Cardiac magnetic resonance imaging of myocardial mass and fibrosis in primary aldosteronism.

abstract：:Polycystic ovarian syndrome (PCOS) affects 18-22% of women at reproductive age. We conducted a systematic review and meta-analysis evaluating the expected benefits of lifestyle (exercise plus diet) interventions on the reproductive endocrine profile in women with PCOS. Potential studies were identified by systematical...

journal_title：Endocrine connections

authors： Haqq L,McFarlane J,Dieberg G,Smart N

更新日期：2014-02-28 00:00:00

abstract：Aims:Neprilysin degrades natriuretic peptides in circulation and is also suggested to degrade the gut hormones gastrin and cholecystokinin. Neprilysin inhibition has become a therapeutic strategy and thus a regimen in need of further testing in terms of other hormonal axes besides natriuretic peptides. The aim of this ...

journal_title：Endocrine connections

authors： Andersen UØ,Terzic D,Wewer Albrechtsen NJ,Dall Mark P,Plomgaard P,Rehfeld JF,Gustafsson F,Goetze JP

更新日期：2020-05-01 00:00:00

abstract：:Insufficient insulin release plays a crucial role in the development of unhealthy status in patients with obesity; the present study aimed to classify these patients by the indices for insulin resistance and insulin release. After the indices from OGTT were assessed to achieve high differentiability and low redundancy...

journal_title：Endocrine connections

authors： Li L,Song Q,Yang X

更新日期：2020-02-01 00:00:00

abstract：:Many biomarkers are associated with type 2 diabetes (T2D) risk in epidemiological observations. The aim of this study was to identify and summarize current evidence for causal effects of biomarkers on T2D. A systematic literature search in PubMed and EMBASE (until April 2015) was done to identify Mendelian randomizati...

journal_title：Endocrine connections

authors： Abbasi A

更新日期：2015-12-01 00:00:00

abstract：Objectives:The aims of this paper were to evaluate the levels of Vitamin D (VitD) in patients with heart failure (HF), compared to a control group, to assess the effects of VitD on HF outcome and to compare VitD measurement between LIAISON immunoassay and HPLC-MS-MS methods in this population. Design and Methods:We co...

journal_title：Endocrine connections

authors： Saponaro F,Saba A,Frascarelli S,Frontera C,Clerico A,Scalese M,Sessa MR,Cetani F,Borsari S,Pardi E,Marvelli A,Marcocci C,Passino C,Zucchi R

更新日期：2018-09-01 00:00:00

abstract：Objective:Multiple endocrine neoplasia type 2A (MEN 2A) is a rare syndrome caused by RET germline mutations and has been associated with primary hyperparathyroidism (PHPT) in up to 30% of cases. Recommendations on RET screening in patients with apparently sporadic PHPT are unclear. We aimed to estimate the prevalence o...

journal_title：Endocrine connections

authors： Larsen LV,Mirebeau-Prunier D,Imai T,Alvarez-Escola C,Hasse-Lazar K,Censi S,Castroneves LA,Sakurai A,Kihara M,Horiuchi K,Barbu VD,Borson-Chazot F,Gimenez-Roqueplo AP,Pigny P,Pinson S,Wohllk N,Eng C,Aydogan BI,Saranath

更新日期：2020-06-01 00:00:00

abstract：Background:The effect of isolated maternal hypothyroxinaemia (IMH) on pregnancy complications and neonatal outcomes in human beings is still controversial. Methods:This was a retrospective cohort study based on the electronic medical register system. The records of women with a singleton pregnancy who sought antenatal...

journal_title：Endocrine connections

authors： Su X,Zhao Y,Cao Z,Yang Y,Duan T,Hua J

更新日期：2019-04-01 00:00:00

abstract：:Tumor cells require large amounts of energy to sustain growth. Through the mediated transport of glucose transporters, the uptake and utilization of glucose by tumor cells are significantly enhanced in the hypoxic microenvironment. Pituitary adenomas are benign tumors with high-energy metabolisms. We aimed to investig...

journal_title：Endocrine connections

authors： Mei T,Zhang J,Wei L,Qi X,Ma Y,Liu X,Chen S,Li S,Wu J,Wang S

更新日期：2018-12-01 00:00:00

abstract：:Phaeochromocytomas and paragangliomas (PPGLs) are tumours of the adrenal medulla and extra-adrenal sympathetic nervous system which often secrete catecholamines. Variants of the SDHX (SDHA, -AF2, -B, -C, -D) genes are a frequent cause of familial PPGLs. In this study from a single tertiary centre, we aimed to characte...

journal_title：Endocrine connections

authors： Main AM,Rossing M,Borgwardt L,Grønkær Toft B,Rasmussen ÅK,Feldt-Rasmussen U

更新日期：2020-08-01 00:00:00

abstract：:The role of G protein-coupled estrogen receptor 1 (GPER) signaling, including promotion of Ezrin phosphorylation (which could be activated by estrogen), has not yet been clearly identified in triple-negative breast cancer (TNBC). This study aimed to evaluate the prognostic value of GPER and Ezrin in TNBC patients. Cli...

journal_title：Endocrine connections

authors： Ye S,Xu Y,Li J,Zheng S,Sun P,Wang T

更新日期：2019-06-01 00:00:00

abstract：:According to its incidence patterns, colorectal cancer (CRC) tends to occur more frequently in males than in females, and the evidence shows that CRC is a hormone-related tumor. These findings indicate that androgen receptor (AR) gene methylation might be important for the regulation of the CRC risk in the different s...

journal_title：Endocrine connections

authors： Xia T,Sun H,Huang H,Bi H,Pu R,Zhang L,Zhang Y,Liu Y,Xu J,Onwuka JU,Liu Y,Cui B,Zhao Y

更新日期：2019-07-01 00:00:00

abstract：:Thyroid hormones stimulate bone turnover in adults by increasing osteoclastic bone resorption. TSH suppressive therapy is usually applied in patients with differentiated thyroid cancer (DTC) to improve the disease outcome. Over the last decades several authors have closely monitored the potential harm suffered by the ...

journal_title：Endocrine connections

authors： Brancatella A,Marcocci C

更新日期：2020-07-01 00:00:00

abstract：:Sex development is a process under genetic control directing both the bi-potential gonads to become either a testis or an ovary, and the consequent differentiation of internal ducts and external genitalia. This complex series of events can be altered by a large number of genetic and non-genetic factors. Disorders of s...

journal_title：Endocrine connections

authors： Laino L,Majore S,Preziosi N,Grammatico B,De Bernardo C,Scommegna S,Rapone AM,Marrocco G,Bottillo I,Grammatico P

更新日期：2014-12-01 00:00:00

abstract：:Steroid hormones play clinically important and specific regulatory roles in the development, growth, metabolism, reproduction and brain function in human. The type 1 and 2 11-beta hydroxysteroid dehydrogenase enzymes (11β-HSD1 and 2) have key roles in the pre-receptor modification of glucocorticoids allowing aldostero...

journal_title：Endocrine connections

authors： Bird AD,Greatorex S,Reser D,Lavery GG,Cole TJ

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:Preoperative preparation for adrenalectomy for pheochromocytomas and paragangliomas (PPGL) is universally recognized as necessary, while the optimal strategy remains controversial. Our aims were to increase intraoperative hemodynamic stability, expedite postoperative recovery, decrease side effects and reduce c...

journal_title：Endocrine connections

authors： Liu C,Lv Q,Chen X,Ni G,Hu L,Tong N,Zhang Y

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Worldwide there is a high prevalence of 25-hydroxyvitamin D (25OHD) deficiency and has been associated with adverse outcomes during pregnancy. OBJECTIVE:This is a nested, case-control study in a longitudinal cohort to compare the serum 25OHD levels and other biomarkers throughout pregnancy in a group of 20 ...

journal_title：Endocrine connections

authors： Agudelo-Zapata Y,Maldonado-Acosta LM,Sandoval-Alzate HF,Poveda NE,Garcés MF,Cortés-Vásquez JA,Linares-Vaca AF,Mancera-Rodríguez CA,Perea-Ariza SA,Ramírez-Iriarte KY,Castro-Saldarriaga CA,Arteaga-Diaz JM,Franco-Vega R,Ángel-Müll

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:Metyrapone has been approved for the treatment of patients with Cushing's syndrome (CS), but only few retrospective clinical studies are available. The aim of our study was the prospective assessment of metyrapone as pre-operative treatment. DESIGN AND METHODS:Before adrenalectomy, 7 patients with ACTH-indep...

journal_title：Endocrine connections

authors： Puglisi S,Perotti P,Barbot M,Cosio P,Scaroni C,Stigliano A,Lardo P,Morelli V,Polledri E,Chiodini I,Reimondo G,Pia A,Terzolo M

更新日期：2018-09-01 00:00:00

abstract：:Hormonal cancers affect over 400,000 men and women and contribute collectively to over 100,000 deaths in the United States alone. Thanks to advances in the understanding of these cancers at the molecular level and to the discovery of several disease-modifying therapeutics, the last decade has seen a plateauing or even...

journal_title：Endocrine connections

authors： Ulm M,Ramesh AV,McNamara KM,Ponnusamy S,Sasano H,Narayanan R

更新日期：2019-02-01 00:00:00

abstract：:The renin-angiotensin system (RAS), mainly associated with the regulation of blood pressure, has been recently investigated in female reproductive organs and the developing foetus. Angiotensin II (Ang II) influences oviductal gamete movements and foetal development, but there is no information about RAS in the early e...

journal_title：Endocrine connections

authors： Pijacka W,Hunter MG,Broughton Pipkin F,Luck MR

更新日期：2012-06-21 00:00:00

abstract：:Background The combination of mitotane and platinum-etoposide chemotherapy is a front-line treatment in metastatic adrenocortical carcinoma (ACC), although this regimen shows limited efficacy. Pharmacokinetic drug-drug interaction between mitotane, a strong CYP3A4 inducer, and etoposide, which is a substrate of CYP3A4...

journal_title：Endocrine connections

authors： Jouinot A,Royer B,Chatelut E,Moeung S,Assié G,Thomas-Schoemann A,Bertherat J,Goldwasser F,Blanchet B

更新日期：2018-12-01 00:00:00

abstract：:The purpose of this study was to assess the relationship between vitamin D receptor gene (VDR) expression and prognostic factors in papillary thyroid cancer (PTC). mRNA sequencing and somatic mutation data from The Cancer Genome Atlas (TCGA) were analyzed. VDR mRNA expression was compared to clinicopathologic variable...

journal_title：Endocrine connections

authors： Choi JY,Yi JW,Lee JH,Song RY,Yu H,Kwon H,Chai YJ,Kim SJ,Lee KE

更新日期：2017-04-01 00:00:00

abstract：:Primary hyperparathyroidism (PHPT) is a common endocrinopathy, frequently caused by a parathyroid adenoma, rarely by a parathyroid carcinoma that lacks effective oncological treatment. As the majority of cases are present in postmenopausal women, oestrogen signalling has been implicated in the tumourigenesis. Oestroge...

journal_title：Endocrine connections

authors： Haglund F,Rosin G,Nilsson IL,Juhlin CC,Pernow Y,Norenstedt S,Dinets A,Larsson C,Hartman J,Höög A

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:The value of postoperative radiotherapy in the treatment of medullary thyroid carcinoma (MTC) has not been unequivocally demonstrated. Therefore our study aimed to answer the question of whether adjuvant radiotherapy showed any impact on the risk of local recurrence and whether there were any differences in ...

journal_title：Endocrine connections

authors： Kukulska A,Krajewska J,Kolosza Z,Paliczka-Cieslik E,Kropinska A,Pawlaczek A,Puch Z,Ficek K,Lisik T,Sygula D,Wygoda Z,Roskosz J,Wydmanski J,Jarzab B

更新日期：2019-11-01 00:00:00

abstract：Background:Non-adherence to r-hGH treatments occurs in a variable percentage of subjects. One problem found when evaluating adherence is the great variability in methods of detection and definitions utilized in studies. This study assessed the level of adherence in subjects receiving r-hGH with the easypod™ electronic ...

journal_title：Endocrine connections

authors： Rodríguez Arnao MD,Rodríguez Sánchez A,Díez López I,Ramírez Fernández J,Bermúdez de la Vega JA,Yeste Fernández D,Chueca Guindulain M,Corripio Collado R,Pérez Sánchez J,Fernández González A

更新日期：2019-09-01 00:00:00

abstract：:To date, the value of fasting plasma acylated ghrelin (AG) and unacylated ghrelin (UAG) as potential novel biomarkers in patients with neuroendocrine tumors (NETs) is unknown. The aims of this study are to (i) compare fasting AG and UAG levels between nonobese, nondiabetic NET patients (N=28) and age- (±3 years) and s...

journal_title：Endocrine connections

authors： van Adrichem RC,van der Lely AJ,Huisman M,Kramer P,Feelders RA,Delhanty PJ,de Herder WW

更新日期：2016-07-01 00:00:00

abstract：:Macroprolactinomas are the most common functional pituitary tumours. Hypotheses proposed to explain predominance of large tumours in males are: i) diagnostic delay, as hyperprolactinaemia remains under recognised in males and ii) gender-specific difference in tumour proliferation indices. Our study objectives are to c...

journal_title：Endocrine connections

authors： Khare S,Lila AR,Patt H,Yerawar C,Goroshi M,Bandgar T,Shah NS

更新日期：2016-01-01 00:00:00

abstract：:Acromegaly is a rare and insidious disease characterized by the overproduction of growth hormone (GH) and insulin-like growth factor 1 (IGF1) and is most commonly due to a pituitary adenoma. Patients with acromegaly who experience prolonged exposure to elevated levels of GH and IGF1 have an increased mortality risk an...

journal_title：Endocrine connections

authors： Silverstein JM

更新日期：2015-12-01 00:00:00

abstract：Purpose:Gallbladder neuroendocrine neoplasm (GB-NEN) is a relatively rare neoplasm, accounting for 0.5% of all neuroendocrine neoplasm cases and 2.1% of gallbladder cancers. Because of the limited understanding of GB-NEN, the aim of this study was to explore the clinicopathology and survival of GB-NEN patients selected...

journal_title：Endocrine connections

authors： Cen D,Liu H,Wan Z,Lin Z,Wang Y,Xu J,Liang Y

更新日期：2019-09-01 00:00:00

abstract：:The goal of this study was to explore the relationship of the BRAFV600E mutation with clinicopathologic factors and evaluate the effect of radioactive iodine (RAI) therapy in a large group of intermediate- and high-risk papillary thyroid cancer (PTC) patients with the BRAFV600E mutation and without distant metastases....

journal_title：Endocrine connections

authors： Zhu G,Deng Y,Pan L,Ouyang W,Feng H,Wu J,Chen P,Wang J,Chen Y,Luo J

更新日期：2019-06-01 00:00:00

abstract：:Hormonal changes during pregnancy can trigger gestational diabetes (GDM), which is constantly increasing. Its main characteristic is pronounced insulin resistance, but it appears to be a multifactorial process involving several metabolic factors; taken together, the latter leads to silent or clinically evident cardiov...

journal_title：Endocrine connections

authors： Patti AM,Pafili K,Papanas N,Rizzo M

更新日期：2018-05-01 00:00:00