Abstract:
:Adverse drug reaction (ADR) risk-prediction models for use in older adults have been developed, but it is not clear if they are suitable for use in clinical practice. This systematic review aimed to identify and investigate the quality of validated ADR risk-prediction models for use in older adults. Standard computerized databases, the gray literature, bibliographies, and citations were searched (2012) to identify relevant peer-reviewed studies. Studies that developed and validated an ADR prediction model for use in patients over 65 years old, using a multivariable approach in the design and analysis, were included. Data were extracted and their quality assessed by independent reviewers using a standard approach. Of the 13,423 titles identified, only 549 were associated with adverse outcomes of medicines use. Four met the inclusion criteria. All were conducted in inpatient cohorts in Western Europe. None of the models satisfied the four key stages in the creation of a quality risk prediction model; development and validation were completed, but impact and implementation were not assessed. Model performance was modest; area under the receiver operator curve ranged from 0.623 to 0.73. Study quality was difficult to assess due to poor reporting, but inappropriate methods were apparent. Further work needs to be conducted concerning the existing models to enable the development of a robust ADR risk-prediction model that is externally validated, with practical design and good performance. Only then can implementation and impact be assessed with the aim of generating a model of high enough quality to be considered for use in clinical care to prioritize older people at high risk of suffering an ADR.
journal_name
Clin Interv Agingjournal_title
Clinical interventions in agingauthors
Stevenson JM,Williams JL,Burnham TG,Prevost AT,Schiff R,Erskine SD,Davies JGdoi
10.2147/CIA.S65475subject
Has Abstractpub_date
2014-09-19 00:00:00pages
1581-93eissn
1176-9092issn
1178-1998pii
cia-9-1581journal_volume
9pub_type
杂志文章,评审abstract:BACKGROUND:Life style and physical activity play a pivotal role in prevention and treatment of osteoporosis. The mechanism for better bone metabolism and improvement of physical disorders is not clear yet. Trace minerals such as Ca, Mn, Cu, and Zn are essential precursors for most vital biological process, especially t...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S100566
更新日期:2016-02-29 00:00:00
abstract::Data on the oral health of the elderly depict a worrying situation, with an elevated prevalence of caries and moderate periodontal disease, frequent edentulism, and numerous cases of dry mouth and oral cancer. There is wide evidence that periodontitis is a risk factor for certain systemic diseases, and impaired oral h...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S54630
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abstract::Considerable research over the past decade has garnered support for the notion that the mind is both embodied and relational. Jointly, these terms imply that the brain, physical attributes of the self, and features of our interpersonal relationships and of the environments in which we live jointly regulate energy and ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S44797
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
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abstract:OBJECTIVE:To investigate both short-term and long-term therapeutic efficacy and safety of carotid artery stenting (CAS) and carotid artery endarterectomy (CEA) for elderly patients with severe and symptomatic carotid artery stenosis. METHODS:PubMed, EMBASE, Cochrane Library, Clinical Trials Register Centers, and Googl...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,meta分析
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S32536
更新日期:2012-01-01 00:00:00
abstract::Apligraf (Organogenesis, Canton, MA) is a bi-layered bioengineered skin substitute and was the first engineered skin US Food and Drug Administration (FDA)-approved to promote the healing of ulcers that have failed standard wound care. Constructed by culturing human foreskin-derived neonatal fibroblasts in a bovine typ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/ciia.2007.2.1.93
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S188499
更新日期:2019-01-15 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
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journal_title:Clinical interventions in aging
pub_type: 杂志文章,meta分析,评审
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更新日期:2019-10-01 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S85216
更新日期:2015-07-07 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/cia.s5203
更新日期:2009-01-01 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/cia.s1632
更新日期:2007-01-01 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S222655
更新日期:2019-10-23 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S243211
更新日期:2020-03-04 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S135364
更新日期:2017-05-26 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S167782
更新日期:2018-09-12 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
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更新日期:2019-05-08 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S277118
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journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
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更新日期:2010-08-09 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
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更新日期:2019-10-29 00:00:00
abstract::Age remains the most powerful prognostic factor among glioblastoma (GBM) patients. Half of all patients with GBM are aged 65 years or older at the time of diagnosis, and the incidence rate of GBM in patients aged over 65 years is increasing rapidly. Median survival for elderly GBM patients is less than 6 months and re...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S44259
更新日期:2014-02-21 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
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更新日期:2014-10-23 00:00:00
abstract:Background and Aim:Caregivers in the home environment have an important role in timely detecting and responding to abuse. The aim of this review was to provide insight into both the existing tools for the assessment of and interventions for elder abuse by formal and informal caregivers in the home environment, and to c...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
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更新日期:2020-09-28 00:00:00
abstract:PURPOSE:The effects of a multicomponent dyadic intervention on the mood, behavior, and physical health of people with dementia living in the community were evaluated in a randomized controlled trial. This multicomponent dyadic intervention is a translated and adapted version of an intervention that has been shown to be...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S95789
更新日期:2016-03-31 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
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abstract:Purpose:The aim of this study was to investigate the relationship between obesity and cognitive impairment in the Chinese elderly. Patients and methods:Patients aged 60 years or above were enrolled from the Department of Geriatrics of The First Affiliated Hospital of Chongqing Medical University from March 2013 to May...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
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更新日期:2019-02-15 00:00:00
abstract:BACKGROUND:It is important to obtain knowledge about the prevalence of nutritional risk and associated factors among older home-dwelling people in order to be able to meet nutritional challenges in this group in the future and to plan appropriate interventions. The aim of this survey was to investigate the prevalence o...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S35986
更新日期:2012-01-01 00:00:00