Diabetes and ischemic heart disease: double jeopardy with regard to depressive mood and reduced quality of life.

abstract：:Tumor cells require large amounts of energy to sustain growth. Through the mediated transport of glucose transporters, the uptake and utilization of glucose by tumor cells are significantly enhanced in the hypoxic microenvironment. Pituitary adenomas are benign tumors with high-energy metabolisms. We aimed to investig...

journal_title：Endocrine connections

authors： Mei T,Zhang J,Wei L,Qi X,Ma Y,Liu X,Chen S,Li S,Wu J,Wang S

更新日期：2018-12-01 00:00:00

abstract：Objective:Multiple endocrine neoplasia type 2A (MEN 2A) is a rare syndrome caused by RET germline mutations and has been associated with primary hyperparathyroidism (PHPT) in up to 30% of cases. Recommendations on RET screening in patients with apparently sporadic PHPT are unclear. We aimed to estimate the prevalence o...

journal_title：Endocrine connections

authors： Larsen LV,Mirebeau-Prunier D,Imai T,Alvarez-Escola C,Hasse-Lazar K,Censi S,Castroneves LA,Sakurai A,Kihara M,Horiuchi K,Barbu VD,Borson-Chazot F,Gimenez-Roqueplo AP,Pigny P,Pinson S,Wohllk N,Eng C,Aydogan BI,Saranath

更新日期：2020-06-01 00:00:00

abstract：:The role of G protein-coupled estrogen receptor 1 (GPER) signaling, including promotion of Ezrin phosphorylation (which could be activated by estrogen), has not yet been clearly identified in triple-negative breast cancer (TNBC). This study aimed to evaluate the prognostic value of GPER and Ezrin in TNBC patients. Cli...

journal_title：Endocrine connections

authors： Ye S,Xu Y,Li J,Zheng S,Sun P,Wang T

更新日期：2019-06-01 00:00:00

abstract：:The rapid increase of obesity during the last decades and its future prospects are alarming. Besides the general discussed causes of obesity, the 'Developmental Origins of Health and Disease' (DOHaD) hypothesis received more attention in recent years. This hypothesis postulates an adverse influence during early develo...

journal_title：Endocrine connections

authors： Ernst J,Gert K,Kraus FB,Rolle-Kampczyk UE,Wabitsch M,Dehghani F,Schaedlich K

更新日期：2020-07-01 00:00:00

abstract：CONTEXT:Women with polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease (CVD), and biomarkers can be used to detect early subclinical CVD. Midregional-pro-adrenomedullin (MR-proADM), midregional-pro-atrial natriuretic peptide (MR-proANP) and copeptin are all associated with CVD and part of ...

journal_title：Endocrine connections

authors： Frøssing S,Nylander M,Kistorp C,Skouby SO,Faber J

更新日期：2018-01-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is known to be associated with insulin resistance, atherosclerosis, and low serum IGF1 levels. We have described a large cohort of patients with isolated GH deficiency (IGHD) due to the c.57+1G→A mutation in the GHRH receptor gene. These subjects have increased insulin sensitiv...

journal_title：Endocrine connections

authors： Diniz RD,Souza RM,Salvatori R,Franca A,Gomes-Santos E,Ferrão TO,Oliveira CR,Santana JA,Pereira FA,Barbosa RA,Souza AH,Pereira RM,Oliveira-Santos AA,Silva AM,Santana-Júnior FJ,Valença EH,Campos VC,Aguiar-Oliveira MH

更新日期：2014-09-01 00:00:00

abstract：:To date, the value of fasting plasma acylated ghrelin (AG) and unacylated ghrelin (UAG) as potential novel biomarkers in patients with neuroendocrine tumors (NETs) is unknown. The aims of this study are to (i) compare fasting AG and UAG levels between nonobese, nondiabetic NET patients (N=28) and age- (±3 years) and s...

journal_title：Endocrine connections

authors： van Adrichem RC,van der Lely AJ,Huisman M,Kramer P,Feelders RA,Delhanty PJ,de Herder WW

更新日期：2016-07-01 00:00:00

abstract：:Insufficient insulin release plays a crucial role in the development of unhealthy status in patients with obesity; the present study aimed to classify these patients by the indices for insulin resistance and insulin release. After the indices from OGTT were assessed to achieve high differentiability and low redundancy...

journal_title：Endocrine connections

authors： Li L,Song Q,Yang X

更新日期：2020-02-01 00:00:00

abstract：:Sex development is a process under genetic control directing both the bi-potential gonads to become either a testis or an ovary, and the consequent differentiation of internal ducts and external genitalia. This complex series of events can be altered by a large number of genetic and non-genetic factors. Disorders of s...

journal_title：Endocrine connections

authors： Laino L,Majore S,Preziosi N,Grammatico B,De Bernardo C,Scommegna S,Rapone AM,Marrocco G,Bottillo I,Grammatico P

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:Little is known about how women with isolated GnRH deficiency cope with their condition. This study aimed to examine the health and informational needs of women with congenital hypogonadotropic hypogonadism (CHH) and evaluate if their experiences differ from women with more common forms of infertility. DESIG...

journal_title：Endocrine connections

authors： Dzemaili S,Tiemensma J,Quinton R,Pitteloud N,Morin D,Dwyer AA

更新日期：2017-08-01 00:00:00

abstract：:Polycystic ovarian syndrome (PCOS) affects 18-22% of women at reproductive age. We conducted a systematic review and meta-analysis evaluating the expected benefits of lifestyle (exercise plus diet) interventions on the reproductive endocrine profile in women with PCOS. Potential studies were identified by systematical...

journal_title：Endocrine connections

authors： Haqq L,McFarlane J,Dieberg G,Smart N

更新日期：2014-02-28 00:00:00

abstract：:The antihypertensive actions of glucagon-like peptide-1 (GLP1) receptor agonists have been linked to the release of atrial natriuretic peptide (ANP) in mice. Whether a GLP1-ANP axis exists in humans is unknown. In this study, we examined 12 healthy young males in a randomized, controlled, double-blinded, single-day, c...

journal_title：Endocrine connections

authors： Skov J,Holst JJ,Gøtze JP,Frøkiær J,Christiansen JS

更新日期：2014-01-21 00:00:00

abstract：Objective:Accurate measurement of steroid hormones remains challenging. Mass spectrometry affords a reliable means for quantitating steroid profiles accurately. Our objective was to establish and define (1) the extent of diurnal fluctuations in steroid concentrations that potentially necessitate strict adherence to tim...

journal_title：Endocrine connections

authors： Parikh TP,Stolze B,Ozarda Y,Jonklaas J,Welsh K,Masika L,Hill M,DeCherney A,Soldin SJ

更新日期：2018-12-01 00:00:00

abstract：Objective:The remarkable success of iodine deficiency disorders (IDD) elimination in China has been achieved through a mandatory universal salt iodization (USI) program. The study aims to estimate the relationship between urinary iodine concentration (UIC) and iodine content in edible salt to assess the current iodine ...

journal_title：Endocrine connections

authors： Yao N,Zhou C,Xie J,Li X,Zhou Q,Chen J,Zhou S

更新日期：2020-05-01 00:00:00

abstract：:Macroprolactinomas are the most common functional pituitary tumours. Hypotheses proposed to explain predominance of large tumours in males are: i) diagnostic delay, as hyperprolactinaemia remains under recognised in males and ii) gender-specific difference in tumour proliferation indices. Our study objectives are to c...

journal_title：Endocrine connections

authors： Khare S,Lila AR,Patt H,Yerawar C,Goroshi M,Bandgar T,Shah NS

更新日期：2016-01-01 00:00:00

abstract：:Estradiol has been used to prevent metabolic diseases, bone loss and menopausal symptoms, even though it might raise the risk of cancer. Metformin is usually prescribed for type 2 diabetes mellitus and lowers food intake and body mass while improving insulin resistance and the lipid profile. Ovariectomized rats show i...

journal_title：Endocrine connections

authors： Barthem CS,Rossetti CL,Carvalho DP,da-Silva WS

更新日期：2019-12-01 00:00:00

abstract：:Hypercalcemic crisis is a severe but rare complication of primary hyperparathyroidism (PHPT), and data on denosumab treatment of patients with this disease is still very limited. The aim of this paper is to investigate the hypocalcemic effect of denosumab in PHPT patients with severe hypercalcemia when surgery should ...

journal_title：Endocrine connections

authors： Eremkina A,Krupinova J,Dobreva E,Gorbacheva A,Bibik E,Samsonova M,Ajnetdinova A,Mokrysheva N

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:Preoperative preparation for adrenalectomy for pheochromocytomas and paragangliomas (PPGL) is universally recognized as necessary, while the optimal strategy remains controversial. Our aims were to increase intraoperative hemodynamic stability, expedite postoperative recovery, decrease side effects and reduce c...

journal_title：Endocrine connections

authors： Liu C,Lv Q,Chen X,Ni G,Hu L,Tong N,Zhang Y

更新日期：2017-11-01 00:00:00

abstract：:N/A. ...

journal_title：Endocrine connections

authors： Koehrle J

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is a rare autosomal recessive disorder caused by mutations of the autoimmune regulator (AIRE) gene, whose loss of function leads to the escape of self-reactive T cells from the thymus and autoimmunity. APECED patients typically develop t...

journal_title：Endocrine connections

authors： Kluger N,Krohn K,Ranki A

更新日期：2013-02-25 00:00:00

abstract：:Phaeochromocytomas and paragangliomas (PPGLs) are tumours of the adrenal medulla and extra-adrenal sympathetic nervous system which often secrete catecholamines. Variants of the SDHX (SDHA, -AF2, -B, -C, -D) genes are a frequent cause of familial PPGLs. In this study from a single tertiary centre, we aimed to characte...

journal_title：Endocrine connections

authors： Main AM,Rossing M,Borgwardt L,Grønkær Toft B,Rasmussen ÅK,Feldt-Rasmussen U

更新日期：2020-08-01 00:00:00

abstract：:The vasoactive intestinal peptide receptor 2 (VPAC2) is widely distributed throughout the body and is also overexpressed in a variety of human neoplastic tissues. However, little is known about its precise tissue distribution, regulation and function, which is in part be due to the lack of specific monoclonal anti-VPA...

journal_title：Endocrine connections

authors： Schulz S,Mann A,Novakhov B,Piggins HD,Lupp A

更新日期：2015-03-01 00:00:00

abstract：:Acromegaly is a rare and insidious disease characterized by the overproduction of growth hormone (GH) and insulin-like growth factor 1 (IGF1) and is most commonly due to a pituitary adenoma. Patients with acromegaly who experience prolonged exposure to elevated levels of GH and IGF1 have an increased mortality risk an...

journal_title：Endocrine connections

authors： Silverstein JM

更新日期：2015-12-01 00:00:00

abstract：:This study aims to summarize and analyze the clinical manifestations, genetic characteristics, treatment modalities and long-term prognosis of congenital hyperinsulinemia (CHI) in Chinese children. Sixty children with CHI, who were treated at Beijing Children's Hospital from January 2014 to August 2017, and their fami...

journal_title：Endocrine connections

authors： Xu ZD,Zhang W,Liu M,Wang HM,Hui PP,Liang XJ,Yan J,Wu YJ,Sang YM,Zhu C,Ni GC

更新日期：2018-11-12 00:00:00

abstract：Background:The effect of isolated maternal hypothyroxinaemia (IMH) on pregnancy complications and neonatal outcomes in human beings is still controversial. Methods:This was a retrospective cohort study based on the electronic medical register system. The records of women with a singleton pregnancy who sought antenatal...

journal_title：Endocrine connections

authors： Su X,Zhao Y,Cao Z,Yang Y,Duan T,Hua J

更新日期：2019-04-01 00:00:00

abstract：AIMS:Gestational diabetes mellitus (GDM)-induced macrosomia is predominantly characterized by fat accumulation, which is closely related to adipocyte differentiation. An unknown long noncoding RNA RP11-290L1.3, referred to as RP11, was identified to be dramatically upregulated in the umbilical cord blood of women with ...

journal_title：Endocrine connections

authors： Lin Y,Zhang Y,Xu L,Long W,Shan C,Ding H,You L,Zhao C,Shi Z

更新日期：2021-01-01 00:00:00

abstract：:Islet transplantation is currently the only minimally invasive therapy available for patients with type 1 diabetes that can lead to insulin independence; however, it is limited to only a small number of patients. Although clinical procedures have improved in the isolation and culture of islets, a large number of islet...

journal_title：Endocrine connections

authors： Rojas-Canales DM,Waibel M,Forget A,Penko D,Nitschke J,Harding FJ,Delalat B,Blencowe A,Loudovaris T,Grey ST,Thomas HE,Kay TWH,Drogemuller CJ,Voelcker NH,Coates PT

更新日期：2018-03-01 00:00:00

abstract：:This study aimed to evaluate the evolving trends in clinicopathological features of pancreatic neuroendocrine tumors and to analyze the predictors of recurrence after curative resection. Data collected retrospectively from a single center between January 1990 and December 2017 were analyzed. Patients were categorized ...

journal_title：Endocrine connections

authors： Kim H,Song KB,Hwang DW,Lee JH,Alshammary S,Kim SC

更新日期：2019-07-01 00:00:00

abstract：Aims:Neprilysin degrades natriuretic peptides in circulation and is also suggested to degrade the gut hormones gastrin and cholecystokinin. Neprilysin inhibition has become a therapeutic strategy and thus a regimen in need of further testing in terms of other hormonal axes besides natriuretic peptides. The aim of this ...

journal_title：Endocrine connections

authors： Andersen UØ,Terzic D,Wewer Albrechtsen NJ,Dall Mark P,Plomgaard P,Rehfeld JF,Gustafsson F,Goetze JP

更新日期：2020-05-01 00:00:00

abstract：:The purpose of this study was to assess the relationship between vitamin D receptor gene (VDR) expression and prognostic factors in papillary thyroid cancer (PTC). mRNA sequencing and somatic mutation data from The Cancer Genome Atlas (TCGA) were analyzed. VDR mRNA expression was compared to clinicopathologic variable...

journal_title：Endocrine connections

authors： Choi JY,Yi JW,Lee JH,Song RY,Yu H,Kwon H,Chai YJ,Kim SJ,Lee KE

更新日期：2017-04-01 00:00:00