Abstract:
:Acromegaly is a rare and insidious disease characterized by the overproduction of growth hormone (GH) and insulin-like growth factor 1 (IGF1) and is most commonly due to a pituitary adenoma. Patients with acromegaly who experience prolonged exposure to elevated levels of GH and IGF1 have an increased mortality risk and progressive worsening of disease-related comorbidities. Multimodal treatment with surgery, medical therapy, and radiotherapy provides biochemical control, defined by recent acromegaly clinical guidelines from the Endocrine Society as a reduction of GH levels to <1.0 ng/ml and normalization of IGF1 levels, to a substantial proportion of patients and is associated with improved clinical outcomes. Patients with acromegaly, even those without clinical symptoms of disease, require long-term monitoring of GH and IGF1 levels if the benefits associated with biochemical control are to be maintained and the risk of developing recurrent disease is to be abated. However, suboptimal monitoring is common in patients with acromegaly, and this can have negative health effects due to delays in detection of recurrent disease and implementation of appropriate treatment. Because of the significant health consequences associated with prolonged exposure to elevated levels of GH and IGF1, optimal monitoring in patients with acromegaly is needed. This review article will discuss the biochemical assessments used for therapeutic monitoring in acromegaly, the importance of monitoring after surgery and medical therapy or radiotherapy, the consequences of suboptimal monitoring, and the need for improved monitoring algorithms for patients with acromegaly.
journal_name
Endocr Connectjournal_title
Endocrine connectionsauthors
Silverstein JMdoi
10.1530/EC-15-0064subject
Has Abstractpub_date
2015-12-01 00:00:00pages
R59-67issue
4issn
2049-3614pii
EC-15-0064journal_volume
4pub_type
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-15-0105
更新日期:2016-01-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-17-0119
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pub_type: 杂志文章
doi:10.1530/EC-19-0088
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-20-0045
更新日期:2020-05-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0286
更新日期:2018-08-23 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0568
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pub_type: 杂志文章
doi:10.1530/EC-20-0279
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-17-0349
更新日期:2018-03-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-13-0087
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-15-0015
更新日期:2015-06-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-15-0087
更新日期:2015-12-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-21-0013
更新日期:2021-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1530/EC-18-0425
更新日期:2019-02-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0123
更新日期:2018-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1530/EC-17-0001
更新日期:2017-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0039
更新日期:2018-03-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-17-0095
更新日期:2017-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1530/EC-19-0394
更新日期:2019-10-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
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更新日期:2019-06-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1530/EC-19-0164
更新日期:2019-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1530/EC-12-0074
更新日期:2013-02-25 00:00:00
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pub_type: 杂志文章
doi:10.1530/EC-18-0207
更新日期:2018-09-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-12-0013
更新日期:2012-06-21 00:00:00
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journal_title:Endocrine connections
pub_type: 社论
doi:10.1530/EC-18-0130
更新日期:2018-05-01 00:00:00