Abstract:
:Insufficient insulin release plays a crucial role in the development of unhealthy status in patients with obesity; the present study aimed to classify these patients by the indices for insulin resistance and insulin release. After the indices from OGTT were assessed to achieve high differentiability and low redundancy in classifying patients, HOMA-IR and IGI30min were chosen to classify the patients using K-means clustering method. A total of 249 non-diabetic patients with obesity were classified into four groups. In Group 1, 19 patients were characteristic of high insulin resistance and high insulin release, as well as well-controlled glucose levels, the highest BMI, the youngest age, and the highest early phase release of insulin. In Group 2, 38 patients were unhealthiest in terms of high insulin resistance, reduced insulin release and IGT status. Group 3 consisted of 63 patients that were healthiest with low insulin resistance and high insulin release. In Group 4, 46 IGT patients and 14 IFG patients were identified among 129 patients that showed low insulin resistance, low insulin release, moderate obesity and older age. These concurrent impotent insulin release, older age, and moderate obesity indicated decreasing obesity with increasing age and reduced insulin release. The classification of patients with obesity using K-means clustering method by HOMA-IR and IGI30min provides more information about the development of obesity and unhealthy status. The patients with distinct insulin resistance and insulin release should be followed up, especially for those with reduced or even absent insulin response to glucose stimulation.
journal_name
Endocr Connectjournal_title
Endocrine connectionsauthors
Li L,Song Q,Yang Xdoi
10.1530/EC-19-0476subject
Has Abstractpub_date
2020-02-01 00:00:00pages
135-143issue
2issn
2049-3614pii
EC-19-0476journal_volume
9pub_type
杂志文章abstract::B lymphocytes are the source of autoantibodies against the thyroid-stimulating hormone receptor (TSHR) in Graves' disease (GD). Characterization of autoimmune B-cell expression profiles might enable a better understanding of GD pathogenesis. To reveal this, the expression levels of long noncoding RNAs (lncRNAs) and mR...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-20-0045
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is a rare autosomal recessive disorder caused by mutations of the autoimmune regulator (AIRE) gene, whose loss of function leads to the escape of self-reactive T cells from the thymus and autoimmunity. APECED patients typically develop t...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-12-0074
更新日期:2013-02-25 00:00:00
abstract:Objectives:Walking and postural balance are extremely important to obtain food and to work. Both are critical for quality of life and ability to survive. While walking reflects musculoskeletal and cardiopulmonary systems, postural balance depends on body size, muscle tone, visual, vestibular and nervous systems. Since ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0103
更新日期:2019-04-01 00:00:00
abstract:INTRODUCTION AND AIM:Ectopic ACTH secretion (EAS) is mostly secondary to thoracic/abdominal neuroendocrine tumours (NETs), or small cell-lung carcinoma (SCLC). We studied the diagnostic accuracy of computed tomography (CT) with 68Ga-Dota derivatives (68Ga-SSTR) positron emission tomography (PET) in localizing ACTH-secr...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-20-0089
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:Little is known about how women with isolated GnRH deficiency cope with their condition. This study aimed to examine the health and informational needs of women with congenital hypogonadotropic hypogonadism (CHH) and evaluate if their experiences differ from women with more common forms of infertility. DESIG...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-17-0095
更新日期:2017-08-01 00:00:00
abstract:Objective:First-line chemotherapy in metastatic neuroendocrine carcinomas (NECs) is based on etoposide and platinum. However, there is no standard concerning second-line treatment. The objective of this study was to evaluate efficacy and tolerance of dacarbazine or temozolomide in metastatic digestive NEC as post first...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-20-0192
更新日期:2020-06-01 00:00:00
abstract::To date, the value of fasting plasma acylated ghrelin (AG) and unacylated ghrelin (UAG) as potential novel biomarkers in patients with neuroendocrine tumors (NETs) is unknown. The aims of this study are to (i) compare fasting AG and UAG levels between nonobese, nondiabetic NET patients (N=28) and age- (±3 years) and s...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-16-0021
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:The value of postoperative radiotherapy in the treatment of medullary thyroid carcinoma (MTC) has not been unequivocally demonstrated. Therefore our study aimed to answer the question of whether adjuvant radiotherapy showed any impact on the risk of local recurrence and whether there were any differences in ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0387
更新日期:2019-11-01 00:00:00
abstract:Objective:Multiple endocrine neoplasia type 2A (MEN 2A) is a rare syndrome caused by RET germline mutations and has been associated with primary hyperparathyroidism (PHPT) in up to 30% of cases. Recommendations on RET screening in patients with apparently sporadic PHPT are unclear. We aimed to estimate the prevalence o...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-20-0163
更新日期:2020-06-01 00:00:00
abstract::The genetic aetiology of congenital hypopituitarism (CH) is not entirely elucidated. FGFR1 and PROKR2 loss-of-function mutations are classically involved in hypogonadotrophic hypogonadism (HH), however, due to the clinical and genetic overlap of HH and CH; these genes may also be involved in the pathogenesis of CH. Us...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-15-0015
更新日期:2015-06-01 00:00:00
abstract::The role of G protein-coupled estrogen receptor 1 (GPER) signaling, including promotion of Ezrin phosphorylation (which could be activated by estrogen), has not yet been clearly identified in triple-negative breast cancer (TNBC). This study aimed to evaluate the prognostic value of GPER and Ezrin in TNBC patients. Cli...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0164
更新日期:2019-06-01 00:00:00
abstract::Classic galactosemia is a rare inborn error of galactose metabolism with a birth prevalence of about 1/30 000-60 000. Long-term complications occurring despite dietary treatment consist of premature ovarian insufficiency (POI) and neurodevelopmental impairments. We performed with the French Reference Centers for Rare ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-21-0013
更新日期:2021-01-01 00:00:00
abstract::Few data are available on the association between serum lipids and insulin secretion (ISEC) in children. We evaluated the association of triglycerides (TG), HDL cholesterol (HDL-C) and LDL cholesterol (LDL-C) with ISEC in 1150 non-diabetic obese children and adolescents using multivariable robust median regression. Th...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0333
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Worldwide there is a high prevalence of 25-hydroxyvitamin D (25OHD) deficiency and has been associated with adverse outcomes during pregnancy. OBJECTIVE:This is a nested, case-control study in a longitudinal cohort to compare the serum 25OHD levels and other biomarkers throughout pregnancy in a group of 20 ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0055
更新日期:2018-05-01 00:00:00
abstract::Hormonal changes during pregnancy can trigger gestational diabetes (GDM), which is constantly increasing. Its main characteristic is pronounced insulin resistance, but it appears to be a multifactorial process involving several metabolic factors; taken together, the latter leads to silent or clinically evident cardiov...
journal_title:Endocrine connections
pub_type: 社论
doi:10.1530/EC-18-0130
更新日期:2018-05-01 00:00:00
abstract:INTRODUCTION:Patients with acromegaly can be treated with surgery, medical therapy and/or radiation therapy. For the patients not being cured with surgery, treatment with somatostatin analogues (SSAs) is the primary therapy. SSA can be taken by self- or partner-administered injections in addition to being given by a nu...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-16-0038
更新日期:2016-07-01 00:00:00
abstract::N/A. ...
journal_title:Endocrine connections
pub_type: 杂志文章,评审
doi:10.1530/EC-21-0044
更新日期:2021-01-01 00:00:00
abstract:Background:A high level of free triiodothyronine (FT3) within the reference range may be a potential metabolic risk marker. However, the relationship between different fat depots and FT3 has remained unclear. Objective:We aimed to explore the relationships between segmental fat distribution and FT3 in euthyroid middle...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0394
更新日期:2019-10-01 00:00:00
abstract::Promotion of brown adipose tissue (BAT) activity or browning of white adipose tissue has shown great potential as anti-obesity strategy in numerous preclinical models. The discovery of active BAT in humans and the recent advances in the understanding of human BAT biology and function have significantly propelled this ...
journal_title:Endocrine connections
pub_type: 杂志文章,评审
doi:10.1530/EC-17-0037
更新日期:2017-07-01 00:00:00
abstract::Hormonal cancers affect over 400,000 men and women and contribute collectively to over 100,000 deaths in the United States alone. Thanks to advances in the understanding of these cancers at the molecular level and to the discovery of several disease-modifying therapeutics, the last decade has seen a plateauing or even...
journal_title:Endocrine connections
pub_type: 杂志文章,评审
doi:10.1530/EC-18-0425
更新日期:2019-02-01 00:00:00
abstract::Failure to suppress testosterone below 0.7 nM in castrated prostate cancer patients is associated with poor clinical outcomes. Testosterone levels in castrated patients are therefore routinely measured. Although mass spectrometry is the gold standard used to measure testosterone, most hospitals use an immunoassay meth...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0476
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:The European Reference Network on Rare Endocrine Conditions (Endo-ERN), operational since 2017, consists of 71 health care providers (HCPs) in 19 EU member states. Our objective was to assess education and knowledge on rare endocrine conditions. DESIGN AND METHODS:A survey was developed and sent through the ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-20-0480
更新日期:2020-12-01 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD) is known to be associated with insulin resistance, atherosclerosis, and low serum IGF1 levels. We have described a large cohort of patients with isolated GH deficiency (IGHD) due to the c.57+1G→A mutation in the GHRH receptor gene. These subjects have increased insulin sensitiv...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-14-0078
更新日期:2014-09-01 00:00:00
abstract::Many biomarkers are associated with type 2 diabetes (T2D) risk in epidemiological observations. The aim of this study was to identify and summarize current evidence for causal effects of biomarkers on T2D. A systematic literature search in PubMed and EMBASE (until April 2015) was done to identify Mendelian randomizati...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-15-0087
更新日期:2015-12-01 00:00:00
abstract::Islet transplantation is currently the only minimally invasive therapy available for patients with type 1 diabetes that can lead to insulin independence; however, it is limited to only a small number of patients. Although clinical procedures have improved in the isolation and culture of islets, a large number of islet...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-17-0349
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:Metyrapone has been approved for the treatment of patients with Cushing's syndrome (CS), but only few retrospective clinical studies are available. The aim of our study was the prospective assessment of metyrapone as pre-operative treatment. DESIGN AND METHODS:Before adrenalectomy, 7 patients with ACTH-indep...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0400
更新日期:2018-09-01 00:00:00
abstract::The aim of this study was to test i) whether patients having diabetes and ischemic heart disease (IHD), i.e., patients suffering from two chronic diseases, demonstrate a higher degree of chronic stress when compared with patients suffering from IHD alone, and ii) whether suffering from the two chronic diseases results...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-14-0083
更新日期:2014-12-01 00:00:00
abstract::The current investigation examined the association between the aging-related biomarkers dehydroepiandrosterone (DHEA) and telomere length (TL) in community-recruited African-American youth. The examination of DHEA included stress reactive, basal and diurnal sampling, in order to elucidate the underlying physiological ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-16-0007
更新日期:2016-05-01 00:00:00
abstract::Background and objectives Glucocorticoids are used to manage adrenal insufficiency (AI). We describe treatments used in the United Kingdom and real-world clinical outcomes for each treatment. Methods We used 2010-2016 primary care data from The Health Improvement Network (THIN). Descriptive analyses were conducted, an...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0418
更新日期:2019-01-01 00:00:00
abstract::Macroprolactinomas are the most common functional pituitary tumours. Hypotheses proposed to explain predominance of large tumours in males are: i) diagnostic delay, as hyperprolactinaemia remains under recognised in males and ii) gender-specific difference in tumour proliferation indices. Our study objectives are to c...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-15-0105
更新日期:2016-01-01 00:00:00