Critical appraisal of the long-term impact of memantine in treatment of moderate to severe Alzheimer's disease.

Abstract:

:Alzheimer's disease is the most common cause of dementia in older adults. The clinical features include progressive memory decline as well as cognitive deficits with executive dysfunction, language, visual perceptual difficulties, apraxia and agnosia. During the moderate to severe stage of the disease, there is a major decline in memory and function, while neuropsychiatric disturbances often emerge and patients become difficult to manage. These distressing symptoms increase caregiver burden and add to the direct costs of care of the patients. Any improvements in patient function and behavioral symptoms can reduce caregiver burden. Memantine has been available for a number of years in Europe and in North America. In this article, we examine the pharmacological rationale for its use, and the current clinical evidence for its efficacy and long-term effectiveness in the management of cognitive and behavioral symptoms in moderate to severe stages of Alzheimer's disease.

authors

Puangthong U,Hsiung GY

doi

10.2147/ndt.s5021

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

553-61

eissn

1176-6328

issn

1178-2021

journal_volume

5

pub_type

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