    abstract:OBJECTIVE:To study clinical correlates of religiosity in Parkinson's disease (PD). METHODS:Measures of life goals, religiosity, mood, and neuropsychologic function were assessed in 22 persons with mid-stage PD and 20 age-matched healthy controls. Levodopa dose equivalents (LDE) were also computed for the patients. RE...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/nedt.2006.2.3.341

    authors: McNamara P,Durso R,Brown A

    更新日期:2006-09-01 00:00:00

  • Fluvoxamine in the treatment of anxiety disorders.

    abstract::Fluvoxamine is a selective-serotonin reuptake inhibitor (SSRI) that has proved effective in large double-blind, randomized, controlled trials involving patients with social anxiety disorder (SAD), obsessive-compulsive disorder (OCD), and panic disorder. Improvements have also been demonstrated in patients with post-tr...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:

    authors: Irons J

    更新日期:2005-12-01 00:00:00

  • Imitation and communication skills development in children with pervasive developmental disorders.

    abstract::This study evaluates the correlation between failure to develop spontaneous imitation and language skills in pervasive developmental disorders. Sixty-four children between the age of 3 and 8 years were assessed using the Autism Diagnostic Interview-Revised (ADI-R), the Childhood Autism Rating Scale (CARS), and the Aut...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/ndt.s5679

    authors: De Giacomo A,Portoghese C,Martinelli D,Fanizza I,L'abate L,Margari L

    更新日期:2009-01-01 00:00:00

  • New and extended-action treatments in the management of ADHD: a critical appraisal of lisdexamfetamine in adults and children.

    abstract::Treatment guidelines from the American Academy of Child and Adolescent Psychiatry and the American Academy of Pediatrics state that stimulant medications have the most evidence for safety and efficacy in the treatment of childhood attention deficit hyperactivity disorder (ADHD). Longer-acting stimulants are thus consi...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/ndt.s3328

    authors: Domnitei D,Madaan V

    更新日期:2010-05-25 00:00:00

  • miR-455 inhibits neuronal cell death by targeting TRAF3 in cerebral ischemic stroke.

    abstract::Ischemic stroke is one of the leading causes of brain disease, with high morbidity, disability, and mortality. MicroRNAs (miRNAs) have been identified as vital gene regulators in various types of human diseases. Accumulating evidence has suggested that aberrant expression of miRNAs play critical roles in the pathologi...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S121183

    authors: Yao S,Tang B,Li G,Fan R,Cao F

    更新日期:2016-12-05 00:00:00

  • Secondary central nervous system lymphoma: spectrum of morphological MRI appearances.

    abstract:Background:Secondary central nervous system lymphoma (SCNSL) is a rare and aggressive disease, which is defined as secondary central nervous system (CNS) involvement in patients with systemic lymphoma. According to previous reports, SCNSL presents mostly with leptomeningeal spread; however, our experience differs. In t...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S157959

    authors: Malikova H,Burghardtova M,Koubska E,Mandys V,Kozak T,Weichet J

    更新日期:2018-03-12 00:00:00

  • Factors associated with caregiver burden among pharmacotherapy-treated children/adolescents with ADHD in the Caregiver Perspective on Pediatric ADHD survey in Europe.

    abstract:BACKGROUND:Burden on caregivers of children/adolescents with attention-deficit/hyperactivity disorder (ADHD) is multidimensional, but incompletely understood. OBJECTIVE:To analyze caregiver burden across the concepts of work, social/family life, and parental worry/stress, in relation to selected contributing factors. ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S121391

    authors: Fridman M,Banaschewski T,Sikirica V,Quintero J,Erder MH,Chen KS

    更新日期:2017-02-07 00:00:00

  • Aberrantly expressed long noncoding RNAs and genes in Parkinson's disease.

    abstract:Purpose:Parkinson's disease (PD) is a common neurodegenerative movement disorder, but the pathogenesis remains elusive. This study was aimed to explore key genes and long noncoding RNAs (lncRNAs) associated with PD. Materials and methods:Three patients with PD and three normal controls were enrolled in the present stu...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S178435

    authors: Zhou Y,Gu C,Li J,Zhu L,Huang G,Dai J,Huang H

    更新日期:2018-11-22 00:00:00

  • Alterations Of Glycerophospholipid And Fatty Acyl Metabolism In Multiple Brain Regions Of Schizophrenia Microbiota Recipient Mice.

    abstract:Background:Schizophrenia is a debilitating psychiatric disorder characterized by molecular and anatomical abnormalities of multiple brain regions. Our recent study showed that dysbiosis of the gut microbiota contributes to the onset of schizophrenia-relevant behaviors, but the underlying mechanisms remain largely unkno...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S225982

    authors: Liang W,Huang Y,Tan X,Wu J,Duan J,Zhang H,Yin B,Li Y,Zheng P,Wei H,Xie P

    更新日期:2019-11-19 00:00:00

  • Social support networks and eating disorders: an integrative review of the literature.

    abstract:AIMS:This study aimed to analyze the scientific literature about social networks and social support in eating disorders (ED). METHODS:By combining keywords, an integrative review was performed. It included publications from 2006-2013, retrieved from the MEDLINE, LILACS, PsycINFO, and CINAHL databases. The selection of...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章,评审

    doi:10.2147/NDT.S60735

    authors: Leonidas C,Dos Santos MA

    更新日期:2014-05-21 00:00:00

  • Effectiveness of methylphenidate as augmentation therapy after failure of adjunctive neuromodulation for patients with treatment-refractory bipolar depression: a case report.

    abstract::Adjunctive use of methylphenidate, a central stimulant, has been considered as a potential therapeutic choice for patients with refractory unipolar, geriatric, or bipolar depression, and depression secondary to medical illness. We present a case of bipolar depression in which the patient responded significantly to aug...

    journal_title:Neuropsychiatric disease and treatment

    pub_type:

    doi:10.2147/NDT.S58644

    authors: Adida M,Azorin JM

    更新日期:2014-04-02 00:00:00

  • Status epilepticus in patients with genetic (idiopathic) generalized epilepsy.

    abstract:Aim of the study:Genetic (idiopathic) generalized epilepsies (GGEs) account for nearly one-third of all epilepsies. The frequency of status epilepticus (SE) in patients with GGEs has been poorly studied. Therefore, this study aimed to evaluate the frequency of different forms of SE in a cohort of patients with GGEs. M...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S209084

    authors: Bosak M,Pawełczak D,Słowik A

    更新日期:2019-06-20 00:00:00

  • Analysis concerning nutritional behaviors in the context of the risk of orthorexia.

    abstract::Orthorexia is recognized as an eating disorder, an obsessive-compulsive spectrum disorder, or a somatoform disorder. The aim of our research was to analyze nutritional behaviors for the assessment of the risk of orthorexia. The authors developed a questionnaire in which 981 respondents participated and used it as a re...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S129660

    authors: Olejniczak D,Bugajec D,Panczyk M,Brytek-Matera A,Religioni U,Czerw A,Grąbczewska A,Juszczyk G,Jabłkowska-Górecka K,Staniszewska A

    更新日期:2017-02-21 00:00:00

  • Are 24-hour motor activity patterns associated with continued rapid response to ketamine?

    abstract:Purpose:This study examined the links between 24-hour activity patterns (specifically, amplitude and timing of wrist activity) and the persisting qualities of clinical antidepressant response to the glutamatergic modulator ketamine. Methods:Twenty-four-hour activity patterns were compared across 5 days of 24-hour acti...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S172089

    authors: Duncan WC Jr,Slonena EE,Hejazi NS,Brutsche N,Park LT,Henter ID,Ballard ED,Zarate CA Jr

    更新日期:2018-10-16 00:00:00

  • Changes in peripheral benzodiazepine receptors in patients with bipolar disorder.

    abstract::Peripheral benzodiazepine (BDZ) receptors were investigated by means of the binding of the specific ligand (3)H-PK 11195 to platelet membranes in patients suffering from bipolar disorder and in healthy controls. The results showed that the density (Bmax) of peripheral BDZ receptors was significantly higher in patients...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/nedt.1.2.151.61046

    authors: Marazziti D,Dell'Osso B,Baroni S,Masala I,Nasso ED,Giannaccini G,Dell'Osso L

    更新日期:2005-06-01 00:00:00

  • Thyroid functions in patients with bipolar disorder and the impact of quetiapine monotherapy: a retrospective, naturalistic study.

    abstract:Objective:Previous studies have demonstrated a potentially close relationship between mood disorders and thyroid abnormalities. The aims of this study are to investigate: 1) whether significant differences of thyroid profiles exist between manic and depressive episodes in patients with bipolar disorder (BD); 2) the imp...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S196661

    authors: Li C,Lai J,Huang T,Han Y,Du Y,Xu Y,Hu S

    更新日期:2019-08-09 00:00:00

  • Delirium as a complication of the surgical intensive care.

    abstract:BACKGROUND:The aim of this study was to examine the impact of somatic illnesses, electrolyte imbalance, red blood cell count, hypotension, and antipsychotic and opioid treatment on the duration of delirium in Central Intensive Care Unit for Surgery. PATIENTS AND METHODS:Patients who were admitted to the Department of ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S115800

    authors: Horacek R,Krnacova B,Prasko J,Latalova K

    更新日期:2016-09-22 00:00:00

  • Attitudes toward antipsychotic treatment among patients with bipolar disorders and their clinicians: a systematic review.

    abstract:INTRODUCTION:Antipsychotics are recommended as first-line therapy for acute mania and maintenance treatment of bipolar disorder; however, published literature suggests their real-world use remains limited. Understanding attitudes toward these medications may help identify barriers and inform personalized therapy. This ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章,评审

    doi:10.2147/NDT.S139557

    authors: Sajatovic M,DiBiasi F,Legacy SN

    更新日期:2017-08-30 00:00:00

  • Efficacy, tolerability, and safety of oral paliperidone extended release in the treatment of schizophrenia: a 24-week, open-label, prospective switch study in different settings in Taiwan.

    abstract:Purpose:Paliperidone extended release (ER) is an oral psychotropic treatment formulated to release paliperidone at a controlled, gradually ascending rate. We evaluated the efficacy and safety of switching to paliperidone ER in Taiwanese patients with schizophrenia who were unresponsive or intolerant to previous antipsy...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S161186

    authors: Chen CY,Tang TC,Chen TT,Bai YM,Tsai HH,Chen HL,Huang CJ,Chen CK,Chen CC,Hsiao MC,Liu CY,Yeh HS,Chiu NY,Hsiao CC,Chen CS,Su TP

    更新日期:2018-03-08 00:00:00

  • Hormone replacement therapy and Parkinson's disease risk in women: a meta-analysis of 14 observational studies.

    abstract:BACKGROUND AND PURPOSE:Published data on the relationship of hormone replacement therapy (HRT) with Parkinson's disease (PD) were inconclusive. Thus, a systematic meta-analysis of observational studies was performed to clarify this topic. METHODS:The databases of PubMed and EMBASE were searched for case-control or coh...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S69918

    authors: Wang P,Li J,Qiu S,Wen H,Du J

    更新日期:2014-12-31 00:00:00

  • Obsessive-compulsive disorder with bipolar diathesis following isotretinoin therapy remitting upon treatment with olanzapine and fluvoxamine.

    abstract::Isotretinoin, a drug used for moderate to severe acne, has been repeatedly associated with various psychiatric complications, although a definitive causal relationship has not been established to date. This case report describes a 25-year-old male who developed obsessive-compulsive disorder at the age of 23 years foll...

    journal_title:Neuropsychiatric disease and treatment

    pub_type:

    doi:10.2147/NDT.S14438

    authors: Fornaro M

    更新日期:2010-10-29 00:00:00

  • Predictors of sleep disturbance in heroin users receiving methadone maintenance therapy: a naturalistic study in Taiwan.

    abstract:Introduction:Sleep disturbance is a major health concern for heroin users receiving methadone maintenance treatment (MMT). The present study was aimed to investigate the predictors for new-onset clinically predominant sleep disturbance (CPSD) among heroin users receiving MMT. Methods:This 2-year retrospective study in...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S177370

    authors: Li DJ,Chung KS,Wu HC,Hsu CY,Yen CF

    更新日期:2018-10-26 00:00:00

  • Acute parietal lobe infarction presenting as Gerstmann's syndrome and cognitive decline mimicking senile dementia.

    abstract::Gerstmann's syndrome encompasses the tetrad of finger agnosia, agraphia, acalculia, and right-left confusion. An elderly man with a history of several cardiovascular diseases was initially brought to the psychiatric outpatient department by his family because of worsening of recent memory, executive function, and mixe...

    journal_title:Neuropsychiatric disease and treatment

    pub_type:

    doi:10.2147/NDT.S43527

    authors: Chen TY,Chen CY,Yen CH,Kuo SC,Yeh YW,Chang S,Huang SY

    更新日期:2013-01-01 00:00:00

  • Impact of anxiety symptoms on outcomes of depression: an observational study in Asian patients.

    abstract:OBJECTIVE:To investigate the impact of anxiety symptoms on depression outcomes in Asian patients with major depressive disorder (MDD) (n=714). METHODS:The 17-item Hamilton Depression Scale (HAMD-17), overall severity, somatic symptoms, and quality of life (QOL) (EuroQOL Questionnaire-5 Dimensions [EQ-5D]) were assesse...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S90134

    authors: Novick D,Montgomery W,Aguado J,Peng X,Haro JM

    更新日期:2016-04-11 00:00:00

  • Critical appraisal of the long-term impact of memantine in treatment of moderate to severe Alzheimer's disease.

    abstract::Alzheimer's disease is the most common cause of dementia in older adults. The clinical features include progressive memory decline as well as cognitive deficits with executive dysfunction, language, visual perceptual difficulties, apraxia and agnosia. During the moderate to severe stage of the disease, there is a majo...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/ndt.s5021

    authors: Puangthong U,Hsiung GY

    更新日期:2009-01-01 00:00:00

  • Intranasal Delivery of Bone Marrow Stromal Cells Preconditioned with Fasudil to Treat a Mouse Model of Parkinson's Disease.

    abstract:Objective:Stem cell transplantation is a promising strategy with great potential to treat Parkinson's disease (PD). Nevertheless, improving the cell delivery route and optimising implanted cells are necessary to increase the therapeutic effect. Herein, we investigated whether intranasal delivery of bone marrow stromal ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S238646

    authors: Tang Y,Han L,Bai X,Liang X,Zhao J,Huang F,Wang J

    更新日期:2020-01-23 00:00:00

  • Bupropion interferes with the image diagnosis of Parkinson's disease.

    abstract::Major depressive disorder (MDD) and Parkinson's disease (PD) share symptoms such as tremor. Bupropion, a norepinephrine-dopamine reuptake inhibitor, shows weak dopamine transporter (DAT) occupancy. We report here on a patient with MDD whose hand tremors might have been misdiagnosed as PD by single-photon emission comp...

    journal_title:Neuropsychiatric disease and treatment

    pub_type:

    doi:10.2147/NDT.S150912

    authors: Lin CH,Lane HY

    更新日期:2017-10-19 00:00:00