Pharmacokinetic interaction between mitotane and etoposide in adrenal carcinoma: a pilot study.

abstract：Objective:First-line chemotherapy in metastatic neuroendocrine carcinomas (NECs) is based on etoposide and platinum. However, there is no standard concerning second-line treatment. The objective of this study was to evaluate efficacy and tolerance of dacarbazine or temozolomide in metastatic digestive NEC as post first...

journal_title：Endocrine connections

authors： Couronne T,Girot P,Hadoux J,Lecomte T,Durand A,Fine C,Vandevoorde K,Lombard-Bohas C,Walter T

更新日期：2020-06-01 00:00:00

abstract：:Islet transplantation is currently the only minimally invasive therapy available for patients with type 1 diabetes that can lead to insulin independence; however, it is limited to only a small number of patients. Although clinical procedures have improved in the isolation and culture of islets, a large number of islet...

journal_title：Endocrine connections

authors： Rojas-Canales DM,Waibel M,Forget A,Penko D,Nitschke J,Harding FJ,Delalat B,Blencowe A,Loudovaris T,Grey ST,Thomas HE,Kay TWH,Drogemuller CJ,Voelcker NH,Coates PT

更新日期：2018-03-01 00:00:00

abstract：Background:A high level of free triiodothyronine (FT3) within the reference range may be a potential metabolic risk marker. However, the relationship between different fat depots and FT3 has remained unclear. Objective:We aimed to explore the relationships between segmental fat distribution and FT3 in euthyroid middle...

journal_title：Endocrine connections

authors： Nie X,Xu Y,Ma X,Shen Y,Wang Y,Bao Y

更新日期：2019-10-01 00:00:00

abstract：:Steroid hormones play clinically important and specific regulatory roles in the development, growth, metabolism, reproduction and brain function in human. The type 1 and 2 11-beta hydroxysteroid dehydrogenase enzymes (11β-HSD1 and 2) have key roles in the pre-receptor modification of glucocorticoids allowing aldostero...

journal_title：Endocrine connections

authors： Bird AD,Greatorex S,Reser D,Lavery GG,Cole TJ

更新日期：2017-10-01 00:00:00

abstract：:Few data are available on the association between serum lipids and insulin secretion (ISEC) in children. We evaluated the association of triglycerides (TG), HDL cholesterol (HDL-C) and LDL cholesterol (LDL-C) with ISEC in 1150 non-diabetic obese children and adolescents using multivariable robust median regression. Th...

journal_title：Endocrine connections

authors： Bedogni G,Mari A,De Col A,Tamini S,Gastaldelli A,Sartorio A

更新日期：2019-10-01 00:00:00

abstract：:Thyroid hormones stimulate bone turnover in adults by increasing osteoclastic bone resorption. TSH suppressive therapy is usually applied in patients with differentiated thyroid cancer (DTC) to improve the disease outcome. Over the last decades several authors have closely monitored the potential harm suffered by the ...

journal_title：Endocrine connections

authors： Brancatella A,Marcocci C

更新日期：2020-07-01 00:00:00

abstract：:The genetic aetiology of congenital hypopituitarism (CH) is not entirely elucidated. FGFR1 and PROKR2 loss-of-function mutations are classically involved in hypogonadotrophic hypogonadism (HH), however, due to the clinical and genetic overlap of HH and CH; these genes may also be involved in the pathogenesis of CH. Us...

journal_title：Endocrine connections

authors： Correa FA,Trarbach EB,Tusset C,Latronico AC,Montenegro LR,Carvalho LR,Franca MM,Otto AP,Costalonga EF,Brito VN,Abreu AP,Nishi MY,Jorge AA,Arnhold IJ,Sidis Y,Pitteloud N,Mendonca BB

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:Little is known about how women with isolated GnRH deficiency cope with their condition. This study aimed to examine the health and informational needs of women with congenital hypogonadotropic hypogonadism (CHH) and evaluate if their experiences differ from women with more common forms of infertility. DESIG...

journal_title：Endocrine connections

authors： Dzemaili S,Tiemensma J,Quinton R,Pitteloud N,Morin D,Dwyer AA

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:Insulin-like growth factors are implicated in the development of diabetic nephropathy. IGF-binding protein 2 (IGFBP2) and IGF2 are expressed in the kidney, but their associations with diabetic nephropathy are unclear. We therefore tested the hypothesis that circulating levels of IGF2 and IGFBP2 predict longit...

journal_title：Endocrine connections

authors： Narayanan RP,Fu B,Heald AH,Siddals KW,Oliver RL,Hudson JE,Payton A,Anderson SG,White A,Ollier WE,Gibson JM

更新日期：2012-10-24 00:00:00

abstract：:The purpose of this study was to assess the relationship between vitamin D receptor gene (VDR) expression and prognostic factors in papillary thyroid cancer (PTC). mRNA sequencing and somatic mutation data from The Cancer Genome Atlas (TCGA) were analyzed. VDR mRNA expression was compared to clinicopathologic variable...

journal_title：Endocrine connections

authors： Choi JY,Yi JW,Lee JH,Song RY,Yu H,Kwon H,Chai YJ,Kim SJ,Lee KE

更新日期：2017-04-01 00:00:00

abstract：:Chemerin is a recently discovered adipokine with inflammatory and metabolic actions relevant for chronic disease development. However, evidence from human research on the role of chemerin in chronic disease risk is still lacking. We assessed the reliability of plasma chemerin concentrations measured on two occasions o...

journal_title：Endocrine connections

authors： Eichelmann F,Weikert C,di Giuseppe R,Biemann R,Isermann B,Schulze MB,Boeing H,Aleksandrova K

更新日期：2017-07-01 00:00:00

abstract：:Hormonal changes during pregnancy can trigger gestational diabetes (GDM), which is constantly increasing. Its main characteristic is pronounced insulin resistance, but it appears to be a multifactorial process involving several metabolic factors; taken together, the latter leads to silent or clinically evident cardiov...

journal_title：Endocrine connections

authors： Patti AM,Pafili K,Papanas N,Rizzo M

更新日期：2018-05-01 00:00:00

abstract：:Hypercalcemic crisis is a severe but rare complication of primary hyperparathyroidism (PHPT), and data on denosumab treatment of patients with this disease is still very limited. The aim of this paper is to investigate the hypocalcemic effect of denosumab in PHPT patients with severe hypercalcemia when surgery should ...

journal_title：Endocrine connections

authors： Eremkina A,Krupinova J,Dobreva E,Gorbacheva A,Bibik E,Samsonova M,Ajnetdinova A,Mokrysheva N

更新日期：2020-10-01 00:00:00

abstract：INTRODUCTION AND AIM:Ectopic ACTH secretion (EAS) is mostly secondary to thoracic/abdominal neuroendocrine tumours (NETs), or small cell-lung carcinoma (SCLC). We studied the diagnostic accuracy of computed tomography (CT) with 68Ga-Dota derivatives (68Ga-SSTR) positron emission tomography (PET) in localizing ACTH-secr...

journal_title：Endocrine connections

authors： Ceccato F,Cecchin D,Gregianin M,Ricci G,Campi C,Crimì F,Bergamo M,Versari A,Lacognata C,Rea F,Barbot M,Scaroni C

更新日期：2020-03-01 00:00:00

abstract：:Classic galactosemia is a rare inborn error of galactose metabolism with a birth prevalence of about 1/30 000-60 000. Long-term complications occurring despite dietary treatment consist of premature ovarian insufficiency (POI) and neurodevelopmental impairments. We performed with the French Reference Centers for Rare ...

journal_title：Endocrine connections

authors： Flechtner I,Viaud M,Kariyawasam D,Perrissin-Fabert M,Bidet M,Bachelot A,Touraine P,Labrune P,De Lonlay P,Polak M,Galactosemia Study Group GSG

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:Chromogranin A (CgA) and neuron-specific enolase (NSE) are important markers for neuroendocrine tumors; however, the clinical value of combining these markers has not been well studied. In this study, we investigated the utility of each marker individually and in combination for patients with nonfunctional panc...

journal_title：Endocrine connections

authors： Lv Y,Han X,Zhang C,Fang Y,Pu N,Ji Y,Wang D,Xuefeng X,Lou W

更新日期：2018-01-01 00:00:00

abstract：:B lymphocytes are the source of autoantibodies against the thyroid-stimulating hormone receptor (TSHR) in Graves' disease (GD). Characterization of autoimmune B-cell expression profiles might enable a better understanding of GD pathogenesis. To reveal this, the expression levels of long noncoding RNAs (lncRNAs) and mR...

journal_title：Endocrine connections

authors： Jiang X,Wang Y,Li X,He L,Yang Q,Wang W,Liu J,Zha B

更新日期：2020-05-01 00:00:00

abstract：CONTEXT:Women with polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease (CVD), and biomarkers can be used to detect early subclinical CVD. Midregional-pro-adrenomedullin (MR-proADM), midregional-pro-atrial natriuretic peptide (MR-proANP) and copeptin are all associated with CVD and part of ...

journal_title：Endocrine connections

authors： Frøssing S,Nylander M,Kistorp C,Skouby SO,Faber J

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Recently, mutations in KCNQ1, a potassium channel gene usually linked to long QT syndrome, were reported to cause maternally inherited gingival fibromatosis and growth hormone deficiency (GHD). Expression of the mutated KCNQ1 with the auxiliary potassium channel subunit KCNE2 was shown to reduce pituitary hor...

journal_title：Endocrine connections

authors： Iivonen AP,Känsäkoski J,Karppinen A,Kivipelto L,Schalin-Jäntti C,Karhu A,Raivio T

更新日期：2018-05-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is known to be associated with insulin resistance, atherosclerosis, and low serum IGF1 levels. We have described a large cohort of patients with isolated GH deficiency (IGHD) due to the c.57+1G→A mutation in the GHRH receptor gene. These subjects have increased insulin sensitiv...

journal_title：Endocrine connections

authors： Diniz RD,Souza RM,Salvatori R,Franca A,Gomes-Santos E,Ferrão TO,Oliveira CR,Santana JA,Pereira FA,Barbosa RA,Souza AH,Pereira RM,Oliveira-Santos AA,Silva AM,Santana-Júnior FJ,Valença EH,Campos VC,Aguiar-Oliveira MH

更新日期：2014-09-01 00:00:00

abstract：:Acromegaly is a rare disease due to chronic excess growth hormone (GH) and IGF-1. Aryl hydrocarbon receptor interacting protein (AIP) mutations are associated with an aggressive, inheritable form of acromegaly that responds poorly to SST2-specific somatostatin analogs (SSA). The role of pasireotide, an SSA with affini...

journal_title：Endocrine connections

authors： Daly AF,Rostomyan L,Betea D,Bonneville JF,Villa C,Pellegata NS,Waser B,Reubi JC,Waeber Stephan C,Christ E,Beckers A

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Primary aldosteronism (PA) is associated with increased cardiovascular morbidity, presumably due to left ventricular (LV) hypertrophy and fibrosis. However, the degree of fibrosis has not been extensively studied. Cardiac magnetic resonance imaging (CMR) contrast enhancement and novel sensitive T1 mapping to...

journal_title：Endocrine connections

authors： Grytaas MA,Sellevåg K,Thordarson HB,Husebye ES,Løvås K,Larsen TH

更新日期：2018-03-01 00:00:00

abstract：:Failure to suppress testosterone below 0.7 nM in castrated prostate cancer patients is associated with poor clinical outcomes. Testosterone levels in castrated patients are therefore routinely measured. Although mass spectrometry is the gold standard used to measure testosterone, most hospitals use an immunoassay meth...

journal_title：Endocrine connections

authors： Rouleau M,Lemire F,Déry M,Thériault B,Dubois G,Fradet Y,Toren P,Guillemette C,Lacombe L,Klotz L,Saad F,Guérette D,Pouliot F

更新日期：2019-02-01 00:00:00

abstract：:Insufficient insulin release plays a crucial role in the development of unhealthy status in patients with obesity; the present study aimed to classify these patients by the indices for insulin resistance and insulin release. After the indices from OGTT were assessed to achieve high differentiability and low redundancy...

journal_title：Endocrine connections

authors： Li L,Song Q,Yang X

更新日期：2020-02-01 00:00:00

abstract：:The vasoactive intestinal peptide receptor 2 (VPAC2) is widely distributed throughout the body and is also overexpressed in a variety of human neoplastic tissues. However, little is known about its precise tissue distribution, regulation and function, which is in part be due to the lack of specific monoclonal anti-VPA...

journal_title：Endocrine connections

authors： Schulz S,Mann A,Novakhov B,Piggins HD,Lupp A

更新日期：2015-03-01 00:00:00

abstract：:Many biomarkers are associated with type 2 diabetes (T2D) risk in epidemiological observations. The aim of this study was to identify and summarize current evidence for causal effects of biomarkers on T2D. A systematic literature search in PubMed and EMBASE (until April 2015) was done to identify Mendelian randomizati...

journal_title：Endocrine connections

authors： Abbasi A

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:The Institute of Medicine 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D specified higher intakes for all age groups compared to the 1997 report, but also cautioned against spurious claims about an epidemic of vitamin D deficiency and against advocates of higher intake requirements. Over ...

journal_title：Endocrine connections

authors： McKenna MJ,Murray BF,O'Keane M,Kilbane MT

更新日期：2015-09-01 00:00:00

abstract：:Sex development is a process under genetic control directing both the bi-potential gonads to become either a testis or an ovary, and the consequent differentiation of internal ducts and external genitalia. This complex series of events can be altered by a large number of genetic and non-genetic factors. Disorders of s...

journal_title：Endocrine connections

authors： Laino L,Majore S,Preziosi N,Grammatico B,De Bernardo C,Scommegna S,Rapone AM,Marrocco G,Bottillo I,Grammatico P

更新日期：2014-12-01 00:00:00

abstract：:Tumor cells require large amounts of energy to sustain growth. Through the mediated transport of glucose transporters, the uptake and utilization of glucose by tumor cells are significantly enhanced in the hypoxic microenvironment. Pituitary adenomas are benign tumors with high-energy metabolisms. We aimed to investig...

journal_title：Endocrine connections

authors： Mei T,Zhang J,Wei L,Qi X,Ma Y,Liu X,Chen S,Li S,Wu J,Wang S

更新日期：2018-12-01 00:00:00

abstract：:The PI3K-Akt-mTOR pathway plays a central role in the development of non-medullary thyroid carcinoma (NMTC). Although somatic mutations have been identified in these genes in NMTC patients, the role of germline variants has not been investigated. Here, we selected frequently occurring genetic variants in AKT1, AKT2, A...

journal_title：Endocrine connections

authors： Crezee T,Petrulea M,Piciu D,Jaeger M,Smit JWA,Plantinga TS,Georgescu CE,Netea-Maier R

更新日期：2020-11-01 00:00:00