Abstract：
:Traumatic brain injury (TBI) is widespread and leads to death and disability in millions of individuals around the world each year. Overall incidence and prevalence of TBI are likely to increase in absolute terms in the future. Tackling the problem of treating TBI successfully will require improvements in the understanding of normal cerebral anatomy, physiology, and function throughout the lifespan, as well as the pathological and recuperative responses that result from trauma. New treatment approaches and combinations will need to be targeted to the heterogeneous needs of TBI populations. This article explores and evaluates the research evidence in areas that will likely lead to a reduction in TBI-related morbidity and improved outcomes. These include emerging assessment instruments and techniques in areas of structural/chemical and functional neuroimaging and neuropsychology, advances in the realms of cell-based therapies and genetics, promising cognitive rehabilitation techniques including cognitive remediation and the use of electronic technologies including assistive devices and virtual reality, and the emerging field of complementary and alternative medicine.
journal_name
Neuropsychiatr Dis Treatjournal_title
Neuropsychiatric disease and treatmentauthors
Flanagan SR,Cantor JB,Ashman TAdoi
10.2147/ndt.s1985subject
Has Abstractpub_date
2008-10-01 00:00:00pages
877-92issue
5eissn
1176-6328issn
1178-2021journal_volume
4pub_type
杂志文章abstract：INTRODUCTION:Telomere shortening is strongly associated with higher mortality rates and has been shown in a number of age-related diseases, such as cardiovascular disorders, diabetes mellitus, Alzheimer's disease, and psychiatric disorders. Oxidative stress is known to induce DNA breaks and genome instability. Telomeri...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章
doi：10.2147/NDT.S82468
更新日期：2015-06-22 00:00:00
abstract：:Studies on unmet needs during the last decades have played a significant role in the development and dissemination of evidence-based community practices for persistent schizophrenia and other severe mental disorders. This review has thoroughly considered several blocks of unmet needs, which are frequently related to s...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章,评审
doi：10.2147/NDT.S41063
更新日期：2014-01-16 00:00:00
abstract：:Neuropsychiatric symptoms are common in older adults with dementia and can be associated with a rapid decline in cognitive and functional status. This article reviews the current literature supporting the use of atypical antipsychotic medications in this population. Among the currently available atypical antipsychotic...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章
doi：10.2147/nedt.2006.2.4.521
更新日期：2006-12-01 00:00:00
abstract：:Obsessive compulsive and impulsive symptoms are prevalent in patients with Tourette's Syndrome (TS) and well recognized as part of the TS spectrum. However, some complex obsessive compulsive and impulsive behaviors may be mistaken for other symptoms, such as complex tics or psychotic behavior. In addition, the overlap...
journal_title：Neuropsychiatric disease and treatment
pub_type：
doi：
更新日期：2007-01-01 00:00:00
abstract：OBJECTIVE:To explore the abnormal intrinsic functional hubs in alcohol dependence using voxelwise degree centrality analysis approach, and their relationships with clinical features. MATERIALS AND METHODS:Twenty-four male alcohol dependence subjects free of medicine (mean age, 50.21±9.62 years) and 24 age- and educati...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章
doi：10.2147/NDT.S142742
更新日期：2017-07-28 00:00:00
abstract：:Lacosamide is a newly registered antiepileptic drug with dual mechanisms of action. It selectively enhances slow inactivation of voltage-gated sodium channels, resulting in stabilization of hyperexcitable neuronal membranes and inhibition of repetitive neuronal firing. It also binds to a collapsing-response mediator p...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章
doi：10.2147/ndt.s7967
更新日期：2010-09-07 00:00:00
abstract：BACKGROUND:We assessed the effect of switching patients with major depressive disorder to milnacipran following an initial selective serotonin reuptake inhibitor treatment failure, and explored potential biomarkers in their blood. METHODS:We conducted a prospective, open-label, 24-week trial. Depression was assessed w...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章
doi：10.2147/NDT.S95067
更新日期：2015-12-10 00:00:00
abstract：:Previous studies on cognitive training in Alzheimer's disease (AD) were principally aimed at making patients learn items not related to functional needs. However, AD patients also experience difficulties with instrumental activities of daily living (IADL). The goal of the present multiple baseline case report study wa...
journal_title：Neuropsychiatric disease and treatment
pub_type：
doi：10.2147/ndt.s3684
更新日期：2008-10-01 00:00:00
abstract：:Abnormal prion proteins are responsible for several fatal neurodegenerative diseases in humans and in animals, including Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker disease, and fatal familial insomnia. Genetics is important in prion diseases, but in the most cases, cause of diseases remained unkno...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章,评审
doi：10.2147/NDT.S165445
更新日期：2018-08-14 00:00:00
abstract：Purpose:Relatively little attention has been paid to the meaning of reversion from mild cognitive impairment (MCI) to cognitively normal (CN), compared to MCI progression studies. The purpose of the study was to investigate the characteristics contributing to reversion from MCI to CN and to identify the associated fact...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章
doi：10.2147/NDT.S223958
更新日期：2019-10-25 00:00:00
abstract：:Despite its high prevalence and individual as well as societal burden, migraine remains underdiagnosed and undertreated. In recent years, the options for the management of migraine patients have greatly expanded. A number of drugs belonging to various pharmacological classes and deliverable by several routes are now a...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章
doi：10.2147/ndt.s3045
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND:PULSE was a large, observational, multicenter study designed to evaluate the efficacy and safety of agomelatine in the treatment of major depression in patients with cardiovascular disease (CVD). METHODS:Patients with mild-to-moderate major depressive episodes, without psychotic symptoms, were treated as ou...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章
doi：10.2147/NDT.S129793
更新日期：2017-04-21 00:00:00
abstract：Introduction:The study was designed to explore the possible adverse effects of prenatal polycyclic aromatic hydrocarbons (PAHs) on the neurodevelopment of the infants at the age of 12 months in a birth cohort in Qingdao of China. Benzo[a]pyrene (BaP)-DNA adduct level in umbilical cord blood was measured by enzyme immun...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章
doi：10.2147/NDT.S219244
更新日期：2019-12-02 00:00:00
abstract：BACKGROUND:The aim of this paper is to report maternal and neonatal outcomes in pregnant women treated with escitalopram during pregnancy and breastfeeding. METHODS:Women enrolled in the DEGRA Database at the Clinic of Affective Disorders in Pregnancy and Postpartum in Italy, treated during pregnancy with escitalopram...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章
doi：10.2147/NDT.S45951
更新日期：2013-01-01 00:00:00
abstract：:Dystonia is a rare manifestation of multiple sclerosis (MS), but it always interferes with the functional performance and quality of life. We report a rare case of long-lasting paroxysmal dystonia associated with MS. The patient was a 40-year-old woman with relapsing- remitting MS for 6 years. During the latest attack...
journal_title：Neuropsychiatric disease and treatment
pub_type：
doi：10.2147/NDT.S43688
更新日期：2013-01-01 00:00:00
abstract：PURPOSE:The aim of this study was to ascertain the clinical characteristics of drug-induced sleep-related eating disorder (SRED). PATIENTS AND METHODS:We retrospectively reviewed the medical records of 30 patients with primary SRED (without any comorbid sleep disorders and who were not taking any possible causative me...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章
doi：10.2147/NDT.S107462
更新日期：2016-05-26 00:00:00
abstract：BACKGROUND:Previous studies have demonstrated that long noncoding RNA cancer susceptibility candidate 2 (lncRNA CASC2) is frequently downregulated in several types of tumors and functions as a tumor-suppressive factor. However, the clinical significance and function of CASC2 in human glioma remain largely unknown. The ...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章
doi：10.2147/NDT.S137171
更新日期：2017-07-11 00:00:00
abstract：Background:Various personality traits mediate the association between childhood stress and depressive symptoms in adulthood. The aim of this study was to clarify the indirect effects of the experience of child maltreatment on depressive symptoms and appraisal of life events in adulthood through trait anxiety. Subjects...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章
doi：10.2147/NDT.S182783
更新日期：2018-11-27 00:00:00
abstract：PURPOSE:Infant resting-state networks do not exhibit the same connectivity patterns as those of young children and adults. Current theories of brain development emphasize developmental progression in regional and network specialization. We compared infant and adult functional connectivity, predicting that infants would...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章
doi：10.2147/NDT.S63773
更新日期：2014-07-21 00:00:00
abstract：:A series of cases are reported in which patients on aripiprazole have developed akathisia, although the literature states that the rate is negligible. ...
journal_title：Neuropsychiatric disease and treatment
pub_type：
doi：10.2147/nedt.2006.2.2.241
更新日期：2006-06-01 00:00:00
abstract：:[This retracts the article DOI: 10.2147/NDT.S229513.]. ...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章,撤回出版物
doi：10.2147/NDT.S257261
更新日期：2020-04-16 00:00:00
abstract：:Autism spectrum disorder (ASD) is a common neurodevelopmental disorder characterized by pervasive difficulties since early childhood across reciprocal social communication and restricted, repetitive interests and behaviors. Although early ASD research focused primarily on children, there is increasing recognition that...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章,评审
doi：10.2147/NDT.S65455
更新日期：2016-07-07 00:00:00
abstract：Background:Early-onset major depressive disorder (EO-MDD), beginning during childhood and adolescence, is associated with more illness burden and a worse prognosis than adult-onset MDD (AO-MDD), but little is known about the neural features distinguishing these subgroup phenotypes. Functional abnormalities of the amygd...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章
doi：10.2147/NDT.S145042
更新日期：2018-01-14 00:00:00
abstract：Purpose:This randomized, double-blind (DB), non-inferiority phase 3 study was conducted to assess the efficacy and safety of paliperidone palmitate 3-month (PP3M) vs 1-month formulation (PP1M) in European and non-European patients with schizophrenia. Patients and methods:In this randomized, DB, parallel-group study, a...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章
doi：10.2147/NDT.S189668
更新日期：2019-02-21 00:00:00
abstract：BACKGROUND:Burden on caregivers of children/adolescents with attention-deficit/hyperactivity disorder (ADHD) is multidimensional, but incompletely understood. OBJECTIVE:To analyze caregiver burden across the concepts of work, social/family life, and parental worry/stress, in relation to selected contributing factors. ...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章
doi：10.2147/NDT.S121391
更新日期：2017-02-07 00:00:00
abstract：:Capgras syndrome consists of the delusional belief that a person or persons have been replaced by doubles or impostors. It can occur in the context of both psychiatric and organic illness, and seems to be related to lesions of the bifrontal and right limbic and temporal regions. Indeed, magnetic resonance imaging has ...
journal_title：Neuropsychiatric disease and treatment
pub_type：
doi：10.2147/NDT.S47293
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Major depressive disorder (MDD) significantly impacts performance of both work- and nonwork-related routine daily activities. We have shown that work productivity is significantly impaired in employed MDD patients, but the extent of impairments in nonwork-related routine activities and its association with a...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章
doi：10.2147/NDT.S128407
更新日期：2017-03-15 00:00:00
abstract：INTRODUCTION:Antipsychotics are recommended as first-line therapy for acute mania and maintenance treatment of bipolar disorder; however, published literature suggests their real-world use remains limited. Understanding attitudes toward these medications may help identify barriers and inform personalized therapy. This ...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章,评审
doi：10.2147/NDT.S139557
更新日期：2017-08-30 00:00:00
abstract：Purpose:Although there are highly precise and advanced diagnostic methods, the etiology and pathophysiology of schizophrenia remain poorly understood. There are several theories about schizophrenia origin, among which the neurodevelopmental theory is widely accepted. Our study aimed to assess minor physical anomalies a...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章
doi：10.2147/NDT.S275582
更新日期：2020-10-28 00:00:00
abstract：:Epilepsy is a common pediatric neurologic disorder that is difficult to manage in a substantial portion of children. Levetiracetam (LEV) is a novel antiepileptic drug (AED) that has recently been approved as add-on treatment for various seizure types in epilepsy populations that include children: for refractory partia...
journal_title：Neuropsychiatric disease and treatment
pub_type： 杂志文章
doi：
更新日期：2007-08-01 00:00:00
