Abstract:
PURPOSE:Preoperative preparation for adrenalectomy for pheochromocytomas and paragangliomas (PPGL) is universally recognized as necessary, while the optimal strategy remains controversial. Our aims were to increase intraoperative hemodynamic stability, expedite postoperative recovery, decrease side effects and reduce costs for patients with PPGL undergoing adrenalectomy. METHODS:We identified 526 patients undergoing open adrenalectomy for PPGL in the West China Hospital of Sichuan University between May, 2007 and December, 2016. 149 patients received preoperative selective α-blockade with phenoxybenzamine, and 377 patients received non-selective α-blockade with prazosin, doxazosin or terazosin. There were no statistical differences between groups regarding preoperative patient and tumor characteristics. Operations were planned once hypertensive patients were well-controlled with blood pressure ≤130/85 mmHg. Intraoperatively, all patients received arterial blood pressure monitoring, and indwelling urinary catheters to record urine output. We recorded intraoperative hemodynamics, status in the postanesthesia or intensive care unit, postoperative recovery and complications. RESULTS:Patients in the non-selective group showed a more significant decline in postoperative systolic blood pressure than the selective group (P = 0.041). Also, patients in the non-selective group appeared to receive a long-term anti-hypertensive effect, especially for diastolic blood pressure (P = 0.037), which was a novel finding, based on the current literature. CONCLUSIONS:Our results confirmed that non-selective α-blockade produced a more significant anti-hypertensive effect than selective α-blockade. However, we found no significant difference in intraoperative hemodynamic instability, postoperative recovery and postoperative complications between groups.
journal_name
Endocr Connectjournal_title
Endocrine connectionsauthors
Liu C,Lv Q,Chen X,Ni G,Hu L,Tong N,Zhang Ydoi
10.1530/EC-17-0232subject
Has Abstractpub_date
2017-11-01 00:00:00pages
830-838issue
8issn
2049-3614pii
EC-17-0232journal_volume
6pub_type
杂志文章abstract:Purpose:Gallbladder neuroendocrine neoplasm (GB-NEN) is a relatively rare neoplasm, accounting for 0.5% of all neuroendocrine neoplasm cases and 2.1% of gallbladder cancers. Because of the limited understanding of GB-NEN, the aim of this study was to explore the clinicopathology and survival of GB-NEN patients selected...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0124
更新日期:2019-09-01 00:00:00
abstract::Hypercalcemic crisis is a severe but rare complication of primary hyperparathyroidism (PHPT), and data on denosumab treatment of patients with this disease is still very limited. The aim of this paper is to investigate the hypocalcemic effect of denosumab in PHPT patients with severe hypercalcemia when surgery should ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-20-0380
更新日期:2020-10-01 00:00:00
abstract:INTRODUCTION:Patients with acromegaly can be treated with surgery, medical therapy and/or radiation therapy. For the patients not being cured with surgery, treatment with somatostatin analogues (SSAs) is the primary therapy. SSA can be taken by self- or partner-administered injections in addition to being given by a nu...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-16-0038
更新日期:2016-07-01 00:00:00
abstract::Acromegaly is a rare disease due to chronic excess growth hormone (GH) and IGF-1. Aryl hydrocarbon receptor interacting protein (AIP) mutations are associated with an aggressive, inheritable form of acromegaly that responds poorly to SST2-specific somatostatin analogs (SSA). The role of pasireotide, an SSA with affini...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0004
更新日期:2019-04-01 00:00:00
abstract::Phaeochromocytomas and paragangliomas (PPGLs) are tumours of the adrenal medulla and extra-adrenal sympathetic nervous system which often secrete catecholamines. Variants of the SDHX (SDHA, -AF2, -B, -C, -D) genes are a frequent cause of familial PPGLs. In this study from a single tertiary centre, we aimed to characte...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-20-0279
更新日期:2020-08-01 00:00:00
abstract:Objective:The remarkable success of iodine deficiency disorders (IDD) elimination in China has been achieved through a mandatory universal salt iodization (USI) program. The study aims to estimate the relationship between urinary iodine concentration (UIC) and iodine content in edible salt to assess the current iodine ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0568
更新日期:2020-05-01 00:00:00
abstract::Background The combination of mitotane and platinum-etoposide chemotherapy is a front-line treatment in metastatic adrenocortical carcinoma (ACC), although this regimen shows limited efficacy. Pharmacokinetic drug-drug interaction between mitotane, a strong CYP3A4 inducer, and etoposide, which is a substrate of CYP3A4...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0428
更新日期:2018-12-01 00:00:00
abstract::Promotion of brown adipose tissue (BAT) activity or browning of white adipose tissue has shown great potential as anti-obesity strategy in numerous preclinical models. The discovery of active BAT in humans and the recent advances in the understanding of human BAT biology and function have significantly propelled this ...
journal_title:Endocrine connections
pub_type: 杂志文章,评审
doi:10.1530/EC-17-0037
更新日期:2017-07-01 00:00:00
abstract:Objectives:Walking and postural balance are extremely important to obtain food and to work. Both are critical for quality of life and ability to survive. While walking reflects musculoskeletal and cardiopulmonary systems, postural balance depends on body size, muscle tone, visual, vestibular and nervous systems. Since ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0103
更新日期:2019-04-01 00:00:00
abstract::This study aims to summarize and analyze the clinical manifestations, genetic characteristics, treatment modalities and long-term prognosis of congenital hyperinsulinemia (CHI) in Chinese children. Sixty children with CHI, who were treated at Beijing Children's Hospital from January 2014 to August 2017, and their fami...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0240
更新日期:2018-11-12 00:00:00
abstract:Objective:Accurate measurement of steroid hormones remains challenging. Mass spectrometry affords a reliable means for quantitating steroid profiles accurately. Our objective was to establish and define (1) the extent of diurnal fluctuations in steroid concentrations that potentially necessitate strict adherence to tim...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0417
更新日期:2018-12-01 00:00:00
abstract::N/A. ...
journal_title:Endocrine connections
pub_type: 杂志文章,评审
doi:10.1530/EC-21-0044
更新日期:2021-01-01 00:00:00
abstract:CONTEXT:Women with polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease (CVD), and biomarkers can be used to detect early subclinical CVD. Midregional-pro-adrenomedullin (MR-proADM), midregional-pro-atrial natriuretic peptide (MR-proANP) and copeptin are all associated with CVD and part of ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-17-0327
更新日期:2018-01-01 00:00:00
abstract::The aim of this study was to test i) whether patients having diabetes and ischemic heart disease (IHD), i.e., patients suffering from two chronic diseases, demonstrate a higher degree of chronic stress when compared with patients suffering from IHD alone, and ii) whether suffering from the two chronic diseases results...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-14-0083
更新日期:2014-12-01 00:00:00
abstract::The PI3K-Akt-mTOR pathway plays a central role in the development of non-medullary thyroid carcinoma (NMTC). Although somatic mutations have been identified in these genes in NMTC patients, the role of germline variants has not been investigated. Here, we selected frequently occurring genetic variants in AKT1, AKT2, A...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-20-0311
更新日期:2020-11-01 00:00:00
abstract:AIMS:Gestational diabetes mellitus (GDM)-induced macrosomia is predominantly characterized by fat accumulation, which is closely related to adipocyte differentiation. An unknown long noncoding RNA RP11-290L1.3, referred to as RP11, was identified to be dramatically upregulated in the umbilical cord blood of women with ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-20-0584
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:The value of postoperative radiotherapy in the treatment of medullary thyroid carcinoma (MTC) has not been unequivocally demonstrated. Therefore our study aimed to answer the question of whether adjuvant radiotherapy showed any impact on the risk of local recurrence and whether there were any differences in ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0387
更新日期:2019-11-01 00:00:00
abstract::The antihypertensive actions of glucagon-like peptide-1 (GLP1) receptor agonists have been linked to the release of atrial natriuretic peptide (ANP) in mice. Whether a GLP1-ANP axis exists in humans is unknown. In this study, we examined 12 healthy young males in a randomized, controlled, double-blinded, single-day, c...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-13-0087
更新日期:2014-01-21 00:00:00
abstract::Sex development is a process under genetic control directing both the bi-potential gonads to become either a testis or an ovary, and the consequent differentiation of internal ducts and external genitalia. This complex series of events can be altered by a large number of genetic and non-genetic factors. Disorders of s...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-14-0085
更新日期:2014-12-01 00:00:00
abstract:Objective:First-line chemotherapy in metastatic neuroendocrine carcinomas (NECs) is based on etoposide and platinum. However, there is no standard concerning second-line treatment. The objective of this study was to evaluate efficacy and tolerance of dacarbazine or temozolomide in metastatic digestive NEC as post first...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-20-0192
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:Little is known about how women with isolated GnRH deficiency cope with their condition. This study aimed to examine the health and informational needs of women with congenital hypogonadotropic hypogonadism (CHH) and evaluate if their experiences differ from women with more common forms of infertility. DESIG...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-17-0095
更新日期:2017-08-01 00:00:00
abstract::Tumor cells require large amounts of energy to sustain growth. Through the mediated transport of glucose transporters, the uptake and utilization of glucose by tumor cells are significantly enhanced in the hypoxic microenvironment. Pituitary adenomas are benign tumors with high-energy metabolisms. We aimed to investig...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0444
更新日期:2018-12-01 00:00:00
abstract:Objectives:The aims of this paper were to evaluate the levels of Vitamin D (VitD) in patients with heart failure (HF), compared to a control group, to assess the effects of VitD on HF outcome and to compare VitD measurement between LIAISON immunoassay and HPLC-MS-MS methods in this population. Design and Methods:We co...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0207
更新日期:2018-09-01 00:00:00
abstract::The renin-angiotensin system (RAS), mainly associated with the regulation of blood pressure, has been recently investigated in female reproductive organs and the developing foetus. Angiotensin II (Ang II) influences oviductal gamete movements and foetal development, but there is no information about RAS in the early e...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-12-0013
更新日期:2012-06-21 00:00:00
abstract::Many biomarkers are associated with type 2 diabetes (T2D) risk in epidemiological observations. The aim of this study was to identify and summarize current evidence for causal effects of biomarkers on T2D. A systematic literature search in PubMed and EMBASE (until April 2015) was done to identify Mendelian randomizati...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-15-0087
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:Metyrapone has been approved for the treatment of patients with Cushing's syndrome (CS), but only few retrospective clinical studies are available. The aim of our study was the prospective assessment of metyrapone as pre-operative treatment. DESIGN AND METHODS:Before adrenalectomy, 7 patients with ACTH-indep...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0400
更新日期:2018-09-01 00:00:00
abstract::Failure to suppress testosterone below 0.7 nM in castrated prostate cancer patients is associated with poor clinical outcomes. Testosterone levels in castrated patients are therefore routinely measured. Although mass spectrometry is the gold standard used to measure testosterone, most hospitals use an immunoassay meth...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0476
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Worldwide there is a high prevalence of 25-hydroxyvitamin D (25OHD) deficiency and has been associated with adverse outcomes during pregnancy. OBJECTIVE:This is a nested, case-control study in a longitudinal cohort to compare the serum 25OHD levels and other biomarkers throughout pregnancy in a group of 20 ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0055
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:Recently, mutations in KCNQ1, a potassium channel gene usually linked to long QT syndrome, were reported to cause maternally inherited gingival fibromatosis and growth hormone deficiency (GHD). Expression of the mutated KCNQ1 with the auxiliary potassium channel subunit KCNE2 was shown to reduce pituitary hor...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0123
更新日期:2018-05-01 00:00:00
abstract::The current investigation examined the association between the aging-related biomarkers dehydroepiandrosterone (DHEA) and telomere length (TL) in community-recruited African-American youth. The examination of DHEA included stress reactive, basal and diurnal sampling, in order to elucidate the underlying physiological ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-16-0007
更新日期:2016-05-01 00:00:00