Abstract：
:Cholinergic neurons in the central nervous system play a vital role in higher brain functions, such as learning and memory. Choline is essential for the synthesis of the neurotransmitter acetylcholine by cholinergic neurons. The synthesis and metabolism of acetylcholine are important mechanisms for regulating neuronal activity. Choline is a positively charged quaternary ammonium compound that requires transporters to pass through the plasma membrane. Currently, there are three groups of choline transporters with different characteristics, such as affinity for choline, tissue distribution, and sodium dependence. They include (I) polyspecific organic cation transporters (OCT1-3: SLC22A1-3) with a low affinity for choline, (II) high-affinity choline transporter 1 (CHT1: SLC5A7), and (III) choline transporter-like proteins (CTL1-5: SLC44A1-5). Brain microvascular endothelial cells, which comprise part of the blood-brain barrier, take up extracellular choline via intermediate-affinity choline transporter-like protein 1 (CTL1) and low-affinity CTL2 transporters. CTL2 is responsible for excreting a high concentration of choline taken up by the brain microvascular endothelial cells on the brain side of the blood-brain barrier. CTL2 is also highly expressed in mitochondria and may be involved in the oxidative pathway of choline metabolism. Therefore, CTL1- and CTL2-mediated choline transport to the brain through the blood-brain barrier plays an essential role in various functions of the central nervous system by acting as the rate-limiting step of cholinergic neuronal activity.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Inazu Mdoi
10.3390/nu11102265subject
Has Abstractpub_date
2019-09-20 00:00:00issue
10issn
2072-6643pii
nu11102265journal_volume
11pub_type
杂志文章相关文献
Nutrients文献大全abstract：:Folate deficiency is strongly associated with cardiovascular disease. We aimed to explore the joint effect of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MTR) A2756G, and methionine synthase reductase (MTRR) A66G polymorphisms on folate deficiency in a Chinese hypertensive po...
journal_title：Nutrients
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.3390/nu7085303
更新日期：2015-08-10 00:00:00
abstract：:Vascular disease poses a major public health problem worldwide. Trigonelline isolated from Raphanus sativus cv. Sakurajima Daikon (Sakurajima radish) induces nitric oxide production from vascular endothelial cells and enhances vascular function. Here, we investigated the characteristics of trigonelline and its effects...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061872
更新日期：2020-06-23 00:00:00
abstract：:The aim of this study was a large-scale ecological analysis of nutritional and other environmental factors potentially associated with the incidence of cardiovascular diseases (CVDs) in the global context. Indicators of CVDs from 158 countries were compared with the statistics of mean intake (supply) of 60 food items ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10040411
更新日期：2018-03-26 00:00:00
abstract：:Evidence from numerous observational and clinical studies suggest that polyphenolic phytochemicals such as phenolic acids in olive oil, flavonols in tea, chocolate and grapes, and isoflavones in soy products reduce the risk of breast cancer. A dietary food pattern naturally rich in polyphenols is the Mediterranean die...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu8090547
更新日期：2016-09-06 00:00:00
abstract：:The Eastern Mediterranean region is characterized by one of the highest burdens of paediatric obesity worldwide. This study aims at examining dietary, lifestyle, and socio-economic correlates of overweight, obesity, and abdominal adiposity amongst children and adolescents in Lebanon, a country of the Eastern Mediterra...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu6031038
更新日期：2014-03-10 00:00:00
abstract：:Nonalcoholic fatty liver disease (NAFLD) is a hepatic ailment with a rapidly increasing incidence due to dietary hypernutrition and subsequent obesity. Fatty liver disease can lead to steatohepatitis, fibrosis, cirrhosis, and even cancer, which is associated with various complications. Discovering effective natural ma...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7042440
更新日期：2015-04-02 00:00:00
abstract：:This paper continues the systematic review on proanthocyanidins and flavan-3-ols in the prevention and treatment of periodontal disease and covers the immunomodulatory effects, and animal- and clinical studies, while the other part discussed the direct antibacterial properties. Inflammation as a major response of the ...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu13010239
更新日期：2021-01-15 00:00:00
abstract：:The human skin hosts innumerable microorganisms and maintains homeostasis with the local immune system despite the challenges offered by environmental factors such as ultraviolet radiation (UVR). UVR causes cutaneous alterations such as acute (i.e., sunburn) and chronic inflammation, tanning, photoaging, skin cancer, ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061795
更新日期：2020-06-17 00:00:00
abstract：:Qualified health claims (QHC) describe diet-disease relationships and summarize the quality and strength of evidence for a claim. Companies assert that QHCs increase sales and take legal action to ensure claims reflect their interests. Yet, there is no empirical evidence that QHCs influence consumers. Using green tea ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11040921
更新日期：2019-04-24 00:00:00
abstract：:This study examines how preconception folic acid supplement use varied in immigrant women compared with non-immigrant women. We analyzed national population-based data from Norway from 1999-2016, including 1,055,886 pregnancies, of which 202,234 and 7,965 were to 1st and 2nd generation immigrant women, respectively. F...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11102300
更新日期：2019-09-27 00:00:00
abstract：:Several recent experimental studies have investigated the effects of caffeine and chlorogenic acid (CGA), representative ingredients of coffee, on nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH). However, the results are conflicting, and their effects are yet to be clarified. In the presen...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12123886
更新日期：2020-12-18 00:00:00
abstract：:Maternal antibody transfer to the newborn provides essential support for the infant's naïve immune system. Preterm infants normally receive maternal antibodies through mother's own breast milk (MBM) or, when mothers are unable to provide all the milk required, donor breast milk (DBM). DBM is pasteurized and exposed to...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11040920
更新日期：2019-04-24 00:00:00
abstract：:Plant-based diets are associated with reduced risk of lifestyle-induced chronic diseases. The thousands of phytochemicals they contain are implicated in cellular-based mechanisms to promote antioxidant defense and reduce inflammation. While recommendations encourage the intake of fruits and vegetables, most people fal...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12102929
更新日期：2020-09-24 00:00:00
abstract：:Hyperhomocysteinemia (HHcy) is recognized as a risk factor for cardiovascular disease. However, the prevalence of HHcy and its role in association with target organ damage in patients with chronickidney disease (CKD) are not well understood. This cross-sectional study included 1042 CKD patients who were admitted to ou...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu8100645
更新日期：2016-10-20 00:00:00
abstract：:Rheumatoid arthritis (RA) is a debilitating, chronic, inflammatory, autoimmune disease associated with cachexia. The substitutive therapy of gut hormone ghrelin has been pointed at as a potential countermeasure for the management of metabolic and inflammatory complications in RA. The recent discovery of liver-expresse...
journal_title：Nutrients
pub_type： 临床试验,杂志文章
doi：10.3390/nu12041006
更新日期：2020-04-06 00:00:00
abstract：:Chronic low-grade inflammation is a primary characteristic of obesity and can lead to other metabolic complications including insulin resistance and type 2 diabetes (T2D). Several anti-inflammatory dietary bioactives decrease inflammation that accompanies metabolic diseases. We are specifically interested in delta-toc...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113356
更新日期：2020-10-30 00:00:00
abstract：:The relationship between vitamin D status, calcium intake and the risk of developing type 2 diabetes (T2D) is a topic of growing interest. One of the most interesting non-skeletal functions of vitamin D is its potential role in glucose homeostasis. This possible association is related to the secretion of insulin by pa...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11030642
更新日期：2019-03-16 00:00:00
abstract：BACKGROUND:In South Africa, the increased consumption of sugary drinks has been associated with increased obesity rates. Mass media campaigns can play a crucial role in improving knowledge, shifting attitudes, and building support for government action on reducing sugary drink consumption. No study to date has evaluate...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061878
更新日期：2020-06-23 00:00:00
abstract：:Women experience physical, mental, and social changes during menopause. It is important to maintain a healthy diet for effective menopause management. The effect of germinated Superjami, a deep violet colored rice cultivar, on the body weight, glucose level, antioxidant defense system, and bone metabolism in a menopau...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11092184
更新日期：2019-09-11 00:00:00
abstract：:Metabonomics is a well established analytical approach for the analysis of physiological regulatory processes via the metabolic profiling of biofluids and tissues in living organisms. Its potential is fully exploited in the field of "nutrimetabonomics" that aims at assessing the metabolic effects of active ingredients...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu1010101
更新日期：2009-01-01 00:00:00
abstract：:Ingestion of pure fructose stimulates de novo lipogenesis and gluconeogenesis. This may however not be relevant to typical nutritional situations, where fructose is invariably ingested with glucose. We therefore assessed the metabolic fate of fructose incorporated in a mixed meal without or with glucose in eight healt...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu6072632
更新日期：2014-07-15 00:00:00
abstract：:The Mediterranean diet has demonstrated efficacy for improving cardiovascular and cognitive health. However, a traditional Mediterranean diet delivers fewer serves of dairy and less dietary calcium than is currently recommended in Australia, which may limit long-term sustainability. The present study aims to evaluate ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9020145
更新日期：2017-02-16 00:00:00
abstract：:Vitamin C (ascorbate, ASC) is a critical antioxidant in the body with specific roles in the brain. Despite a recent interest in vitamin C therapies for critical care medicine, little is known about vitamin C regulation during acute inflammation and critical illnesses such as sepsis. Using a cecal slurry (CS) model of ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12040911
更新日期：2020-03-26 00:00:00
abstract：:Nutrition support practitioners are currently dealing with shortages of parenteral nutrition micronutrients, including multivitamins (MVI), selenium and zinc. A recent survey from the American Society of Enteral and Parenteral Nutrition (ASPEN) indicates that this shortage is having a profound effect on clinical pract...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu4121977
更新日期：2012-12-07 00:00:00
abstract：:In this prospective controlled study, we examined 25 adults with adequately controlled (HbA1c level < 8.0%) type 1 diabetes mellitus (T1DM) and 49 conditionally healthy adults, intending to reveal the diversity of vitamin D metabolism in the setting of cholecalciferol intake at a therapeutic dose. All patients receive...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12123873
更新日期：2020-12-18 00:00:00
abstract：:Bacterial vaginosis and vulvovaginal candidiasis are common causes of impaired health and quality of life for women. Although antimicrobial agents remain the main strategy for the treatment of vaginal infections, their repeated use involves high rates of resistance and recurrence. Alternative approaches such as probio...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12082211
更新日期：2020-07-24 00:00:00
abstract：:It is becoming increasingly clear that vitamin D has a broad range of actions in the human body. Besides its well-known effects on calcium/phosphate homeostasis, vitamin D influences muscle function, cardiovascular homeostasis, nervous function, and the immune response. Vitamin D deficiency/insufficiency has been asso...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu2040408
更新日期：2010-04-01 00:00:00
abstract：:In New Zealand, there is a high prevalence of childhood poverty and food insecurity, which can impact a family's ability to provide high quality, nutrient dense foods for their children. In an attempt to increase the quality of the food consumed by children attending a decile two (low socio-economic) kindergarten and ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9091031
更新日期：2017-09-18 00:00:00
abstract：BACKGROUND:Malnutrition is associated with poor outcomes in patients with cancer, heart failure and chronic kidney disease. This study aimed to investigate the predictive value of the Controlling Nutritional Status (CONUT) score in coronary artery disease (CAD) patients. METHODS:We recruited a cohort of 3118 patients ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12051295
更新日期：2020-05-02 00:00:00
abstract：:The fatty acid compositions of plasma lipids and cell membranes of certain tissues are modified by dietary fatty acid composition. Furthermore, many other factors (age, sex, ethnicity, health status, genes, and gene × diet interactions) affect the fatty acid composition of cell membranes or plasma lipid compartments. ...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu10111785
更新日期：2018-11-16 00:00:00
