Abstract:
:Hypothyroidism is associated with increased risk of atherosclerosis. We assessed carotid intima-media thickness (CIMT), as a marker of atherosclerosis, and endothelial function in patients with hypothyroidism. We included 70 female patients with hypothyroidism in the study, 40 patients with overt and 30 patients with subclinical hypothyroidism. Forty, age- and sex-matched, subjects with normal thyroid functions were also included as a control group. CIMT was measured using high-resolution color-coded Doppler ultrasonography. Endothelial function was assessed by measuring the percent of change in blood flow following heat-mediated vasodilation using laser Doppler flowmetry. CIMT was significantly higher in patients with overt and subclinical hypothyroidism as compared with the control group (0.7 ± 0.2 and 0.6 ± 0.2 mm respectively vs 0.45 ± 0.07 mm, P < 0.001 for both). The percent of change in blood flow following heat-mediated vasodilation was significantly impaired in patients with overt and subclinical hypothyroidism as compared with the control group (328 ± 17 and 545 ± 406% respectively vs 898 ± 195%, P < 0.001 for both). The impairment was more significant in overt as compared with subclinical hypothyroidism (P = 0.014). CIMT negatively correlated with percent of change in blood flow following heat-mediated vasodilation in patients with overt and subclinical hypothyroidism (P < 0.001 for both). We concluded that CIMT is significantly higher in patients with overt and subclinical hypothyroidism compared with normal control subjects. Impairment of endothelial function is a contributing factor to the increased risk of atherosclerosis in both groups of patients.
journal_name
Endocr Connectjournal_title
Endocrine connectionsauthors
Saif A,Mousa S,Assem M,Tharwat N,Abdelhamid Adoi
10.1530/EC-18-0194subject
Has Abstractpub_date
2018-10-01 00:00:00pages
1075-1080issue
10issn
2049-3614pii
/journals/ec/7/10/EC-18-0194.xmljournal_volume
7pub_type
杂志文章abstract::Acromegaly is a rare and insidious disease characterized by the overproduction of growth hormone (GH) and insulin-like growth factor 1 (IGF1) and is most commonly due to a pituitary adenoma. Patients with acromegaly who experience prolonged exposure to elevated levels of GH and IGF1 have an increased mortality risk an...
journal_title:Endocrine connections
pub_type: 杂志文章,评审
doi:10.1530/EC-15-0064
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:The European Reference Network on Rare Endocrine Conditions (Endo-ERN), operational since 2017, consists of 71 health care providers (HCPs) in 19 EU member states. Our objective was to assess education and knowledge on rare endocrine conditions. DESIGN AND METHODS:A survey was developed and sent through the ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-20-0480
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0568
更新日期:2020-05-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-20-0311
更新日期:2020-11-01 00:00:00
abstract:INTRODUCTION AND AIM:Ectopic ACTH secretion (EAS) is mostly secondary to thoracic/abdominal neuroendocrine tumours (NETs), or small cell-lung carcinoma (SCLC). We studied the diagnostic accuracy of computed tomography (CT) with 68Ga-Dota derivatives (68Ga-SSTR) positron emission tomography (PET) in localizing ACTH-secr...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-20-0089
更新日期:2020-03-01 00:00:00
abstract::The experience in the field of islet transplantation shows that it is possible to replace β cells in a patient with type 1 diabetes (T1D), but this cell therapy is limited by the scarcity of organ donors and by the danger associated to the immunosuppressive drugs. Stem cell therapy is becoming a concrete opportunity t...
journal_title:Endocrine connections
pub_type: 杂志文章,评审
doi:10.1530/EC-18-0012
更新日期:2018-03-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0103
更新日期:2019-04-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0240
更新日期:2018-11-12 00:00:00
abstract:AIMS:The cumulative effect of gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) on postpartum cardio-metabolic diseases is equivocal. We aimed to assess the associations of GDM and HDP's individual and synergic contribution to risks of postpartum cardio-metabolic diseases (metabolic synd...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-17-0359
更新日期:2018-03-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-15-0087
更新日期:2015-12-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0400
更新日期:2018-09-01 00:00:00
abstract::N/A. ...
journal_title:Endocrine connections
pub_type: 杂志文章,评审
doi:10.1530/EC-21-0044
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is a rare autosomal recessive disorder caused by mutations of the autoimmune regulator (AIRE) gene, whose loss of function leads to the escape of self-reactive T cells from the thymus and autoimmunity. APECED patients typically develop t...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-12-0074
更新日期:2013-02-25 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-17-0098
更新日期:2017-07-01 00:00:00
abstract:Aims:Neprilysin degrades natriuretic peptides in circulation and is also suggested to degrade the gut hormones gastrin and cholecystokinin. Neprilysin inhibition has become a therapeutic strategy and thus a regimen in need of further testing in terms of other hormonal axes besides natriuretic peptides. The aim of this ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0563
更新日期:2020-05-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-17-0232
更新日期:2017-11-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0282
更新日期:2019-07-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0164
更新日期:2019-06-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-17-0001
更新日期:2017-04-01 00:00:00
abstract::The rapid increase of obesity during the last decades and its future prospects are alarming. Besides the general discussed causes of obesity, the 'Developmental Origins of Health and Disease' (DOHaD) hypothesis received more attention in recent years. This hypothesis postulates an adverse influence during early develo...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0549
更新日期:2020-07-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-17-0276
更新日期:2018-01-01 00:00:00
abstract:Purpose:Gallbladder neuroendocrine neoplasm (GB-NEN) is a relatively rare neoplasm, accounting for 0.5% of all neuroendocrine neoplasm cases and 2.1% of gallbladder cancers. Because of the limited understanding of GB-NEN, the aim of this study was to explore the clinicopathology and survival of GB-NEN patients selected...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0124
更新日期:2019-09-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
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更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Worldwide there is a high prevalence of 25-hydroxyvitamin D (25OHD) deficiency and has been associated with adverse outcomes during pregnancy. OBJECTIVE:This is a nested, case-control study in a longitudinal cohort to compare the serum 25OHD levels and other biomarkers throughout pregnancy in a group of 20 ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0055
更新日期:2018-05-01 00:00:00
abstract:Background:A high level of free triiodothyronine (FT3) within the reference range may be a potential metabolic risk marker. However, the relationship between different fat depots and FT3 has remained unclear. Objective:We aimed to explore the relationships between segmental fat distribution and FT3 in euthyroid middle...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0394
更新日期:2019-10-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-14-0109
更新日期:2015-03-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0123
更新日期:2018-05-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-12-0053
更新日期:2012-10-24 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章,评审
doi:10.1530/EC-18-0425
更新日期:2019-02-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0476
更新日期:2019-02-01 00:00:00