Abstract:
Purpose:Gallbladder neuroendocrine neoplasm (GB-NEN) is a relatively rare neoplasm, accounting for 0.5% of all neuroendocrine neoplasm cases and 2.1% of gallbladder cancers. Because of the limited understanding of GB-NEN, the aim of this study was to explore the clinicopathology and survival of GB-NEN patients selected from the Surveillance, Epidemiology, and End Results (SEER) database. Methods:A total of 248 GB-NEN patients from the SEER database diagnosed between 2004 and 2015 were included. Kaplan-Meier curves were used to examine the survival time. Multivariate Cox proportional hazard models were used to estimate hazard ratios with 95% confidence intervals to analyze the impact of factors on overall survival and cancer-specific survival. Results:The majority of the GB-NEN patients were women (67.3%), white (77%), and married (61.7%). Most tumors were <2 cm in size (31.0%), G3 stage (25.8%), and distant SEER stage (41.1%). 62.9% and 64.5% of cases showed an absence of lymph node metastasis and tumor metastasis, respectively. Patients who received gallbladder surgery had significantly better survival outcomes (P < 0.001). However, patients who received both gallbladder surgery and lymph node resection did not have better survival outcome compared with patients who received only gallbladder surgery. Multivariate Cox proportional hazard models indicated that older age, unmarried status, large tumor size (>5 cm), and distant SEER stage were significant independent predictors for decreased overall survival time and cancer-specific survival time (P < 0.05). Conclusion:Age, marital status, tumor size, and SEER stage were predictors for the survival of GB-NEN patients. Gallbladder surgery was associated with better survival, but the combination of gallbladder surgery and lymphadenectomy had no effect on survival outcomes.
journal_name
Endocr Connectjournal_title
Endocrine connectionsauthors
Cen D,Liu H,Wan Z,Lin Z,Wang Y,Xu J,Liang Ydoi
10.1530/EC-19-0124subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1273-1281issue
9issn
2049-3614pii
EC-19-0124.R4journal_volume
8pub_type
杂志文章abstract::Sex development is a process under genetic control directing both the bi-potential gonads to become either a testis or an ovary, and the consequent differentiation of internal ducts and external genitalia. This complex series of events can be altered by a large number of genetic and non-genetic factors. Disorders of s...
journal_title:Endocrine connections
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doi:10.1530/EC-14-0085
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journal_title:Endocrine connections
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journal_title:Endocrine connections
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journal_title:Endocrine connections
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abstract::N/A. ...
journal_title:Endocrine connections
pub_type: 杂志文章,评审
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journal_title:Endocrine connections
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journal_title:Endocrine connections
pub_type: 杂志文章
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journal_title:Endocrine connections
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更新日期:2017-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1530/EC-18-0428
更新日期:2018-12-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
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journal_title:Endocrine connections
pub_type: 杂志文章
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journal_title:Endocrine connections
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journal_title:Endocrine connections
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更新日期:2013-02-25 00:00:00
abstract::Vitamin D deficiency is common in pregnant women and may contribute to adverse events in pregnancy such as preeclampsia (PET). To date, studies of vitamin D and PET have focused primarily on serum concentrations vitamin D, 25-hydroxyvitamin D3 (25(OH)D3) later in pregnancy. The aim here was to determine whether a more...
journal_title:Endocrine connections
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更新日期:2018-01-01 00:00:00
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journal_title:Endocrine connections
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pub_type: 杂志文章
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journal_title:Endocrine connections
pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
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更新日期:2020-10-01 00:00:00