The Danish National Prescription Registry in studies of a biological pharmaceutical: palivizumab - validation against two external data sources.

Abstract:

BACKGROUND:National prescription databases are important tools in pharmacoepidemiological studies investigating potential long-term adverse events after drug use. Palivizumab is a biological pharmaceutical used as passive prophylaxis against severe infection with respiratory syncytial virus in high-risk children. OBJECTIVE:To assess the registration of palivizumab in the Danish National Prescription Registry (DNPR) and to examine if palivizumab reimbursement data obtained from the Danish Health and Medicines Authority could serve as a supplement to data from the DNPR. METHODS:Registration of palivizumab exposure in the DNPR between 1999 and 2010 was compared to two external data sources: registration of palivizumab exposure in medical records, and palivizumab reimbursement data. RESULTS:During the study period, 182 children with palivizumab exposure were registered in the DNPR. A total of 207 children were registered for palivizumab reimbursement. The sensitivity of palivizumab registration in the DNPR was 26% (20%-34%), and the specificity of no palivizumab registration in the DNPR was 97% (94%-99%), with data from the medical record as the reference. Palivizumab registration sensitivity in reimbursement data was 29% (22%-36%), and the specificity of no palivizumab registration in the DNPR was 97% (94%-99%), with data from the medical record as the reference. CONCLUSION:Exposure to palivizumab was underestimated in the DNPR. Reimbursement data are a readily accessible data supplement, which only slightly increased the sensitivity of palivizumab registration in the DNPR. Our findings underline the need to improve DNPR information concerning drugs administered in hospitals.

journal_name

Clin Epidemiol

journal_title

Clinical epidemiology

authors

Haerskjold A,Henriksen L,Way S,Malham M,Hallas J,Pedersen L,Stensballe LG

doi

10.2147/CLEP.S73355

subject

Has Abstract

pub_date

2015-05-08 00:00:00

pages

305-12

issn

1179-1349

pii

clep-7-305

journal_volume

7

pub_type

杂志文章
  • The impact of comorbidity on cancer survival: a review.

    abstract:BACKGROUND:A number of studies have shown poorer survival among cancer patients with comorbidity. Several mechanisms may underlie this finding. In this review we summarize the current literature on the association between patient comorbidity and cancer prognosis. Prognostic factors examined include tumor biology, diagn...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章,评审

    doi:10.2147/CLEP.S47150

    authors: Søgaard M,Thomsen RW,Bossen KS,Sørensen HT,Nørgaard M

    更新日期:2013-11-01 00:00:00

  • Labor augmentation during birth and later cognitive ability in young adulthood.

    abstract:Purpose:Synthetic oxytocin for labor augmentation during birth has been linked to negative neurodevelopment effects in children. We examined whether maternal labor augmentation was associated with lower cognitive ability in young adulthoods. Patients and methods:We identified 330,107 individuals (96.6% were men), with...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S181012

    authors: Stokholm L,Talge NM,Christensen GT,Juhl M,Mortensen LH,Strandberg-Larsen K

    更新日期:2018-11-26 00:00:00

  • Registration in the Danish Regional Nonmelanoma Skin Cancer Dermatology Database: completeness of registration and accuracy of key variables.

    abstract:OBJECTIVE:To validate a clinical database for nonmelanoma skin cancer (NMSC) with the aim of monitoring and predicting the prognosis of NMSC treated by dermatologists in clinics in the central and north Denmark regions. METHODS:We assessed the completeness of registration of patients and follow-up visits, and positive...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/clep.s9959

    authors: Lamberg AL,Cronin-Fenton D,Olesen AB

    更新日期:2010-08-09 00:00:00

  • Incidence of ICD-Based Diagnoses of Alcohol-Related Disorders and Diseases from Swedish Nationwide Registers and Suggestions for Coding.

    abstract:Aim:To improve consistency between register studies in Sweden and ensure valid comparisons of possible changes in alcohol-related disorders and diseases (ARDDs) over time, we propose a definition of ARDDs. Based on this definition, we examined Sweden's incidence rates of ARDDs from 1970 to 2018 in non-primary healthcar...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S285936

    authors: Bergman D,Hagström H,Capusan AJ,Mårild K,Nyberg F,Sundquist K,Ludvigsson JF

    更新日期:2020-12-31 00:00:00

  • Emergent trends in the reported incidence of prostate cancer in Nigeria.

    abstract:BACKGROUND:To date there has not been any nationwide age-standardized incidence data reported for prostate cancer in Nigeria. We examined and integrated diverse trends in the age-specific incidence of prostate cancer into a comprehensive trend for Nigeria, and examined how best the existing data could generate a countr...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S23536

    authors: Ifere GO,Abebe F,Ananaba GA

    更新日期:2012-01-01 00:00:00

  • Hypertrophic scarring in cleft lip repair: a comparison of incidence among ethnic groups.

    abstract:BACKGROUND:Although hypertrophic scar (HTS) formation following cleft lip repair is relatively common, published rates vary widely, from 1% to nearly 50%. The risk factors associated with HTS formation in cleft patients are not well characterized. The primary aim of this retrospective study of 180 cleft lip repairs is ...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S31119

    authors: Soltani AM,Francis CS,Motamed A,Karatsonyi AL,Hammoudeh JA,Sanchez-Lara PA,Reinisch JF,Urata MM

    更新日期:2012-01-01 00:00:00

  • Familial aggregation of Parkinson's disease and coaggregation with neuropsychiatric diseases: a population-based cohort study.

    abstract:Background:Individuals with a family history of Parkinson's disease (PD) appear to have a higher risk of developing PD and other neuropsychiatric diseases. However, estimates of the relative risks (RRs) of PD and the roles of genetic and environmental factors in PD susceptibility are unclear. The aim of this study was ...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S164330

    authors: Liu FC,Lin HT,Kuo CF,Hsieh MY,See LC,Yu HP

    更新日期:2018-05-30 00:00:00

  • The database of the Danish Renal Cancer Group.

    abstract:AIM OF THE DATABASE:The main purpose of the database of the Danish Renal Cancer Group (DaRenCaData) is to improve the quality of renal cancer treatment in Denmark and secondarily to conduct observational research. STUDY POPULATION:DaRenCaData includes all Danish patients with a first-time diagnosis of renal cancer in ...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章,评审

    doi:10.2147/CLEP.S106042

    authors: Petersen AC,Søgaard M,Mehnert F,Larsen EH,Donskov F,Azawi NH,Kromann-Andersen B

    更新日期:2016-10-25 00:00:00

  • New national Biobank of The Danish Center for Strategic Research on Type 2 Diabetes (DD2).

    abstract::Long-term storage of biological samples from patients has become increasingly important in studies of disease control and treatment. The first nationwide Danish diabetes project, ie, The Danish Center for Strategic Research in Type II Diabetes (DD2), aims to improve treatment and the long-term outcome of patients with...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S33042

    authors: Christensen H,Nielsen JS,Sørensen KM,Melbye M,Brandslund I

    更新日期:2012-01-01 00:00:00

  • Comparative anti-fracture effectiveness of different oral anti-osteoporosis therapies based on "real-world" data: a meta-analysis of propensity-matched cohort findings from the UK Clinical Practice Research Database and the Catalan SIDIAP Database.

    abstract:Purpose:This paper aims to compare the clinical effectiveness of oral anti-osteoporosis drugs based on the observed risk of fracture while on treatment in primary care actual practice. Materials and methods:We investigated two primary care records databases covering UK National Health Service (Clinical Practice Resear...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S164112

    authors: Khalid S,Calderon-Larrañaga S,Hawley S,Ali MS,Judge A,Arden N,van Staa T,Cooper C,Javaid MK,Prieto-Alhambra D

    更新日期:2018-10-09 00:00:00

  • Positive predictive values of ICD-10 codes to identify incident acute pancreatitis and incident primary malignancy in the Scandinavian national patient registries among women with postmenopausal osteoporosis.

    abstract:BACKGROUND:Validation of definitions used to identify conditions of interest is imperative to epidemiologic studies based on routinely collected data. The objective of the study was thus to estimate positive predictive values (PPVs) of International Classification of Diseases, 10th Revision (ICD-10) codes to identify c...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S139895

    authors: Munch T,Christensen LB,Adelborg K,Tell GS,Apalset EM,Westerlund A,Lagerros YT,Kahlert J,Xue F,Ehrenstein V

    更新日期:2017-08-17 00:00:00

  • Epidemiology Of Vestibular Schwannomas - Prospective 40-Year Data From An Unselected National Cohort.

    abstract:Objective:Reports on the epidemiology of vestibular schwannoma (VS) indicate an increase in diagnosed cases, often based on selected materials over a limited period of time. This report presents prospective 40-year epidemiological data from an unselected national cohort of all patients diagnosed with a VS in Denmark si...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S218670

    authors: Reznitsky M,Petersen MMBS,West N,Stangerup SE,Cayé-Thomasen P

    更新日期:2019-11-08 00:00:00

  • Attributing diseases to multiple pathways: a causal-pie modeling approach.

    abstract::Characterizing the relations between exposures and diseases is the central tenet of epidemiology. Researchers may want to evaluate exposure-disease causation by assessing whether the disease under concern is induced by the various exposures - the so-called "attribution". In this paper, the authors propose a method to ...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S160205

    authors: Chen C,Lee WC

    更新日期:2018-04-27 00:00:00

  • Concordance of metabolic enzyme genotypes assayed from paraffin-embedded, formalin-fixed breast tumors and normal lymphatic tissue.

    abstract:OBJECTIVES:Translational epidemiology studies often use archived tumor specimens to evaluate genetic hypotheses involving cancer outcomes. When the exposure of interest is a germline polymorphism, a key concern is whether the genotype assayed from tumor-derived DNA is representative of the germline. We evaluated the co...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S13811

    authors: Ahern TP,Christensen M,Cronin-Fenton DP,Lunetta KL,Rosenberg CL,Sørensen HT,Lash TL,Hamilton-Dutoit S

    更新日期:2010-10-22 00:00:00

  • The Danish Hip Arthroscopy Registry: Registration Completeness and Patient Characteristics Between Responders and Non-Responders.

    abstract:Purpose:To report completeness of registered surgeries in the Danish hip arthroscopy registry (DHAR) and proportion of patients completing patient-reported outcome measures (PROMs) prior to surgery and at 1-year follow-up. Patients and Methods:Completeness was determined as the number of surgeries registered in DHAR i...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S264683

    authors: Poulsen E,Lund B,Roos EM

    更新日期:2020-08-04 00:00:00

  • The Danish Nonmelanoma Skin Cancer Dermatology Database.

    abstract:AIM OF DATABASE:The Danish Nonmelanoma Skin Cancer Dermatology Database was established in 2008. The aim of this database was to collect data on nonmelanoma skin cancer (NMSC) treatment and improve its treatment in Denmark. NMSC is the most common malignancy in the western countries and represents a significant challen...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章,评审

    doi:10.2147/CLEP.S99464

    authors: Lamberg AL,Sølvsten H,Lei U,Vinding GR,Stender IM,Jemec GB,Vestergaard T,Thormann H,Hædersdal M,Dam TN,Olesen AB

    更新日期:2016-10-25 00:00:00

  • Age-specific cancer survival in Estonia: recent trends and data quality.

    abstract:BACKGROUND:A number of population-based studies have demonstrated lower cancer survival in elderly patients than among middle-aged or younger patients. Also, data quality in cancer registries has been shown to be associated with age. The objective of this study was to examine the recent age-specific cancer survival tre...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S87699

    authors: Innos K,Lang K,Pärna K,Aareleid T

    更新日期:2015-07-29 00:00:00

  • Antidepressants and the risk of traumatic brain injury in the elderly: differences between individual agents.

    abstract:Objective:To determine the association of individual antidepressants (ADs) with the risk of traumatic brain injury (TBI) in the elderly. Patients and methods:We conducted a case-control study nested in a cohort of new users of ADs aged ≥65 years, identified in the German Pharmacoepidemiological Research Database durin...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S173667

    authors: Pisa FE,Reinold J,Kollhorst B,Haug U,Schink T

    更新日期:2019-02-15 00:00:00

  • Validity of an algorithm to identify osteonecrosis of the jaw in women with postmenopausal osteoporosis in the Danish National Registry of Patients.

    abstract:BACKGROUND:Osteonecrosis of the jaw (ONJ) is an adverse effect of drugs that suppress bone turnover - for example, drugs used for the treatment of postmenopausal osteoporosis. The Danish National Registry of Patients (DNRP) is potentially valuable for monitoring ONJ and its prognosis; however, no specific code for ONJ ...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S45226

    authors: Gammelager H,Sværke C,Noerholt SE,Neumann-Jensen B,Xue F,Critchlow C,Bergdahl J,Lagerros YT,Kieler H,Tell GS,Ehrenstein V

    更新日期:2013-08-01 00:00:00

  • Long-Term Risk of Stroke and Poststroke Outcomes in Patients with Heart Failure: Two Nationwide Studies.

    abstract:Objective:To evaluate the long-term risk of stroke and poststroke adverse outcomes in patients with heart failure (HF). Methods:We used research data from Taiwan's National Health Insurance Program from 2000 to 2005 and identified 20,072 adults aged ≥30 years who were newly diagnosed with HF. Frequency matching based ...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S261179

    authors: Tai YH,Chang CC,Yeh CC,Sung LC,Hu CJ,Cherng YG,Chen TL,Liao CC

    更新日期:2020-11-05 00:00:00

  • Population-based Aarhus Sarcoma Registry: validity, completeness of registration, and incidence of bone and soft tissue sarcomas in western Denmark.

    abstract:BACKGROUND:The aim of the present study was to validate the data in the Aarhus Sarcoma Registry (ASR), to determine if this registry is population-based for western Denmark, and to examine the incidence of sarcomas using validated, population-based registry data. METHODS:This study was based on patients with bone and ...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S41835

    authors: Maretty-Nielsen K,Aggerholm-Pedersen N,Keller J,Safwat A,Baerentzen S,Pedersen AB

    更新日期:2013-03-06 00:00:00

  • Quality assessment of observational studies in a drug-safety systematic review, comparison of two tools: the Newcastle-Ottawa Scale and the RTI item bank.

    abstract:BACKGROUND:The study objective was to compare the Newcastle-Ottawa Scale (NOS) and the RTI item bank (RTI-IB) and estimate interrater agreement using the RTI-IB within a systematic review on the cardiovascular safety of glucose-lowering drugs. METHODS:We tailored both tools and added four questions to the RTI-IB. Two ...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S66677

    authors: Margulis AV,Pladevall M,Riera-Guardia N,Varas-Lorenzo C,Hazell L,Berkman ND,Viswanathan M,Perez-Gutthann S

    更新日期:2014-10-10 00:00:00

  • Survival of invasive bladder cancer patients, 1998-2009; a central and northern Denmark population-based cohort study.

    abstract:OBJECTIVE:Invasive bladder cancer (IBC) is a common urological malignancy accounting for 4%-5% of all cancers in Denmark. Our aim was to examine possible changes in short- and long-term survival of patients with IBC during 1998-2009. STUDY DESIGN AND SETTING:Data on all patients (N = 4032) with an incident diagnosis o...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S20615

    authors: Lund L,Erichsen R,Nørgaard M,Larsen EH,Borre M,Jacobsen J

    更新日期:2011-01-01 00:00:00

  • Arachidonic acid and colorectal adenoma risk: a Mendelian randomization study.

    abstract:Background:Previous studies have shown a link between increased dietary intake of arachidonic acid (ARA) and colorectal neoplasms. It has been shown that erythrocyte phospholipid membrane concentrations of ARA are strongly determined by genetic variation. Fatty acid desaturase (FADS) controls the rate limiting step in ...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S186883

    authors: Isom CA,Shrubsole MJ,Cai Q,Smalley WE,Ness RM,Zheng W,Murff HJ

    更新日期:2018-12-18 00:00:00

  • Validity of ICD-10-CM Codes Used to Identify Patients with Chronic Hepatitis B and C Virus Infection in Administrative Claims Data from the Taiwan National Health Insurance Outpatient Claims Dataset.

    abstract:Purpose:To validate the use of International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) codes to identify patients with chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in the Taiwan National Health Insurance (NHI) Outpatient Claims Dataset. Methods:We conducted ...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S236823

    authors: Sheu MJ,Liang FW,Li ST,Li CY,Lu TH

    更新日期:2020-02-20 00:00:00

  • Corticosteroids Prior to Embryo Transfer in Assisted Reproduction in Women with Crohn's Disease and Ulcerative Colitis - A Nationwide Cohort Study.

    abstract:Purpose:Former studies have suggested that women with Crohn's disease (CD) and ulcerative colitis (UC) have a decreased chance of a live born child after assisted reproductive technology (ART) treatment. It is debated whether corticosteroids before ART may improve outcomes, either by decreasing inflammatory bowel disea...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S234996

    authors: Nørgård BM,Larsen MD,Friedman S,Fedder J

    更新日期:2020-03-23 00:00:00

  • The RECORD reporting guidelines: meeting the methodological and ethical demands of transparency in research using routinely-collected health data.

    abstract::Routinely-collected health data (RCD) are now used for a wide range of studies, including observational studies, comparative effectiveness research, diagnostics, studies of adverse effects, and predictive analytics. At the same time, limitations inherent in using data collected without specific a priori research quest...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S110528

    authors: Nicholls SG,Langan SM,Sørensen HT,Petersen I,Benchimol EI

    更新日期:2016-10-19 00:00:00

  • Physical activity and mortality among Norwegian women - the Norwegian Women and Cancer Study.

    abstract:BACKGROUND:Physical activity (PA) and its relationship with all-cause mortality suggest a strong and consistent inverse association. This study prospectively investigated the association between PA level and mortality among participants of the Norwegian Women and Cancer (NOWAC) Study. METHODS:A total of 66,136 NOWAC p...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S22681

    authors: Borch KB,Braaten T,Lund E,Weiderpass E

    更新日期:2011-01-01 00:00:00

  • Prevalence and characteristics of patients with low levels of low-density lipoprotein cholesterol in northern Denmark: a descriptive study.

    abstract:BACKGROUND:With the emergence of new lipid-lowering therapies, more patients are expected to achieve substantial lowering of low-density lipoprotein cholesterol (LDL-C). However, there are limited data examining the clinical experience of patients with low (<1.3 mmol/L) or very low (<0.65 mmol/L) levels of LDL-C. To pr...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S77676

    authors: Schmidt SA,Heide-Jørgensen U,Manthripragada AD,Ehrenstein V

    更新日期:2015-02-26 00:00:00

  • Diagnostic Screening for Lumbar Spinal Stenosis.

    abstract:Purpose:To develop a self-administered diagnostic screening questionnaire for lumbar spinal stenosis (LSS) consisting of items with high content validity and to investigate the diagnostic value of the questionnaire and the items. Patients and Methods:A self-reported diagnostic LSS screening questionnaire was developed...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S263646

    authors: Jensen RK,Lauridsen HH,Andresen ADK,Mieritz RM,Schiøttz-Christensen B,Vach W

    更新日期:2020-08-19 00:00:00