Abstract:
BACKGROUND:The use of immune-checkpoint inhibitors in cancer treatment has become increasingly common, resulting in an increase in the incidence of related side effects. Diarrhoea and colitis have been previously documented as gastrointestinal tract-related side effects of immune-checkpoint inhibitors. Although PD-1/PD-L1 inhibitors produce fewer side effects than CTLA-4 inhibitors, diarrhoea and colitis continue to be reported. However, little is known about the endoscopic features associated with PD-1/PD-L1 inhibitors. In this report, we describe three cases of colitis induced by a PD-1 inhibitor nivolumab. These cases showed endoscopic findings characteristic of ulcerative colitis (UC). Treatment was in accordance with UC therapy, which resulted in beneficial outcomes. CASE PRESENTATION:Three patients with lung cancer treated with nivolumab presented with diarrhoea with (case 2) or without haematochezia (cases 1 and 3). Treatment with nivolumab was ceased and colonoscopy was performed, revealing endoscopic features similar to those of UC. These patients were diagnosed with nivolumab-induced colitis. Case 1 was treated with mesalazine, whereas cases 2 and 3 were treated with corticosteroids. Subsequently, their symptoms improved. CONCLUSIONS:Nivolumab-induced colitis exhibited similar characteristics to UC. Treatment was similar to that for UC and was successful.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Yamauchi R,Araki T,Mitsuyama K,Tokito T,Ishii H,Yoshioka S,Kuwaki K,Mori A,Yoshimura T,Tsuruta O,Torimura Tdoi
10.1186/s12876-018-0864-1subject
Has Abstractpub_date
2018-08-31 00:00:00pages
135issue
1issn
1471-230Xpii
10.1186/s12876-018-0864-1journal_volume
18pub_type
杂志文章,评审abstract:BACKGROUND:Treatment effectiveness of Helicobacter pylori varies regionally and is decreasing worldwide, principally as a result of antibiotic resistant bacterium. Tetracycline is generally included in second line H. pylori eradication regimens. In Brazil, a high level of tetracycline resistance (TetR) is mainly associ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-49
更新日期:2012-05-17 00:00:00
abstract:BACKGROUND:Acute pancreatitis is the most common complication of diagnostic and therapeutic endoscopic retrograde cholangiopancreatography (ERCP). In spite of continuing research, no pharmacologic agent capable of effectively reducing the incidence of ERCP-induced pancreatitis has found its way into clinical practise. ...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-230X-13-11
更新日期:2013-01-15 00:00:00
abstract:BACKGROUND:Patients with familial adenomatous polyposis (FAP) frequently undergo colectomy to reduce the 70 to 90% lifetime risk of colorectal cancer. After risk-reducing colectomy, duodenal cancer and complications from duodenal surgeries are the main cause of morbidity. Our objective was to prospectively describe the...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-018-0841-8
更新日期:2018-07-16 00:00:00
abstract:BACKGROUND:Transient elastography (TE) is an innovative, noninvasive technique to assess liver fibrosis by measuring liver stiffness in patients with chronic liver diseases. The purpose of this study has been to explore the accuracy of TE and clinical parameters in predicting the presence of esophageal/gastric varices ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-11-41
更新日期:2011-04-18 00:00:00
abstract:BACKGROUND:Recent studies have shown that bile acids (BAs) are closely related to metabolic and inflammatory diseases. Our study aimed to investigate whether circulating total bile acid (TBA) levels were associated with the severity of acute pancreatitis (AP). METHODS:We retrospectively collected data on patients diag...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01243-w
更新日期:2020-07-13 00:00:00
abstract:BACKGROUND:Current literature has demonstrated that host glutamine depletion facilitates tumorigenesis. Likewise, the glutamine transporter SLC38A1 is putatively associated with malignant transformation and tumor progression. Taken together, this forms the premise for undertaking the current study. The twofold aim of t...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-14-70
更新日期:2014-04-09 00:00:00
abstract:PURPOSE:To determine the indications for adjuvant chemotherapy (AC) in patients with stage IIa gastric cancer (T3N0M0 and T1N2M0) according to the 7th American Joint Committee on Cancer (AJCC). METHODS:A total of 1593 patients with T3N0M0 or T1N2M0 stage gastric cancer were identified from the Surveillance, Epidemiolo...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12876-019-1096-8
更新日期:2019-12-02 00:00:00
abstract:BACKGROUND:The rate of H. pylori infection in Vietnam is reportedly high, but the spectrum of H. pylori-associated gastroduodenal diseases has not been systematically investigated. Moreover, despite the similarities of ethnicity and diet, the age-standardized incidence rate of gastric cancer in the northern city of Han...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-230X-10-114
更新日期:2010-09-30 00:00:00
abstract:BACKGROUND:Benign biliary strictures may be a consequence of surgical procedures, chronic pancreatitis or iatrogenic injuries to the ampulla. Stents are increasingly being used for this indication, however it is not completely clear which stent type should be preferred. METHODS:A systematic review on stent placement f...
journal_title:BMC gastroenterology
pub_type: 杂志文章,评审
doi:10.1186/1471-230X-9-96
更新日期:2009-12-17 00:00:00
abstract:BACKGROUND:Capsule endoscopy (CE) is the preferred diagnostic test of choice in the investigation of obscure gastrointestinal bleeding (OGIB). Although, a conservative strategy is recommended in the short-term, for cases with a negative result from CE, the impact of CE on long-term re-bleeding still remains unclear. He...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-1137-3
更新日期:2019-12-16 00:00:00
abstract:BACKGROUND:Patients often experience severe weight loss after oesophagectomy. Enteral nutrition via a feeding jejunostomy tube (FT) is commonly practised. This study aimed to assess the effect of severe weight loss postoperatively and enteral nutrition via an FT on long-term prognosis after oesophagectomy. METHODS:Thi...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01543-1
更新日期:2020-12-03 00:00:00
abstract:BACKGROUND:Kawasaki disease (KD) or mucocutaneous lymph node syndrome is a vasculitis that mostly occurs in young children. Adult-onset KD (AKD) is rare and often misdiagnosed. Here we report a rare case of KD with cholestasis as principal symptom. CASE PRESENTATION:A 43-year-old caucasian man was admitted to our hosp...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01495-6
更新日期:2020-10-28 00:00:00
abstract:BACKGROUND:Carrageenan is a traditional ingredient that has been widely used in the food industry. In the present study, we propose a hypothesis that carrageenan is a conditional inflammatory agent. When the intestinal tract is in an "unhealthy" state such as that during bacterial infection or acute inflammation, carra...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-016-0459-7
更新日期:2016-03-25 00:00:00
abstract:BACKGROUND:The <80 % Helicobacter pylori eradication rate with sequential therapy is unsatisfactory. Modified bismuth quadruple therapy, replacing metronidazole with amoxicillin, could be promising because H. pylori resistance to tetracycline or to amoxicillin is relatively low. A 14-day modified bismuth quadruple prot...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12876-016-0490-8
更新日期:2016-07-26 00:00:00
abstract:BACKGROUND:Polyethylene glycol is commonly used to manage constipation and is available with or without electrolytes. The addition of electrolytes dates back to its initial development as lavage solutions in preparation for gastrointestinal interventions. The clinical utility of the addition of electrolytes to polyethy...
journal_title:BMC gastroenterology
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12876-016-0457-9
更新日期:2016-03-31 00:00:00
abstract:BACKGROUND:Intestinal metaplasia (IM) is an important precursor lesion in the development of gastric cancer (GC). The aim of this study was to investigate genetic factors previously linked to GC risk for their possible association with IM. A total of 18 polymorphisms in 14 candidate genes were evaluated in a Singapore-...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-9-76
更新日期:2009-10-13 00:00:00
abstract:BACKGROUND:The aims of this study were to assess the prevalence of hepatitis C virus (HCV) infection in Japanese patients with oral lichen planus and identify the impact of amino acid (aa) substitutions in the HCV core region and IFN-sensitivity-determining region (ISDR) of nonstructural protein 5A (NS5A) associated wi...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-31
更新日期:2012-04-10 00:00:00
abstract:BACKGROUND:A tenth of patients with involuntary weight loss (IWL) have gastrointestinal cancer. Ferritin is the first parameter to be modified during the process leading to iron deficiency anaemia, therefore it should be the most sensitive. The aim of this study was to assess the ability of ferritin to rule out gastroi...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-86
更新日期:2012-07-09 00:00:00
abstract:BACKGROUND:The transitional-CpG sites between weakly methylated genes and densely methylated retroelements are overmethylated in the gastric mucosa infected with Helicobacter pylori (H. pylori) and they are undermethylated in the gastric cancers depending on the level of loss of heterozygosity (LOH) events. This study ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-10-137
更新日期:2010-11-20 00:00:00
abstract:BACKGROUND:Adult lactase non-persistence (LNP) is due to low lactase expression, resulting in lactose malabsorption (LM). LNP is a genetic trait, but is typically determined by LM markers including breath H2, blood glucose, and urinary galactose after a lactose tolerance test. Known validity of these markers using milk...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01352-6
更新日期:2020-06-29 00:00:00
abstract:BACKGROUND:Feeding related peptides have been shown to be additionally involved in the central autonomic control of gastrointestinal functions. Recent studies have shown that ghrelin, a stomach-derived orexigenic peptide, is involved in the autonomic regulation of GI function besides feeding behavior. Pharmacological e...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-5-5
更新日期:2005-02-18 00:00:00
abstract:BACKGROUND:Real-world comparisons of biologic treatment outcomes for ulcerative colitis (UC) or Crohn's disease (CD) patients are limited. We sought to evaluate the real-world effectiveness of vedolizumab (VDZ) and anti-tumor necrosis factor alpha (anti-TNFα) in UC and CD patients in Germany. METHODS:A retrospective c...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01332-w
更新日期:2020-07-08 00:00:00
abstract:BACKGROUND:The evidence on the role of gut microbiota in post-infectious irritable bowel syndrome (PI-IBS) is convincing. Lactobacillus spp. positively affect IBS symptoms, although the mechanisms through which probiotics exert their beneficial effects are largely unknown. The aim of the study is to evaluate the role o...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-017-0605-x
更新日期:2017-04-14 00:00:00
abstract:BACKGROUND:Microcirculatory disturbance is an important factor in the pathogenesis of Inflammatory Bowel Disease (IBD) but there have been few studies in this field. Confocal Laser Endomicroscopy (CLE) has been used over the last 10 years and has made it possible to explore the changes in microcirculation of the coloni...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-1037-6
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Faecal calprotectin (FC) is one of the most widely used non-invasive tests for the diagnosis and assessment of Crohn's disease (CD) activity. Despite this, factors other than disease activity which affect levels have not been extensively reviewed. This is of importance when using FC in the diagnostic setting...
journal_title:BMC gastroenterology
pub_type: 杂志文章,评审
doi:10.1186/s12876-016-0535-z
更新日期:2016-10-07 00:00:00
abstract:BACKGROUND:It is unknown whether narrow-band imaging (NBI) could be more effective than high-definition white-light endoscopy (HD-WLE) in detecting serrated lesions in patients with prior serrated lesions > 5 mm not completely fulfilling serrated polyposis syndrome (SPS) criteria. METHODS:We conducted a randomized, cr...
journal_title:BMC gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12876-020-01257-4
更新日期:2020-04-16 00:00:00
abstract:BACKGROUND:Diminished bone mineral density (BMD) is of significant concern in pediatric inflammatory bowel disease (IBD). Exact etiology is debatable. The recognition of fibroblast growth factor 23 (FGF23), a phosphaturic hormone related to tumor necrosis factor alpha (TNF-α) makes it plausible to hypothesize its possi...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-44
更新日期:2012-05-02 00:00:00
abstract:BACKGROUND:The mortality due to hemorrhage of esophageal varices (EV) is still high. The predominant cause for EV is liver cirrhosis, which has a high prevalence in Western Europe. Therefore, non-invasive screening markers for the presence of EV are of interest. Here, we aim to investigate whether non-inflammatory gall...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-018-0852-5
更新日期:2018-08-02 00:00:00
abstract:BACKGROUND:Efficacy of maintenance therapy in ulcerative colitis (UC) in the remission stage has been reported to depend on release profile or dosing regimen of oral 5-aminosalicylic acid (5-ASA) products used. Aim of this study is to investigate real life results in using oral 5-ASA products for maintaining mild to mo...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12876-017-0604-y
更新日期:2017-04-04 00:00:00
abstract:BACKGROUND:Diet may play a role in disease status in patients with inflammatory bowel disease. We tested whether the inflammatory potential of diet, based on a summation of pro- and anti-inflammatory nutrients, is associated with disease activity in patients with Crohn's disease and ulcerative colitis. METHODS:Partici...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01435-4
更新日期:2020-09-29 00:00:00