The relation between plasma tyrosine concentration and fatigue in primary biliary cirrhosis and primary sclerosing cholangitis.

Abstract:

BACKGROUND:In primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) fatigue is a major clinical problem. Abnormal amino acid (AA) patterns have been implicated in the development of fatigue in several non-hepatological conditions but for PBC and PSC no data are available. This study aimed to identify abnormalities in AA patterns and to define their relation with fatigue. METHODS:Plasma concentrations of tyrosine, tryptophan, phenylalanine, valine, leucine and isoleucine were determined in plasma of patients with PBC (n = 45), PSC (n = 27), chronic hepatitis C (n = 22) and healthy controls (n = 73). Fatigue and quality of life were quantified using the Fisk fatigue severity scale, a visual analogue scale and the SF-36. RESULTS:Valine, isoleucine, leucine were significantly decreased in PBC and PSC. Tyrosine and phenylalanine were increased (p < 0.0002) and tryptophan decreased (p < 0.0001) in PBC. In PBC, but not in PSC, a significant inverse relation between tyrosine concentrations and fatigue and quality of life was found. Patients without fatigue and with good quality of life had increased tyrosine concentrations compared to fatigued patients. Multivariate analysis indicated that this relation was independent from disease activity or severity or presence of cirrhosis. CONCLUSION:In patients with PBC and PSC, marked abnormalities in plasma AA patterns occur. Normal tyrosine concentrations, compared to increased concentrations, may be associated with fatigue and diminished quality of life.

journal_name

BMC Gastroenterol

journal_title

BMC gastroenterology

authors

ter Borg PC,Fekkes D,Vrolijk JM,van Buuren HR

doi

10.1186/1471-230X-5-11

keywords:

subject

Has Abstract

pub_date

2005-03-24 00:00:00

pages

11

issn

1471-230X

pii

1471-230X-5-11

journal_volume

5

pub_type

杂志文章
  • Rumination syndrome in children and adolescents: a school survey assessing prevalence and symptomatology.

    abstract:BACKGROUND:Rumination syndrome (RS) is a functional gastrointestinal disorder (FGD) increasingly recognized in children and adolescents. The epidemiology of this condition in school aged children is poorly understood. The main objective of this study was to assess the prevalence of rumination and other related associat...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-12-163

    authors: Rajindrajith S,Devanarayana NM,Crispus Perera BJ

    更新日期:2012-11-16 00:00:00

  • Remifentanil ameliorates intestinal ischemia-reperfusion injury.

    abstract:BACKGROUND:Intestinal ischemia-reperfusion injury (IRI) can occur in clinical scenarios such as organ transplantation, trauma and cardio-pulmonary bypass, as well as in neonatal necrotizing enterocolitis or persistent ductus arteriosus. Pharmacological protection by pretreating ("preconditioning") with opioids attenuat...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-13-69

    authors: Cho SS,Rudloff I,Berger PJ,Irwin MG,Nold MF,Cheng W,Nold-Petry CA

    更新日期:2013-04-22 00:00:00

  • The prevalence, incidence and natural history of primary sclerosing cholangitis in an ethnically diverse population.

    abstract:BACKGROUND:Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic liver disease often associated with inflammatory bowel diseases (IBD). Current epidemiological data are limited to studies of predominantly Caucasian populations. Our aim was to define the epidemiology of PSC in a large, ethnically diverse US...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-11-83

    authors: Toy E,Balasubramanian S,Selmi C,Li CS,Bowlus CL

    更新日期:2011-07-18 00:00:00

  • Hypophosphataemia after ferric carboxymaltose is unrelated to symptoms, intestinal inflammation or vitamin D status.

    abstract:BACKGROUND:Intravenous iron replacement is recommended for iron-deficient patients with inflammatory bowel disease (IBD), but may be associated with hypophosphataemia, predisposing to osteomalacia and fractures. This study aimed to evaluate the incidence and risk factors for hypophosphataemia following intravenous ferr...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01298-9

    authors: Fang W,Kenny R,Rizvi QU,McMahon LP,Garg M

    更新日期:2020-06-10 00:00:00

  • Wirsung atraumatic rupture in patient with pancreatic pseudocysts: a case presentation.

    abstract:BACKGROUND:Pancreatic duct disruption is a challenging condition leading to pancreatic juice leakage and consequently to pancreatic fluid collections. The manifestations of pancreatic main duct leak include pseudocysts, walled-off necrosis, pancreatic fistulas, ascites, pleural and pericardial effusions. Pseudocyst for...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-018-0781-3

    authors: Gerosa M,Chiarelli M,Guttadauro A,De Simone M,Tagliabue F,Costa M,Terragni S,Cioffi U

    更新日期:2018-04-23 00:00:00

  • GDNF protects enteric glia from apoptosis: evidence for an autocrine loop.

    abstract:BACKGROUND:Enteric glia cells (EGC) play an important role in the maintenance of intestinal mucosa integrity. During the course of acute Crohn's disease (CD), mucosal EGC progressively undergo apoptosis, though the mechanisms are largely unknown. We investigated the role of Glial-derived neurotrophic factor (GDNF) in t...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-12-6

    authors: Steinkamp M,Gundel H,Schulte N,Spaniol U,Pflueger C,Zizer E,von Boyen GB

    更新日期:2012-01-17 00:00:00

  • Diagnostic sensitivity of carbohydrate deficient transferrin in heavy drinkers.

    abstract:BACKGROUND AND AIM:Carbohydrate deficient transferrin (CDT) is the most specific serum biomarker of heavy alcohol consumption, defined as ≥ 350-420 g alcohol/week. Despite introduction of a standardized reference measurement technique, widespread use of CDT remains limited due to low sensitivity. The aim of this study ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-14-97

    authors: Fagan KJ,Irvine KM,McWhinney BC,Fletcher LM,Horsfall LU,Johnson L,O'Rourke P,Martin J,Scott I,Pretorius CJ,Ungerer JP,Powell EE

    更新日期:2014-05-22 00:00:00

  • Comparison of sequential therapy and amoxicillin/tetracycline containing bismuth quadruple therapy for the first-line eradication of Helicobacter pylori: a prospective, multi-center, randomized clinical trial.

    abstract:BACKGROUND:The <80 % Helicobacter pylori eradication rate with sequential therapy is unsatisfactory. Modified bismuth quadruple therapy, replacing metronidazole with amoxicillin, could be promising because H. pylori resistance to tetracycline or to amoxicillin is relatively low. A 14-day modified bismuth quadruple prot...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/s12876-016-0490-8

    authors: Lee JY,Kim N,Park KS,Kim HJ,Park SM,Baik GH,Shim KN,Oh JH,Choi SC,Kim SE,Kim WH,Park SY,Kim GH,Lee BE,Jo Y,Hong SJ

    更新日期:2016-07-26 00:00:00

  • Leukocytoclastic vasculitis as a rare dermatologic manifestation of Crohn's disease mimicking cellulitis: a case report.

    abstract:BACKGROUND:Leukocytoclastic vasculitis (LCV) is an immune-complex mediated vasculitis characterized by neutrophilic inflammation and nuclear debris in post capillary venules. LCV is a rare dermatologic manifestation of Crohn's disease (CD) and may occur with the onset of the disease or any time after the diagnosis incl...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01371-3

    authors: Buck M,Dumic I,McDermott W,Nordstrom C,Dawan S,Virata A,Martin S,Hudson A,Milovanovic T,Nordin T

    更新日期:2020-07-29 00:00:00

  • Acute cholestasis as uncommon onset of Kawasaki disease: a case report.

    abstract:BACKGROUND:Kawasaki disease (KD) or mucocutaneous lymph node syndrome is a vasculitis that mostly occurs in young children. Adult-onset KD (AKD) is rare and often misdiagnosed. Here we report a rare case of KD with cholestasis as principal symptom. CASE PRESENTATION:A 43-year-old caucasian man was admitted to our hosp...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01495-6

    authors: Gallerani M,Pala M,Fabbian F,De Giorgi A

    更新日期:2020-10-28 00:00:00

  • The overmethylated genes in Helicobacter pylori-infected gastric mucosa are demethylated in gastric cancers.

    abstract:BACKGROUND:The transitional-CpG sites between weakly methylated genes and densely methylated retroelements are overmethylated in the gastric mucosa infected with Helicobacter pylori (H. pylori) and they are undermethylated in the gastric cancers depending on the level of loss of heterozygosity (LOH) events. This study ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-10-137

    authors: Hong SJ,Oh JH,Jeon EJ,Min KO,Kang MI,Choi SW,Rhyu MG

    更新日期:2010-11-20 00:00:00

  • Effect of antecolic or retrocolic reconstruction of the gastro/duodenojejunostomy on delayed gastric emptying after pancreaticoduodenectomy: a meta-analysis.

    abstract:BACKGROUND:Delayed gastric emptying (DGE) is one of the most frequent complications after pancreaticoduodenectomy (PD). This meta-analysis aimed to evaluate the effect of antecolic versus retrocolic reconstruction of gastro/duodenojejunostomy on DGE after PD. METHODS:Randomized controlled trials (RCTs) comparing antec...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12876-015-0300-8

    authors: Zhou Y,Lin J,Wu L,Li B,Li H

    更新日期:2015-06-16 00:00:00

  • A self administered reliable questionnaire to assess lower bowel symptoms.

    abstract:BACKGROUND:Bowel symptoms are considered indicators of the presence of colorectal cancer and other bowel diseases. Self administered questionnaires that elicit information about lower bowel symptoms have not been assessed for reliability, although this has been done for upper bowel symptoms. Our aim was to develop a se...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-8-8

    authors: Adelstein BA,Irwig L,Macaskill P,Katelaris PH,Jones DB,Bokey L

    更新日期:2008-03-01 00:00:00

  • Unsedated peroral wireless pH capsule placement vs. standard pH testing: a randomized study and cost analysis.

    abstract:BACKGROUND:Wireless capsule pH-metry (WC) is better tolerated than standard nasal pH catheter (SC), but endoscopic placement is expensive. AIMS:to confirm that non-endoscopic peroral manometric placement of WC is as effective and better tolerated than SC and to perform a cost analysis of the available esophageal pH-me...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/1471-230X-12-58

    authors: Andrews CN,Sadowski DC,Lazarescu A,Williams C,Neshev E,Storr M,Au F,Heitman SJ

    更新日期:2012-05-31 00:00:00

  • The characteristics of nivolumab-induced colitis: an evaluation of three cases and a literature review.

    abstract:BACKGROUND:The use of immune-checkpoint inhibitors in cancer treatment has become increasingly common, resulting in an increase in the incidence of related side effects. Diarrhoea and colitis have been previously documented as gastrointestinal tract-related side effects of immune-checkpoint inhibitors. Although PD-1/PD...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1186/s12876-018-0864-1

    authors: Yamauchi R,Araki T,Mitsuyama K,Tokito T,Ishii H,Yoshioka S,Kuwaki K,Mori A,Yoshimura T,Tsuruta O,Torimura T

    更新日期:2018-08-31 00:00:00

  • A multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data.

    abstract:BACKGROUND:Intussusception (IS) is a form of acute intestinal obstruction that occurs mainly in infants and is usually of unknown cause. An association between IS and the first licensed rotavirus vaccine, a reassortant-tetravalent, rhesus-based rotavirus vaccine (RRV-TV), led to the withdrawal of the vaccine. New rotav...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-13-95

    authors: Sáez-Llorens X,Velázquez FR,Lopez P,Espinoza F,Linhares AC,Abate H,Nuñez E,Venegas G,Vergara R,Jimenez AL,Rivera M,Aranza C,Richardson V,Macias-Parra M,Palacios GR,Rivera L,Ortega-Barria E,Cervantes Y,Rüttimann R,Ru

    更新日期:2013-05-27 00:00:00

  • Collagenous colitis presenting as spontaneous perforation in an 80 year old woman: Report of a Case.

    abstract:BACKGROUND:Perforation of the colon occurring during or shortly following colonoscopy or barium enema is a rare complication of collagenous colitis (CC). "Spontaneous" perforation in CC, in which no instigating factor is identified, is even less common, with only five cases reported to date. We report herein an additio...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-016-0533-1

    authors: Mitchell A,Dugas A

    更新日期:2016-10-06 00:00:00

  • Steroid-refractory ulcerative colitis treated with corticosteroids, metronidazole and vancomycin: a case report.

    abstract:BACKGROUND:Increasing evidence elucidating the pathogenic mechanisms of ulcerative colitis (UC) has accumulated and the disease is widely assumed to be the consequence of genetic susceptibility and an abnormal immune response to commensal bacteria. However evidence regarding an infectious etiology in UC remains elusive...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-5-3

    authors: Miner J,Gillan MM,Alex P,Centola M

    更新日期:2005-01-24 00:00:00

  • Sulphite oxidase (SO) - a mitochondrial autoantigen as target for humoral and cellular immune reactions in primary sclerosing cholangitis.

    abstract:BACKGROUND:In a recent study we had evidence that sulphite oxidase (SO) may be a relevant autoantigen in primary sclerosing cholangitis (PSC). Aim of the present study was, therefore, to analyse humoral and cellular immune-reactivity towards SO in these patients in more detail. METHODS:Sera from 53 patients with PSC (...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-018-0787-x

    authors: Preuß BE,Berg CP,Werner C,Plankenhorn S,Malek NP,Klein R

    更新日期:2018-05-02 00:00:00

  • Desmoid tumors complicating Familial Adenomatous Polyposis: a meta-analysis mutation spectrum of affected individuals.

    abstract:BACKGROUND:Desmoid tumors are a group of benign, invasive, solid tumors that are relatively rare in the general population, but can occur in up to 21 % of patients with Familial Adenomatous Polyposis (FAP). They can be difficult to treat and have high rates of recurrence even after resection. Our goal with this study w...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12876-015-0306-2

    authors: Slowik V,Attard T,Dai H,Shah R,Septer S

    更新日期:2015-07-16 00:00:00

  • Peritumoral ductular reaction can be a prognostic factor for intrahepatic cholangiocarcinoma.

    abstract:BACKGROUND:Peritumoral ductular reaction (DR) was reported to be related to the prognosis of combined hepatocellular-cholangiocarcinoma and hepatocellular carcinoma. Non-mucin-producing intrahepatic cholangiocarcinoma (ICC) which may be derived from small bile duct cells or liver progenitor cells (LPCs) was known to us...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01471-0

    authors: Shen Z,Xiao J,Wang J,Lu L,Wan X,Cai X

    更新日期:2020-10-02 00:00:00

  • Endoscopic stent placement above the sphincter of Oddi for biliary strictures after living donor liver transplantation.

    abstract:BACKGROUND:Endoscopic balloon dilation and/or plastic stent placement has been a standard method for treating biliary strictures complicated post living donor liver transplantation (LDLT). The strictures may be refractory to endoscopic treatment and require long-term stent placement. However, consensus on the optimal p...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-020-01226-x

    authors: Koizumi M,Kumagi T,Kuroda T,Imamura Y,Kanemitsu K,Ogawa K,Takada Y,Hiasa Y

    更新日期:2020-04-06 00:00:00

  • Faecal calprotectin level for assessing endoscopic activity and predicting future clinical course in patients with moderately active ulcerative colitis undergoing granulomonocytapheresis: a prospective cohort study.

    abstract:BACKGROUND:Calprotectin is a stable neutrophil protein, which can be measured in faecal samples. The faecal level of calprotectin increases during disease activity in ulcerative colitis (UC). Nonetheless, the relevance of faecal calprotectin (FC) measurement during granulomonocytapheresis (GMA) for UC has not yet been ...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-018-0853-4

    authors: Shimoyama T,Yamamoto T,Umegae S,Matsumoto K

    更新日期:2018-08-01 00:00:00

  • Access to primary care is associated with better autoimmune hepatitis outcomes in an urban county hospital.

    abstract:BACKGROUND:Autoimmune hepatitis causes chronic hepatitis and often leads to cirrhosis and death without treatment. We wanted to see if having access to primary care or insurance prior to diagnosis is associated with better outcomes for patients in an urban, public hospital with mostly socioeconomically disadvantaged Hi...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-015-0318-y

    authors: Kim D,Eshtiaghpour D,Alpern J,Datta A,Eysselein VE,Yee HF

    更新日期:2015-07-28 00:00:00

  • Validation of the BARD scoring system in Polish patients with nonalcoholic fatty liver disease (NAFLD).

    abstract:BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) includes a wide spectrum of liver diseases, ranging from pure steatosis to nonalcoholic steatohepatitis (NASH), and eventually to liver cirrhosis with its complications. Identifying advanced fibrosis in patients is crucial to evaluating prognosis and possible therapeu...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/1471-230X-10-67

    authors: Raszeja-Wyszomirska J,Szymanik B,Ławniczak M,Kajor M,Chwist A,Milkiewicz P,Hartleb M

    更新日期:2010-06-28 00:00:00

  • A proposal for a new clinical classification of chronic pancreatitis.

    abstract:BACKGROUND:The clinical course of chronic pancreatitis is still unpredictable, which relates to the lack of the availability of a clinical classification. Therefore, patient populations cannot be compared, the course and the outcome of the disease remain undetermined in the individual patient, and treatment is not stan...

    journal_title:BMC gastroenterology

    pub_type: 信件

    doi:10.1186/1471-230X-9-93

    authors: Büchler MW,Martignoni ME,Friess H,Malfertheiner P

    更新日期:2009-12-14 00:00:00

  • Case report of cryptogenic multifocal ulcerous stenosing enteritis (CMUSE): a rare disease may contribute to endoscopy-capsule retention in the small intestine.

    abstract:BACKGROUND:CMUSE is a rare disease whose diagnosis remains difficult because the lesion is confined to the small bowel. CASE PRESENTATION:Here, we present a case of 43-year-old female patient suffered chronic abdominal pain for 20 years, and finally diagnosed with CMUSE. Capsule endoscopy was performed when general en...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-019-0962-8

    authors: Tao EW,Zou TH,Wang YF,Tang JT,Chen YX,Gao QY

    更新日期:2019-04-03 00:00:00

  • Role of vitamin D3 combined to alginates in preventing acid and oxidative injury in cultured gastric epithelial cells.

    abstract:BACKGROUND:Gastric diseases are a worldwide problem in modern society, as reported in the USA, in the range of 0.5-2 episodes/year/person and an incidence of 5-100 episodes/1000/week according to seasons and age. There is convincing evidence that oxidative stress is involved in the pathogenesis of acute gastric injury....

    journal_title:BMC gastroenterology

    pub_type: 杂志文章

    doi:10.1186/s12876-016-0543-z

    authors: Uberti F,Bardelli C,Morsanuto V,Ghirlanda S,Molinari C

    更新日期:2016-10-07 00:00:00

  • Haemodynamic effects of plasma-expansion with hyperoncotic albumin in cirrhotic patients with renal failure: a prospective interventional study.

    abstract:BACKGROUND:Patients with advanced cirrhosis of the liver typically display circulatory disturbance. Haemodynamic management may be critical for avoiding and treating functional renal failure in such patients. This study investigated the effects of plasma expansion with hyperoncotic albumin solution and the role of stat...

    journal_title:BMC gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1186/1471-230X-8-39

    authors: Umgelter A,Wagner K,Reindl W,Nurtsch N,Huber W,Schmid RM

    更新日期:2008-08-27 00:00:00

  • Indications for adjuvant chemotherapy in patients with AJCC stage IIa T3N0M0 and T1N2M0 gastric cancer-an east and west multicenter study.

    abstract:PURPOSE:To determine the indications for adjuvant chemotherapy (AC) in patients with stage IIa gastric cancer (T3N0M0 and T1N2M0) according to the 7th American Joint Committee on Cancer (AJCC). METHODS:A total of 1593 patients with T3N0M0 or T1N2M0 stage gastric cancer were identified from the Surveillance, Epidemiolo...

    journal_title:BMC gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12876-019-1096-8

    authors: Huang ZN,Desiderio J,Chen QY,Zheng CH,Li P,Xie JW,Wang JB,Lin JX,Lu J,Cao LL,Lin M,Tu RH,Lin JL,Zheng HL,Huang CM

    更新日期:2019-12-02 00:00:00