The impact of comorbidity on cancer survival: a review.

Abstract:

BACKGROUND:A number of studies have shown poorer survival among cancer patients with comorbidity. Several mechanisms may underlie this finding. In this review we summarize the current literature on the association between patient comorbidity and cancer prognosis. Prognostic factors examined include tumor biology, diagnosis, treatment, clinical quality, and adherence. METHODS:All English-language articles published during 2002-2012 on the association between comorbidity and survival among patients with colon cancer, breast cancer, and lung cancer were identified from PubMed, MEDLINE and Embase. Titles and abstracts were reviewed to identify eligible studies and their main results were then extracted. RESULTS:Our search yielded more than 2,500 articles related to comorbidity and cancer, but few investigated the prognostic impact of comorbidity as a primary aim. Most studies found that cancer patients with comorbidity had poorer survival than those without comorbidity, with 5-year mortality hazard ratios ranging from 1.1 to 5.8. Few studies examined the influence of specific chronic conditions. In general, comorbidity does not appear to be associated with more aggressive types of cancer or other differences in tumor biology. Presence of specific severe comorbidities or psychiatric disorders were found to be associated with delayed cancer diagnosis in some studies, while chronic diseases requiring regular medical visits were associated with earlier cancer detection in others. Another finding was that patients with comorbidity do not receive standard cancer treatments such as surgery, chemotherapy, and radiation therapy as often as patients without comorbidity, and their chance of completing a course of cancer treatment is lower. Postoperative complications and mortality are higher in patients with comorbidity. It is unclear from the literature whether the apparent undertreatment reflects appropriate consideration of greater toxicity risk, poorer clinical quality, patient preferences, or poor adherence among patients with comorbidity. CONCLUSION:Despite increasing recognition of the importance of comorbid illnesses among cancer patients, major challenges remain. Both treatment effectiveness and compliance appear compromised among cancer patients with comorbidity. Data on clinical quality is limited.

journal_name

Clin Epidemiol

journal_title

Clinical epidemiology

authors

Søgaard M,Thomsen RW,Bossen KS,Sørensen HT,Nørgaard M

doi

10.2147/CLEP.S47150

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

3-29

issue

Suppl 1

issn

1179-1349

pii

clep-5-003

journal_volume

5

pub_type

杂志文章,评审
  • The optimal hormonal replacement modality selection for multiple organ procurement from brain-dead organ donors.

    abstract::The management of brain-dead organ donors is complex. The use of inotropic agents and replacement of depleted hormones (hormonal replacement therapy) is crucial for successful multiple organ procurement, yet the optimal hormonal replacement has not been identified, and the statistical adjustment to determine the best ...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S71403

    authors: Mi Z,Novitzky D,Collins JF,Cooper DK

    更新日期:2014-12-22 00:00:00

  • Gastroenteritis attributable to rotavirus in hospitalized Saudi Arabian children in the period 2007-2008.

    abstract:PURPOSE:Rotavirus (RV) is a leading cause of severe gastroenteritis (GE) in children across the world. As there is a lack of epidemiological data for RV gastroenteritis (RVGE) in Saudi Arabia, this hospital-based study was designed to estimate the disease burden of RVGE and assess the prevalent RV types in Saudi childr...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S69502

    authors: Khalil M,Azhar E,Kao M,Al-Kaiedi N,Alhani H,Al Olayan I,Pawinski R,Gopala K,Kandeil W,Anis S,Van Doorn LJ,DeAntonio R

    更新日期:2015-02-11 00:00:00

  • Prevalence and characteristics of patients with low levels of low-density lipoprotein cholesterol in northern Denmark: a descriptive study.

    abstract:BACKGROUND:With the emergence of new lipid-lowering therapies, more patients are expected to achieve substantial lowering of low-density lipoprotein cholesterol (LDL-C). However, there are limited data examining the clinical experience of patients with low (<1.3 mmol/L) or very low (<0.65 mmol/L) levels of LDL-C. To pr...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S77676

    authors: Schmidt SA,Heide-Jørgensen U,Manthripragada AD,Ehrenstein V

    更新日期:2015-02-26 00:00:00

  • Familial aggregation of Parkinson's disease and coaggregation with neuropsychiatric diseases: a population-based cohort study.

    abstract:Background:Individuals with a family history of Parkinson's disease (PD) appear to have a higher risk of developing PD and other neuropsychiatric diseases. However, estimates of the relative risks (RRs) of PD and the roles of genetic and environmental factors in PD susceptibility are unclear. The aim of this study was ...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S164330

    authors: Liu FC,Lin HT,Kuo CF,Hsieh MY,See LC,Yu HP

    更新日期:2018-05-30 00:00:00

  • Existing data sources for clinical epidemiology: The Danish National Database of Reimbursed Prescriptions.

    abstract::The Danish health care system provides partial reimbursement of most prescription medications in Denmark. The dispensation of prescription medications is registered in administrative databases. Each time a prescription is redeemed at a pharmacy, an electronic record is generated with information related to the user, p...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S37587

    authors: Johannesdottir SA,Horváth-Puhó E,Ehrenstein V,Schmidt M,Pedersen L,Sørensen HT

    更新日期:2012-01-01 00:00:00

  • Antidepressants and the risk of traumatic brain injury in the elderly: differences between individual agents.

    abstract:Objective:To determine the association of individual antidepressants (ADs) with the risk of traumatic brain injury (TBI) in the elderly. Patients and methods:We conducted a case-control study nested in a cohort of new users of ADs aged ≥65 years, identified in the German Pharmacoepidemiological Research Database durin...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S173667

    authors: Pisa FE,Reinold J,Kollhorst B,Haug U,Schink T

    更新日期:2019-02-15 00:00:00

  • The Danish Hip Arthroscopy Registry: Registration Completeness and Patient Characteristics Between Responders and Non-Responders.

    abstract:Purpose:To report completeness of registered surgeries in the Danish hip arthroscopy registry (DHAR) and proportion of patients completing patient-reported outcome measures (PROMs) prior to surgery and at 1-year follow-up. Patients and Methods:Completeness was determined as the number of surgeries registered in DHAR i...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S264683

    authors: Poulsen E,Lund B,Roos EM

    更新日期:2020-08-04 00:00:00

  • Validity of the recorded codes of gonadotropin-releasing hormone agonist treatment and orchiectomies in the Danish National Patient Registry.

    abstract:PURPOSE:Large-scale observational studies based on existing medical databases may have an important role in studies of long-term effects of different treatments in prostate cancer patients if the coding of the treatment is valid. We therefore estimated the positive predictive value (PPV) and negative predictive value (...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S32313

    authors: Jespersen CG,Borre M,Nørgaard M

    更新日期:2012-01-01 00:00:00

  • Diagnostic Screening for Lumbar Spinal Stenosis.

    abstract:Purpose:To develop a self-administered diagnostic screening questionnaire for lumbar spinal stenosis (LSS) consisting of items with high content validity and to investigate the diagnostic value of the questionnaire and the items. Patients and Methods:A self-reported diagnostic LSS screening questionnaire was developed...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S263646

    authors: Jensen RK,Lauridsen HH,Andresen ADK,Mieritz RM,Schiøttz-Christensen B,Vach W

    更新日期:2020-08-19 00:00:00

  • HPV self-sampling in cervical cancer screening: the effect of different invitation strategies in various socioeconomic groups - a randomized controlled trial.

    abstract:Background:Participation in cervical cancer screening varies by socioeconomic status. The aims were to assess if offering human papilloma virus (HPV) self-sampling kits has an effect on screening participation among various socioeconomic groups and to determine if two invitation strategies for offering self-sampling in...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S164826

    authors: Tranberg M,Bech BH,Blaakær J,Jensen JS,Svanholm H,Andersen B

    更新日期:2018-08-23 00:00:00

  • A prospective study of statin use and mortality among 67,385 blacks and whites in the Southeastern United States.

    abstract:PURPOSE:The primary objective of this study is to examine the race-specific associations between statin use and overall mortality, as well as cardiovascular and cancer mortality, among blacks and whites in the Southeastern United States (US). Little is known about these associations in blacks. PATIENTS AND METHODS:The...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S53492

    authors: Lipworth L,Fazio S,Kabagambe EK,Munro HM,Nwazue VC,Tarone RE,McLaughlin JK,Blot WJ,Sampson UK

    更新日期:2013-12-19 00:00:00

  • Validity of a procedure to identify patients with chronic idiopathic thrombocytopenic purpura in the Danish National Registry of Patients.

    abstract:BACKGROUND:Administrative data may be useful for epidemiological studies of chronic idiopathic thrombocytopenic purpura (ITP). However, the quality of the recorded diagnoses needs evaluation. AIM:We evaluated the validity in predicting chronic ITP of the International Classification of Diseases (ICD)-10 diagnoses of I...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/clep.s4832

    authors: Heden KE,Jensen AØ,Farkas DK,Nørgaard M

    更新日期:2009-08-09 00:00:00

  • The Danish National Prescription Registry in studies of a biological pharmaceutical: palivizumab - validation against two external data sources.

    abstract:BACKGROUND:National prescription databases are important tools in pharmacoepidemiological studies investigating potential long-term adverse events after drug use. Palivizumab is a biological pharmaceutical used as passive prophylaxis against severe infection with respiratory syncytial virus in high-risk children. OBJE...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S73355

    authors: Haerskjold A,Henriksen L,Way S,Malham M,Hallas J,Pedersen L,Stensballe LG

    更新日期:2015-05-08 00:00:00

  • Breast cancer associated with primary hyperparathyroidism: a nested case control study.

    abstract:BACKGROUND:Primary hyperparathyroidism (pHPT) is associated with an increased risk of developing breast cancer, but little is known about the underlying factors. The aim of this study was to compare women with a history of pHPT and a reference population in terms of standard factors predictive of prognosis and response...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S17298

    authors: Norenstedt S,Granath F,Ekbom A,Bergh J,Lambe M,Adolfsson J,Warnberg F,Zedenius J,Nilsson IL

    更新日期:2011-03-25 00:00:00

  • Concordance of metabolic enzyme genotypes assayed from paraffin-embedded, formalin-fixed breast tumors and normal lymphatic tissue.

    abstract:OBJECTIVES:Translational epidemiology studies often use archived tumor specimens to evaluate genetic hypotheses involving cancer outcomes. When the exposure of interest is a germline polymorphism, a key concern is whether the genotype assayed from tumor-derived DNA is representative of the germline. We evaluated the co...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S13811

    authors: Ahern TP,Christensen M,Cronin-Fenton DP,Lunetta KL,Rosenberg CL,Sørensen HT,Lash TL,Hamilton-Dutoit S

    更新日期:2010-10-22 00:00:00

  • Smoking and renal function in people living with human immunodeficiency virus: a Danish nationwide cohort study.

    abstract:INTRODUCTION:Smoking is a main risk factor for morbidity and mortality in people living with human immunodeficiency virus (PLHIV), but its potential association with renal impairment remains to be established. METHODS:We did a nationwide population-based cohort study in Danish PLHIV to evaluate the association between...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S83530

    authors: Ahlström MG,Feldt-Rasmussen B,Legarth R,Kronborg G,Pedersen C,Larsen CS,Gerstoft J,Obel N

    更新日期:2015-08-28 00:00:00

  • Reliability of recurrent pregnancy loss diagnosis coding in the Swedish National Patient Register: a validation study.

    abstract::Background: The Swedish National Patient Registry (NPR) is a nationwide registry that is used extensively for epidemiological research. Using the NPR, we recently found a recurrent pregnancy loss (RPL) incidence of 650/100,000 (0.65%) pregnant women in Sweden. It is of great importance that the quality of the coding i...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S199206

    authors: Rasmark Roepke E,Christiansen OB,Hansson SR

    更新日期:2019-05-08 00:00:00

  • A Novel Method for Quantifying Intestinal Inflammatory Burden in Inflammatory Bowel Disease Using Register Data.

    abstract:Background:The Swedish Quality Register for Inflammatory Bowel Disease (SWIBREG) contains clinical data for the study of inflammatory bowel disease (IBD). The Epidemiology Strengthened by histoPathology Reports in Sweden (ESPRESSO) cohort was recently established for the study of gastrointestinal histopathology. We aim...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S265404

    authors: Axelrad JE,Sachs MC,Ludvigsson JF,Olén O,SWIBREG Study Group.

    更新日期:2020-10-09 00:00:00

  • The Danish National Chronic Lymphocytic Leukemia Registry.

    abstract:AIM:In 2008, the Danish National Chronic Lymphocytic Leukemia Registry was founded within the Danish National Hematology Database. The primary aim of the registry is to assure quality of diagnosis and care of patients with chronic lymphocytic leukemia (CLL) in Denmark. Secondarily, to evaluate adherence to national gui...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章,评审

    doi:10.2147/CLEP.S99486

    authors: da Cunha-Bang C,Geisler CH,Enggaard L,Poulsen CB,de Nully Brown P,Frederiksen H,Bergmann OJ,Pulczynski EJ,Pedersen RS,Nielsen LH,Christiansen I,Niemann CU

    更新日期:2016-10-25 00:00:00

  • Clinical Practice Status of Sentinel Lymph Node Biopsy for Early-Stage Breast Cancer Patients in China: A Multicenter Study.

    abstract:Background:Sentinel lymph node biopsy (SLNB) was introduced over 30 years ago, but the application of SLNB in China is unclear. This study aimed to explore the real-world implementation of SLNB among early-stage breast cancer patients in China. Methods:A multi-center, retrospective study was conducted among primary br...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S264349

    authors: Zhang J,Wang T,Yan C,Huang M,Fan Z,Ling R

    更新日期:2020-09-01 00:00:00

  • Improved understanding of factors driving methicillin-resistant Staphylococcus aureus epidemic waves.

    abstract::Methicillin-resistant Staphylococcus aureus (MRSA) remains one of the most important causes of nosocomial infections worldwide. Since the global spread of MRSA in the 1960s, MRSA strains have evolved with increased pathogenic potential. Notably, some strains are now capable of causing persistent infections not only in...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S37071

    authors: Chatterjee SS,Otto M

    更新日期:2013-07-04 00:00:00

  • Long-Term Risk of Stroke and Poststroke Outcomes in Patients with Heart Failure: Two Nationwide Studies.

    abstract:Objective:To evaluate the long-term risk of stroke and poststroke adverse outcomes in patients with heart failure (HF). Methods:We used research data from Taiwan's National Health Insurance Program from 2000 to 2005 and identified 20,072 adults aged ≥30 years who were newly diagnosed with HF. Frequency matching based ...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S261179

    authors: Tai YH,Chang CC,Yeh CC,Sung LC,Hu CJ,Cherng YG,Chen TL,Liao CC

    更新日期:2020-11-05 00:00:00

  • Cross-national health care database utilization between Spain and France: results from the EPICHRONIC study assessing the prevalence of type 2 diabetes mellitus.

    abstract:Aim:The EPICHRONIC (EPIdemiology of CHRONIC diseases) project investigated the possibility of developing common procedures for French and Spanish electronic health care databases to enable large-scale pharmacoepidemiological studies on chronic diseases. A feasibility study assessed the prevalence of type 2 diabetes mel...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S151890

    authors: Moulis G,Ibañez B,Palmaro A,Aizpuru F,Millan E,Lapeyre-Mestre M,Sailler L,Cambra K

    更新日期:2018-07-27 00:00:00

  • Survival of invasive bladder cancer patients, 1998-2009; a central and northern Denmark population-based cohort study.

    abstract:OBJECTIVE:Invasive bladder cancer (IBC) is a common urological malignancy accounting for 4%-5% of all cancers in Denmark. Our aim was to examine possible changes in short- and long-term survival of patients with IBC during 1998-2009. STUDY DESIGN AND SETTING:Data on all patients (N = 4032) with an incident diagnosis o...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S20615

    authors: Lund L,Erichsen R,Nørgaard M,Larsen EH,Borre M,Jacobsen J

    更新日期:2011-01-01 00:00:00

  • Prediction models for the mortality risk in chronic dialysis patients: a systematic review and independent external validation study.

    abstract:OBJECTIVE:In medicine, many more prediction models have been developed than are implemented or used in clinical practice. These models cannot be recommended for clinical use before external validity is established. Though various models to predict mortality in dialysis patients have been published, very few have been v...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S139748

    authors: Ramspek CL,Voskamp PW,van Ittersum FJ,Krediet RT,Dekker FW,van Diepen M

    更新日期:2017-09-05 00:00:00

  • Young patients with risk factors prevalent in the elderly - differences in comorbidity depending on severity of psoriasis: a nationwide cross-sectional study in Swedish health registers.

    abstract:Background:Association between psoriasis severity and cerebro- and cardiovascular comorbidities has rarely been investigated. Aim:We aimed to investigate differences in cerebro- and cardiovascular comorbidities by psoriasis severity. Materials and methods:Using Swedish nationwide health-care registers, new adult user...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S164918

    authors: Hajiebrahimi M,Linder M,Hägg D,Berglind IA,McElligott S,Valgardsson VS,Villacorta R,Sundström A

    更新日期:2018-06-19 00:00:00

  • Corticosteroids Prior to Embryo Transfer in Assisted Reproduction in Women with Crohn's Disease and Ulcerative Colitis - A Nationwide Cohort Study.

    abstract:Purpose:Former studies have suggested that women with Crohn's disease (CD) and ulcerative colitis (UC) have a decreased chance of a live born child after assisted reproductive technology (ART) treatment. It is debated whether corticosteroids before ART may improve outcomes, either by decreasing inflammatory bowel disea...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S234996

    authors: Nørgård BM,Larsen MD,Friedman S,Fedder J

    更新日期:2020-03-23 00:00:00

  • Physical Activity as an Effect Modifier of the Association Between Obesity and Venous Thromboembolism: A Danish Population-Based Cohort Study.

    abstract:Purpose:Obesity is an established risk factor for venous thromboembolism (VTE), while studies on physical inactivity and VTE risk show conflicting results. We examined whether physical activity modified the association between obesity and VTE. Patients and Methods:We conducted a population-based cohort study by combin...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S275079

    authors: Solli H,Olsen M,Larsen FB,Pedersen L,Schmidt M

    更新日期:2020-12-08 00:00:00

  • Effects of chronic exposure of hydroxychloroquine/chloroquine on the risk of cancer, metastasis, and death: a population-based cohort study on patients with connective tissue diseases.

    abstract:Background:Hydroxychloroquine and chloroquine may reduce the risk of cancer as they inhibit autophagy, in particular, in people with connective tissue diseases. Methods:The hazard ratios of cancers, metastases, and death were assessed in adults with connective tissue diseases prescribed hydroxychloroquine/chloroquine ...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S143563

    authors: Fardet L,Nazareth I,Petersen I

    更新日期:2017-11-03 00:00:00

  • Use of existing data sources in clinical epidemiology: Finnish health care registers in Alzheimer's disease research - the Medication use among persons with Alzheimer's disease (MEDALZ-2005) study.

    abstract::Memory diseases are the most important determinant of health care service use and quality of life among older individuals. Adverse effects of medication are common among older people, but this age group is underrepresented in clinical trials. Finnish statutory health care and prescription registers, together with pers...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S46622

    authors: Tolppanen AM,Taipale H,Koponen M,Lavikainen P,Tanskanen A,Tiihonen J,Hartikainen S

    更新日期:2013-08-07 00:00:00