Abstract:
:Promotion of brown adipose tissue (BAT) activity or browning of white adipose tissue has shown great potential as anti-obesity strategy in numerous preclinical models. The discovery of active BAT in humans and the recent advances in the understanding of human BAT biology and function have significantly propelled this field of research. Pharmacological stimulation of energy expenditure to counteract obesity has always been an intriguing therapeutic concept; with the identification of the specific molecular pathways of brown fat function, this idea has now become as realistic as ever. Two distinct strategies are currently being pursued; one is the activation of bone fide BAT, the other is the induction of BAT-like cells or beige adipocytes within white fat depots, a process called browning. Recent evidence suggests that both phenomena can occur in humans. Cold-induced promotion of BAT activity is strongly associated with enhanced thermogenesis and energy expenditure in humans and has beneficial effects on fat mass and glucose metabolism. Despite these encouraging results, a number of issues deserve additional attention including the distinct characteristics of human vs rodent BAT, the heterogeneity of human BAT depots or the identification of the adipocyte precursors that can give rise to thermogenic cells in human adipose tissue. In addition, many pharmaceutical compounds are being tested for their ability to promote a thermogenic program in human adipocytes. This review summarizes the current knowledge about the various cellular and molecular aspects of human BAT as well as the relevance for energy metabolism including its therapeutic potential for obesity.
journal_name
Endocr Connectjournal_title
Endocrine connectionsauthors
Kiefer FWdoi
10.1530/EC-17-0037subject
Has Abstractpub_date
2017-07-01 00:00:00pages
R70-R79issue
5issn
2049-3614pii
EC-17-0037journal_volume
6pub_type
杂志文章,评审abstract::N/A. ...
journal_title:Endocrine connections
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
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更新日期:2015-09-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章,评审
doi:10.1530/EC-18-0425
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pub_type: 杂志文章
doi:10.1530/EC-19-0088
更新日期:2019-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1530/EC-18-0444
更新日期:2018-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Endocrine connections
pub_type: 杂志文章
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journal_title:Endocrine connections
pub_type: 杂志文章
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abstract:Objectives:Walking and postural balance are extremely important to obtain food and to work. Both are critical for quality of life and ability to survive. While walking reflects musculoskeletal and cardiopulmonary systems, postural balance depends on body size, muscle tone, visual, vestibular and nervous systems. Since ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0103
更新日期:2019-04-01 00:00:00
abstract::To date, the value of fasting plasma acylated ghrelin (AG) and unacylated ghrelin (UAG) as potential novel biomarkers in patients with neuroendocrine tumors (NETs) is unknown. The aims of this study are to (i) compare fasting AG and UAG levels between nonobese, nondiabetic NET patients (N=28) and age- (±3 years) and s...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-16-0021
更新日期:2016-07-01 00:00:00
abstract::Macroprolactinomas are the most common functional pituitary tumours. Hypotheses proposed to explain predominance of large tumours in males are: i) diagnostic delay, as hyperprolactinaemia remains under recognised in males and ii) gender-specific difference in tumour proliferation indices. Our study objectives are to c...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-15-0105
更新日期:2016-01-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
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更新日期:2017-11-01 00:00:00
abstract::Islet transplantation is currently the only minimally invasive therapy available for patients with type 1 diabetes that can lead to insulin independence; however, it is limited to only a small number of patients. Although clinical procedures have improved in the isolation and culture of islets, a large number of islet...
journal_title:Endocrine connections
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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