Abstract:
:The current investigation examined the association between the aging-related biomarkers dehydroepiandrosterone (DHEA) and telomere length (TL) in community-recruited African-American youth. The examination of DHEA included stress reactive, basal and diurnal sampling, in order to elucidate the underlying physiological process that may overlap with TL. One hundred and two participants completed the Trier Social Stressor Test for children (TSST-C). TL was obtained from all youth from buccal swabs on the same day as the TSST-C. Saliva samples from 83 participants were obtained over the course of two additional days to measure waking and diurnal levels of DHEA. DHEA diurnal slope was a robust predictor of TL (B=0.516, P<0.05), while other DHEA values were not significantly associated with TL. This study is one of the first studies to examine basal, diurnal and reactivity measurements of DHEA in youth. Furthermore, this is the first study, to our knowledge, to demonstrate a positive association between DHEA, a putative anti-aging hormone, and TL, an indicator of cellular aging.
journal_name
Endocr Connectjournal_title
Endocrine connectionsauthors
Dismukes AR,Meyer VJ,Shirtcliff EA,Theall KP,Esteves KC,Drury SSdoi
10.1530/EC-16-0007subject
Has Abstractpub_date
2016-05-01 00:00:00pages
107-14issue
3issn
2049-3614pii
EC-16-0007journal_volume
5pub_type
杂志文章abstract:AIMS:The cumulative effect of gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) on postpartum cardio-metabolic diseases is equivocal. We aimed to assess the associations of GDM and HDP's individual and synergic contribution to risks of postpartum cardio-metabolic diseases (metabolic synd...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-17-0359
更新日期:2018-03-01 00:00:00
abstract:Background:A high level of free triiodothyronine (FT3) within the reference range may be a potential metabolic risk marker. However, the relationship between different fat depots and FT3 has remained unclear. Objective:We aimed to explore the relationships between segmental fat distribution and FT3 in euthyroid middle...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0394
更新日期:2019-10-01 00:00:00
abstract::The renin-angiotensin system (RAS), mainly associated with the regulation of blood pressure, has been recently investigated in female reproductive organs and the developing foetus. Angiotensin II (Ang II) influences oviductal gamete movements and foetal development, but there is no information about RAS in the early e...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-12-0013
更新日期:2012-06-21 00:00:00
abstract::Macroprolactinomas are the most common functional pituitary tumours. Hypotheses proposed to explain predominance of large tumours in males are: i) diagnostic delay, as hyperprolactinaemia remains under recognised in males and ii) gender-specific difference in tumour proliferation indices. Our study objectives are to c...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-15-0105
更新日期:2016-01-01 00:00:00
abstract::N/A. ...
journal_title:Endocrine connections
pub_type: 杂志文章,评审
doi:10.1530/EC-21-0044
更新日期:2021-01-01 00:00:00
abstract::To date, the value of fasting plasma acylated ghrelin (AG) and unacylated ghrelin (UAG) as potential novel biomarkers in patients with neuroendocrine tumors (NETs) is unknown. The aims of this study are to (i) compare fasting AG and UAG levels between nonobese, nondiabetic NET patients (N=28) and age- (±3 years) and s...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-16-0021
更新日期:2016-07-01 00:00:00
abstract::Hypercalcemic crisis is a severe but rare complication of primary hyperparathyroidism (PHPT), and data on denosumab treatment of patients with this disease is still very limited. The aim of this paper is to investigate the hypocalcemic effect of denosumab in PHPT patients with severe hypercalcemia when surgery should ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-20-0380
更新日期:2020-10-01 00:00:00
abstract:Objective:First-line chemotherapy in metastatic neuroendocrine carcinomas (NECs) is based on etoposide and platinum. However, there is no standard concerning second-line treatment. The objective of this study was to evaluate efficacy and tolerance of dacarbazine or temozolomide in metastatic digestive NEC as post first...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-20-0192
更新日期:2020-06-01 00:00:00
abstract:Background:Non-adherence to r-hGH treatments occurs in a variable percentage of subjects. One problem found when evaluating adherence is the great variability in methods of detection and definitions utilized in studies. This study assessed the level of adherence in subjects receiving r-hGH with the easypod™ electronic ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0325
更新日期:2019-09-01 00:00:00
abstract::Vitamin D deficiency is common in pregnant women and may contribute to adverse events in pregnancy such as preeclampsia (PET). To date, studies of vitamin D and PET have focused primarily on serum concentrations vitamin D, 25-hydroxyvitamin D3 (25(OH)D3) later in pregnancy. The aim here was to determine whether a more...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-17-0308
更新日期:2018-01-01 00:00:00
abstract:Background:The effect of isolated maternal hypothyroxinaemia (IMH) on pregnancy complications and neonatal outcomes in human beings is still controversial. Methods:This was a retrospective cohort study based on the electronic medical register system. The records of women with a singleton pregnancy who sought antenatal...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0088
更新日期:2019-04-01 00:00:00
abstract::As many as 20-55% of patients with a history of traumatic brain injury (TBI) experience chronic endocrine dysfunction, leading to impaired quality of life, impaired rehabilitation efforts and lowered life expectancy. Endocrine dysfunction after TBI is thought to result from acceleration-deceleration forces to the brai...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-16-0031
更新日期:2016-07-01 00:00:00
abstract::Estradiol has been used to prevent metabolic diseases, bone loss and menopausal symptoms, even though it might raise the risk of cancer. Metformin is usually prescribed for type 2 diabetes mellitus and lowers food intake and body mass while improving insulin resistance and the lipid profile. Ovariectomized rats show i...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0470
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND/AIMS:Growth failure is a difficult but key aspect of care in children with anorexia nervosa (AN). The effects of hGH therapy have not been studied. The aim was to investigate the effect of hGH treatment on height velocity (HV) in children with AN. METHODS:We carried out a retrospective observational study. ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-17-0200
更新日期:2017-11-01 00:00:00
abstract::Hypothyroidism is associated with increased risk of atherosclerosis. We assessed carotid intima-media thickness (CIMT), as a marker of atherosclerosis, and endothelial function in patients with hypothyroidism. We included 70 female patients with hypothyroidism in the study, 40 patients with overt and 30 patients with ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0194
更新日期:2018-10-01 00:00:00
abstract:Aims:Neprilysin degrades natriuretic peptides in circulation and is also suggested to degrade the gut hormones gastrin and cholecystokinin. Neprilysin inhibition has become a therapeutic strategy and thus a regimen in need of further testing in terms of other hormonal axes besides natriuretic peptides. The aim of this ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0563
更新日期:2020-05-01 00:00:00
abstract::The antihypertensive actions of glucagon-like peptide-1 (GLP1) receptor agonists have been linked to the release of atrial natriuretic peptide (ANP) in mice. Whether a GLP1-ANP axis exists in humans is unknown. In this study, we examined 12 healthy young males in a randomized, controlled, double-blinded, single-day, c...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-13-0087
更新日期:2014-01-21 00:00:00
abstract:OBJECTIVE:Patients with non-functioning pituitary adenomas exhibit high morbidity and mortality rates. Growth hormone deficiency and high doses of glucocorticoid substitution therapy have been identified as corresponding risk factors. Interestingly, high levels of endogenous cortisol in, e.g., patients with post-trauma...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0362
更新日期:2018-08-01 00:00:00
abstract::Insufficient insulin release plays a crucial role in the development of unhealthy status in patients with obesity; the present study aimed to classify these patients by the indices for insulin resistance and insulin release. After the indices from OGTT were assessed to achieve high differentiability and low redundancy...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0476
更新日期:2020-02-01 00:00:00
abstract::The goal of this study was to explore the relationship of the BRAFV600E mutation with clinicopathologic factors and evaluate the effect of radioactive iodine (RAI) therapy in a large group of intermediate- and high-risk papillary thyroid cancer (PTC) patients with the BRAFV600E mutation and without distant metastases....
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0045
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Primary aldosteronism (PA) is associated with increased cardiovascular morbidity, presumably due to left ventricular (LV) hypertrophy and fibrosis. However, the degree of fibrosis has not been extensively studied. Cardiac magnetic resonance imaging (CMR) contrast enhancement and novel sensitive T1 mapping to...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0039
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:Recently, mutations in KCNQ1, a potassium channel gene usually linked to long QT syndrome, were reported to cause maternally inherited gingival fibromatosis and growth hormone deficiency (GHD). Expression of the mutated KCNQ1 with the auxiliary potassium channel subunit KCNE2 was shown to reduce pituitary hor...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0123
更新日期:2018-05-01 00:00:00
abstract::This study aims to summarize and analyze the clinical manifestations, genetic characteristics, treatment modalities and long-term prognosis of congenital hyperinsulinemia (CHI) in Chinese children. Sixty children with CHI, who were treated at Beijing Children's Hospital from January 2014 to August 2017, and their fami...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0240
更新日期:2018-11-12 00:00:00
abstract:Objective:Multiple endocrine neoplasia type 2A (MEN 2A) is a rare syndrome caused by RET germline mutations and has been associated with primary hyperparathyroidism (PHPT) in up to 30% of cases. Recommendations on RET screening in patients with apparently sporadic PHPT are unclear. We aimed to estimate the prevalence o...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-20-0163
更新日期:2020-06-01 00:00:00
abstract::Growth hormone (GH) is used to treat short stature and growth failure associated with growth disorders. Birth size and GH status variably modulate response to GH therapy. The aim of this study was to determine the effect of birth size on response to GH therapy, and to determine the impact of GH status in patients born...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0286
更新日期:2018-08-23 00:00:00
abstract::Tumor cells require large amounts of energy to sustain growth. Through the mediated transport of glucose transporters, the uptake and utilization of glucose by tumor cells are significantly enhanced in the hypoxic microenvironment. Pituitary adenomas are benign tumors with high-energy metabolisms. We aimed to investig...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0444
更新日期:2018-12-01 00:00:00
abstract::Primary hyperparathyroidism (PHPT) is a common endocrinopathy, frequently caused by a parathyroid adenoma, rarely by a parathyroid carcinoma that lacks effective oncological treatment. As the majority of cases are present in postmenopausal women, oestrogen signalling has been implicated in the tumourigenesis. Oestroge...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-14-0109
更新日期:2015-03-01 00:00:00
abstract:CONTEXT:Women with polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease (CVD), and biomarkers can be used to detect early subclinical CVD. Midregional-pro-adrenomedullin (MR-proADM), midregional-pro-atrial natriuretic peptide (MR-proANP) and copeptin are all associated with CVD and part of ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-17-0327
更新日期:2018-01-01 00:00:00
abstract::The role of G protein-coupled estrogen receptor 1 (GPER) signaling, including promotion of Ezrin phosphorylation (which could be activated by estrogen), has not yet been clearly identified in triple-negative breast cancer (TNBC). This study aimed to evaluate the prognostic value of GPER and Ezrin in TNBC patients. Cli...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0164
更新日期:2019-06-01 00:00:00
abstract::This study aimed to evaluate the evolving trends in clinicopathological features of pancreatic neuroendocrine tumors and to analyze the predictors of recurrence after curative resection. Data collected retrospectively from a single center between January 1990 and December 2017 were analyzed. Patients were categorized ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0282
更新日期:2019-07-01 00:00:00