Tumour nuclear oestrogen receptor beta 1 correlates inversely with parathyroid tumour weight.

abstract：:Few data are available on the association between serum lipids and insulin secretion (ISEC) in children. We evaluated the association of triglycerides (TG), HDL cholesterol (HDL-C) and LDL cholesterol (LDL-C) with ISEC in 1150 non-diabetic obese children and adolescents using multivariable robust median regression. Th...

journal_title：Endocrine connections

authors： Bedogni G,Mari A,De Col A,Tamini S,Gastaldelli A,Sartorio A

更新日期：2019-10-01 00:00:00

abstract：:The vasoactive intestinal peptide receptor 2 (VPAC2) is widely distributed throughout the body and is also overexpressed in a variety of human neoplastic tissues. However, little is known about its precise tissue distribution, regulation and function, which is in part be due to the lack of specific monoclonal anti-VPA...

journal_title：Endocrine connections

authors： Schulz S,Mann A,Novakhov B,Piggins HD,Lupp A

更新日期：2015-03-01 00:00:00

abstract：Objective:First-line chemotherapy in metastatic neuroendocrine carcinomas (NECs) is based on etoposide and platinum. However, there is no standard concerning second-line treatment. The objective of this study was to evaluate efficacy and tolerance of dacarbazine or temozolomide in metastatic digestive NEC as post first...

journal_title：Endocrine connections

authors： Couronne T,Girot P,Hadoux J,Lecomte T,Durand A,Fine C,Vandevoorde K,Lombard-Bohas C,Walter T

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION AND AIM:Ectopic ACTH secretion (EAS) is mostly secondary to thoracic/abdominal neuroendocrine tumours (NETs), or small cell-lung carcinoma (SCLC). We studied the diagnostic accuracy of computed tomography (CT) with 68Ga-Dota derivatives (68Ga-SSTR) positron emission tomography (PET) in localizing ACTH-secr...

journal_title：Endocrine connections

authors： Ceccato F,Cecchin D,Gregianin M,Ricci G,Campi C,Crimì F,Bergamo M,Versari A,Lacognata C,Rea F,Barbot M,Scaroni C

更新日期：2020-03-01 00:00:00

abstract：CONTEXT:Women with polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease (CVD), and biomarkers can be used to detect early subclinical CVD. Midregional-pro-adrenomedullin (MR-proADM), midregional-pro-atrial natriuretic peptide (MR-proANP) and copeptin are all associated with CVD and part of ...

journal_title：Endocrine connections

authors： Frøssing S,Nylander M,Kistorp C,Skouby SO,Faber J

更新日期：2018-01-01 00:00:00

abstract：:According to its incidence patterns, colorectal cancer (CRC) tends to occur more frequently in males than in females, and the evidence shows that CRC is a hormone-related tumor. These findings indicate that androgen receptor (AR) gene methylation might be important for the regulation of the CRC risk in the different s...

journal_title：Endocrine connections

authors： Xia T,Sun H,Huang H,Bi H,Pu R,Zhang L,Zhang Y,Liu Y,Xu J,Onwuka JU,Liu Y,Cui B,Zhao Y

更新日期：2019-07-01 00:00:00

abstract：:Hormonal changes during pregnancy can trigger gestational diabetes (GDM), which is constantly increasing. Its main characteristic is pronounced insulin resistance, but it appears to be a multifactorial process involving several metabolic factors; taken together, the latter leads to silent or clinically evident cardiov...

journal_title：Endocrine connections

authors： Patti AM,Pafili K,Papanas N,Rizzo M

更新日期：2018-05-01 00:00:00

abstract：:This study aims to summarize and analyze the clinical manifestations, genetic characteristics, treatment modalities and long-term prognosis of congenital hyperinsulinemia (CHI) in Chinese children. Sixty children with CHI, who were treated at Beijing Children's Hospital from January 2014 to August 2017, and their fami...

journal_title：Endocrine connections

authors： Xu ZD,Zhang W,Liu M,Wang HM,Hui PP,Liang XJ,Yan J,Wu YJ,Sang YM,Zhu C,Ni GC

更新日期：2018-11-12 00:00:00

abstract：BACKGROUND:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is a rare autosomal recessive disorder caused by mutations of the autoimmune regulator (AIRE) gene, whose loss of function leads to the escape of self-reactive T cells from the thymus and autoimmunity. APECED patients typically develop t...

journal_title：Endocrine connections

authors： Kluger N,Krohn K,Ranki A

更新日期：2013-02-25 00:00:00

abstract：:Classic galactosemia is a rare inborn error of galactose metabolism with a birth prevalence of about 1/30 000-60 000. Long-term complications occurring despite dietary treatment consist of premature ovarian insufficiency (POI) and neurodevelopmental impairments. We performed with the French Reference Centers for Rare ...

journal_title：Endocrine connections

authors： Flechtner I,Viaud M,Kariyawasam D,Perrissin-Fabert M,Bidet M,Bachelot A,Touraine P,Labrune P,De Lonlay P,Polak M,Galactosemia Study Group GSG

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:Recently, mutations in KCNQ1, a potassium channel gene usually linked to long QT syndrome, were reported to cause maternally inherited gingival fibromatosis and growth hormone deficiency (GHD). Expression of the mutated KCNQ1 with the auxiliary potassium channel subunit KCNE2 was shown to reduce pituitary hor...

journal_title：Endocrine connections

authors： Iivonen AP,Känsäkoski J,Karppinen A,Kivipelto L,Schalin-Jäntti C,Karhu A,Raivio T

更新日期：2018-05-01 00:00:00

abstract：:The rapid increase of obesity during the last decades and its future prospects are alarming. Besides the general discussed causes of obesity, the 'Developmental Origins of Health and Disease' (DOHaD) hypothesis received more attention in recent years. This hypothesis postulates an adverse influence during early develo...

journal_title：Endocrine connections

authors： Ernst J,Gert K,Kraus FB,Rolle-Kampczyk UE,Wabitsch M,Dehghani F,Schaedlich K

更新日期：2020-07-01 00:00:00

abstract：:The genetic aetiology of congenital hypopituitarism (CH) is not entirely elucidated. FGFR1 and PROKR2 loss-of-function mutations are classically involved in hypogonadotrophic hypogonadism (HH), however, due to the clinical and genetic overlap of HH and CH; these genes may also be involved in the pathogenesis of CH. Us...

journal_title：Endocrine connections

authors： Correa FA,Trarbach EB,Tusset C,Latronico AC,Montenegro LR,Carvalho LR,Franca MM,Otto AP,Costalonga EF,Brito VN,Abreu AP,Nishi MY,Jorge AA,Arnhold IJ,Sidis Y,Pitteloud N,Mendonca BB

更新日期：2015-06-01 00:00:00

abstract：Background:A high level of free triiodothyronine (FT3) within the reference range may be a potential metabolic risk marker. However, the relationship between different fat depots and FT3 has remained unclear. Objective:We aimed to explore the relationships between segmental fat distribution and FT3 in euthyroid middle...

journal_title：Endocrine connections

authors： Nie X,Xu Y,Ma X,Shen Y,Wang Y,Bao Y

更新日期：2019-10-01 00:00:00

abstract：:Failure to suppress testosterone below 0.7 nM in castrated prostate cancer patients is associated with poor clinical outcomes. Testosterone levels in castrated patients are therefore routinely measured. Although mass spectrometry is the gold standard used to measure testosterone, most hospitals use an immunoassay meth...

journal_title：Endocrine connections

authors： Rouleau M,Lemire F,Déry M,Thériault B,Dubois G,Fradet Y,Toren P,Guillemette C,Lacombe L,Klotz L,Saad F,Guérette D,Pouliot F

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:Preoperative preparation for adrenalectomy for pheochromocytomas and paragangliomas (PPGL) is universally recognized as necessary, while the optimal strategy remains controversial. Our aims were to increase intraoperative hemodynamic stability, expedite postoperative recovery, decrease side effects and reduce c...

journal_title：Endocrine connections

authors： Liu C,Lv Q,Chen X,Ni G,Hu L,Tong N,Zhang Y

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:Little is known about how women with isolated GnRH deficiency cope with their condition. This study aimed to examine the health and informational needs of women with congenital hypogonadotropic hypogonadism (CHH) and evaluate if their experiences differ from women with more common forms of infertility. DESIG...

journal_title：Endocrine connections

authors： Dzemaili S,Tiemensma J,Quinton R,Pitteloud N,Morin D,Dwyer AA

更新日期：2017-08-01 00:00:00

abstract：:Background and objectives Glucocorticoids are used to manage adrenal insufficiency (AI). We describe treatments used in the United Kingdom and real-world clinical outcomes for each treatment. Methods We used 2010-2016 primary care data from The Health Improvement Network (THIN). Descriptive analyses were conducted, an...

journal_title：Endocrine connections

authors： Iqbal K,Halsby K,Murray RD,Carroll PV,Petermann R

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Worldwide there is a high prevalence of 25-hydroxyvitamin D (25OHD) deficiency and has been associated with adverse outcomes during pregnancy. OBJECTIVE:This is a nested, case-control study in a longitudinal cohort to compare the serum 25OHD levels and other biomarkers throughout pregnancy in a group of 20 ...

journal_title：Endocrine connections

authors： Agudelo-Zapata Y,Maldonado-Acosta LM,Sandoval-Alzate HF,Poveda NE,Garcés MF,Cortés-Vásquez JA,Linares-Vaca AF,Mancera-Rodríguez CA,Perea-Ariza SA,Ramírez-Iriarte KY,Castro-Saldarriaga CA,Arteaga-Diaz JM,Franco-Vega R,Ángel-Müll

更新日期：2018-05-01 00:00:00

abstract：:Macroprolactinomas are the most common functional pituitary tumours. Hypotheses proposed to explain predominance of large tumours in males are: i) diagnostic delay, as hyperprolactinaemia remains under recognised in males and ii) gender-specific difference in tumour proliferation indices. Our study objectives are to c...

journal_title：Endocrine connections

authors： Khare S,Lila AR,Patt H,Yerawar C,Goroshi M,Bandgar T,Shah NS

更新日期：2016-01-01 00:00:00

abstract：:Acromegaly is a rare disease due to chronic excess growth hormone (GH) and IGF-1. Aryl hydrocarbon receptor interacting protein (AIP) mutations are associated with an aggressive, inheritable form of acromegaly that responds poorly to SST2-specific somatostatin analogs (SSA). The role of pasireotide, an SSA with affini...

journal_title：Endocrine connections

authors： Daly AF,Rostomyan L,Betea D,Bonneville JF,Villa C,Pellegata NS,Waser B,Reubi JC,Waeber Stephan C,Christ E,Beckers A

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:The value of postoperative radiotherapy in the treatment of medullary thyroid carcinoma (MTC) has not been unequivocally demonstrated. Therefore our study aimed to answer the question of whether adjuvant radiotherapy showed any impact on the risk of local recurrence and whether there were any differences in ...

journal_title：Endocrine connections

authors： Kukulska A,Krajewska J,Kolosza Z,Paliczka-Cieslik E,Kropinska A,Pawlaczek A,Puch Z,Ficek K,Lisik T,Sygula D,Wygoda Z,Roskosz J,Wydmanski J,Jarzab B

更新日期：2019-11-01 00:00:00

abstract：:Islet transplantation is currently the only minimally invasive therapy available for patients with type 1 diabetes that can lead to insulin independence; however, it is limited to only a small number of patients. Although clinical procedures have improved in the isolation and culture of islets, a large number of islet...

journal_title：Endocrine connections

authors： Rojas-Canales DM,Waibel M,Forget A,Penko D,Nitschke J,Harding FJ,Delalat B,Blencowe A,Loudovaris T,Grey ST,Thomas HE,Kay TWH,Drogemuller CJ,Voelcker NH,Coates PT

更新日期：2018-03-01 00:00:00

abstract：:Steroid hormones play clinically important and specific regulatory roles in the development, growth, metabolism, reproduction and brain function in human. The type 1 and 2 11-beta hydroxysteroid dehydrogenase enzymes (11β-HSD1 and 2) have key roles in the pre-receptor modification of glucocorticoids allowing aldostero...

journal_title：Endocrine connections

authors： Bird AD,Greatorex S,Reser D,Lavery GG,Cole TJ

更新日期：2017-10-01 00:00:00

abstract：:This study aimed to evaluate the evolving trends in clinicopathological features of pancreatic neuroendocrine tumors and to analyze the predictors of recurrence after curative resection. Data collected retrospectively from a single center between January 1990 and December 2017 were analyzed. Patients were categorized ...

journal_title：Endocrine connections

authors： Kim H,Song KB,Hwang DW,Lee JH,Alshammary S,Kim SC

更新日期：2019-07-01 00:00:00

abstract：Objective:Accurate measurement of steroid hormones remains challenging. Mass spectrometry affords a reliable means for quantitating steroid profiles accurately. Our objective was to establish and define (1) the extent of diurnal fluctuations in steroid concentrations that potentially necessitate strict adherence to tim...

journal_title：Endocrine connections

authors： Parikh TP,Stolze B,Ozarda Y,Jonklaas J,Welsh K,Masika L,Hill M,DeCherney A,Soldin SJ

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:Patients with non-functioning pituitary adenomas exhibit high morbidity and mortality rates. Growth hormone deficiency and high doses of glucocorticoid substitution therapy have been identified as corresponding risk factors. Interestingly, high levels of endogenous cortisol in, e.g., patients with post-trauma...

journal_title：Endocrine connections

authors： Athanasoulia-Kaspar AP,Auer MK,Stalla GK,Jakovcevski M

更新日期：2018-08-01 00:00:00

abstract：:The role of G protein-coupled estrogen receptor 1 (GPER) signaling, including promotion of Ezrin phosphorylation (which could be activated by estrogen), has not yet been clearly identified in triple-negative breast cancer (TNBC). This study aimed to evaluate the prognostic value of GPER and Ezrin in TNBC patients. Cli...

journal_title：Endocrine connections

authors： Ye S,Xu Y,Li J,Zheng S,Sun P,Wang T

更新日期：2019-06-01 00:00:00

abstract：Aims:Neprilysin degrades natriuretic peptides in circulation and is also suggested to degrade the gut hormones gastrin and cholecystokinin. Neprilysin inhibition has become a therapeutic strategy and thus a regimen in need of further testing in terms of other hormonal axes besides natriuretic peptides. The aim of this ...

journal_title：Endocrine connections

authors： Andersen UØ,Terzic D,Wewer Albrechtsen NJ,Dall Mark P,Plomgaard P,Rehfeld JF,Gustafsson F,Goetze JP

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE:The European Reference Network on Rare Endocrine Conditions (Endo-ERN), operational since 2017, consists of 71 health care providers (HCPs) in 19 EU member states. Our objective was to assess education and knowledge on rare endocrine conditions. DESIGN AND METHODS:A survey was developed and sent through the ...

journal_title：Endocrine connections

authors： Iotova V,Schalin-Jantti C,Bruegman P,Broesamle M,Bratina N,Tillmann V,Hiort O,Pereira AM

更新日期：2020-12-01 00:00:00