High expression of an unknown long noncoding RNA RP11-290L1.3 from GDM macrosomia and its effect on preadipocyte differentiation.

abstract：:This study aims to summarize and analyze the clinical manifestations, genetic characteristics, treatment modalities and long-term prognosis of congenital hyperinsulinemia (CHI) in Chinese children. Sixty children with CHI, who were treated at Beijing Children's Hospital from January 2014 to August 2017, and their fami...

journal_title：Endocrine connections

authors： Xu ZD,Zhang W,Liu M,Wang HM,Hui PP,Liang XJ,Yan J,Wu YJ,Sang YM,Zhu C,Ni GC

更新日期：2018-11-12 00:00:00

abstract：BACKGROUND:The Institute of Medicine 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D specified higher intakes for all age groups compared to the 1997 report, but also cautioned against spurious claims about an epidemic of vitamin D deficiency and against advocates of higher intake requirements. Over ...

journal_title：Endocrine connections

authors： McKenna MJ,Murray BF,O'Keane M,Kilbane MT

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND/AIMS:Growth failure is a difficult but key aspect of care in children with anorexia nervosa (AN). The effects of hGH therapy have not been studied. The aim was to investigate the effect of hGH treatment on height velocity (HV) in children with AN. METHODS:We carried out a retrospective observational study. ...

journal_title：Endocrine connections

authors： Léger J,Fjellestad-Paulsen A,Bargiacchi A,Doyen C,Ecosse E,Carel JC,Le Heuzey MF

更新日期：2017-11-01 00:00:00

abstract：:Few data are available on the association between serum lipids and insulin secretion (ISEC) in children. We evaluated the association of triglycerides (TG), HDL cholesterol (HDL-C) and LDL cholesterol (LDL-C) with ISEC in 1150 non-diabetic obese children and adolescents using multivariable robust median regression. Th...

journal_title：Endocrine connections

authors： Bedogni G,Mari A,De Col A,Tamini S,Gastaldelli A,Sartorio A

更新日期：2019-10-01 00:00:00

abstract：:B lymphocytes are the source of autoantibodies against the thyroid-stimulating hormone receptor (TSHR) in Graves' disease (GD). Characterization of autoimmune B-cell expression profiles might enable a better understanding of GD pathogenesis. To reveal this, the expression levels of long noncoding RNAs (lncRNAs) and mR...

journal_title：Endocrine connections

authors： Jiang X,Wang Y,Li X,He L,Yang Q,Wang W,Liu J,Zha B

更新日期：2020-05-01 00:00:00

abstract：:The renin-angiotensin system (RAS), mainly associated with the regulation of blood pressure, has been recently investigated in female reproductive organs and the developing foetus. Angiotensin II (Ang II) influences oviductal gamete movements and foetal development, but there is no information about RAS in the early e...

journal_title：Endocrine connections

authors： Pijacka W,Hunter MG,Broughton Pipkin F,Luck MR

更新日期：2012-06-21 00:00:00

abstract：PURPOSE:Chromogranin A (CgA) and neuron-specific enolase (NSE) are important markers for neuroendocrine tumors; however, the clinical value of combining these markers has not been well studied. In this study, we investigated the utility of each marker individually and in combination for patients with nonfunctional panc...

journal_title：Endocrine connections

authors： Lv Y,Han X,Zhang C,Fang Y,Pu N,Ji Y,Wang D,Xuefeng X,Lou W

更新日期：2018-01-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is known to be associated with insulin resistance, atherosclerosis, and low serum IGF1 levels. We have described a large cohort of patients with isolated GH deficiency (IGHD) due to the c.57+1G→A mutation in the GHRH receptor gene. These subjects have increased insulin sensitiv...

journal_title：Endocrine connections

authors： Diniz RD,Souza RM,Salvatori R,Franca A,Gomes-Santos E,Ferrão TO,Oliveira CR,Santana JA,Pereira FA,Barbosa RA,Souza AH,Pereira RM,Oliveira-Santos AA,Silva AM,Santana-Júnior FJ,Valença EH,Campos VC,Aguiar-Oliveira MH

更新日期：2014-09-01 00:00:00

abstract：:The goal of this study was to explore the relationship of the BRAFV600E mutation with clinicopathologic factors and evaluate the effect of radioactive iodine (RAI) therapy in a large group of intermediate- and high-risk papillary thyroid cancer (PTC) patients with the BRAFV600E mutation and without distant metastases....

journal_title：Endocrine connections

authors： Zhu G,Deng Y,Pan L,Ouyang W,Feng H,Wu J,Chen P,Wang J,Chen Y,Luo J

更新日期：2019-06-01 00:00:00

abstract：:Macroprolactinomas are the most common functional pituitary tumours. Hypotheses proposed to explain predominance of large tumours in males are: i) diagnostic delay, as hyperprolactinaemia remains under recognised in males and ii) gender-specific difference in tumour proliferation indices. Our study objectives are to c...

journal_title：Endocrine connections

authors： Khare S,Lila AR,Patt H,Yerawar C,Goroshi M,Bandgar T,Shah NS

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:The European Reference Network on Rare Endocrine Conditions (Endo-ERN), operational since 2017, consists of 71 health care providers (HCPs) in 19 EU member states. Our objective was to assess education and knowledge on rare endocrine conditions. DESIGN AND METHODS:A survey was developed and sent through the ...

journal_title：Endocrine connections

authors： Iotova V,Schalin-Jantti C,Bruegman P,Broesamle M,Bratina N,Tillmann V,Hiort O,Pereira AM

更新日期：2020-12-01 00:00:00

abstract：:Sex development is a process under genetic control directing both the bi-potential gonads to become either a testis or an ovary, and the consequent differentiation of internal ducts and external genitalia. This complex series of events can be altered by a large number of genetic and non-genetic factors. Disorders of s...

journal_title：Endocrine connections

authors： Laino L,Majore S,Preziosi N,Grammatico B,De Bernardo C,Scommegna S,Rapone AM,Marrocco G,Bottillo I,Grammatico P

更新日期：2014-12-01 00:00:00

abstract：:The genetic aetiology of congenital hypopituitarism (CH) is not entirely elucidated. FGFR1 and PROKR2 loss-of-function mutations are classically involved in hypogonadotrophic hypogonadism (HH), however, due to the clinical and genetic overlap of HH and CH; these genes may also be involved in the pathogenesis of CH. Us...

journal_title：Endocrine connections

authors： Correa FA,Trarbach EB,Tusset C,Latronico AC,Montenegro LR,Carvalho LR,Franca MM,Otto AP,Costalonga EF,Brito VN,Abreu AP,Nishi MY,Jorge AA,Arnhold IJ,Sidis Y,Pitteloud N,Mendonca BB

更新日期：2015-06-01 00:00:00

abstract：:Hormonal cancers affect over 400,000 men and women and contribute collectively to over 100,000 deaths in the United States alone. Thanks to advances in the understanding of these cancers at the molecular level and to the discovery of several disease-modifying therapeutics, the last decade has seen a plateauing or even...

journal_title：Endocrine connections

authors： Ulm M,Ramesh AV,McNamara KM,Ponnusamy S,Sasano H,Narayanan R

更新日期：2019-02-01 00:00:00

abstract：:The purpose of this study was to assess the relationship between vitamin D receptor gene (VDR) expression and prognostic factors in papillary thyroid cancer (PTC). mRNA sequencing and somatic mutation data from The Cancer Genome Atlas (TCGA) were analyzed. VDR mRNA expression was compared to clinicopathologic variable...

journal_title：Endocrine connections

authors： Choi JY,Yi JW,Lee JH,Song RY,Yu H,Kwon H,Chai YJ,Kim SJ,Lee KE

更新日期：2017-04-01 00:00:00

abstract：:Tumor cells require large amounts of energy to sustain growth. Through the mediated transport of glucose transporters, the uptake and utilization of glucose by tumor cells are significantly enhanced in the hypoxic microenvironment. Pituitary adenomas are benign tumors with high-energy metabolisms. We aimed to investig...

journal_title：Endocrine connections

authors： Mei T,Zhang J,Wei L,Qi X,Ma Y,Liu X,Chen S,Li S,Wu J,Wang S

更新日期：2018-12-01 00:00:00

abstract：:The rapid increase of obesity during the last decades and its future prospects are alarming. Besides the general discussed causes of obesity, the 'Developmental Origins of Health and Disease' (DOHaD) hypothesis received more attention in recent years. This hypothesis postulates an adverse influence during early develo...

journal_title：Endocrine connections

authors： Ernst J,Gert K,Kraus FB,Rolle-Kampczyk UE,Wabitsch M,Dehghani F,Schaedlich K

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:Patients with non-functioning pituitary adenomas exhibit high morbidity and mortality rates. Growth hormone deficiency and high doses of glucocorticoid substitution therapy have been identified as corresponding risk factors. Interestingly, high levels of endogenous cortisol in, e.g., patients with post-trauma...

journal_title：Endocrine connections

authors： Athanasoulia-Kaspar AP,Auer MK,Stalla GK,Jakovcevski M

更新日期：2018-08-01 00:00:00

abstract：:Many biomarkers are associated with type 2 diabetes (T2D) risk in epidemiological observations. The aim of this study was to identify and summarize current evidence for causal effects of biomarkers on T2D. A systematic literature search in PubMed and EMBASE (until April 2015) was done to identify Mendelian randomizati...

journal_title：Endocrine connections

authors： Abbasi A

更新日期：2015-12-01 00:00:00

abstract：Purpose:Gallbladder neuroendocrine neoplasm (GB-NEN) is a relatively rare neoplasm, accounting for 0.5% of all neuroendocrine neoplasm cases and 2.1% of gallbladder cancers. Because of the limited understanding of GB-NEN, the aim of this study was to explore the clinicopathology and survival of GB-NEN patients selected...

journal_title：Endocrine connections

authors： Cen D,Liu H,Wan Z,Lin Z,Wang Y,Xu J,Liang Y

更新日期：2019-09-01 00:00:00

abstract：:The antihypertensive actions of glucagon-like peptide-1 (GLP1) receptor agonists have been linked to the release of atrial natriuretic peptide (ANP) in mice. Whether a GLP1-ANP axis exists in humans is unknown. In this study, we examined 12 healthy young males in a randomized, controlled, double-blinded, single-day, c...

journal_title：Endocrine connections

authors： Skov J,Holst JJ,Gøtze JP,Frøkiær J,Christiansen JS

更新日期：2014-01-21 00:00:00

abstract：:Insufficient insulin release plays a crucial role in the development of unhealthy status in patients with obesity; the present study aimed to classify these patients by the indices for insulin resistance and insulin release. After the indices from OGTT were assessed to achieve high differentiability and low redundancy...

journal_title：Endocrine connections

authors： Li L,Song Q,Yang X

更新日期：2020-02-01 00:00:00

abstract：Objective:Multiple endocrine neoplasia type 2A (MEN 2A) is a rare syndrome caused by RET germline mutations and has been associated with primary hyperparathyroidism (PHPT) in up to 30% of cases. Recommendations on RET screening in patients with apparently sporadic PHPT are unclear. We aimed to estimate the prevalence o...

journal_title：Endocrine connections

authors： Larsen LV,Mirebeau-Prunier D,Imai T,Alvarez-Escola C,Hasse-Lazar K,Censi S,Castroneves LA,Sakurai A,Kihara M,Horiuchi K,Barbu VD,Borson-Chazot F,Gimenez-Roqueplo AP,Pigny P,Pinson S,Wohllk N,Eng C,Aydogan BI,Saranath

更新日期：2020-06-01 00:00:00

abstract：:Acromegaly is a rare disease due to chronic excess growth hormone (GH) and IGF-1. Aryl hydrocarbon receptor interacting protein (AIP) mutations are associated with an aggressive, inheritable form of acromegaly that responds poorly to SST2-specific somatostatin analogs (SSA). The role of pasireotide, an SSA with affini...

journal_title：Endocrine connections

authors： Daly AF,Rostomyan L,Betea D,Bonneville JF,Villa C,Pellegata NS,Waser B,Reubi JC,Waeber Stephan C,Christ E,Beckers A

更新日期：2019-04-01 00:00:00

abstract：Background:The effect of isolated maternal hypothyroxinaemia (IMH) on pregnancy complications and neonatal outcomes in human beings is still controversial. Methods:This was a retrospective cohort study based on the electronic medical register system. The records of women with a singleton pregnancy who sought antenatal...

journal_title：Endocrine connections

authors： Su X,Zhao Y,Cao Z,Yang Y,Duan T,Hua J

更新日期：2019-04-01 00:00:00

abstract：:Classic galactosemia is a rare inborn error of galactose metabolism with a birth prevalence of about 1/30 000-60 000. Long-term complications occurring despite dietary treatment consist of premature ovarian insufficiency (POI) and neurodevelopmental impairments. We performed with the French Reference Centers for Rare ...

journal_title：Endocrine connections

authors： Flechtner I,Viaud M,Kariyawasam D,Perrissin-Fabert M,Bidet M,Bachelot A,Touraine P,Labrune P,De Lonlay P,Polak M,Galactosemia Study Group GSG

更新日期：2021-01-01 00:00:00

abstract：:The experience in the field of islet transplantation shows that it is possible to replace β cells in a patient with type 1 diabetes (T1D), but this cell therapy is limited by the scarcity of organ donors and by the danger associated to the immunosuppressive drugs. Stem cell therapy is becoming a concrete opportunity t...

journal_title：Endocrine connections

authors： Cito M,Pellegrini S,Piemonti L,Sordi V

更新日期：2018-03-01 00:00:00

abstract：:N/A. ...

journal_title：Endocrine connections

authors： Koehrle J

更新日期：2021-01-01 00:00:00

abstract：:Hypothyroidism is associated with increased risk of atherosclerosis. We assessed carotid intima-media thickness (CIMT), as a marker of atherosclerosis, and endothelial function in patients with hypothyroidism. We included 70 female patients with hypothyroidism in the study, 40 patients with overt and 30 patients with ...

journal_title：Endocrine connections

authors： Saif A,Mousa S,Assem M,Tharwat N,Abdelhamid A

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:Insulin-like growth factors are implicated in the development of diabetic nephropathy. IGF-binding protein 2 (IGFBP2) and IGF2 are expressed in the kidney, but their associations with diabetic nephropathy are unclear. We therefore tested the hypothesis that circulating levels of IGF2 and IGFBP2 predict longit...

journal_title：Endocrine connections

authors： Narayanan RP,Fu B,Heald AH,Siddals KW,Oliver RL,Hudson JE,Payton A,Anderson SG,White A,Ollier WE,Gibson JM

更新日期：2012-10-24 00:00:00