Abstract:
CONTEXT:The aim of this study was to assess the plasma leptin, adiponectin, resistin, visfatin/NAMPT, omentin-1, vaspin, apelin, TNF-α, IL-6 and RBP4 levels in relation to hormonal changes during the menstrual cycle in young, healthy, normal-weight women. METHODS:The study involved 52 young, healthy, normal-weight women. Anthropometric parameters, body composition and levels of plasma leptin, adiponectin, resistin, visfatin/NAMPT, omentin-1, vaspin, apelin, TNF-α, IL-6 and RBP4 in addition to serum FSH, LH, estradiol, progesterone, 17-OH progesterone, androgens, SHBG and insulin concentrations were measured during a morning in fasting state three times: between days 2-4, days 12-14 and days 24-26 of the menstrual cycle. RESULTS:Plasma adiponectin, omentin-1, resistin and visfatin/NAMPT, apelin, TNF-α, IL-6 and RBP4 concentrations were stable during the menstrual cycle, while leptin and vaspin levels were significantly higher in both the midcycle and the luteal phases than those in the follicular phase. Multivariate regression analyses revealed that changes in leptin and vaspin levels between the follicular and the luteal phase are strongly related to changes in total testosterone levels. CONCLUSIONS:Our results revealed stable levels of adipokines during the phases of the physiological menstrual cycle, except for leptin and vaspin, which showed increased levels in both the midcycle and the luteal phases. This effect was significantly associated with changes in the secretion of testosterone, 17-OH progesterone and insulin in the luteal phase.
journal_name
Endocr Connectjournal_title
Endocrine connectionsauthors
Wyskida K,Franik G,Wikarek T,Owczarek A,Delroba A,Chudek J,Sikora J,Olszanecka-Glinianowicz Mdoi
10.1530/EC-17-0186subject
Has Abstractpub_date
2017-11-01 00:00:00pages
892-900issue
8issn
2049-3614pii
EC-17-0186journal_volume
6pub_type
杂志文章abstract:PURPOSE:Chromogranin A (CgA) and neuron-specific enolase (NSE) are important markers for neuroendocrine tumors; however, the clinical value of combining these markers has not been well studied. In this study, we investigated the utility of each marker individually and in combination for patients with nonfunctional panc...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-17-0276
更新日期:2018-01-01 00:00:00
abstract:Objective:Multiple endocrine neoplasia type 2A (MEN 2A) is a rare syndrome caused by RET germline mutations and has been associated with primary hyperparathyroidism (PHPT) in up to 30% of cases. Recommendations on RET screening in patients with apparently sporadic PHPT are unclear. We aimed to estimate the prevalence o...
journal_title:Endocrine connections
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journal_title:Endocrine connections
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abstract:Background:Non-adherence to r-hGH treatments occurs in a variable percentage of subjects. One problem found when evaluating adherence is the great variability in methods of detection and definitions utilized in studies. This study assessed the level of adherence in subjects receiving r-hGH with the easypod™ electronic ...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0325
更新日期:2019-09-01 00:00:00
abstract::Growth hormone (GH) is used to treat short stature and growth failure associated with growth disorders. Birth size and GH status variably modulate response to GH therapy. The aim of this study was to determine the effect of birth size on response to GH therapy, and to determine the impact of GH status in patients born...
journal_title:Endocrine connections
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abstract::Thyroid hormones stimulate bone turnover in adults by increasing osteoclastic bone resorption. TSH suppressive therapy is usually applied in patients with differentiated thyroid cancer (DTC) to improve the disease outcome. Over the last decades several authors have closely monitored the potential harm suffered by the ...
journal_title:Endocrine connections
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abstract::As many as 20-55% of patients with a history of traumatic brain injury (TBI) experience chronic endocrine dysfunction, leading to impaired quality of life, impaired rehabilitation efforts and lowered life expectancy. Endocrine dysfunction after TBI is thought to result from acceleration-deceleration forces to the brai...
journal_title:Endocrine connections
pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
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journal_title:Endocrine connections
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abstract:BACKGROUND:The value of postoperative radiotherapy in the treatment of medullary thyroid carcinoma (MTC) has not been unequivocally demonstrated. Therefore our study aimed to answer the question of whether adjuvant radiotherapy showed any impact on the risk of local recurrence and whether there were any differences in ...
journal_title:Endocrine connections
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journal_title:Endocrine connections
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journal_title:Endocrine connections
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journal_title:Endocrine connections
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journal_title:Endocrine connections
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:Endocrine connections
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更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:Insulin-like growth factors are implicated in the development of diabetic nephropathy. IGF-binding protein 2 (IGFBP2) and IGF2 are expressed in the kidney, but their associations with diabetic nephropathy are unclear. We therefore tested the hypothesis that circulating levels of IGF2 and IGFBP2 predict longit...
journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-12-0053
更新日期:2012-10-24 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-14-0051
更新日期:2015-03-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-14-0078
更新日期:2014-09-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-20-0279
更新日期:2020-08-01 00:00:00
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journal_title:Endocrine connections
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doi:10.1530/EC-18-0400
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-12-0013
更新日期:2012-06-21 00:00:00
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journal_title:Endocrine connections
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doi:10.1530/EC-17-0001
更新日期:2017-04-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章,评审
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更新日期:2019-02-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-18-0207
更新日期:2018-09-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-14-0085
更新日期:2014-12-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-17-0232
更新日期:2017-11-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-14-0109
更新日期:2015-03-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-19-0549
更新日期:2020-07-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-20-0311
更新日期:2020-11-01 00:00:00
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journal_title:Endocrine connections
pub_type: 杂志文章
doi:10.1530/EC-12-0074
更新日期:2013-02-25 00:00:00