Abstract:
BACKGROUND:In primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) fatigue is a major clinical problem. Abnormal amino acid (AA) patterns have been implicated in the development of fatigue in several non-hepatological conditions but for PBC and PSC no data are available. This study aimed to identify abnormalities in AA patterns and to define their relation with fatigue. METHODS:Plasma concentrations of tyrosine, tryptophan, phenylalanine, valine, leucine and isoleucine were determined in plasma of patients with PBC (n = 45), PSC (n = 27), chronic hepatitis C (n = 22) and healthy controls (n = 73). Fatigue and quality of life were quantified using the Fisk fatigue severity scale, a visual analogue scale and the SF-36. RESULTS:Valine, isoleucine, leucine were significantly decreased in PBC and PSC. Tyrosine and phenylalanine were increased (p < 0.0002) and tryptophan decreased (p < 0.0001) in PBC. In PBC, but not in PSC, a significant inverse relation between tyrosine concentrations and fatigue and quality of life was found. Patients without fatigue and with good quality of life had increased tyrosine concentrations compared to fatigued patients. Multivariate analysis indicated that this relation was independent from disease activity or severity or presence of cirrhosis. CONCLUSION:In patients with PBC and PSC, marked abnormalities in plasma AA patterns occur. Normal tyrosine concentrations, compared to increased concentrations, may be associated with fatigue and diminished quality of life.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
ter Borg PC,Fekkes D,Vrolijk JM,van Buuren HRdoi
10.1186/1471-230X-5-11keywords:
subject
Has Abstractpub_date
2005-03-24 00:00:00pages
11issn
1471-230Xpii
1471-230X-5-11journal_volume
5pub_type
杂志文章abstract:BACKGROUND:Rumination syndrome (RS) is a functional gastrointestinal disorder (FGD) increasingly recognized in children and adolescents. The epidemiology of this condition in school aged children is poorly understood. The main objective of this study was to assess the prevalence of rumination and other related associat...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-163
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journal_title:BMC gastroenterology
pub_type: 杂志文章
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pub_type: 杂志文章
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doi:10.1186/s12876-018-0781-3
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pub_type: 杂志文章
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journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,meta分析
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journal_title:BMC gastroenterology
pub_type: 杂志文章
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更新日期:2008-03-01 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
doi:10.1186/1471-230X-13-95
更新日期:2013-05-27 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12876-016-0533-1
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-07-28 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章
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pub_type: 信件
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更新日期:2009-12-14 00:00:00
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pub_type: 杂志文章
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journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-016-0543-z
更新日期:2016-10-07 00:00:00
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journal_title:BMC gastroenterology
pub_type: 临床试验,杂志文章
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更新日期:2008-08-27 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究
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更新日期:2019-12-02 00:00:00