Androstenedione changes steroidogenic activity of SGBS cells.

abstract：:Primary hyperparathyroidism (PHPT) is a common endocrinopathy, frequently caused by a parathyroid adenoma, rarely by a parathyroid carcinoma that lacks effective oncological treatment. As the majority of cases are present in postmenopausal women, oestrogen signalling has been implicated in the tumourigenesis. Oestroge...

journal_title：Endocrine connections

authors： Haglund F,Rosin G,Nilsson IL,Juhlin CC,Pernow Y,Norenstedt S,Dinets A,Larsson C,Hartman J,Höög A

更新日期：2015-03-01 00:00:00

abstract：:The PI3K-Akt-mTOR pathway plays a central role in the development of non-medullary thyroid carcinoma (NMTC). Although somatic mutations have been identified in these genes in NMTC patients, the role of germline variants has not been investigated. Here, we selected frequently occurring genetic variants in AKT1, AKT2, A...

journal_title：Endocrine connections

authors： Crezee T,Petrulea M,Piciu D,Jaeger M,Smit JWA,Plantinga TS,Georgescu CE,Netea-Maier R

更新日期：2020-11-01 00:00:00

abstract：:The antihypertensive actions of glucagon-like peptide-1 (GLP1) receptor agonists have been linked to the release of atrial natriuretic peptide (ANP) in mice. Whether a GLP1-ANP axis exists in humans is unknown. In this study, we examined 12 healthy young males in a randomized, controlled, double-blinded, single-day, c...

journal_title：Endocrine connections

authors： Skov J,Holst JJ,Gøtze JP,Frøkiær J,Christiansen JS

更新日期：2014-01-21 00:00:00

abstract：:Background and objectives Glucocorticoids are used to manage adrenal insufficiency (AI). We describe treatments used in the United Kingdom and real-world clinical outcomes for each treatment. Methods We used 2010-2016 primary care data from The Health Improvement Network (THIN). Descriptive analyses were conducted, an...

journal_title：Endocrine connections

authors： Iqbal K,Halsby K,Murray RD,Carroll PV,Petermann R

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:Chromogranin A (CgA) and neuron-specific enolase (NSE) are important markers for neuroendocrine tumors; however, the clinical value of combining these markers has not been well studied. In this study, we investigated the utility of each marker individually and in combination for patients with nonfunctional panc...

journal_title：Endocrine connections

authors： Lv Y,Han X,Zhang C,Fang Y,Pu N,Ji Y,Wang D,Xuefeng X,Lou W

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Worldwide there is a high prevalence of 25-hydroxyvitamin D (25OHD) deficiency and has been associated with adverse outcomes during pregnancy. OBJECTIVE:This is a nested, case-control study in a longitudinal cohort to compare the serum 25OHD levels and other biomarkers throughout pregnancy in a group of 20 ...

journal_title：Endocrine connections

authors： Agudelo-Zapata Y,Maldonado-Acosta LM,Sandoval-Alzate HF,Poveda NE,Garcés MF,Cortés-Vásquez JA,Linares-Vaca AF,Mancera-Rodríguez CA,Perea-Ariza SA,Ramírez-Iriarte KY,Castro-Saldarriaga CA,Arteaga-Diaz JM,Franco-Vega R,Ángel-Müll

更新日期：2018-05-01 00:00:00

abstract：:Promotion of brown adipose tissue (BAT) activity or browning of white adipose tissue has shown great potential as anti-obesity strategy in numerous preclinical models. The discovery of active BAT in humans and the recent advances in the understanding of human BAT biology and function have significantly propelled this ...

journal_title：Endocrine connections

authors： Kiefer FW

更新日期：2017-07-01 00:00:00

abstract：Objective:Accurate measurement of steroid hormones remains challenging. Mass spectrometry affords a reliable means for quantitating steroid profiles accurately. Our objective was to establish and define (1) the extent of diurnal fluctuations in steroid concentrations that potentially necessitate strict adherence to tim...

journal_title：Endocrine connections

authors： Parikh TP,Stolze B,Ozarda Y,Jonklaas J,Welsh K,Masika L,Hill M,DeCherney A,Soldin SJ

更新日期：2018-12-01 00:00:00

abstract：:According to its incidence patterns, colorectal cancer (CRC) tends to occur more frequently in males than in females, and the evidence shows that CRC is a hormone-related tumor. These findings indicate that androgen receptor (AR) gene methylation might be important for the regulation of the CRC risk in the different s...

journal_title：Endocrine connections

authors： Xia T,Sun H,Huang H,Bi H,Pu R,Zhang L,Zhang Y,Liu Y,Xu J,Onwuka JU,Liu Y,Cui B,Zhao Y

更新日期：2019-07-01 00:00:00

abstract：CONTEXT:The aim of this study was to assess the plasma leptin, adiponectin, resistin, visfatin/NAMPT, omentin-1, vaspin, apelin, TNF-α, IL-6 and RBP4 levels in relation to hormonal changes during the menstrual cycle in young, healthy, normal-weight women. METHODS:The study involved 52 young, healthy, normal-weight wom...

journal_title：Endocrine connections

authors： Wyskida K,Franik G,Wikarek T,Owczarek A,Delroba A,Chudek J,Sikora J,Olszanecka-Glinianowicz M

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:Preoperative preparation for adrenalectomy for pheochromocytomas and paragangliomas (PPGL) is universally recognized as necessary, while the optimal strategy remains controversial. Our aims were to increase intraoperative hemodynamic stability, expedite postoperative recovery, decrease side effects and reduce c...

journal_title：Endocrine connections

authors： Liu C,Lv Q,Chen X,Ni G,Hu L,Tong N,Zhang Y

更新日期：2017-11-01 00:00:00

abstract：:N/A. ...

journal_title：Endocrine connections

authors： Koehrle J

更新日期：2021-01-01 00:00:00

abstract：:Phaeochromocytomas and paragangliomas (PPGLs) are tumours of the adrenal medulla and extra-adrenal sympathetic nervous system which often secrete catecholamines. Variants of the SDHX (SDHA, -AF2, -B, -C, -D) genes are a frequent cause of familial PPGLs. In this study from a single tertiary centre, we aimed to characte...

journal_title：Endocrine connections

authors： Main AM,Rossing M,Borgwardt L,Grønkær Toft B,Rasmussen ÅK,Feldt-Rasmussen U

更新日期：2020-08-01 00:00:00

abstract：Background:Non-adherence to r-hGH treatments occurs in a variable percentage of subjects. One problem found when evaluating adherence is the great variability in methods of detection and definitions utilized in studies. This study assessed the level of adherence in subjects receiving r-hGH with the easypod™ electronic ...

journal_title：Endocrine connections

authors： Rodríguez Arnao MD,Rodríguez Sánchez A,Díez López I,Ramírez Fernández J,Bermúdez de la Vega JA,Yeste Fernández D,Chueca Guindulain M,Corripio Collado R,Pérez Sánchez J,Fernández González A

更新日期：2019-09-01 00:00:00

abstract：Objective:Multiple endocrine neoplasia type 2A (MEN 2A) is a rare syndrome caused by RET germline mutations and has been associated with primary hyperparathyroidism (PHPT) in up to 30% of cases. Recommendations on RET screening in patients with apparently sporadic PHPT are unclear. We aimed to estimate the prevalence o...

journal_title：Endocrine connections

authors： Larsen LV,Mirebeau-Prunier D,Imai T,Alvarez-Escola C,Hasse-Lazar K,Censi S,Castroneves LA,Sakurai A,Kihara M,Horiuchi K,Barbu VD,Borson-Chazot F,Gimenez-Roqueplo AP,Pigny P,Pinson S,Wohllk N,Eng C,Aydogan BI,Saranath

更新日期：2020-06-01 00:00:00

abstract：:Many biomarkers are associated with type 2 diabetes (T2D) risk in epidemiological observations. The aim of this study was to identify and summarize current evidence for causal effects of biomarkers on T2D. A systematic literature search in PubMed and EMBASE (until April 2015) was done to identify Mendelian randomizati...

journal_title：Endocrine connections

authors： Abbasi A

更新日期：2015-12-01 00:00:00

abstract：:Growth hormone (GH) is used to treat short stature and growth failure associated with growth disorders. Birth size and GH status variably modulate response to GH therapy. The aim of this study was to determine the effect of birth size on response to GH therapy, and to determine the impact of GH status in patients born...

journal_title：Endocrine connections

authors： Rapaport R,Lee P,Ross J,Saenger P,Ostrow V,Piccoli G

更新日期：2018-08-23 00:00:00

abstract：Objectives:The aims of this paper were to evaluate the levels of Vitamin D (VitD) in patients with heart failure (HF), compared to a control group, to assess the effects of VitD on HF outcome and to compare VitD measurement between LIAISON immunoassay and HPLC-MS-MS methods in this population. Design and Methods:We co...

journal_title：Endocrine connections

authors： Saponaro F,Saba A,Frascarelli S,Frontera C,Clerico A,Scalese M,Sessa MR,Cetani F,Borsari S,Pardi E,Marvelli A,Marcocci C,Passino C,Zucchi R

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:Insulin-like growth factors are implicated in the development of diabetic nephropathy. IGF-binding protein 2 (IGFBP2) and IGF2 are expressed in the kidney, but their associations with diabetic nephropathy are unclear. We therefore tested the hypothesis that circulating levels of IGF2 and IGFBP2 predict longit...

journal_title：Endocrine connections

authors： Narayanan RP,Fu B,Heald AH,Siddals KW,Oliver RL,Hudson JE,Payton A,Anderson SG,White A,Ollier WE,Gibson JM

更新日期：2012-10-24 00:00:00

abstract：:Polycystic ovarian syndrome (PCOS) affects 18-22% of women at reproductive age. We conducted a systematic review and meta-analysis evaluating the expected benefits of lifestyle (exercise plus diet) interventions on the reproductive endocrine profile in women with PCOS. Potential studies were identified by systematical...

journal_title：Endocrine connections

authors： Haqq L,McFarlane J,Dieberg G,Smart N

更新日期：2014-02-28 00:00:00

abstract：:Hormonal cancers affect over 400,000 men and women and contribute collectively to over 100,000 deaths in the United States alone. Thanks to advances in the understanding of these cancers at the molecular level and to the discovery of several disease-modifying therapeutics, the last decade has seen a plateauing or even...

journal_title：Endocrine connections

authors： Ulm M,Ramesh AV,McNamara KM,Ponnusamy S,Sasano H,Narayanan R

更新日期：2019-02-01 00:00:00

abstract：Purpose:Gallbladder neuroendocrine neoplasm (GB-NEN) is a relatively rare neoplasm, accounting for 0.5% of all neuroendocrine neoplasm cases and 2.1% of gallbladder cancers. Because of the limited understanding of GB-NEN, the aim of this study was to explore the clinicopathology and survival of GB-NEN patients selected...

journal_title：Endocrine connections

authors： Cen D,Liu H,Wan Z,Lin Z,Wang Y,Xu J,Liang Y

更新日期：2019-09-01 00:00:00

abstract：:Insufficient insulin release plays a crucial role in the development of unhealthy status in patients with obesity; the present study aimed to classify these patients by the indices for insulin resistance and insulin release. After the indices from OGTT were assessed to achieve high differentiability and low redundancy...

journal_title：Endocrine connections

authors： Li L,Song Q,Yang X

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:The European Reference Network on Rare Endocrine Conditions (Endo-ERN), operational since 2017, consists of 71 health care providers (HCPs) in 19 EU member states. Our objective was to assess education and knowledge on rare endocrine conditions. DESIGN AND METHODS:A survey was developed and sent through the ...

journal_title：Endocrine connections

authors： Iotova V,Schalin-Jantti C,Bruegman P,Broesamle M,Bratina N,Tillmann V,Hiort O,Pereira AM

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:The value of postoperative radiotherapy in the treatment of medullary thyroid carcinoma (MTC) has not been unequivocally demonstrated. Therefore our study aimed to answer the question of whether adjuvant radiotherapy showed any impact on the risk of local recurrence and whether there were any differences in ...

journal_title：Endocrine connections

authors： Kukulska A,Krajewska J,Kolosza Z,Paliczka-Cieslik E,Kropinska A,Pawlaczek A,Puch Z,Ficek K,Lisik T,Sygula D,Wygoda Z,Roskosz J,Wydmanski J,Jarzab B

更新日期：2019-11-01 00:00:00

abstract：Background:A high level of free triiodothyronine (FT3) within the reference range may be a potential metabolic risk marker. However, the relationship between different fat depots and FT3 has remained unclear. Objective:We aimed to explore the relationships between segmental fat distribution and FT3 in euthyroid middle...

journal_title：Endocrine connections

authors： Nie X,Xu Y,Ma X,Shen Y,Wang Y,Bao Y

更新日期：2019-10-01 00:00:00

abstract：Objective:First-line chemotherapy in metastatic neuroendocrine carcinomas (NECs) is based on etoposide and platinum. However, there is no standard concerning second-line treatment. The objective of this study was to evaluate efficacy and tolerance of dacarbazine or temozolomide in metastatic digestive NEC as post first...

journal_title：Endocrine connections

authors： Couronne T,Girot P,Hadoux J,Lecomte T,Durand A,Fine C,Vandevoorde K,Lombard-Bohas C,Walter T

更新日期：2020-06-01 00:00:00

abstract：:Hypercalcemic crisis is a severe but rare complication of primary hyperparathyroidism (PHPT), and data on denosumab treatment of patients with this disease is still very limited. The aim of this paper is to investigate the hypocalcemic effect of denosumab in PHPT patients with severe hypercalcemia when surgery should ...

journal_title：Endocrine connections

authors： Eremkina A,Krupinova J,Dobreva E,Gorbacheva A,Bibik E,Samsonova M,Ajnetdinova A,Mokrysheva N

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:Metyrapone has been approved for the treatment of patients with Cushing's syndrome (CS), but only few retrospective clinical studies are available. The aim of our study was the prospective assessment of metyrapone as pre-operative treatment. DESIGN AND METHODS:Before adrenalectomy, 7 patients with ACTH-indep...

journal_title：Endocrine connections

authors： Puglisi S,Perotti P,Barbot M,Cosio P,Scaroni C,Stigliano A,Lardo P,Morelli V,Polledri E,Chiodini I,Reimondo G,Pia A,Terzolo M

更新日期：2018-09-01 00:00:00

abstract：:The role of G protein-coupled estrogen receptor 1 (GPER) signaling, including promotion of Ezrin phosphorylation (which could be activated by estrogen), has not yet been clearly identified in triple-negative breast cancer (TNBC). This study aimed to evaluate the prognostic value of GPER and Ezrin in TNBC patients. Cli...

journal_title：Endocrine connections

authors： Ye S,Xu Y,Li J,Zheng S,Sun P,Wang T

更新日期：2019-06-01 00:00:00