Reduced brain resting-state network specificity in infants compared with adults.

Abstract:

PURPOSE:Infant resting-state networks do not exhibit the same connectivity patterns as those of young children and adults. Current theories of brain development emphasize developmental progression in regional and network specialization. We compared infant and adult functional connectivity, predicting that infants would exhibit less regional specificity and greater internetwork communication compared with adults. PATIENTS AND METHODS:Functional magnetic resonance imaging at rest was acquired in 12 healthy, term infants and 17 adults. Resting-state networks were extracted, using independent components analysis, and the resulting components were then compared between the adult and infant groups. RESULTS:Adults exhibited stronger connectivity in the posterior cingulate cortex node of the default mode network, but infants had higher connectivity in medial prefrontal cortex/anterior cingulate cortex than adults. Adult connectivity was typically higher than infant connectivity within structures previously associated with the various networks, whereas infant connectivity was frequently higher outside of these structures. Internetwork communication was significantly higher in infants than in adults. CONCLUSION:We interpret these findings as consistent with evidence suggesting that resting-state network development is associated with increasing spatial specificity, possibly reflecting the corresponding functional specialization of regions and their interconnections through experience.

authors

Wylie KP,Rojas DC,Ross RG,Hunter SK,Maharajh K,Cornier MA,Tregellas JR

doi

10.2147/NDT.S63773

subject

Has Abstract

pub_date

2014-07-21 00:00:00

pages

1349-59

eissn

1176-6328

issn

1178-2021

pii

ndt-10-1349

journal_volume

10

pub_type

杂志文章
  • Unmet needs in the management of schizophrenia.

    abstract::Studies on unmet needs during the last decades have played a significant role in the development and dissemination of evidence-based community practices for persistent schizophrenia and other severe mental disorders. This review has thoroughly considered several blocks of unmet needs, which are frequently related to s...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章,评审

    doi:10.2147/NDT.S41063

    authors: Torres-González F,Ibanez-Casas I,Saldivia S,Ballester D,Grandón P,Moreno-Küstner B,Xavier M,Gómez-Beneyto M

    更新日期:2014-01-16 00:00:00

  • Are 24-hour motor activity patterns associated with continued rapid response to ketamine?

    abstract:Purpose:This study examined the links between 24-hour activity patterns (specifically, amplitude and timing of wrist activity) and the persisting qualities of clinical antidepressant response to the glutamatergic modulator ketamine. Methods:Twenty-four-hour activity patterns were compared across 5 days of 24-hour acti...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S172089

    authors: Duncan WC Jr,Slonena EE,Hejazi NS,Brutsche N,Park LT,Henter ID,Ballard ED,Zarate CA Jr

    更新日期:2018-10-16 00:00:00

  • Can a physician predict the clinical response to first-line immunomodulatory treatment in relapsing-remitting multiple sclerosis?

    abstract:BACKGROUND:Decreased relapse rate and slower disease progression have been reported with long-term use of immunomodulatory treatments (IMTs, interferon beta or glatiramer acetate) in relapsing-remitting multiple sclerosis. There are, however, patients who do not respond to such treatments, and they can be potential can...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S36771

    authors: Mezei Z,Bereczki D,Racz L,Csiba L,Csepany T

    更新日期:2012-01-01 00:00:00

  • Towards an Outpatient Model of Care for Motor Functional Neurological Disorders: A Neuropsychiatric Perspective.

    abstract::Functional neurological disorder (FND), a condition at the intersection of neurology and psychiatry, is a common and disabling outpatient referral to neurology and neuropsychiatry clinics. In this perspective article, we focus on the motor spectrum of FND (mFND), including individuals with functional movement disorder...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章,评审

    doi:10.2147/NDT.S247119

    authors: Saxena A,Godena E,Maggio J,Perez DL

    更新日期:2020-09-18 00:00:00

  • The role of family therapy in the management of schizophrenia: challenges and solutions.

    abstract::Family interventions for schizophrenia have been amply demonstrated to be effective and are recommended by most of the international clinical guidelines. However, their implementation in the clinical setting as well as in treatment protocols of patients with psychosis has not been fully achieved yet. With the increasi...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章,评审

    doi:10.2147/NDT.S51331

    authors: Caqueo-Urízar A,Rus-Calafell M,Urzúa A,Escudero J,Gutiérrez-Maldonado J

    更新日期:2015-01-14 00:00:00

  • Affect regulation: a systems neuroscience perspective.

    abstract:OBJECTIVE:TO INTEGRATE: (1) the neuroanatomical model of affect regulation; (2) a functional model of affect regulation; and (3) the evolving picture of affect dysregulation as exemplified by bipolar disorder. METHODOLOGY:A computerized search for articles on related topics was augmented by additional selected studies...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/nedt.1.1.9.52299

    authors: Pavuluri MN,Herbener ES,Sweeney JA

    更新日期:2005-03-01 00:00:00

  • Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy in an Israeli family.

    abstract::Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of hereditary cerebral microangiopathy, and is caused by over 170 different mutations in the NOTCH3 gene at locus 19p13.1-13.26. We report the first study of familial CADASIL in a 39-y...

    journal_title:Neuropsychiatric disease and treatment

    pub_type:

    doi:10.2147/NDT.S19399

    authors: Shahien R,Bianchi S,Bowirrat A

    更新日期:2011-01-01 00:00:00

  • Twelve-week physical exercise does not have a long-lasting effect on kynurenines in plasma of depressed patients.

    abstract:BACKGROUND:Physical exercise has well-characterized positive effects on depressive symptoms. The underlying biologic mechanisms are, however, far from established. A recently discovered mechanism has linked the enhanced conversion of kynurenine to kynurenic acid (KYNA) to an increased resilience toward stress-induced d...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S131746

    authors: Millischer V,Erhardt S,Ekblom Ö,Forsell Y,Lavebratt C

    更新日期:2017-03-31 00:00:00

  • Catatonia in Down syndrome; a treatable cause of regression.

    abstract:OBJECTIVE:The main aim of this case series report is to alert physicians to the occurrence of catatonia in Down syndrome (DS). A second aim is to stimulate the study of regression in DS and of catatonia. A subset of individuals with DS is noted to experience unexplained regression in behavior, mood, activities of daily...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S77307

    authors: Ghaziuddin N,Nassiri A,Miles JH

    更新日期:2015-04-02 00:00:00

  • Balance and gait in older electroconvulsive therapy recipients: a pilot study.

    abstract:BACKGROUND:Electroconvulsive therapy (ECT) is commonly used to treat depression in older adults. Despite its efficacy in this regard, an associated increase in the risk of falls in this population is a downside of treatment. ECT research has focused on the incidence of falls, but its effect on balance and gait - intrin...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S42628

    authors: Plakiotis C,Barson F,Vengadasalam B,Haines TP,O'Connor DW

    更新日期:2013-01-01 00:00:00

  • Factors associated with caregiver burden among pharmacotherapy-treated children/adolescents with ADHD in the Caregiver Perspective on Pediatric ADHD survey in Europe.

    abstract:BACKGROUND:Burden on caregivers of children/adolescents with attention-deficit/hyperactivity disorder (ADHD) is multidimensional, but incompletely understood. OBJECTIVE:To analyze caregiver burden across the concepts of work, social/family life, and parental worry/stress, in relation to selected contributing factors. ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S121391

    authors: Fridman M,Banaschewski T,Sikirica V,Quintero J,Erder MH,Chen KS

    更新日期:2017-02-07 00:00:00

  • Complex obsessive compulsive and impulsive symptoms in Tourette's syndrome.

    abstract::Obsessive compulsive and impulsive symptoms are prevalent in patients with Tourette's Syndrome (TS) and well recognized as part of the TS spectrum. However, some complex obsessive compulsive and impulsive behaviors may be mistaken for other symptoms, such as complex tics or psychotic behavior. In addition, the overlap...

    journal_title:Neuropsychiatric disease and treatment

    pub_type:

    doi:

    authors: Palumbo D,Kurlan R

    更新日期:2007-01-01 00:00:00

  • Association between the high-dose use of benzodiazepines and rehospitalization in patients with schizophrenia: a 2-year naturalistic study.

    abstract:BACKGROUND:High-dose use of benzodiazepines (BZPs) reportedly causes adverse effects on cognitive function and quality of life in patients with schizophrenia. However, effects of BZPs on the clinical course of schizophrenia have not been clarified. This study was set out to investigate the association between BZPs and ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S118759

    authors: Takita Y,Takaesu Y,Ono K,Futenma K,Shimura A,Murakoshi A,Komada Y,Inoue Y,Inoue T

    更新日期:2016-12-15 00:00:00

  • Decreased mean platelet volume in panic disorder.

    abstract:AIM:The relationship between psychological stress and platelet activation has been widely studied. It is well known that platelets may reflect certain biochemical changes that occur in the brain when different mental conditions occur. Platelet 5-hydroxytryptamine (5-HT) is also extensively studied in psychiatry. The me...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S69922

    authors: Göğçegöz Gül I,Eryılmaz G,Ozten E,Hızlı Sayar G

    更新日期:2014-09-04 00:00:00

  • miR-455 inhibits neuronal cell death by targeting TRAF3 in cerebral ischemic stroke.

    abstract::Ischemic stroke is one of the leading causes of brain disease, with high morbidity, disability, and mortality. MicroRNAs (miRNAs) have been identified as vital gene regulators in various types of human diseases. Accumulating evidence has suggested that aberrant expression of miRNAs play critical roles in the pathologi...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S121183

    authors: Yao S,Tang B,Li G,Fan R,Cao F

    更新日期:2016-12-05 00:00:00

  • Population-based study of acquired cerebellar ataxia in Al-Kharga district, New Valley, Egypt.

    abstract:BACKGROUND:The aim of this research was to determine the prevalence and etiology of acquired ataxia in Al-Kharga district, New Valley, Egypt. METHODS:A population-based study of acquired ataxia was conducted in a defined geographical region with a total population of 62,583. A door-to-door survey was used to identify ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S14497

    authors: Farghaly WM,El-Tallawy HN,Shehata GA,Rageh TA,Hakeem NA,Abo-Elfetoh NM

    更新日期:2011-01-01 00:00:00

  • Analysis of HAM-D scores and working ability in an observational study of Japanese patients with major depressive disorder and painful physical symptoms treated with duloxetine or SSRI monotherapy.

    abstract:Objective:To investigate the relationship between Hamilton Depression Rating Scale (HAM-D) score and psychiatrists' judgment of working ability in patients with major depressive disorder (MDD) and painful physical symptoms. Methods:This was a prospective, observational, 12-week study in patients who received duloxetin...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S195445

    authors: Kuga A,Otsubo T,Tsuji T,Hayashi S,Imagawa H,Fujikoshi S,Escobar R

    更新日期:2019-04-05 00:00:00

  • Mental toughness, sleep disturbances, and physical activity in patients with multiple sclerosis compared to healthy adolescents and young adults.

    abstract:BACKGROUND:Multiple sclerosis (MS) is the most common chronic autoimmune demyelinating and inflammatory disease of the central nervous system, afflicting both the body and mind. The risk of suffering from MS is 2.5-3.5 times greater in females than in males. While there is extant research on fatigue, depression, and co...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S111208

    authors: Sadeghi Bahmani D,Gerber M,Kalak N,Lemola S,Clough PJ,Calabrese P,Shaygannejad V,Pühse U,Holsboer-Trachsler E,Brand S

    更新日期:2016-06-27 00:00:00

  • Cortical gyrification in schizophrenia: current perspectives.

    abstract::The cerebral cortex of the human brain has a complex morphological structure consisting of folded or smooth cortical surfaces. These morphological features are referred to as cortical gyrification and are characterized by the gyrification index (GI). A number of cortical gyrification studies have been published using ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章,评审

    doi:10.2147/NDT.S145273

    authors: Matsuda Y,Ohi K

    更新日期:2018-07-19 00:00:00

  • Memory deficit in patients with schizophrenia and posttraumatic stress disorder: relational vs item-specific memory.

    abstract::It has been well established that patients with schizophrenia have impairments in cognitive functioning and also that patients who experienced traumatic events suffer from cognitive deficits. Of the cognitive deficits revealed in schizophrenia or posttraumatic stress disorder (PTSD) patients, the current article provi...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章,评审

    doi:10.2147/NDT.S104384

    authors: Jung W,Lee SH

    更新日期:2016-05-10 00:00:00

  • Clinical features and imaging findings in a case of Capgras syndrome.

    abstract::Capgras syndrome consists of the delusional belief that a person or persons have been replaced by doubles or impostors. It can occur in the context of both psychiatric and organic illness, and seems to be related to lesions of the bifrontal and right limbic and temporal regions. Indeed, magnetic resonance imaging has ...

    journal_title:Neuropsychiatric disease and treatment

    pub_type:

    doi:10.2147/NDT.S47293

    authors: Luca M,Bordone A,Luca A,Patti A,Sortino G,Calandra C

    更新日期:2013-01-01 00:00:00

  • The abnormal activation of D1R/Shp-2 complex involved in levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned Parkinson's rats.

    abstract:Background:Levodopa-induced dyskinesia (LID) is a troublesome problem in the treatment of Parkinson's disease (PD). The mechanisms of LID are still mysterious. Recently, the interaction between Shp-2 and D1 dopamine receptor (D1R) has been identified to be indispensable in the D1R-mediated extracellular signal-regulate...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S162562

    authors: Wu N,Wan Y,Song L,Qi C,Liu Z,Gan J

    更新日期:2018-07-05 00:00:00

  • Ropinirole for the treatment of restless legs syndrome.

    abstract::Dopaminergic agents, anticonvulsants, benzodiazepines, opiates, and iron supplementation comprise the classes of medications commonly used to treat restless legs syndrome (RLS), which is a disorder that is estimated to affect about 1 in 10 individuals worldwide and impacts an affected patient's sleep, mood, daytime fu...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/nedt.2006.2.4.407

    authors: Kushida CA

    更新日期:2006-12-01 00:00:00

  • Post hoc analyses of the impact of previous medication on the efficacy of lisdexamfetamine dimesylate in the treatment of attention-deficit/hyperactivity disorder in a randomized, controlled trial.

    abstract:BACKGROUND:Following the approval of lisdexamfetamine dimesylate (LDX) in several European countries for the treatment of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents with an inadequate response to methylphenidate (MPH) treatment, the aim of the present analysis was to establish the respo...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S68273

    authors: Coghill DR,Banaschewski T,Lecendreux M,Soutullo C,Zuddas A,Adeyi B,Sorooshian S

    更新日期:2014-10-29 00:00:00

  • The association of post-stroke anhedonia with salivary cortisol levels and stroke lesion in hippocampal/parahippocampal region.

    abstract:BACKGROUND:Anhedonia constitutes a coherent construct, with neural correlates and negative clinical impact, independent of depression. However, little is known about the neural correlates of anhedonia in stroke patients. In this study, we investigated the association of post-stroke anhedonia with salivary cortisol leve...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S73722

    authors: Terroni L,Amaro E Jr,Iosifescu DV,Mattos P,Yamamoto FI,Tinone G,Conforto AB,Sobreiro MF,Guajardo VD,De Lucia MC,Moreira AC,Scaff M,Leite CC,Fraguas R

    更新日期:2015-02-03 00:00:00

  • Association between COMT Val158Met and DAT1 polymorphisms and depressive symptoms in the obese population.

    abstract:OBJECTIVES:Depressive symptoms are common among patients with obesity. Abnormalities in dopamine signaling involved in the reward circuit may ensue excessive consumption of food, resulting in obesity and leading to neuropsychiatric disorders such as depression. This study sought to investigate the association of polymo...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S138565

    authors: Bieliński M,Jaracz M,Lesiewska N,Tomaszewska M,Sikora M,Junik R,Kamińska A,Tretyn A,Borkowska A

    更新日期:2017-08-18 00:00:00

  • Whole genome association studies of neuropsychiatric disease: An emerging era of collaborative genetic discovery.

    abstract::Family history, which includes both common environmental and genetic effects, is associated with an increased risk for many neuropsychiatric diseases. Investigators have identified several disease-causing mutations for specific neuropsychiatric disorders that display Mendelian segregation. Such discoveries can lead to...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:

    authors: Keller MA,Gwinn K,Nash J,Horsford J,Zhang R,Rich SS,Corriveau RA

    更新日期:2007-01-01 00:00:00

  • Comparison of treatment outcomes in severe personality disorder patients with or without substance use disorders: a 36-month prospective pragmatic follow-up study.

    abstract:BACKGROUND:Concurrent personality disorder (PD) and substance use disorder (SUD) are common in clinical practice. However, SUD is the main criterion for study exclusion in most psychotherapeutic studies of PD. As a result, data on treatment outcomes in patients with concurrent PD/SUD are scarce. METHODS:The study samp...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/NDT.S106270

    authors: Lana F,Sánchez-Gil C,Adroher ND,Pérez V,Feixas G,Martí-Bonany J,Torrens M

    更新日期:2016-06-21 00:00:00

  • Mycophenolate mofetil for myasthenia gravis: a clear and present controversy.

    abstract::Mycophenolate mofetil (MMF) has been used to treat myasthenia gravis (MG) for over 10 years. MMF's use in the MG population stems from its theoretical mechanism of action and the medical literature that supports its benefit in MG patients. Recently, two large, double-blinded, placebo-controlled, randomized clinical tr...

    journal_title:Neuropsychiatric disease and treatment

    pub_type: 杂志文章

    doi:10.2147/ndt.s3309

    authors: Heatwole C,Ciafaloni E

    更新日期:2008-12-01 00:00:00

  • Normal pressure hydrocephalus co-existing with a second dementia disorder.

    abstract::An 87-year-old woman had both Lewy body dementia and normal pressure hydrocephalus simultaneously. One should not automatically exclude the possibility of normal pressure hydrocephalus simply because another neurodegenerative disorder is present, especially if the second disorder masks typical symptoms of normal press...

    journal_title:Neuropsychiatric disease and treatment

    pub_type:

    doi:10.2147/ndt.s2027

    authors: Alisky J

    更新日期:2008-02-01 00:00:00